Genomes and Genes
David T Rubin
Affiliation: University of Oxford
- Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel diseaseDermot P B McGovern
Thw Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK
Hum Mol Genet 14:1245-50. 2005..04). These findings in two independent populations provide strong evidence for a role for NOD1 variants in IBD susceptibility and reinforce the role of the innate immune system in IBD pathogenesis...
- To test or "NOD-2" test: what are the questions? The balanced viewpointDavid T Rubin
Section of Gastroenterology, Reva and David Logan Center for Inflammatory Bowel Disease, The MacLean Center for Clinical Medical Ethics, University of Chicago, Illinois, USA
Inflamm Bowel Dis 11:510-2. 2005
- Risks and benefits of azathioprine therapyD P B McGovern
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
Gut 54:1055-9. 2005..The increased risk could be a result of the medications, the severity of the underlying disease, or a combination of the two...
- New IBD genes?D McGovern
The Wellcome Trust Centre for Human Genetics and Gastroenterology Unit, University of Oxford, UK
Gut 54:1060-1. 2005
- TUCAN (CARD8) genetic variants and inflammatory bowel diseaseDermot P B McGovern
Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK
Gastroenterology 131:1190-6. 2006..TUCAN (CARD8) is located beneath a CD peak of linkage on chromosome 19q. TUCAN is expressed in the gut and is a negative regulator of NFkappaB, making it an excellent candidate gene for gastrointestinal inflammation...
- Outcome after surveillance of low-grade and indefinite dysplasia in patients with ulcerative colitisJoel R Pekow
University of Chicago, Section of Gastroenterology, Hepatology, and Nutrition, Chicago, Illinois, USA
Inflamm Bowel Dis 16:1352-6. 2010..The management of low-grade (LGD) and indefinite dysplasia (IND) in patients with ulcerative colitis (UC) remains controversial, as outcomes after a diagnosis of LGD or IND in previous studies vary widely...
- The impact of ulcerative colitis on patients' lives compared to other chronic diseases: a patient surveyDavid T Rubin
Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 4076, Chicago, IL, 60637, USA
Dig Dis Sci 55:1044-52. 2010..Overall, 451 patients with UC, 309 with rheumatoid arthritis, 305 with asthma, and 305 with migraine headaches were recruited in an Internet survey designed to assess a variety of disease-impact indices...
- Genetic testing for inflammatory bowel disease: focus group analysis of patients and family membersJeffrey R Lewis
Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
Genet Test Mol Biomarkers 13:495-503. 2009..Further, preferences and concerns of patients and their family members regarding a genetic test for this condition are not well studied...
- Active Crohn's disease in the small bowel: evaluation by diffusion weighted imaging and quantitative dynamic contrast enhanced MR imagingAytekin Oto
Department of Radiology, The University of Chicago, Chicago, Illinois, USA
J Magn Reson Imaging 33:615-24. 2011..To determine relative diagnostic value of MR diffusion and perfusion parameters in detection of active small bowel inflammation in patients with Crohn's disease (CD)...
- miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenesJoel R Pekow
Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Illinois, USA
Inflamm Bowel Dis 18:94-100. 2012..We speculated that miR-143 and miR-145 might also be downregulated and contribute to malignant transformation of colonic epithelium in longstanding ulcerative colitis (UC)...
- Association of colorectal cancer and prostate cancer and impact of radiation therapyDezheng Huo
Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
Cancer Epidemiol Biomarkers Prev 18:1979-85. 2009..The decreased prostate cancer risk in men who received radiation therapy for rectal cancer may be related to the use of PSA for prostate cancer screening or the cure of occult prostate cancer...
- Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitisDavid T Rubin
The Reva and David Logan Center for Research in Gastrointestinal Diseases, University of Chicago, Chicago, Illinois, USA
Clin Gastroenterol Hepatol 4:1346-50. 2006..Aminosalicylates have been suggested as chemopreventive agents for colorectal cancer (CRC) in ulcerative colitis (UC). We studied the effect of aminosalicylate use on dysplasia and CRC risk in chronic UC...
- Identification of patients at increased risk for colorectal cancer in an open access endoscopy centerJeffrey W Nathanson
Section of Gastroenterology, University of Chicago Medical Center, Chicago, IL 60637, USA
J Clin Gastroenterol 42:1025-31. 2008..To determine whether patients referred for open access endoscopy (OAE) are being appropriately identified as "increased risk" or "average risk" for colorectal cancer (CRC) by referring physicians...
- Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformationChristopher R Weber
Department of Pathology, University of Chicago, Chicago, IL 60637, USA
Lab Invest 88:1110-20. 2008..We speculate that increased claudin-1 and claudin-2 expression may be involved at early stages of transformation in IBD-associated neoplasia...
- Performance of CT colonography in clinical trialsJonathan A Rosenberg
Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 4076, Chicago, IL 60637 1463, USA
Gastrointest Endosc Clin N Am 20:193-207. 2010..The data suggest that CTC is effective especially for the detection of larger lesions and when more advanced imaging technology is used...
- Fecal bacteriotherapy for ulcerative colitis: patients are ready, are we?Stacy A Kahn
University of Chicago, Inflammatory Bowel Disease Center, Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, MacLean Center for Clinical Medical Ethics, Chicago, Illinois 60637, USA
Inflamm Bowel Dis 18:676-84. 2012..We performed a qualitative study to explore the attitudes and concerns of adult patients and parents of children with UC regarding FB as a potential treatment...
- Predictors of adalimumab dose escalation in patients with Crohn's disease at a tertiary referral centerRussell D Cohen
Inflammatory Bowel Disease Center, University of Chicago, Illinois, USA
Inflamm Bowel Dis 18:10-6. 2012..Our objective was to determine which patient-, disease-, and therapy-related factors were associated with DE in CD patients treated with ADA...
- Quantitative analysis of dynamic contrast enhanced MRI for assessment of bowel inflammation in Crohn's disease pilot studyAytekin Oto
Department of Radiology, University of Chicago, 5841 S Maryland Avenue, MC 2026, Chicago, IL 60637, USA
Acad Radiol 16:1223-30. 2009..The aim of this study was to evaluate the feasibility of quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data in the detection of bowel inflammation in patients with Crohn's disease...
- Impact of ulcerative colitis from patients' and physicians' perspectives: Results from the UC: NORMAL surveyDavid T Rubin
Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
Inflamm Bowel Dis 15:581-8. 2009..Two national internet surveys were conducted to understand how patients perceive the impact of ulcerative colitis (UC) relative to gastroenterologists...
- Association between colorectal cancer and urologic cancersAudrey H Calderwood
Department of Medicine, Section of Gastroenterology, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
Arch Intern Med 168:1003-9. 2008..We sought to quantify the risk for CRC after urologic cancer and the risk for urologic cancer after CRC in patients without known genetic syndromes...
- Do patients with inflammatory bowel disease want genetic testing?Vani Konda
Reva and David Logan Gastrointestinal Clinical Research Center, University of Chicago, Chicago, Illinois 60637, USA
Inflamm Bowel Dis 12:497-502. 2006..Thus, the goal of this study was to assess the interest of patients with IBD in genetic testing and their willingness to accept the uncertainty inherent in complex genetics...
- Colonic infiltration with chronic myelomonocytic leukemiaAndelka D LoSavio
Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL 60637, USA
Nat Clin Pract Gastroenterol Hepatol 4:229-33. 2007..Over several months, the patient's symptoms progressed, which resulted in significant weight loss. The patient's course of disease was ultimately complicated by acute disseminated encephalomyelitis and death...
