A G Rossi

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation
    A E Leitch
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Cell Death Differ 19:1950-61. 2012
  2. pmc A novel assay of antimycobacterial activity and phagocytosis by human neutrophils
    David M Lowe
    Department of Medicine, Imperial College London, W2 1PG, UK
    Tuberculosis (Edinb) 93:167-78. 2013
  3. pmc Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps
    Robert D Gray
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, Scotland, UK
    J Inflamm (Lond) 10:12. 2013
  4. pmc Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis
    Catherine A Shaw
    Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    J Inflamm (Lond) 6:14. 2009
  5. ncbi request reprint Getting to grips with the granulocyte: manipulation of granulocyte behaviour and apoptosis by protein transduction methods
    A G Rossi
    MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Biochem Soc Trans 32:452-5. 2004
  6. ncbi request reprint Modulation of granulocyte apoptosis can influence the resolution of inflammation
    A G Rossi
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, UK
    Biochem Soc Trans 35:288-91. 2007
  7. pmc A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages
    Catriona M Turnbull
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK
    J Inflamm (Lond) 5:12. 2008
  8. ncbi request reprint Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
    Adriano G Rossi
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Nat Med 12:1056-64. 2006
  9. ncbi request reprint Regulation of macrophage phagocytosis of apoptotic cells by cAMP
    A G Rossi
    Department of Medicine RIE, Rayne Laboratory, The University of Edinburgh Medical School, Scotland, UK
    J Immunol 160:3562-8. 1998
  10. ncbi request reprint Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets
    C Ward
    The Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh Medical School, Teviot Place, Edinburgh, UK EH8 9AG
    Trends Pharmacol Sci 20:503-9. 1999

Collaborators

Detail Information

Publications35

  1. pmc Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation
    A E Leitch
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Cell Death Differ 19:1950-61. 2012
    ..Thus, we highlight a novel mechanism that controls both primary human neutrophil transcription and apoptosis that could be targeted by selective CDK inhibitor drugs to resolve established inflammation...
  2. pmc A novel assay of antimycobacterial activity and phagocytosis by human neutrophils
    David M Lowe
    Department of Medicine, Imperial College London, W2 1PG, UK
    Tuberculosis (Edinb) 93:167-78. 2013
    ..The same multiplicity of infection and serum conditions are optimal to demonstrate both internalisation and restriction of mycobacterial growth...
  3. pmc Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps
    Robert D Gray
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, Scotland, UK
    J Inflamm (Lond) 10:12. 2013
    ..Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation...
  4. pmc Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis
    Catherine A Shaw
    Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    J Inflamm (Lond) 6:14. 2009
    ....
  5. ncbi request reprint Getting to grips with the granulocyte: manipulation of granulocyte behaviour and apoptosis by protein transduction methods
    A G Rossi
    MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Biochem Soc Trans 32:452-5. 2004
    ..In this paper, we review recent literature highlighting important developments using this system in isolated human granulocytes and in inflammatory process in vivo where these cells play a prominent role...
  6. ncbi request reprint Modulation of granulocyte apoptosis can influence the resolution of inflammation
    A G Rossi
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, UK
    Biochem Soc Trans 35:288-91. 2007
    ..Thus manipulation of apoptotic pathways, together with ensuring macrophage clearance of apoptotic cells, appears to be a viable pharmacological target for reducing established inflammation...
  7. pmc A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages
    Catriona M Turnbull
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK
    J Inflamm (Lond) 5:12. 2008
    ....
  8. ncbi request reprint Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
    Adriano G Rossi
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Nat Med 12:1056-64. 2006
    ..Thus, CDK inhibitors enhance the resolution of established inflammation by promoting apoptosis of inflammatory cells, thereby demonstrating a hitherto unrecognized potential for the treatment of inflammatory disorders...
  9. ncbi request reprint Regulation of macrophage phagocytosis of apoptotic cells by cAMP
    A G Rossi
    Department of Medicine RIE, Rayne Laboratory, The University of Edinburgh Medical School, Scotland, UK
    J Immunol 160:3562-8. 1998
    ....
  10. ncbi request reprint Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets
    C Ward
    The Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh Medical School, Teviot Place, Edinburgh, UK EH8 9AG
    Trends Pharmacol Sci 20:503-9. 1999
    ..It is suggested that apoptosis can be specifically regulated pharmacologically and could be exploited to develop new drug therapies...
  11. ncbi request reprint Cyclic AMP regulation of neutrophil apoptosis occurs via a novel protein kinase A-independent signaling pathway
    M C Martin
    Medical Research Council Centre for Inflammation Research, Respiratory Medicine Unit, University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 276:45041-50. 2001
    ....
  12. ncbi request reprint Regulation of granulocyte apoptosis by NF-kappaB
    C Ward
    Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Biochem Soc Trans 32:465-7. 2004
    ..Although NF-kappaB is an important target for anti-inflammatory therapy, the timing of inhibition in vivo may be crucial, to ensure that production of PGD2 and its sequential metabolites can occur...
  13. ncbi request reprint Regulation of granulocyte apoptosis by hemopoietic growth factors, cytokines and drugs: potential relevance to allergic inflammation
    A Walker
    Respiratory Medicine Unit, Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK
    Curr Drug Targets Inflamm Allergy 2:339-47. 2003
    ..Here we review the progress that has been made in the understanding of granulocyte apoptosis and the implications for immunotherapy and pharmacological strategies in the treatment of allergic inflammatory diseases for therapeutic gain...
  14. ncbi request reprint Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation
    S J Heasman
    MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    J Endocrinol 178:29-36. 2003
    ....
  15. ncbi request reprint Constitutive neutrophil apoptosis in culture is modulated by cell density independently of beta2 integrin-mediated adhesion
    S Hannah
    Department of Medicine R I E, University of Edinburgh Medical School, Scotland, UK
    FEBS Lett 421:141-6. 1998
    ....
  16. ncbi request reprint Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa
    A E Leitch
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Mucosal Immunol 1:350-63. 2008
    ..Therapeutic strategies to drive resolution of inflammation may be directed at the induction of granulocyte apoptosis and the enhancement of granulocyte clearance...
  17. ncbi request reprint Dissociation of DNA fragmentation from other hallmarks of apoptosis in nitric oxide-treated neutrophils: differences between individual nitric oxide donor drugs
    E L Taylor
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH8 9AG, United Kingdom
    Biochem Biophys Res Commun 289:1229-36. 2001
    ....
  18. ncbi request reprint Temperature-dependent arrest of neutrophil apoptosis. Failure of Bax insertion into mitochondria at 15 degrees C prevents the release of cytochrome c
    J G Pryde
    Rayne Laboratory, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 275:33574-84. 2000
    ..Bax insertion was only sensitive to zVAD-fmk when added at the start of the 15 degrees C culture period, suggesting that a cytoplasmic substrate of the effector caspases may mediate in the mechanism of Bax insertion into mitochondria...
  19. ncbi request reprint Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac
    K M Giles
    Medical Research Council Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, United Kingdom
    J Immunol 167:976-86. 2001
    ..We propose that changes in the capacity for reorganization of cytoskeletal elements induced by glucocorticoids are essential for efficient phagocytic uptake of apoptotic cells...
  20. pmc Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents
    A E Leitch
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, UK
    Br J Pharmacol 158:1004-16. 2009
    ..This review will discuss current understanding of the processes of inflammation and resolution but will focus on CDKis and their potential mechanisms of action...
  21. pmc Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung
    C D Lucas
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Mucosal Immunol 7:857-68. 2014
    ..Therefore, manipulating inflammatory cell Mcl-1 accelerates inflammation resolution without detriment to host defense against bacteria, and represents a target for treating infection-associated inflammation. ..
  22. ncbi request reprint Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization
    M H Ruchaud-Sparagano
    Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 275:15758-64. 2000
    ....
  23. pmc 5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects
    C Yang
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 164:1661-71. 2011
    ..5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors. This study compares the effects of 5αTHB on inflammation and metabolism in vitro and in vivo...
  24. ncbi request reprint Granulocyte apoptosis: who would work with a 'real' inflammatory cell?
    I Dransfield
    MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Biochem Soc Trans 32:447-51. 2004
    ..Although study of granulocyte cell death has especial difficulties when compared with other cell types, there are clearly potential benefits for new therapeutic approaches to treat inflammatory diseases...
  25. pmc Sildenafil reduces alcohol-induced gastric damage: just say 'NO'
    R Duffin
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 153:623-4. 2008
    ..Therefore, in addition to exerting anti-impotence efficacy, PDE V inhibitors may provide significant beneficial effects from mucosal injury induced by alcohol...
  26. doi request reprint Imaging inflammation: molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution
    D A Dorward
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Pharmacol Ther 135:182-99. 2012
    ....
  27. ncbi request reprint Neutrophils: dead or effete? Cell surface phenotype and implications for phagocytic clearance
    I Dransfield
    MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Cell Death Differ 12:1363-7. 2005
  28. ncbi request reprint Combined dysfunctions of immune cells predict nosocomial infection in critically ill patients
    A Conway Morris
    MRC University Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Br J Anaesth 111:778-87. 2013
    ..This study examined the temporal occurrence of immune dysfunction across three immune cell types, and their relationship with the development of nosocomial infection...
  29. ncbi request reprint Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis
    E L Taylor
    Centre for Inflammation Research, Rayne Laboratory, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Cell Death Differ 10:418-30. 2003
    ..This review summarises the differential effects of NO on inflammatory cell apoptosis and outlines potential mechanisms that have been proposed to explain such actions...
  30. pmc Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators
    M M Teixeira
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 113:1363-71. 1994
    ..Moreover, our results confirm previous findings which suggest a dominant role for nitric oxide in maintaining cutaneous blood flow in the guinea-pig...
  31. ncbi request reprint Release of TNFalpha in response to SiC fibres: differential effects in rodent and human primary macrophages, and in macrophage-like cell lines
    C E Fisher
    Department of Biological Sciences, Napier University, Edinburgh EH10 5DT, UK
    Toxicol In Vitro 14:25-31. 2000
    ..Primary rat cells and primary human cells behaved in a similar manner as regards to TNFalpha production; the cell lines behaved quite differently to their primary counterparts with regards to TNFalpha production in this study...
  32. ncbi request reprint Hypoxic regulation of neutrophil apoptosis role: of reactive oxygen intermediates in constitutive and tumor necrosis factor alpha-induced cell death
    J Murray
    Respiratory Medicine Division, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge CB2 2QQ, UK
    Ann N Y Acad Sci 1010:417-25. 2003
    ..Thus ROS do not appear to modulate constitutive apoptosis in neutrophils or appear sufficient to mediate the pro-apoptotic effect of TNFalpha...
  33. pmc Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig
    M M Teixeira
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 112:332-40. 1994
    ....
  34. ncbi request reprint Eating their way out of trouble: selective uptake of apoptotic eosinophils by bronchial epithelial cells
    N Farahi
    Clin Exp Allergy 34:1503-6. 2004
  35. pmc Ascaris suum-derived products induce human neutrophil activation via a G protein-coupled receptor that interacts with the interleukin-8 receptor pathway
    F H Falcone
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, United Kingdom
    Infect Immun 69:4007-18. 2001
    ..Our results provide the first evidence for a direct interaction between a parasite-derived chemotactic factor and the host's chemotactic network, via a novel G protein-coupled receptor which interacts with the IL-8 receptor pathway...