J Alexandra Rowe

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia
    Helen M Kyriacou
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 150:211-8. 2006
  2. pmc Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum
    Ashfaq Ghumra
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e16414. 2011
  3. pmc Strain variation in early innate cytokine induction by Plasmodium falciparum
    R A Corrigan
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Parasite Immunol 32:512-27. 2010
  4. pmc Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes
    Nicolas Smargiasso
    Mass Spectrometry Laboratory, GIGA Research, University of Liege, Liege, Belgium
    BMC Genomics 10:362. 2009
  5. pmc Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention
    J Alexandra Rowe
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Curr Opin Hematol 16:480-7. 2009
  6. pmc Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications
    J Alexandra Rowe
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, UK
    Expert Rev Mol Med 11:e16. 2009
  7. pmc Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
    J Alexandra Rowe
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 104:17471-6. 2007
  8. ncbi request reprint Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates
    J A Rowe
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 165:6341-6. 2000
  9. pmc The role of Plasmodium falciparum var genes in malaria in pregnancy
    J A Rowe
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Microbiol 53:1011-9. 2004
  10. ncbi request reprint Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility
    J A Rowe
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
    Genes Immun 3:497-500. 2002

Collaborators

Detail Information

Publications39

  1. pmc Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia
    Helen M Kyriacou
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 150:211-8. 2006
    ..These results suggest that var genes with DBLalpha1-like domains (Group A or B/A) may be implicated in the pathogenesis of cerebral malaria, while var genes with DBLalpha0-like domains promote less virulent malaria infections...
  2. pmc Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum
    Ashfaq Ghumra
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e16414. 2011
    ..PfEMP1 is a possible target for a vaccine to induce antibodies to inhibit rosetting and prevent severe malaria...
  3. pmc Strain variation in early innate cytokine induction by Plasmodium falciparum
    R A Corrigan
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Parasite Immunol 32:512-27. 2010
    ....
  4. pmc Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes
    Nicolas Smargiasso
    Mass Spectrometry Laboratory, GIGA Research, University of Liege, Liege, Belgium
    BMC Genomics 10:362. 2009
    ..falciparum PQS in vitro...
  5. pmc Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention
    J Alexandra Rowe
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Curr Opin Hematol 16:480-7. 2009
    ....
  6. pmc Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications
    J Alexandra Rowe
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, UK
    Expert Rev Mol Med 11:e16. 2009
    ..Further research is needed to realise the untapped potential of antiadhesion adjunctive therapies, which could revolutionize the treatment of severe malaria and reduce the high mortality rate of the disease...
  7. pmc Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
    J Alexandra Rowe
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 104:17471-6. 2007
    ..falciparum rosetting. This work provides insights into malaria pathogenesis and suggests that the selective pressure imposed by malaria may contribute to the variable global distribution of ABO blood groups in the human population...
  8. ncbi request reprint Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates
    J A Rowe
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 165:6341-6. 2000
    ..falciparum isolates, and could therefore be a potential target for future therapeutic interventions to treat severe malaria...
  9. pmc The role of Plasmodium falciparum var genes in malaria in pregnancy
    J A Rowe
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Microbiol 53:1011-9. 2004
    ..This review examines the evidence for and against the involvement of var genes in placental adhesion, and considers whether the most appropriate vaccine candidates have yet been identified...
  10. ncbi request reprint Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility
    J A Rowe
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
    Genes Immun 3:497-500. 2002
    ..1, Student's t-test). The conclusions of a previous study of erythrocyte CR1 expression level and malaria susceptibility in West Africa that was based on HindIII RFLP genotyping may therefore need to be re-evaluated...
  11. ncbi request reprint Identification of a conserved Plasmodium falciparum var gene implicated in malaria in pregnancy
    J Alexandra Rowe
    Institute of Cell, Animal, and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    J Infect Dis 185:1207-11. 2002
    ..These results indicate the need for reevaluation of previous assumptions of a minimal overlap between var gene repertoires from different parasite isolates...
  12. ncbi request reprint Short report: Positive correlation between rosetting and parasitemia in Plasmodium falciparum clinical isolates
    J Alexandra Rowe
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Am J Trop Med Hyg 66:458-60. 2002
    ..001, n = 74, for 2000 study). Rosetting may enhance parasite growth and survival by facilitating invasion or promoting immune evasion, thus allowing higher parasitemia to develop and increasing the likelihood of severe malaria...
  13. ncbi request reprint Nonimmune IgM, but not IgG binds to the surface of Plasmodium falciparum-infected erythrocytes and correlates with rosetting and severe malaria
    J Alexandra Rowe
    Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom
    Am J Trop Med Hyg 66:692-9. 2002
    ..However, we could not confirm previous suggestions that infected erythrocytes are coated with nonimmune IgG, which could lead to their interaction with host Fcgamma receptors...
  14. pmc Low multiplication rates of African Plasmodium falciparum isolates and lack of association of multiplication rate and red blood cell selectivity with malaria virulence
    Anne Marie Deans
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Am J Trop Med Hyg 74:554-63. 2006
    ..This raises the possibility of differences in the mechanisms of malaria virulence between sub-Saharan Africa and Asia...
  15. pmc Platelet-mediated clumping of Plasmodium falciparum infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in African children
    Monica Arman
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Am J Trop Med Hyg 77:943-6. 2007
    ..001) but not with disease category (F(2,122) = 1.8, P = 0.17). Therefore platelet-mediated clumping in Malian P. falciparum isolates is primarily associated with high parasitemia and not with severe clinical manifestations of malaria...
  16. ncbi request reprint Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum erythrocyte membrane protein 1 domains
    Yvonne Adams
    Centre for Immunity, Infection and Evolution, Institute of Infection and Immunity, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Infect Immun 82:949-59. 2014
    ..These data show that IT4var09-expressing parasites are capable of dual interactions with both endothelial cells and uninfected erythrocytes via distinct receptor-ligand interactions. ..
  17. pmc Invasion pathways and malaria severity in Kenyan Plasmodium falciparum clinical isolates
    Anne Marie Deans
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh, UK
    Infect Immun 75:3014-20. 2007
    ..falciparum infections...
  18. pmc Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites
    Ashfaq Ghumra
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Pathog 8:e1002665. 2012
    ..The existence of shared surface epitopes amongst functionally similar disease-associated P. falciparum parasite isolates suggests that development of therapeutic interventions to prevent severe malaria is a realistic goal...
  19. pmc Nonspecific immunoglobulin M binding and chondroitin sulfate A binding are linked phenotypes of Plasmodium falciparum isolates implicated in malaria during pregnancy
    Alison M Creasey
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Infect Immun 71:4767-71. 2003
    ..We also show that a wide range of mouse monoclonal antibodies of the IgM class bind nonspecifically to CSA-selected iRBC, an important consideration in the interpretation of immunological assays performed on these parasite lines...
  20. pmc Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies
    Jean Philippe Semblat
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, UK
    Mol Biochem Parasitol 146:192-7. 2006
    ..These results show that PfEMP1 is a parasite ligand for non-immune IgM and are the first demonstration of a specific adhesive function for PfEMP1 epsilon type domains...
  21. pmc A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells
    Antoine Claessens
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 109:E1772-81. 2012
    ..58). This work describes a binding phenotype for virulence-associated group A P. falciparum erythrocyte membrane protein 1 variants and identifies targets for interventions to treat or prevent cerebral malaria...
  22. pmc Plasmodium falciparum: Rosettes do not protect merozoites from invasion-inhibitory antibodies
    Anne Marie Deans
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Kings Buildings, EH9 3JT Edinburgh, UK
    Exp Parasitol 112:269-73. 2006
    ..63, Student's t test, TM284 and R29, respectively). These results do not support the hypothesis that rosettes protect merozoites from inhibitory antibodies during invasion. The biological function of rosetting remains unknown...
  23. pmc Experimental conditions affect the outcome of Plasmodium falciparum platelet-mediated clumping assays
    Monica Arman
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Rd, Edinburgh, EH9 3JT, UK
    Malar J 7:243. 2008
    ..It is unknown whether these experimental variables affect the outcome of parasite clumping assays...
  24. pmc A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria
    Ian A Cockburn
    Institute of Cell Animal and Population Biology, Ashworth Laboratories, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 101:272-7. 2004
    ..We have therefore identified CR1 as a new malaria resistance gene and provided compelling evidence that rosetting is an important parasite virulence phenotype that should be a target for drug and vaccine development...
  25. pmc A method for positive and negative selection of Plasmodium falciparum platelet-mediated clumping parasites and investigation of the role of CD36
    Monica Arman
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e55453. 2013
    ..falciparum laboratory strains. CD36-binding is necessary but not sufficient for clumping, and the molecular differences between clumping positive and negative parasite lines responsible for the phenotype require further investigation...
  26. pmc Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria
    Patience B Tetteh-Quarcoo
    The Institute of Structural and Molecular Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e34820. 2012
    ..falciparum or for rosette disruption. Neither differences in complement-regulatory functionality, nor interactions with P. falciparum proteins tested here, appear to have driven the non-uniform geographic distribution of these alleles...
  27. pmc In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate
    Helen M Kyriacou
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Antimicrob Agents Chemother 51:1321-6. 2007
    ..The strong ability to inhibit rosetting suggests that CRDS has the potential to reduce the severe complications and mortality rates from P. falciparum malaria among African children. Our data support further clinical trials of CRDS...
  28. ncbi request reprint Plasmodium chabaudi: rosetting in a rodent malaria model
    Margaret J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Rd, Edinburgh, East Lothian, UK
    Exp Parasitol 101:121-8. 2002
    ..The molecular basis of rosetting in P. chabaudi is unknown at present, but the results suggest that the molecules involved may differ from those in human-infecting species...
  29. pmc The effect of anti-rosetting agents against malaria parasites under physiological flow conditions
    Yvonne Adams
    Institute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e73999. 2013
    ..The new flow assay is a valuable addition to the tools available to study rosetting. However, the static assay has good predictive value and remains useful as the standard screening test for rosette-disrupting interventions. ..
  30. pmc Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes
    Antoine Claessens
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Rd, Edinburgh, EH9 3JT, UK
    Malar J 10:180. 2011
    ..falciparum strains. However, many P. falciparum genomes have recently been sequenced, allowing the development of specific microarray probes for each VSA gene...
  31. ncbi request reprint A simple method for accurate quantification of complement receptor 1 on erythrocytes preserved by fixing or freezing
    I A Cockburn
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, UK
    J Immunol Methods 271:59-64. 2002
    ..Such procedures will be of particular benefit for future investigations of erythrocyte CR1 expression level and malaria susceptibility...
  32. pmc A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern
    Sue A Kyes
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, Headington, Oxford OX3 9DS, UK
    Mol Microbiol 48:1339-48. 2003
    ..Although varCSA has been shown to encode a chondroitin sulphate A (CSA)-binding PfEMP1, we find that the presence of full-length varCSA transcripts does not correlate with the CSA-binding phenotype...
  33. pmc Transcribed var genes associated with placental malaria in Malawian women
    Michael F Duffy
    Department of Medicine RMH, University of Melbourne, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Infect Immun 74:4875-83. 2006
    ..The diversity of var2csa sequences may be important for understanding immunity and for the development of vaccines for malaria during pregnancy...
  34. pmc Expression of Plasmodium falciparum genes involved in erythrocyte invasion varies among isolates cultured directly from patients
    Susana Nery
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Mol Biochem Parasitol 149:208-15. 2006
    ..Groups II and III are, respectively, characterized by high levels of Rh2b and Rh4, and are more likely to be associated with sialic acid-independent invasion...
  35. pmc Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study
    Mirjam Kaestli
    Swiss Tropical Institute, Basel, Switzerland
    J Infect Dis 193:1567-74. 2006
    ..Furthermore, parasites forming rosettes showed a significant up-regulation of var group A transcripts...
  36. ncbi request reprint Expanding the paradigms of placental malaria
    James G Beeson
    Trends Parasitol 18:145-7. 2002
  37. pmc Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
    Ashfaq Ghumra
    Institute of Genetics, Queens Medical Centre, University of Nottingham, Nottingham, England, United Kingdom
    J Immunol 181:1988-2000. 2008
    ..We have therefore shown that PfEMP1 is an Fc-binding protein of malaria parasites specific for polymeric human IgM, and that it shows functional similarities with Fc-binding proteins from pathogenic bacteria...
  38. pmc CR1 Knops blood group alleles are not associated with severe malaria in the Gambia
    P A Zimmerman
    The Center for Global Health and Diseases, Case Western Reserve University, School of Medicine, Cleveland, OH 44106 4983, USA
    Genes Immun 4:368-73. 2003
    ..Factors underlying the lack of association between Sl 2 and McC(b) with severe malaria may involve variation in CR1 expression levels...