James H F Rudd

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc (18)FDG PET imaging can quantify increased cellular metabolism in pulmonary arterial hypertension: A proof-of-principle study
    Guy Hagan
    Pulmonary Vascular Disease Unit, Papworth Hospital, Papworth Everard, United Kingdom
    Pulm Circ 1:448-55. 2011
  2. pmc Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    Circ Cardiovasc Imaging 2:107-15. 2009
  3. pmc Inflammation imaging in atherosclerosis
    James H F Rudd
    Division of Cardiovascular Medicine, Cambridge University, UK
    Arterioscler Thromb Vasc Biol 29:1009-16. 2009
  4. doi request reprint Imaging atherosclerotic plaque inflammation
    James H F Rudd
    Cardiovascular Medicine at Cambridge University and Addenbrooke s Hospital, Cambridge, UK
    Nat Clin Pract Cardiovasc Med 5:S11-7. 2008
  5. ncbi request reprint Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    J Nucl Med 49:871-8. 2008
  6. ncbi request reprint Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time?
    James H F Rudd
    Division of Cardiovascular Medicine, University of Cambridge, Cambridge, England
    J Am Coll Cardiol 55:2527-35. 2010
  7. pmc Relationship of serum inflammatory biomarkers with plaque inflammation assessed by FDG PET/CT: the dal-PLAQUE study
    Raphael Duivenvoorden
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York
    JACC Cardiovasc Imaging 6:1087-94. 2013
  8. ncbi request reprint FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis
    John R Davies
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Int J Cardiovasc Imaging 26:41-8. 2010
  9. pmc Regression of inflammation in atherosclerosis by the LXR agonist R211945: a noninvasive assessment and comparison with atorvastatin
    Esad Vucic
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA
    JACC Cardiovasc Imaging 5:819-28. 2012
  10. pmc Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptake
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 59:2080-8. 2012

Detail Information

Publications40

  1. pmc (18)FDG PET imaging can quantify increased cellular metabolism in pulmonary arterial hypertension: A proof-of-principle study
    Guy Hagan
    Pulmonary Vascular Disease Unit, Papworth Hospital, Papworth Everard, United Kingdom
    Pulm Circ 1:448-55. 2011
    ..Further evaluation of the impact of targeted therapies in treatment-naïve patients and the significance of right ventricular uptake is suggested...
  2. pmc Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    Circ Cardiovasc Imaging 2:107-15. 2009
    ..We also tested the hypotheses that the degree of local arterial inflammation measured by PET is correlated with the extent of systemic inflammation and presence of risk factors for vascular disease...
  3. pmc Inflammation imaging in atherosclerosis
    James H F Rudd
    Division of Cardiovascular Medicine, Cambridge University, UK
    Arterioscler Thromb Vasc Biol 29:1009-16. 2009
    ..The imaging modalities are discussed in relation to their potential use in these areas...
  4. doi request reprint Imaging atherosclerotic plaque inflammation
    James H F Rudd
    Cardiovascular Medicine at Cambridge University and Addenbrooke s Hospital, Cambridge, UK
    Nat Clin Pract Cardiovasc Med 5:S11-7. 2008
    ..We summarize several alternative imaging techniques--CT, MRI, and nuclear imaging--that are close to the clinical arena, and we provide the relative advantages of each...
  5. ncbi request reprint Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    J Nucl Med 49:871-8. 2008
    ..We also reviewed the literature on quantification methods to determine the optimal measures of arterial 18F-FDG uptake for future studies...
  6. ncbi request reprint Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time?
    James H F Rudd
    Division of Cardiovascular Medicine, University of Cambridge, Cambridge, England
    J Am Coll Cardiol 55:2527-35. 2010
    ..This review sets out the background and current and potential future applications of this emerging biomarker of cardiovascular risk, along with its limitations...
  7. pmc Relationship of serum inflammatory biomarkers with plaque inflammation assessed by FDG PET/CT: the dal-PLAQUE study
    Raphael Duivenvoorden
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York
    JACC Cardiovasc Imaging 6:1087-94. 2013
    ....
  8. ncbi request reprint FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis
    John R Davies
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Int J Cardiovasc Imaging 26:41-8. 2010
    ....
  9. pmc Regression of inflammation in atherosclerosis by the LXR agonist R211945: a noninvasive assessment and comparison with atorvastatin
    Esad Vucic
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA
    JACC Cardiovasc Imaging 5:819-28. 2012
    ..The aim of this study was to noninvasively detect the anti-inflammatory properties of the novel liver X receptor agonist R211945...
  10. pmc Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptake
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 59:2080-8. 2012
    ..In this study, the impact of noninsulin-dependent type 2 diabetes mellitus on carotid wall (18)F-fluorodeoxyglucose (FDG) uptake in patients with documented or suspected cardiovascular disease was evaluated...
  11. doi request reprint Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: reproducibility, partial volume correction, and correlation between methods
    David Izquierdo-Garcia
    Wolfson Brain Imaging Centre, University of Cambridge, Box 65, Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK
    Stroke 40:86-93. 2009
    ..We used MRI to correct carotid plaque FDG uptake for partial volume error...
  12. pmc Pioglitazone modulates vascular inflammation in atherosclerotic rabbits noninvasive assessment with FDG-PET-CT and dynamic contrast-enhanced MR imaging
    Esad Vucic
    Translational and Molecular Imaging Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    JACC Cardiovasc Imaging 4:1100-9. 2011
    ..We sought to determine the antiatherosclerotic properties of pioglitazone using multimethod noninvasive imaging techniques...
  13. doi request reprint Carotid plaque inflammation is associated with cerebral microembolism in patients with recent transient ischemic attack or stroke: a pilot study
    Ramez Reda Moustafa
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Circ Cardiovasc Imaging 3:536-41. 2010
    ..We hypothesized that microembolic signals (MES) on transcranial Doppler will be associated with carotid plaque inflammation on (18)F fluorodeoxyglucose positron-emission tomography (FDG PET) in recently symptomatic patients...
  14. pmc Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries
    Stephane S Silvera
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Atherosclerosis 207:139-43. 2009
    ....
  15. doi request reprint Quantification of inflammation within rabbit atherosclerotic plaques using the macrophage-specific CT contrast agent N1177: a comparison with 18F-FDG PET/CT and histology
    Fabien Hyafil
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Nucl Med 50:959-65. 2009
    ..In this study, we tested whether the intensity of enhancement detected with CT in the aortic wall of rabbits injected with N1177 correlated with inflammatory activity evaluated with (18)F-FDG PET/CT and macrophage density on histology...
  16. pmc Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET
    Claudia Calcagno
    FAHA, FACC, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 28:1311-7. 2008
    ..Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, to quantify inflammation expressed as plaque neovessels content in a rabbit model of atherosclerosis...
  17. pmc Prevalence and risk factors of carotid vessel wall inflammation in coronary artery disease patients: FDG-PET and CT imaging study
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 4:1195-205. 2011
    ..We investigated the prevalence and clinical risk factors of carotid vessel wall inflammation by means of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in a population consisting of coronary artery disease (CAD) patients...
  18. ncbi request reprint (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 50:892-6. 2007
    ..This study tested the near-term reproducibility of (18)fluorodeoxyglucose positron emission tomography (FDG-PET) imaging of atherosclerosis...
  19. pmc Correlation between arterial FDG uptake and biomarkers in peripheral artery disease
    Kelly S Myers
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 5:38-45. 2012
    ....
  20. pmc The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis
    Claudia Calcagno
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY, 10029, USA
    Eur J Nucl Med Mol Imaging 40:1884-93. 2013
    ..We studied the relationship between DCE-MRI and (18)F-FDG PET data from the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD risk equivalent, as a substudy of the dal-PLAQUE trial (NCT00655473)...
  21. pmc Arterial and fat tissue inflammation are highly correlated : a prospective (18)F-FDG PET/CT study
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, P O Box 1234, New York, NY, 10029, USA
    Eur J Nucl Med Mol Imaging 41:934-45. 2014
    ..18)F-FDG uptake on PET is a surrogate marker of vessel wall inflammation. The aim of the study was to measure FDG uptake in both regions using PET and identify links between adipose and arterial inflammation...
  22. pmc Optimizing 18F-FDG PET/CT imaging of vessel wall inflammation: the impact of 18F-FDG circulation time, injected dose, uptake parameters, and fasting blood glucose levels
    Jan Bucerius
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, P O Box 1234, New York, NY, 10029, USA
    Eur J Nucl Med Mol Imaging 41:369-83. 2014
    ..However, limited data are available on the impact of methodological variables, i.e. prescan fasting glucose, FDG circulation time and injected FDG dose, and of different FDG uptake parameters, in vascular FDG PET imaging...
  23. pmc Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial
    Zahi A Fayad
    Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 378:1547-59. 2011
    ..dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints...
  24. pmc Rationale and design of dal-PLAQUE: a study assessing efficacy and safety of dalcetrapib on progression or regression of atherosclerosis using magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography
    Zahi A Fayad
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am Heart J 162:214-221.e2. 2011
    ..Results are expected in 2011...
  25. pmc Predictors of change in carotid atherosclerotic plaque inflammation and burden as measured by 18-FDG-PET and MRI, respectively, in the dal-PLAQUE study
    Venkatesh Mani
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
    Int J Cardiovasc Imaging 30:571-82. 2014
    ..These findings may help determine patients most suitable for clinical trials employing plaque inflammation or burden changes as endpoints...
  26. pmc Dual-energy computed tomography imaging to determine atherosclerotic plaque composition: a prospective study with tissue validation
    Daniel R Obaid
    Division of Cardiovascular Medicine, University of Cambridge, ACCI, Hills Road, Cambridge, CB2 0QQ, UK Papworth Hospital NHS Foundation Trust, Cambridge, CB23 3RE, UK
    J Cardiovasc Comput Tomogr 8:230-7. 2014
    ..Using x-rays with differing energies alters attenuation values of these components, depending on their material composition...
