David T Rubin

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease
    Dermot P B McGovern
    Thw Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK
    Hum Mol Genet 14:1245-50. 2005
  2. ncbi To test or "NOD-2" test: what are the questions? The balanced viewpoint
    David T Rubin
    Section of Gastroenterology, Reva and David Logan Center for Inflammatory Bowel Disease, The MacLean Center for Clinical Medical Ethics, University of Chicago, Illinois, USA
    Inflamm Bowel Dis 11:510-2. 2005
  3. pmc Risks and benefits of azathioprine therapy
    D P B McGovern
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Gut 54:1055-9. 2005
  4. pmc New IBD genes?
    D McGovern
    The Wellcome Trust Centre for Human Genetics and Gastroenterology Unit, University of Oxford, UK
    Gut 54:1060-1. 2005
  5. ncbi TUCAN (CARD8) genetic variants and inflammatory bowel disease
    Dermot P B McGovern
    Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK
    Gastroenterology 131:1190-6. 2006
  6. pmc Outcome after surveillance of low-grade and indefinite dysplasia in patients with ulcerative colitis
    Joel R Pekow
    University of Chicago, Section of Gastroenterology, Hepatology, and Nutrition, Chicago, Illinois, USA
    Inflamm Bowel Dis 16:1352-6. 2010
  7. doi Genetic testing for inflammatory bowel disease: focus group analysis of patients and family members
    Jeffrey R Lewis
    Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
    Genet Test Mol Biomarkers 13:495-503. 2009
  8. doi The impact of ulcerative colitis on patients' lives compared to other chronic diseases: a patient survey
    David T Rubin
    Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 4076, Chicago, IL, 60637, USA
    Dig Dis Sci 55:1044-52. 2010
  9. doi Active Crohn's disease in the small bowel: evaluation by diffusion weighted imaging and quantitative dynamic contrast enhanced MR imaging
    Aytekin Oto
    Department of Radiology, The University of Chicago, Chicago, Illinois, USA
    J Magn Reson Imaging 33:615-24. 2011
  10. doi Safety and effectiveness of long-term allopurinol-thiopurine maintenance treatment in inflammatory bowel disease
    Frank Hoentjen
    Inflammatory Bowel Disease Center, University of Chicago, Chicago, Illinois, USA
    Inflamm Bowel Dis 19:363-9. 2013

Collaborators

Detail Information

Publications37

  1. ncbi Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease
    Dermot P B McGovern
    Thw Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK
    Hum Mol Genet 14:1245-50. 2005
    ..04). These findings in two independent populations provide strong evidence for a role for NOD1 variants in IBD susceptibility and reinforce the role of the innate immune system in IBD pathogenesis...
  2. ncbi To test or "NOD-2" test: what are the questions? The balanced viewpoint
    David T Rubin
    Section of Gastroenterology, Reva and David Logan Center for Inflammatory Bowel Disease, The MacLean Center for Clinical Medical Ethics, University of Chicago, Illinois, USA
    Inflamm Bowel Dis 11:510-2. 2005
  3. pmc Risks and benefits of azathioprine therapy
    D P B McGovern
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Gut 54:1055-9. 2005
    ..The increased risk could be a result of the medications, the severity of the underlying disease, or a combination of the two...
  4. pmc New IBD genes?
    D McGovern
    The Wellcome Trust Centre for Human Genetics and Gastroenterology Unit, University of Oxford, UK
    Gut 54:1060-1. 2005
  5. ncbi TUCAN (CARD8) genetic variants and inflammatory bowel disease
    Dermot P B McGovern
    Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK
    Gastroenterology 131:1190-6. 2006
    ..TUCAN (CARD8) is located beneath a CD peak of linkage on chromosome 19q. TUCAN is expressed in the gut and is a negative regulator of NFkappaB, making it an excellent candidate gene for gastrointestinal inflammation...