- Surveillance of dysplasia in inflammatory bowel disease: The gastroenterologist-pathologist partnershipDavid T Rubin
Department of Medicine, University of Chicago, Chicago, Illinois, USA
Clin Gastroenterol Hepatol 4:1309-13. 2006..We address the challenge of management of polypoid lesions and incorporate new information about degree of inflammation as an additional risk of neoplasia in these patients...
- Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reductionFrank Hoentjen
Inflammatory Bowel Disease Center, University of Chicago, Chicago, IL, USA
Dig Dis Sci 57:250-3. 2012....
- What is the most effective way to communicate results after endoscopy?David T Rubin
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Gastrointest Endosc 66:108-12. 2007....
- Low-dose smoking resumption in ex-smokers with refractory ulcerative colitisEmma Calabrese
Section of Gastroenterology, Hepatology and Nutrition, University of Chicago, Chicago, IL 60637, USA
J Crohns Colitis 6:756-62. 2012..We report outcomes of ex-smokers with refractory UC who resumed low-dose cigarette smoking...
- Role of antibiotics in the management of inflammatory bowel disease: a reviewDavid T Rubin
Reva and David Logan Inflammatory Bowel Disease Center, University of Chicago, Chicago, Illinois, USA
Rev Gastroenterol Disord 5:S10-5. 2005..A proposal for future therapies is provided that might include a combination therapy aimed at both a reduction in pathogenetic bacteria and immune modulation to achieve the most durable remission of disease...
- Surveillance for cancer and dysplasia in inflammatory bowel diseaseDavid T Rubin
Section of Gastroenterology, and the MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL 60637, USA
Gastroenterol Clin North Am 35:581-604. 2006..In meantime, existing guidelines should be emphasized and ongoing education of clinicians and patients must occur...
- Superior mesenteric vein thrombosis after colectomy in a patient with Crohn's diseaseAndrew S Ross
Department of Surgery, University of Chicago, IL, USA
Nat Clin Pract Gastroenterol Hepatol 2:281-5; quiz 1 p following 285. 2005..DIAGNOSIS: Acute mesenteric ischemia secondary to superior mesenteric vein thrombosis. MANAGEMENT: Resection of necrotic bowel, antibiotics and systemic anticoagulation...
- Fever and right upper quadrant pain in a pregnant woman at 30 weeks' gestationLaura E Harrell
Section of Gastroenterology and Nutrition, University of Chicago, IL, USA
Nat Clin Pract Gastroenterol Hepatol 1:113-6; quiz 1 p following 116. 2004..DIAGNOSIS: Crohn's disease flare complicated by an intra-abdominal abscess. MANAGEMENT: Antibiotics (ceftizoxime, metronidazole and amoxicillin/clavulanate potassium), parenteral nutrition and ileocecectomy...
- LPIN2 is associated with type 2 diabetes, glucose metabolism, and body compositionYurii S Aulchenko
Department of Epidemiology and Biostatistics, Erasmus Medical Centre Rotterdam, Postbus 2040, 3000 CA Rotterdam, Netherlands
Diabetes 56:3020-6. 2007..To identify the type 2 diabetes gene located at chromosome 18p11...
- Single-point haplotype scores telomeric to human leukocyte antigen-C give a high susceptibility major histocompatibility complex haplotype for psoriasis in a Caucasian populationNick Lench
Oxagen Limited, Abingdon, Oxon, UK
J Invest Dermatol 124:545-52. 2005..53; p=0.0051). Our results give scores as high as the highest single-point scores suggesting that it is unlikely to be able to discriminate the origin of the association on this analysis on strength of association...
- Genome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on chromosome 17Martin Farrall
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
PLoS Genet 2:e72. 2006..The region on Chromosome 17 provides a compelling target within which to identify novel genes underlying CAD. Understanding the genetic aetiology of CAD may lead to novel preventative and/or therapeutic strategies...
- Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26Susan A Treloar
Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Melbourne, Australia
Am J Hum Genet 77:365-76. 2005..Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments...