James A Ross

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Expression of the proteolysis-inducing factor core peptide mRNA is upregulated in both tumour and adjacent normal tissue in gastro-oesophageal malignancy
    D A C Deans
    Department of Clinical and Surgical Sciences, Cell Injury and Apoptosis Section, Tissue Injury and Repair Group, Edinburgh University, Chancellor s Building SU227, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Br J Cancer 94:731-6. 2006
  2. pmc Latent effects of fibronectin, alpha5beta1 integrin, alphaVbeta5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion
    A G Lowrie
    Tissue Injury and Repair Group, 6th Floor, Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Br J Cancer 91:1327-34. 2004
  3. pmc Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver
    N M Wheelhouse
    Cell Injury and Apoptosis Group, Edinburgh MRC Centre for Inflammation Research, College of Medicine and Veterinary Medicine, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Br J Cancer 92:1268-72. 2005
  4. pmc Reply: Expression of the proteolysis-inducing factor core-peptide mRNA is upregulated in both tumour and adjacent normal tissue in gastrooesophageal malignancy
    D A C Deans
    1Tissue Injury and Repair Group, Clinical and Surgical Sciences, University of Edinburgh, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Br J Cancer 98:243. 2008
  5. ncbi request reprint Eicosanoid-dependent cancer cachexia and wasting
    James A Ross
    Lister Research Laboratories, University Department of Clinical and Surgical Sciences, Royal Infirmary of Edinburgh, Edinburgh, UK
    Curr Opin Clin Nutr Metab Care 5:241-8. 2002
  6. ncbi request reprint The anti-catabolic effects of n-3 fatty acids
    J A Ross
    Lister Research Laboratories, University Department of Surgery, Royal Infirmary of Edinburgh, UK
    Curr Opin Clin Nutr Metab Care 2:219-26. 1999
  7. ncbi request reprint Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumour cells
    James A Ross
    Tissue Injury and Repair Group, Centre for Inflammation Research, University of Edinburgh Department of Clinical and Surgical Sciences, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Int J Oncol 23:1733-8. 2003
  8. doi request reprint Portal venous endothelium in developing human liver contains haematopoietic and epithelial progenitor cells
    John D Terrace
    Centre for Regenerative Medicine, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Exp Cell Res 316:1637-47. 2010
  9. doi request reprint c-Jun terminal kinase-2 gene deleted mice overexpress hemeoxygenase-1 and are protected from hepatic ischemia reperfusion injury
    Luke Devey
    Centre for Inflammation Research, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Transplantation 88:308-16. 2009
  10. ncbi request reprint De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1
    Stephen J Wigmore
    Tissue Injury and Repair Group, MRC Centre for Inflammation Research, Medical School 6th Floor, Edinburgh EH8 9AG, UK
    Int J Mol Med 19:413-20. 2007