  6. pmc Outcome after surveillance of low-grade and indefinite dysplasia in patients with ulcerative colitis
    Joel R Pekow
    University of Chicago, Section of Gastroenterology, Hepatology, and Nutrition, Chicago, Illinois, USA
    Inflamm Bowel Dis 16:1352-6. 2010
    ..The management of low-grade (LGD) and indefinite dysplasia (IND) in patients with ulcerative colitis (UC) remains controversial, as outcomes after a diagnosis of LGD or IND in previous studies vary widely...
  7. doi Genetic testing for inflammatory bowel disease: focus group analysis of patients and family members
    Jeffrey R Lewis
    Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
    Genet Test Mol Biomarkers 13:495-503. 2009
    ..Further, preferences and concerns of patients and their family members regarding a genetic test for this condition are not well studied...
  8. doi The impact of ulcerative colitis on patients' lives compared to other chronic diseases: a patient survey
    David T Rubin
    Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 4076, Chicago, IL, 60637, USA
    Dig Dis Sci 55:1044-52. 2010
    ..Overall, 451 patients with UC, 309 with rheumatoid arthritis, 305 with asthma, and 305 with migraine headaches were recruited in an Internet survey designed to assess a variety of disease-impact indices...
  9. doi Active Crohn's disease in the small bowel: evaluation by diffusion weighted imaging and quantitative dynamic contrast enhanced MR imaging
    Aytekin Oto
    Department of Radiology, The University of Chicago, Chicago, Illinois, USA
    J Magn Reson Imaging 33:615-24. 2011
    ..To determine relative diagnostic value of MR diffusion and perfusion parameters in detection of active small bowel inflammation in patients with Crohn's disease (CD)...
  10. doi Safety and effectiveness of long-term allopurinol-thiopurine maintenance treatment in inflammatory bowel disease
    Frank Hoentjen
    Inflammatory Bowel Disease Center, University of Chicago, Chicago, Illinois, USA
    Inflamm Bowel Dis 19:363-9. 2013
    ..The aim of this study was to assess long-term maintenance effectiveness and tolerability of allopurinol-thiopurine therapy in a larger multicenter cohort of IBD patients...
  11. doi miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes
    Joel R Pekow
    Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Illinois, USA
    Inflamm Bowel Dis 18:94-100. 2012
    ..We speculated that miR-143 and miR-145 might also be downregulated and contribute to malignant transformation of colonic epithelium in longstanding ulcerative colitis (UC)...
  12. doi Association of colorectal cancer and prostate cancer and impact of radiation therapy
    Dezheng Huo
    Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    Cancer Epidemiol Biomarkers Prev 18:1979-85. 2009
    ..The decreased prostate cancer risk in men who received radiation therapy for rectal cancer may be related to the use of PSA for prostate cancer screening or the cure of occult prostate cancer...
  13. pmc Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation
    Christopher R Weber
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Lab Invest 88:1110-20. 2008
    ..We speculate that increased claudin-1 and claudin-2 expression may be involved at early stages of transformation in IBD-associated neoplasia...
  14. doi Identification of patients at increased risk for colorectal cancer in an open access endoscopy center
    Jeffrey W Nathanson
    Section of Gastroenterology, University of Chicago Medical Center, Chicago, IL 60637, USA
    J Clin Gastroenterol 42:1025-31. 2008
    ..To determine whether patients referred for open access endoscopy (OAE) are being appropriately identified as "increased risk" or "average risk" for colorectal cancer (CRC) by referring physicians...
  15. ncbi Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitis
    David T Rubin
    The Reva and David Logan Center for Research in Gastrointestinal Diseases, University of Chicago, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 4:1346-50. 2006
    ..Aminosalicylates have been suggested as chemopreventive agents for colorectal cancer (CRC) in ulcerative colitis (UC). We studied the effect of aminosalicylate use on dysplasia and CRC risk in chronic UC...
  16. doi Performance of CT colonography in clinical trials
    Jonathan A Rosenberg
    Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 4076, Chicago, IL 60637 1463, USA
    Gastrointest Endosc Clin N Am 20:193-207. 2010
    ..The data suggest that CTC is effective especially for the detection of larger lesions and when more advanced imaging technology is used...
  17. doi Low-dose smoking resumption in ex-smokers with refractory ulcerative colitis
    Emma Calabrese
    Section of Gastroenterology, Hepatology and Nutrition, University of Chicago, Chicago, IL 60637, USA
    J Crohns Colitis 6:756-62. 2012
    ..We report outcomes of ex-smokers with refractory UC who resumed low-dose cigarette smoking...
  18. pmc Fecal bacteriotherapy for ulcerative colitis: patients are ready, are we?
    Stacy A Kahn
    University of Chicago, Inflammatory Bowel Disease Center, Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, MacLean Center for Clinical Medical Ethics, Chicago, Illinois 60637, USA
    Inflamm Bowel Dis 18:676-84. 2012
    ..We performed a qualitative study to explore the attitudes and concerns of adult patients and parents of children with UC regarding FB as a potential treatment...
  19. doi Predictors of adalimumab dose escalation in patients with Crohn's disease at a tertiary referral center
    Russell D Cohen
    Inflammatory Bowel Disease Center, University of Chicago, Illinois, USA
    Inflamm Bowel Dis 18:10-6. 2012
    ..Our objective was to determine which patient-, disease-, and therapy-related factors were associated with DE in CD patients treated with ADA...
  20. ncbi Colonic infiltration with chronic myelomonocytic leukemia
    Andelka D LoSavio
    Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL 60637, USA
    Nat Clin Pract Gastroenterol Hepatol 4:229-33. 2007
    ..Over several months, the patient's symptoms progressed, which resulted in significant weight loss. The patient's course of disease was ultimately complicated by acute disseminated encephalomyelitis and death...
  21. doi Quantitative analysis of dynamic contrast enhanced MRI for assessment of bowel inflammation in Crohn's disease pilot study
    Aytekin Oto
    Department of Radiology, University of Chicago, 5841 S Maryland Avenue, MC 2026, Chicago, IL 60637, USA
    Acad Radiol 16:1223-30. 2009
    ..The aim of this study was to evaluate the feasibility of quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data in the detection of bowel inflammation in patients with Crohn's disease...
  22. doi Impact of ulcerative colitis from patients' and physicians' perspectives: Results from the UC: NORMAL survey
    David T Rubin
    Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
    Inflamm Bowel Dis 15:581-8. 2009
    ..Two national internet surveys were conducted to understand how patients perceive the impact of ulcerative colitis (UC) relative to gastroenterologists...
  23. ncbi Do patients with inflammatory bowel disease want genetic testing?
    Vani Konda
    Reva and David Logan Gastrointestinal Clinical Research Center, University of Chicago, Chicago, Illinois 60637, USA
    Inflamm Bowel Dis 12:497-502. 2006
    ..Thus, the goal of this study was to assess the interest of patients with IBD in genetic testing and their willingness to accept the uncertainty inherent in complex genetics...
  24. pmc Surveillance of dysplasia in inflammatory bowel disease: The gastroenterologist-pathologist partnership
    David T Rubin
    Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 4:1309-13. 2006
    ..We address the challenge of management of polypoid lesions and incorporate new information about degree of inflammation as an additional risk of neoplasia in these patients...
  25. doi Association between colorectal cancer and urologic cancers
    Audrey H Calderwood
    Department of Medicine, Section of Gastroenterology, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Arch Intern Med 168:1003-9. 2008
    ..We sought to quantify the risk for CRC after urologic cancer and the risk for urologic cancer after CRC in patients without known genetic syndromes...
  26. doi Curbing our enthusiasm for fecal transplantation in ulcerative colitis
    David T Rubin
    Inflammatory Bowel Disease Center, Associate Faculty, MacLean Center for Clinical Medical Ethics, University of Chicago Medicine, Chicago, Illinois, USA
    Am J Gastroenterol 108:1631-3. 2013
    ..I discuss the important observations from this study and point out that the lack of clinical efficacy and observed side effects warrant caution in the ongoing pursuit of this treatment option. ..
  27. pmc Patient perceptions of fecal microbiota transplantation for ulcerative colitis
    Stacy A Kahn
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Chicago, 5841 South Maryland Avenue, MC 4065, Chicago, IL 60637, USA
    Inflamm Bowel Dis 19:1506-13. 2013
    ..Our objective was to describe patient interest in and social concerns around FMT...
  28. pmc Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction
    Frank Hoentjen
    Inflammatory Bowel Disease Center, University of Chicago, Chicago, IL, USA
    Dig Dis Sci 57:250-3. 2012
    ....
  29. ncbi What is the most effective way to communicate results after endoscopy?
    David T Rubin
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Gastrointest Endosc 66:108-12. 2007
    ....
  30. ncbi Superior mesenteric vein thrombosis after colectomy in a patient with Crohn's disease
    Andrew S Ross
    Department of Surgery, University of Chicago, IL, USA
    Nat Clin Pract Gastroenterol Hepatol 2:281-5; quiz 1 p following 285. 2005
    ..Azathioprine was added to the treatment regimen and the patient tapered off prednisone. At this stage the patient continued to do well clinically up until presentation...
  31. ncbi Surveillance for cancer and dysplasia in inflammatory bowel disease
    David T Rubin
    Section of Gastroenterology, and the MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL 60637, USA
    Gastroenterol Clin North Am 35:581-604. 2006
    ..In meantime, existing guidelines should be emphasized and ongoing education of clinicians and patients must occur...
  32. ncbi Role of antibiotics in the management of inflammatory bowel disease: a review
    David T Rubin
    Reva and David Logan Inflammatory Bowel Disease Center, University of Chicago, Chicago, Illinois, USA
    Rev Gastroenterol Disord 5:S10-5. 2005
    ..A proposal for future therapies is provided that might include a combination therapy aimed at both a reduction in pathogenetic bacteria and immune modulation to achieve the most durable remission of disease...
  33. ncbi Fever and right upper quadrant pain in a pregnant woman at 30 weeks' gestation
    Laura E Harrell
    Section of Gastroenterology and Nutrition, University of Chicago, IL, USA
    Nat Clin Pract Gastroenterol Hepatol 1:113-6; quiz 1 p following 116. 2004
    ..Ultimately, a CT scan revealed marked thickening of the distal ileum and confirmed diagnosis of an abscess in continuity with the inflamed bowel...
  34. ncbi LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition
    Yurii S Aulchenko
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre Rotterdam, Postbus 2040, 3000 CA Rotterdam, Netherlands
    Diabetes 56:3020-6. 2007
    ..To identify the type 2 diabetes gene located at chromosome 18p11...
  35. ncbi Single-point haplotype scores telomeric to human leukocyte antigen-C give a high susceptibility major histocompatibility complex haplotype for psoriasis in a Caucasian population
    Nick Lench
    Oxagen Limited, Abingdon, Oxon, UK
    J Invest Dermatol 124:545-52. 2005
    ..53; p=0.0051). Our results give scores as high as the highest single-point scores suggesting that it is unlikely to be able to discriminate the origin of the association on this analysis on strength of association...
  36. pmc Genome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on chromosome 17
    Martin Farrall
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    PLoS Genet 2:e72. 2006
    ..The region on Chromosome 17 provides a compelling target within which to identify novel genes underlying CAD. Understanding the genetic aetiology of CAD may lead to novel preventative and/or therapeutic strategies...
  37. pmc Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26
    Susan A Treloar
    Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Melbourne, Australia
    Am J Hum Genet 77:365-76. 2005
    ..Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments...