P M Rothwell

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint A systematic review of the risks of stroke and death due to endarterectomy for symptomatic carotid stenosis
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Stroke 27:260-5. 1996
  2. ncbi request reprint A systematic comparison of the risks of stroke and death due to carotid endarterectomy for symptomatic and asymptomatic stenosis
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Stroke 27:266-9. 1996
  3. pmc Clinical and angiographic predictors of stroke and death from carotid endarterectomy: systematic review
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh
    BMJ 315:1571-7. 1997
  4. doi request reprint General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial
    S C Lewis
    Neurosciences Trials Unit, Division of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Lancet 372:2132-42. 2008
  5. pmc The 12 year prognosis of unilateral functional weakness and sensory disturbance
    J Stone
    Division of Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 74:591-6. 2003
  6. ncbi request reprint Long-term durability of carotid endarterectomy for symptomatic stenosis and risk factors for late postoperative stroke
    E J Cunningham
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 33:2658-63. 2002
  7. ncbi request reprint Effect of age and glycaemic control on the association between fibrinogen and risk of acute coronary events after transient ischaemic attack or stroke
    S C Howard
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Cerebrovasc Dis 25:136-43. 2008
  8. ncbi request reprint Performance of the ABCD and ABCD2 scores in TIA patients with carotid stenosis and atrial fibrillation
    S Koton
    Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cerebrovasc Dis 24:231-5. 2007
  9. ncbi request reprint Asymptomatic recurrent cerebral ischaemic lesions on diffusion-weighted imaging in the subacute and chronic phase after transient ischaemic attack or minor ischaemic stroke
    S Mazzucco
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 24:133-5. 2007
  10. ncbi request reprint Apolipoproteins as predictors of ischaemic stroke in patients with a previous transient ischaemic attack
    M Bhatia
    Stroke Prevention Research Unit, Radcliffe Infirmary, Centre for Statistics in Medicine, University of Oxford, UK
    Cerebrovasc Dis 21:323-8. 2006

Collaborators

Detail Information

Publications22

  1. ncbi request reprint A systematic review of the risks of stroke and death due to endarterectomy for symptomatic carotid stenosis
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Stroke 27:260-5. 1996
    ..However, the benefit is limited by the risks of stroke and death associated with the operation. Although reported surgical risks vary enormously, there has been no systematic review of the published literature...
  2. ncbi request reprint A systematic comparison of the risks of stroke and death due to carotid endarterectomy for symptomatic and asymptomatic stenosis
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Stroke 27:266-9. 1996
    ..Is endarterectomy for asymptomatic carotid stenosis really safer than surgery for recently symptomatic stenosis?..
  3. pmc Clinical and angiographic predictors of stroke and death from carotid endarterectomy: systematic review
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh
    BMJ 315:1571-7. 1997
    ..To identify risk factors for operative stroke and death from carotid endarterectomy...
  4. doi request reprint General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial
    S C Lewis
    Neurosciences Trials Unit, Division of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Lancet 372:2132-42. 2008
    ..We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia...
  5. pmc The 12 year prognosis of unilateral functional weakness and sensory disturbance
    J Stone
    Division of Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 74:591-6. 2003
    ..Although the symptoms of unilateral "medically unexplained" or "functional" weakness and sensory disturbance present commonly to neurologists, little is known about their long term prognosis...
  6. ncbi request reprint Long-term durability of carotid endarterectomy for symptomatic stenosis and risk factors for late postoperative stroke
    E J Cunningham
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 33:2658-63. 2002
    ..To determine the long-term risk of stroke after CEA and to identify risk factors, we studied patients in the European Carotid Study Trial (ECST), the largest published cohort with long-term follow-up by physicians after CEA...
  7. ncbi request reprint Effect of age and glycaemic control on the association between fibrinogen and risk of acute coronary events after transient ischaemic attack or stroke
    S C Howard
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Cerebrovasc Dis 25:136-43. 2008
    ..We hypothesised that if this effect of fibrinogen were causally related to risk of vascular events, the risk relationship would be affected by the two other factors that affect fibrin clot permeability - age and glycaemic control...
  8. ncbi request reprint Performance of the ABCD and ABCD2 scores in TIA patients with carotid stenosis and atrial fibrillation
    S Koton
    Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cerebrovasc Dis 24:231-5. 2007
    ..It has been suggested that scores for risk stratification of TIA patients might not identify patients with carotid stenosis or atrial fibrillation (AF) and that this might undermine the usefulness of such scores...
  9. ncbi request reprint Asymptomatic recurrent cerebral ischaemic lesions on diffusion-weighted imaging in the subacute and chronic phase after transient ischaemic attack or minor ischaemic stroke
    S Mazzucco
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 24:133-5. 2007
  10. ncbi request reprint Apolipoproteins as predictors of ischaemic stroke in patients with a previous transient ischaemic attack
    M Bhatia
    Stroke Prevention Research Unit, Radcliffe Infirmary, Centre for Statistics in Medicine, University of Oxford, UK
    Cerebrovasc Dis 21:323-8. 2006
    ..However, there are very few published data on apolipoproteins and stroke risk and no studies in patients with previous transient ischaemic attack (TIA)...
  11. pmc Predictors of risk of intracerebral haemorrhage in patients with a history of TIA or minor ischaemic stroke
    M J Ariesen
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 77:92-4. 2006
    ..07), blood glucose level (> or = 7 mmol/l, HR 0.33), systolic blood pressure (> or = 140 mm Hg, HR 2.17), and antihypertensive drugs (HR 1.53). The highest risk quartile was associated with five times more ICHs than the lowest quartile...
  12. ncbi request reprint Population-based study of delays in carotid imaging and surgery and the risk of recurrent stroke
    J F Fairhead
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Neurology 65:371-5. 2005
    ..Benefit from carotid endarterectomy is greatest when performed within 2 weeks of a presenting TIA or stroke and decreases rapidly thereafter...
  13. ncbi request reprint A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack
    P M Rothwell
    Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Lancet 366:29-36. 2005
    ..Effective early management of patients with transient ischaemic attacks (TIA) is undermined by an inability to predict who is at highest early risk of stroke...
  14. ncbi request reprint Direct assessment of completeness of ascertainment in a stroke incidence study
    A J Coull
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, UK
    Stroke 35:2041-5. 2004
    ..We report the first use of direct methods to determine the completeness of different ascertainment strategies in a population-based stroke incidence study (Oxford Vascular Study)...
  15. ncbi request reprint Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 363:915-24. 2004
    ..Benefit depends on the degree of stenosis, and we aimed to see whether it might also depend on other clinical and angiographic characteristics, and on the timing of surgery...
  16. ncbi request reprint Clinical and radiographic risk factors for operative stroke and death in the European carotid surgery trial
    R Bond
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford, UK
    Eur J Vasc Endovasc Surg 23:108-16. 2002
    ..The surgical arm of the European Carotid Surgery Trial (ECST) is such a cohort...
  17. pmc Evidence of underdiagnosis of myasthenia gravis in older people
    A Vincent
    Department of Clinical Neurology and Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    J Neurol Neurosurg Psychiatry 74:1105-8. 2003
    ..There is anecdotal evidence that the diagnosis is sometimes missed in older patients...
  18. ncbi request reprint Differences in vascular risk factors between etiological subtypes of ischemic stroke: importance of population-based studies
    U G R Schulz
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford OX2 6HE UK
    Stroke 34:2050-9. 2003
    ..If risk factors differ between patients who are admitted and those who are not, then case-control studies will be biased. If the likelihood of admission also depends on stroke subtype, then case-case comparisons may also be biased...
  19. pmc Abnormalities on diffusion weighted magnetic resonance imaging performed several weeks after a minor stroke or transient ischaemic attack
    U G R Schulz
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    J Neurol Neurosurg Psychiatry 74:734-8. 2003
    ..This study investigated the sensitivity and the observer reproducibility of DWI in cerebral TIA and minor ischaemic stroke patients scanned more than two weeks after the last symptomatic event...
  20. pmc Long term risks of stroke, myocardial infarction, and vascular death in "low risk" patients with a non-recent transient ischaemic attack
    T G Clark
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 74:577-80. 2003
    ..However, the majority of patients survive for many years after a TIA, and the need for continued preventive treatment to lower vascular risk will need to be reassessed at a later date...
  21. ncbi request reprint Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 361:107-16. 2003
    ..To accurately assess the overall effect of surgery, and to increase power for secondary analyses, we pooled trial data and reassessed carotid angiograms...
  22. pmc Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services
    A J Coull
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:326. 2004
    ..To estimate the very early stroke risk after a transient ischaemic attack (TIA) or minor stroke and thereby inform the planning of effective stroke prevention services...