Peter M Rothwell

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Medical treatment in acute and long-term secondary prevention after transient ischaemic attack and ischaemic stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 377:1681-92. 2011
  2. pmc Transient isolated brainstem symptoms preceding posterior circulation stroke: a population-based study
    Nicola L M Paul
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 12:65-71. 2013
  3. doi request reprint Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford Vascular Study
    Dominic P J Howard
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, UK
    Circulation 127:2031-7. 2013
  4. doi request reprint Aspirin in prevention of sporadic colorectal cancer: current clinical evidence and overall balance of risks and benefits
    Peter M Rothwell
    Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, Oxford, OX39DU, UK
    Recent Results Cancer Res 191:121-42. 2013
  5. ncbi request reprint Increased cerebral arterial pulsatility in patients with leukoaraiosis: arterial stiffness enhances transmission of aortic pulsatility
    Alastair J S Webb
    Stroke Prevention Research Unit, University of Oxford, Oxford, UK
    Stroke 43:2631-6. 2012
  6. pmc Population-based study of capsular warning syndrome and prognosis after early recurrent TIA
    Nicola L M Paul
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Neurology 79:1356-62. 2012
  7. pmc Age- and sex-specific rates of leukoaraiosis in TIA and stroke patients: population-based study
    Michela Simoni
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, UK
    Neurology 79:1215-22. 2012
  8. doi request reprint Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1591-601. 2012
  9. doi request reprint Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1602-12. 2012
  10. pmc Five years of Trials
    Douglas G Altman
    Centre for Statistics in Medicine, Wolfson College Annexe, Linton Road, Oxford OX2 6UD, UK
    Trials 12:248. 2011

Detail Information

Publications154 found, 100 shown here

  1. doi request reprint Medical treatment in acute and long-term secondary prevention after transient ischaemic attack and ischaemic stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 377:1681-92. 2011
    ..We review the main medical treatments that should be considered for most patients with transient ischaemic attack or ischaemic stroke in the acute phase and the long term, and draw attention to recent developments...
  2. pmc Transient isolated brainstem symptoms preceding posterior circulation stroke: a population-based study
    Nicola L M Paul
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 12:65-71. 2013
    ..We aimed to assess the frequency of TNAs before vertebrobasilar ischaemic stroke...
  3. doi request reprint Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford Vascular Study
    Dominic P J Howard
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, UK
    Circulation 127:2031-7. 2013
    ..However, there have been no prospective population-based studies of incidence or outcome to inform an understanding of risk factors, strategies for prevention, or projections for future clinical service provision...
  4. doi request reprint Aspirin in prevention of sporadic colorectal cancer: current clinical evidence and overall balance of risks and benefits
    Peter M Rothwell
    Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, Oxford, OX39DU, UK
    Recent Results Cancer Res 191:121-42. 2013
    ..Updated clinical guidelines are currently awaited...
  5. ncbi request reprint Increased cerebral arterial pulsatility in patients with leukoaraiosis: arterial stiffness enhances transmission of aortic pulsatility
    Alastair J S Webb
    Stroke Prevention Research Unit, University of Oxford, Oxford, UK
    Stroke 43:2631-6. 2012
    ..In the absence of previous studies in patients with recent transient ischemic attack or stroke, we determined the associations between leukoaraiosis and aortic and middle cerebral artery stiffness and pulsatility...
  6. pmc Population-based study of capsular warning syndrome and prognosis after early recurrent TIA
    Nicola L M Paul
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Neurology 79:1356-62. 2012
    ..However, it is unclear whether all patients with multiple TIAs are at high early risk of stroke and whether treatable underlying pathologies are more prevalent in this group...
  7. pmc Age- and sex-specific rates of leukoaraiosis in TIA and stroke patients: population-based study
    Michela Simoni
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, UK
    Neurology 79:1215-22. 2012
    ..To determine any sex differences in age-specific prevalence or severity of leukoaraiosis, a marker of white matter ischemia, in population-based and clinic cohorts of TIA/stroke and in a systematic review of the literature...
  8. doi request reprint Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1591-601. 2012
    ..We established the frequency of distant metastasis in patients who developed cancer during trials of daily aspirin versus control...
  9. doi request reprint Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1602-12. 2012
    ..We studied cancer deaths in all trials of daily aspirin versus control and the time course of effects of low-dose aspirin on cancer incidence and other outcomes in trials in primary prevention...
  10. pmc Five years of Trials
    Douglas G Altman
    Centre for Statistics in Medicine, Wolfson College Annexe, Linton Road, Oxford OX2 6UD, UK
    Trials 12:248. 2011
    ..These include the publication of raw data, extended versions of previously published trial-related articles, descriptions of 'lessons learned', negative results, and educational articles regarding ethics and reporting bias...
  11. pmc Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Trials 11:85. 2010
    ..A standardized and transparent approach to HTE assessment and reporting could substantially improve clinical trial utility and interpretability...
  12. ncbi request reprint Sex difference in the effect of time from symptoms to surgery on benefit from carotid endarterectomy for transient ischemic attack and nondisabling stroke
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford, UK OX2 6HE
    Stroke 35:2855-61. 2004
    ..To determine the effect of delay to CEA on operative risk and benefit, we pooled data from the North American Symptomatic Carotid Endarterectomy Trial and the European Carotid Surgery Trial...
  13. ncbi request reprint Treating individuals 3: from subgroups to individuals: general principles and the example of carotid endarterectomy
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 365:256-65. 2005
    ....
  14. doi request reprint Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 9:469-80. 2010
    ..We aimed to investigate whether the effects of these drugs on variability in blood pressure might explain these disparities in effect on stroke risk...
  15. doi request reprint Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Lancet 375:938-48. 2010
    ....
  16. ncbi request reprint Lessons from MATCH for future randomised trials in secondary prevention of stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 364:305-7. 2004
  17. ncbi request reprint External validity of randomised controlled trials: "to whom do the results of this trial apply?"
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 365:82-93. 2005
    ..This review discusses those determinants, presents a checklist for clinicians, and makes recommendations for greater consideration of external validity in the design and reporting of RCTs...
  18. ncbi request reprint Treating individuals 2. Subgroup analysis in randomised controlled trials: importance, indications, and interpretation
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 365:176-86. 2005
    ..Formal rules for the planning, analysis, and reporting of subgroup analyses are proposed...
  19. ncbi request reprint Carotid endarterectomy for asymptomatic carotid stenosis: asymptomatic carotid surgery trial
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford OX2 6HE
    Stroke 35:2425-7. 2004
  20. ncbi request reprint Fibrinogen concentration and risk of ischemic stroke and acute coronary events in 5113 patients with transient ischemic attack and minor ischemic stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University of Oxford, UK
    Stroke 35:2300-5. 2004
    ..Fibrinogen is an independent risk factor for coronary events in population-based studies and in patients with coronary heart disease, but there is uncertainty about prediction of stroke, particularly in secondary prevention...
  21. doi request reprint Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Lancet 375:895-905. 2010
    ..We aimed to reliably establish the prognostic significance of visit-to-visit variability in blood pressure, maximum blood pressure reached, untreated episodic hypertension, and residual variability in treated patients...
  22. ncbi request reprint Does transient ischemic attack deserve emergency care?
    Peter M Rothwell
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Nat Clin Pract Neurol 2:174-5. 2006
  23. ncbi request reprint Timing of TIAs preceding stroke: time window for prevention is very short
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK
    Neurology 64:817-20. 2005
    ..Patients with TIA are at increased risk of ischemic stroke and require preventive treatment. However, clinical guidelines differ on how urgently patients should be assessed...
  24. doi request reprint Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 376:1741-50. 2010
    ..The long-term effectiveness of lower doses (75-300 mg daily) is unknown. We assessed the effects of aspirin on incidence and mortality due to colorectal cancer in relation to dose, duration of treatment, and site of tumour...
  25. ncbi request reprint Funding for practice-oriented clinical research
    Peter M Rothwell
    Stroke Prevention Research Unit, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 368:262-6. 2006
  26. ncbi request reprint Observational comparisons of different clinical services
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford OX2 6HE, UK
    Lancet 369:254-5. 2007
  27. ncbi request reprint Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 370:1432-42. 2007
    ..Our aim was to determine the effect of more rapid treatment after TIA and minor stroke in patients who are not admitted direct to hospital...
  28. ncbi request reprint Recent advances in management of transient ischaemic attacks and minor ischaemic strokes
    Peter M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet Neurol 5:323-31. 2006
    ....
  29. ncbi request reprint Current status of carotid endarterectomy and stenting for symptomatic carotid stenosis
    Peter M Rothwell
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 24:116-25. 2007
    ....
  30. ncbi request reprint Transient ischemic attacks: stratifying risk
    Peter M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, University of Oxford, Oxford, UK
    Stroke 37:320-2. 2006
  31. ncbi request reprint Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study)
    P M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 366:1773-83. 2005
    ..In the Oxford Vascular Study, we determined the comparative epidemiology of different acute vascular syndromes, their current burdens, and the potential effect of the ageing population on future rates...
  32. ncbi request reprint Prevention of stroke in patients with diabetes mellitus and the metabolic syndrome
    Peter M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 20:24-34. 2005
    ..Optimization of strategies to prevent vascular complications must be a priority, given the rapid rises in the incidence and prevalence of type 2 diabetes and the metabolic syndrome in most populations across the globe...
  33. ncbi request reprint Risk modeling to identify patients with symptomatic carotid stenosis most at risk of stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Neurol Res 27:S18-28. 2005
    ..In order to take into account all of the relevant factors, a risk prediction model is considered...
  34. doi request reprint Prognostic models
    Peter M Rothwell
    University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Pract Neurol 8:242-53. 2008
    ..This article considers how such models are best derived, and how their reliability should be assessed, drawing on examples from various different neurological disorders...
  35. doi request reprint Medical and surgical management of symptomatic carotid stenosis
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Int J Stroke 1:140-9. 2006
    ..Individual risk modelling has been shown to be useful in selecting patients with the most to gain from endarterectomy for symptomatic stenosis, although timely surgery and optimal medical treatment are of equal importance...
  36. doi request reprint Endarterectomy for symptomatic and asymptomatic carotid stenosis
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    Neurol Clin 26:1079-97, x. 2008
    ..Long-term benefit from endarterectomy for asymptomatic carotid stenosis is limited, and further research is required to identify individuals with asymptomatic stenosis who have the most to gain from surgery...
  37. ncbi request reprint A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack
    P M Rothwell
    Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Lancet 366:29-36. 2005
    ..Effective early management of patients with transient ischaemic attacks (TIA) is undermined by an inability to predict who is at highest early risk of stroke...
  38. ncbi request reprint Symptomatic and asymptomatic carotid stenosis: how, when, and who to treat?
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, United Kingdom
    Curr Atheroscler Rep 8:290-7. 2006
    ..Further research is required in order to determine the role of carotid stenting and to identify those individuals with asymptomatic stenosis who have the most to gain from intervention...
  39. doi request reprint Is intravenous recombinant plasminogen activator effective up to 4.5 h after onset of ischemic stroke?
    Peter M Rothwell
    University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Nat Clin Pract Cardiovasc Med 6:164-5. 2009
    ..Ongoing trials aim to determine whether eligibility for thrombolysis can be extended in other ways, such as to patients aged over 80 years, patients with severe stroke, or patients with lacunar stroke...
  40. ncbi request reprint Clinical trials are too often founded on poor quality pre-clinical research
    P M Rothwell
    Stroke Prevention Research Unit, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Neurol 252:1115. 2005
  41. ncbi request reprint Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study)
    P M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 363:1925-33. 2004
    ..We aimed to obtain these data...
  42. ncbi request reprint Relationship between blood pressure and stroke risk in patients with symptomatic carotid occlusive disease
    P M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford OX2 6HE UK
    Stroke 34:2583-90. 2003
    ..Therefore, we studied the effect of carotid artery disease on the relationship between blood pressure and stroke risk in patients with recent TIA or stroke...
  43. ncbi request reprint Reanalysis of the final results of the European Carotid Surgery Trial
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 34:514-23. 2003
    ..This disparity has led to inconsistent clinical recommendations but may have been due to differences between the trials in the methods of measurement of carotid stenosis and definitions of outcome events...
  44. ncbi request reprint Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 361:107-16. 2003
    ..To accurately assess the overall effect of surgery, and to increase power for secondary analyses, we pooled trial data and reassessed carotid angiograms...
  45. ncbi request reprint Cerebrovascular complications of therapeutic neck manipulation. The need for reliable data on risks and risk factors
    P M Rothwell
    Stroke Prevention Research Unit, Departrment of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    J Neurol 249:1105-6. 2002
  46. ncbi request reprint Evidence of a chronic systemic cause of instability of atherosclerotic plaques
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 355:19-24. 2000
    ....
  47. ncbi request reprint Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists' Collaborative Group
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 31:615-21. 2000
    ..We sought to determine the interrelation between plaque surface morphology, degree of carotid stenosis, and the risk of ipsilateral ischemic stroke...
  48. ncbi request reprint Low risk of ischemic stroke in patients with reduced internal carotid artery lumen diameter distal to severe symptomatic carotid stenosis: cerebral protection due to low poststenotic flow? On behalf of the European Carotid Surgery Trialists' Collaborative
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 31:622-30. 2000
    ....
  49. ncbi request reprint Critical appraisal of the design and reporting of studies of imaging and measurement of carotid stenosis
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 31:1444-50. 2000
    ..We aimed to assess the design and methods of a random sample of published studies of imaging and measurement of carotid stenosis using 9 simple criteria...
  50. ncbi request reprint Analysis of agreement between measurements of continuous variables: general principles and lessons from studies of imaging of carotid stenosis
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    J Neurol 247:825-34. 2000
    ..The advantages and disadvantages of each of the methods are discussed in a non-technical and non-mathematical manner, and illustrated using data from a study of measurement of carotid stenosis by two observers on 1001 carotid angiograms...
  51. ncbi request reprint Carotid artery disease and the risk of ischaemic stroke and coronary vascular events
    P M Rothwell
    Oxford Stroke Prevention Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 10:21-33. 2000
    ..Future studies should also determine the relationship between the various measures of carotid wall disease and the risk of stroke for the different subtypes of ischaemic stroke...
  52. ncbi request reprint Prediction of benefit from carotid endarterectomy in individual patients: a risk-modelling study. European Carotid Surgery Trialists' Collaborative Group
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 353:2105-10. 1999
    ..We investigated whether the efficacy of endarterectomy would be improved if patients with a high risk of stroke on medical treatment and a low risk of operative stroke or death could be identified...
  53. ncbi request reprint Incidence, risk factors and prognosis of stroke and TIA: the need for high-quality, large-scale epidemiological studies and meta-analyses
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Cerebrovasc Dis 16:2-10. 2003
    ..In many cases, this will require meta-analysis of detailed individual patient data from multiple independent studies...
  54. pmc High incidence and prevalence of multiple sclerosis in south east Scotland: evidence of a genetic predisposition
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, Scotland
    J Neurol Neurosurg Psychiatry 64:730-5. 1998
    ..To determine the incidence and prevalence of multiple sclerosis in the Lothian and Border Health Board Regions of south east Scotland...
  55. doi request reprint Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 377:31-41. 2011
    ..We studied deaths due to cancer during and after randomised trials of daily aspirin versus control done originally for prevention of vascular events...
  56. ncbi request reprint Effective stroke prevention in patients with symptomatic carotid stenosis
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 17:89-104. 2004
    ..Such an approach will also be useful in targeting angioplasty and stenting in patients in whom endarterectomy is not possible...
  57. doi request reprint Does blood pressure variability modulate cardiovascular risk?
    Peter M Rothwell
    University Department of Clinical Neurology, John Radcliffe Hospital, Level 6, West Wing, Headington, Oxford OX3 9DU, UK
    Curr Hypertens Rep 13:177-86. 2011
    ....
  58. pmc Clinical and angiographic predictors of stroke and death from carotid endarterectomy: systematic review
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh
    BMJ 315:1571-7. 1997
    ..To identify risk factors for operative stroke and death from carotid endarterectomy...
  59. ncbi request reprint Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 363:915-24. 2004
    ..Benefit depends on the degree of stenosis, and we aimed to see whether it might also depend on other clinical and angiographic characteristics, and on the timing of surgery...
  60. ncbi request reprint For severe carotid stenosis found on ultrasound, further arterial evaluation prior to carotid endarterectomy is unnecessary: the argument against
    Peter M Rothwell
    Radcliffe Infirmary, Stroke Prevention Research Unit, Department of Clinical Neurology, Oxford OX2 6HE, UK
    Stroke 34:1817-9; discussion 1819. 2003
  61. ncbi request reprint Reproducibility of peer review in clinical neuroscience. Is agreement between reviewers any greater than would be expected by chance alone?
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Brain 123:1964-9. 2000
    ....
  62. doi request reprint Poor performance of current prognostic scores for early risk of recurrence after minor stroke
    Arvind Chandratheva
    Department of Clinical Neurology, University of Oxford, on behalf of the Oxford Vascular Study, Stroke Prevention Research Unit, Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Stroke 42:632-7. 2011
    ..The early risk of recurrence after minor stroke is as high but the only validated prognostic scores for use in minor stroke predict long-term risk of recurrence: the Essen Stroke Risk Score and the Stroke Prognosis Instrument II...
  63. doi request reprint Leukoaraiosis on MRI in patients with minimally symptomatic obstructive sleep apnoea
    Ursula G Schulz
    Stroke Prevention Research Unit, Nuffield Department of Neurosciences, John Radcliffe Hospital, Oxford, UK
    Cerebrovasc Dis 35:363-9. 2013
    ..It may therefore also be associated with a higher risk of developing leukoaraiosis. Only few data about the prevalence of leukoaraiosis in patients with OSA, and any association between degrees of severity of either condition, exist...
  64. doi request reprint Population-based study of disability and institutionalization after transient ischemic attack and stroke: 10-year results of the Oxford Vascular Study
    Ramon Luengo-Fernandez
    From the Nuffield Department of Population Health, Health Economics Research Centre, University of Oxford, United Kingdom R L F, A M G and Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom N L M P, S T P, L M B, S J V W, F C C, P M R
    Stroke 44:2854-61. 2013
    ..We evaluated the impact of TIA and stroke on disability and institutionalization over 5 years using data from a population-based study...
  65. doi request reprint Hospitalization resource use and costs before and after TIA and stroke: results from a population-based cohort study (OXVASC)
    Ramon Luengo-Fernandez
    Department of Public Health, Health Economics Research Centre, University of Oxford, Oxford, UK
    Value Health 16:280-7. 2013
    ....
  66. doi request reprint Feasibility, safety and cost of outpatient management of acute minor ischaemic stroke: a population-based study
    Nicola L M Paul
    Nuffield Department of Clinical Neurosciences, Stroke Prevention Research Unit, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 84:356-61. 2013
    ..Outpatient management safely and effectively prevents early recurrent stroke after transient ischaemic attack (TIA), but this approach may not be safe in patients with acute minor stroke...
  67. ncbi request reprint Population-based study of determinants of initial secondary care costs of acute stroke in the United Kingdom
    Ramon Luengo-Fernandez
    Health Economics Research Centre, University of Oxford, Oxford, UK
    Stroke 37:2579-87. 2006
    ..However, very few such data are available and none from population-based studies. We determined the predictors of resource use and acute care costs of stroke using data from a population-based study...
  68. ncbi request reprint Family history of stroke does not predict risk of stroke after transient ischemic attack
    Enrico Flossmann
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
    Stroke 37:544-6. 2006
    ....
  69. doi request reprint Critical cap thickness and rupture in symptomatic carotid plaques: the oxford plaque study
    Jessica N Redgrave
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, UK
    Stroke 39:1722-9. 2008
    ..While a cap thickness <65 microm is the accepted definition of rupture-prone plaque in the coronary circulation, the threshold value for carotid plaques is unknown...
  70. doi request reprint Substantial observer variability in the differentiation between primary intracerebral hemorrhage and hemorrhagic transformation of infarction on CT brain imaging
    Caroline E Lovelock
    Stroke Prevention Research Unit, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Stroke 40:3763-7. 2009
    ..Interobserver reliability in distinguishing hemorrhagic transformation of infarction from intracerebral hemorrhage may depend on delays to CT but has not been reported previously despite the clinical importance of this distinction...
  71. ncbi request reprint Potential consequences for recruitment, power, and external validity of requirements for additional risk factors for eligibility in randomized controlled trials in secondary prevention of stroke
    Sally C Howard
    Department of Clinical Neurology, University of Oxford, United Kingdom
    Stroke 37:209-15. 2006
    ..To increase the number of outcome events, and hence statistical power, some recent stroke prevention trials have required additional vascular risk factors for eligibility...
  72. ncbi request reprint Family history of stroke in patients with transient ischemic attack in relation to hypertension and other intermediate phenotypes
    Enrico Flossmann
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 36:830-5. 2005
    ..Specifically, there are no reliable data on the associations of FHx(stroke) in patients with transient ischemic attack (TIA) in whom relationships with IPs are likely to be determined most reliably...
  73. doi request reprint Lack of reproducibility of assessment of aspirin responsiveness by optical aggregometry and two platelet function tests
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Oxford, UK
    Platelets 19:119-24. 2008
    ..Lack of consistency over time in identification of apparently non-responsiveness individuals is likely to substantially undermine any ability of these tests to predict risk of recurrent vascular events...
  74. doi request reprint Relative familial clustering of cerebral versus coronary ischemic events
    Amitava Banerjee
    Stroke Prevention Research Unit, University of Oxford, United Kingdom
    Circ Cardiovasc Genet 4:390-6. 2011
    ..Differences in heritability of transient ischemic attack and ischemic stroke versus acute coronary syndromes (ACS) may inform risk prediction, genetic studies, and understanding of disease mechanisms...
  75. ncbi request reprint Asymptomatic carotid stenosis: what to do
    Jessica N Redgrave
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, UK
    Curr Opin Neurol 20:58-64. 2007
    ..Patients with asymptomatic carotid stenosis are at increased vascular risk but optimal treatment is controversial. We reviewed the current evidence for medical and surgical intervention in these patients...
  76. ncbi request reprint The need for emergency treatment of transient ischemic attack and minor stroke
    Matthew F Giles
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK
    Expert Rev Neurother 5:203-10. 2005
    ....
  77. ncbi request reprint Differences in vascular risk factors between etiological subtypes of ischemic stroke: importance of population-based studies
    U G R Schulz
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford OX2 6HE UK
    Stroke 34:2050-9. 2003
    ..If risk factors differ between patients who are admitted and those who are not, then case-control studies will be biased. If the likelihood of admission also depends on stroke subtype, then case-case comparisons may also be biased...
  78. ncbi request reprint Clinical and radiographic risk factors for operative stroke and death in the European carotid surgery trial
    R Bond
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford, UK
    Eur J Vasc Endovasc Surg 23:108-16. 2002
    ..The surgical arm of the European Carotid Surgery Trial (ECST) is such a cohort...
  79. doi request reprint ABCD2 score predicts severity rather than risk of early recurrent events after transient ischemic attack
    Arvind Chandratheva
    Stroke Prevention Research Unit, Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, England
    Stroke 41:851-6. 2010
    ..Do patients with high scores also have more severe early recurrent strokes, perhaps further justifying hospital admission? Do patients with low scores have a low early risk of recurrent TIA as well as recurrent stroke?..
  80. doi request reprint Reliability of clinical diagnosis of the symptomatic vascular territory in patients with recent transient ischemic attack or minor stroke
    Enrico Flossmann
    FRCP, Stroke Prevention Research Unit, University Department of Clinical Neurology, Level 6, West Wing, The John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Stroke 39:2457-60. 2008
    ..However, there are few published data on the accuracy of clinical assessment of the vascular territory...
  81. ncbi request reprint Medium-term variability of blood pressure and potential underdiagnosis of hypertension in patients with previous transient ischemic attack or minor stroke
    Robert L Cuffe
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, England
    Stroke 37:2776-83. 2006
    ..The extent of medium-term variability in BP is most marked in patients with a previous transient ischemic attack (TIA) or stroke. We studied the potential impact of this variability on the likely recognition of hypertension...
  82. ncbi request reprint Long-term durability of carotid endarterectomy for symptomatic stenosis and risk factors for late postoperative stroke
    E J Cunningham
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 33:2658-63. 2002
    ..To determine the long-term risk of stroke after CEA and to identify risk factors, we studied patients in the European Carotid Study Trial (ECST), the largest published cohort with long-term follow-up by physicians after CEA...
  83. ncbi request reprint Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies
    J K Lovett
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Neurology 62:569-73. 2004
    ..To study the early risk of recurrent stroke by etiologic subtype...
  84. ncbi request reprint Very early risk of stroke after a first transient ischemic attack
    J K Lovett
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford OX2 6HE UK
    Stroke 34:e138-40. 2003
    ..We used data from the Oxford Community Stroke Project (OCSP) to estimate the very early stroke risk after a TIA and investigated the potential effects of the delays before specialist assessment...
  85. ncbi request reprint Variation in surgical and anaesthetic technique and associations with operative risk in the European carotid surgery trial: implications for trials of ancillary techniques
    R Bond
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford, UK
    Eur J Vasc Endovasc Surg 23:117-26. 2002
    ..To assess the potential for further trials, we studied the variation in use of these techniques by surgeon and by country in the European Carotid Surgery Trial (ECST)...
  86. ncbi request reprint Effect of nonoptimal imaging on the relationship between the measured degree of symptomatic carotid stenosis and risk of ischemic stroke
    R L Cuffe
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 37:1785-91. 2006
    ..However, there are very few published data on the extent to which predictive power varies with type of CAA or the number and quality of views of the stenosis obtained...
  87. pmc Long term risks of stroke, myocardial infarction, and vascular death in "low risk" patients with a non-recent transient ischaemic attack
    T G Clark
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 74:577-80. 2003
    ..However, the majority of patients survive for many years after a TIA, and the need for continued preventive treatment to lower vascular risk will need to be reassessed at a later date...
  88. ncbi request reprint A systematic review of the associations between age and sex and the operative risks of carotid endarterectomy
    R Bond
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 20:69-77. 2005
    ..However, it is uncertain whether these trial-based observations are generalisable to routine clinical practice...
  89. doi request reprint The SCAN rule: a clinical rule to reduce CT misdiagnosis of intracerebral haemorrhage in minor stroke
    C E Lovelock
    University Department of Clinical Neurosciences, Stroke Prevention Research Unit, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 81:271-5. 2010
    ..A clinical rule is needed to identify patients who are likely to have intracerebral haemorrhage (ICH) and require urgent brain imaging and patients who can safely start antiplatelet agents before scanning...
  90. ncbi request reprint Population-based study of delays in carotid imaging and surgery and the risk of recurrent stroke
    J F Fairhead
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Neurology 65:371-5. 2005
    ..Benefit from carotid endarterectomy is greatest when performed within 2 weeks of a presenting TIA or stroke and decreases rapidly thereafter...
  91. ncbi request reprint Screening for aspirin responsiveness after transient ischemic attack and stroke: comparison of 2 point-of-care platelet function tests with optical aggregometry
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Oxford, UK
    Stroke 36:1001-5. 2005
    ..However, there are very few data on whether the different tests produce consistent results. We therefore compared 2 POC tests (PFA-100 device and the Ultegra-RPFA [RPFA]) with conventional light transmission aggregometry (LTA)...
  92. ncbi request reprint Direct assessment of completeness of ascertainment in a stroke incidence study
    A J Coull
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, UK
    Stroke 35:2041-5. 2004
    ..We report the first use of direct methods to determine the completeness of different ascertainment strategies in a population-based stroke incidence study (Oxford Vascular Study)...
  93. ncbi request reprint Regression dilution of systolic and diastolic blood pressure in patients with established cerebrovascular disease
    S C Howard
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    J Clin Epidemiol 56:1084-91. 2003
    ..RDB has been estimated from repeated measurements of BP in population-based studies, but there are no data in patients with established vascular disease...
  94. ncbi request reprint Presence of acute ischaemic lesions on diffusion-weighted imaging is associated with clinical predictors of early risk of stroke after transient ischaemic attack
    J N Redgrave
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 24:86-90. 2007
    ....
  95. ncbi request reprint Change in incidence and aetiology of intracerebral haemorrhage in Oxfordshire, UK, between 1981 and 2006: a population-based study
    C E Lovelock
    Stroke Prevention Research Unit, Department of Neurology, University of Oxford, Oxford, UK
    Lancet Neurol 6:487-93. 2007
    ..Trends in the older population might differ, since cause varies with age. Our aim was to investigate changes in the population-based incidence of intracerebral haemorrhage according to age and likely aetiology...
  96. doi request reprint Addition of brain infarction to the ABCD2 Score (ABCD2I): a collaborative analysis of unpublished data on 4574 patients
    Matthew F Giles
    Stroke Prevention Research Unit M F G, P M R, National Institute for Health Research Biomedical Research Centre, Oxford, UK
    Stroke 41:1907-13. 2010
    ..We therefore performed an international, multicenter collaborative study of the prognostic performance of the ABCD(2) score and brain infarction on imaging to determine the optimal weighting of infarction in the score (ABCD(2)I)...
  97. doi request reprint Systematic review and pooled analysis of published and unpublished validations of the ABCD and ABCD2 transient ischemic attack risk scores
    Matthew F Giles
    Stroke Prevention Research Unit, NIHR Biomedical Research Centre, Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Stroke 41:667-73. 2010
    ..Independent validations have reported conflicting results. We therefore systematically reviewed published and unpublished data to determine predictive value and generalizability to different clinical settings and users...
  98. doi request reprint Underestimation of cognitive impairment by Mini-Mental State Examination versus the Montreal Cognitive Assessment in patients with transient ischemic attack and stroke: a population-based study
    Sarah T Pendlebury
    Stroke Prevention Research Unit, Level 6 West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Stroke 41:1290-3. 2010
    ..The more recently developed Montreal Cognitive Assessment (MoCA), an alternative, brief 30-point global cognitive screen, might pick up more cognitive abnormalities in patients with cerebrovascular disease...
  99. doi request reprint Costs of stroke using patient-level data: a critical review of the literature
    Ramon Luengo-Fernandez
    Department of Public Health, Health Economics Research Centre, University of Oxford, Oxford, USA
    Stroke 40:e18-23. 2009
    ..This study reports the results from a literature review of the costs of cerebrovascular diseases, and assesses the quality of the published evidence against a set of defined criteria...
  100. doi request reprint Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: a systematic review of published and unpublished studies
    Caroline E Lovelock
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU
    Stroke 41:1222-8. 2010
    ..Insights could be gained by pooling data on MB frequency stratified by antithrombotic use in cohorts with ICH and ischemic stroke (IS)/transient ischemic attack (TIA)...
  101. doi request reprint Transient ischaemic attack: clinical relevance, risk prediction and urgency of secondary prevention
    Matthew F Giles
    Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
    Curr Opin Neurol 22:46-53. 2009
    ..We have reviewed recent evidence on the burden of TIA and prediction and prevention of stroke in the acute phase...