Simon Rousseau


Affiliation: University of Dundee
Country: UK


  1. Rousseau S, Morrice N, Peggie M, Campbell D, Gaestel M, Cohen P. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J. 2002;21:6505-14 pubmed
    ..Our data suggest that LPS-induced binding of hnRNP A0 to AREs may contribute to the post-transcriptional regulation of specific mRNAs. ..
  2. Rousseau S, Peggie M, Campbell D, Nebreda A, Cohen P. Nogo-B is a new physiological substrate for MAPKAP-K2. Biochem J. 2005;391:433-40 pubmed
    ..The anisomycin-induced phosphorylation of Ser107 in HeLa cells can be prevented by 'knockdown' of MAPKAP-K2 using siRNA (small interfering RNA). Taken together, our results identify Nogo-B as a new physiological substrate of MAPKAP-K2. ..
  3. request reprint
    Rousseau S, Dolado I, Beardmore V, Shpiro N, Marquez R, Nebreda A, et al. CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway. Cell Signal. 2006;18:1897-905 pubmed
    ..These results demonstrate a general and essential role of the PAK-p38alpha MAPK-MAPKAP-K2-HSP27 signalling pathway in mediating the effects of chemotactic stimuli on cell migration. ..
  4. Rousseau S, Papoutsopoulou M, Symons A, Cook D, Lucocq J, Prescott A, et al. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. J Cell Sci. 2008;121:149-54 pubmed publisher