  27. ncbi request reprint Multimodality imaging of atherosclerosis (magnetic resonance imaging/computed tomography/positron emission tomography-computed tomography)
    James H F Rudd
    Addenbrookes Hospital, University of Cambridge, Cambridge, UK
    Top Magn Reson Imaging 18:379-88. 2007
    ..Future directions and challenges ahead for plaque imaging are also highlighted...
  28. ncbi request reprint Radionuclide imaging for the detection of inflammation in vulnerable plaques
    John R Davies
    Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom
    J Am Coll Cardiol 47:C57-68. 2006
    ..The identification of inflamed lesions within the coronary circulation, however, remains elusive owing to small plaque size, cardiac and respiratory motion, and lack of a suitable specific nuclear tracer...
  29. pmc Feasibility of [18F]-2-Fluoro-A85380-PET imaging of human vascular nicotinic acetylcholine receptors in vivo
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 5:528-36. 2012
    ..Furthermore, potentially different vascular uptake patterns of this new tracer were evaluated in healthy volunteers and in patients with neurodegenerative disorders...
  30. ncbi request reprint Atherosclerotic plaque composition and classification identified by coronary computed tomography: assessment of computed tomography-generated plaque maps compared with virtual histology intravascular ultrasound and histology
    Daniel R Obaid
    Division of Cardiovascular Medicine, and Centre for Applied Medical Statistics, University of Cambridge, Cambridge, United Kingdom and Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom
    Circ Cardiovasc Imaging 6:655-64. 2013
    ..However, the ability of CT to discriminate individual plaque components and classify plaques according to accepted histological definitions is unknown...
  31. ncbi request reprint Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis
    Maysoon Elkhawad
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom
    JACC Cardiovasc Imaging 5:911-22. 2012
    ..This study sought to determine the effects of a p38 mitogen-activated protein kinase inhibitor, losmapimod, on vascular inflammation, by (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography imaging...
  32. ncbi request reprint Radiotracer imaging of atherosclerotic plaque biology
    Maysoon Elkhawad
    Division of Cardiovascular Medicine, Addenbrooke s Hospital, Cambridge, UK
    Cardiol Clin 27:345-54, Table of Contents. 2009
    ..This article discusses several radiotracers that can report on high-risk plaque pathophysiology...
  33. ncbi request reprint Imaging endothelin ET(B) receptors using [18F]-BQ3020: in vitro characterization and positron emission tomography (microPET)
    Peter Johnström
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Centre for Clinical Investigation, Level 6, Box 110, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Exp Biol Med (Maywood) 231:736-40. 2006
    ..Furthermore, in vitro data suggest that [18F]-BQ3020 potentially can be used to image atherosclerotic lesions in vivo using PET...
  34. doi request reprint Anti-tumor necrosis factor-α therapy reduces aortic inflammation and stiffness in patients with rheumatoid arthritis
    Kaisa M Maki-Petaja
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circulation 126:2473-80. 2012
    ..We hypothesized that patients with RA exhibit aortic inflammation, which can be reversed with anti-tumor necrosis factor-α therapy and correlates with aortic stiffness reduction...
  35. pmc Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage
    Zhongzhao Teng
    University Department of Radiology, University of Cambridge, UK
    Atherosclerosis 223:321-6. 2012
    ..Local mechanical environments around neovessels and their relevant pathophysiologic significance have not yet been examined...
  36. doi request reprint FDG PET imaging and cardiovascular inflammation
    Nadine Hiari
    University of Cambridge, Addenbrooke s Hospital, England, UK
    Curr Cardiol Rep 13:43-8. 2011
    ..This review discusses the rationale, utility, potential future applications, and limitations of this emerging biomarker of cardiovascular risk...
  37. ncbi request reprint Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging
    John R Davies
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Stroke 36:2642-7. 2005
    ..In this study, plaque inflammation was quantified before endarterectomy using the combination of 18F fluorodeoxyglucose positron (FDG)-emission tomography (PET) and high-resolution MRI (HRMRI)...
  38. ncbi request reprint PET imaging of inflammation in atherosclerosis
    Jason M Tarkin
    Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke s Centre for Cardiovascular Investigation, Hills Road, Cambridge CB2 2QQ, UK
    Nat Rev Cardiol 11:443-57. 2014
    ..These tracers are designed to track inflammation, hypoxia, neoangiogenesis, or active calcification, which are all precursors to plaque rupture and its clinical sequelae. ..
  39. doi request reprint Non-invasive imaging of atherosclerosis
    Francis R Joshi
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Eur Heart J Cardiovasc Imaging 13:205-18. 2012
    ..Each modality alone has positives and negatives and this review will highlight these, as well as speculating on future developments in this area...
  40. ncbi request reprint Simvastatin and plaque inflammation
    James H F Rudd
    J Am Coll Cardiol 49:1991; author reply 1991-2. 2007