Detail Information

Publications92

  1. pmc Expression of the proteolysis-inducing factor core peptide mRNA is upregulated in both tumour and adjacent normal tissue in gastro-oesophageal malignancy
    D A C Deans
    Department of Clinical and Surgical Sciences, Cell Injury and Apoptosis Section, Tissue Injury and Repair Group, Edinburgh University, Chancellor s Building SU227, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Br J Cancer 94:731-6. 2006
    ..Post-translational modification of PIF may be a key step in determining the biological role of PIF in the patient with advanced cancer and cachexia...
  2. pmc Latent effects of fibronectin, alpha5beta1 integrin, alphaVbeta5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion
    A G Lowrie
    Tissue Injury and Repair Group, 6th Floor, Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Br J Cancer 91:1327-34. 2004
    ..However, the magnitude of IL-8 secretion induced by cytochalasin cannot be accounted for by integrin signalling and may reflect the influence of another signalling pathway or a novel, intrinsic cytoskeletal function...
  3. pmc Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver
    N M Wheelhouse
    Cell Injury and Apoptosis Group, Edinburgh MRC Centre for Inflammation Research, College of Medicine and Veterinary Medicine, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Br J Cancer 92:1268-72. 2005
    ....
  4. pmc Reply: Expression of the proteolysis-inducing factor core-peptide mRNA is upregulated in both tumour and adjacent normal tissue in gastrooesophageal malignancy
    D A C Deans
    1Tissue Injury and Repair Group, Clinical and Surgical Sciences, University of Edinburgh, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Br J Cancer 98:243. 2008
  5. ncbi request reprint Eicosanoid-dependent cancer cachexia and wasting
    James A Ross
    Lister Research Laboratories, University Department of Clinical and Surgical Sciences, Royal Infirmary of Edinburgh, Edinburgh, UK
    Curr Opin Clin Nutr Metab Care 5:241-8. 2002
    ..This review examines the biology of the eicosanoids and the evidence of a role for the eicosanoids in cancer cachexia and wasting...
  6. ncbi request reprint The anti-catabolic effects of n-3 fatty acids
    J A Ross
    Lister Research Laboratories, University Department of Surgery, Royal Infirmary of Edinburgh, UK
    Curr Opin Clin Nutr Metab Care 2:219-26. 1999
    ..The n-3 fatty acids may be able to attenuate catabolism. This review examines the potential sites of action for these fatty acids and the evidence that supports their anti-catabolic properties...
  7. ncbi request reprint Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumour cells
    James A Ross
    Tissue Injury and Repair Group, Centre for Inflammation Research, University of Edinburgh Department of Clinical and Surgical Sciences, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Int J Oncol 23:1733-8. 2003
    ..These results suggest that the omega-3 fatty acid EPA perturbs the NFkappaB pathway by a novel mechanism. This mechanism may be important in delineating alternative pathways to NFkappaB activation...
  8. doi request reprint Portal venous endothelium in developing human liver contains haematopoietic and epithelial progenitor cells
    John D Terrace
    Centre for Regenerative Medicine, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Exp Cell Res 316:1637-47. 2010
    ..This indicates that a temporal relationship might exist between progenitor cells in foetal liver development and adult liver regeneration, which may involve progeny of PVE...
  9. doi request reprint c-Jun terminal kinase-2 gene deleted mice overexpress hemeoxygenase-1 and are protected from hepatic ischemia reperfusion injury
    Luke Devey
    Centre for Inflammation Research, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Transplantation 88:308-16. 2009
    ..We hypothesized that this would lead to induction of hemeoxygenase-1 (HO-1) and confer protection from hepatic ischemia reperfusion injury...
  10. ncbi request reprint De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1
    Stephen J Wigmore
    Tissue Injury and Repair Group, MRC Centre for Inflammation Research, Medical School 6th Floor, Edinburgh EH8 9AG, UK
    Int J Mol Med 19:413-20. 2007
    ....
  11. doi request reprint Side population cells in developing human liver are primarily haematopoietic progenitor cells
    John D Terrace
    Centre for Regenerative Medicine, University of Edinburgh Medical School, Chancellor s Building, 49 Little France Crescent, EH16 4SB, Edinburgh, UK
    Exp Cell Res 315:2141-53. 2009
    ..Improved understanding of developing human liver SP cells will contribute to the generation of novel cell-based therapies for liver disease...
  12. doi request reprint Heat shock protein 90-binding agents protect renal cells from oxidative stress and reduce kidney ischemia-reperfusion injury
    Ewen M Harrison
    Tissue Injury and Repair Group, University of Edinburgh, Edinburgh, UK
    Am J Physiol Renal Physiol 295:F397-405. 2008
    ..Therefore, HBAs mediate upregulation of protective Hsps in mouse kidneys which are associated with reduced I/R injury and may be useful in reducing transplant-associated kidney injury...
  13. ncbi request reprint The cachectic mediator proteolysis inducing factor activates NF-kappaB and STAT3 in human Kupffer cells and monocytes
    Tammy M Watchorn
    Tissue Injury and Repair Group, Cell Injury and Apoptosis Section, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Int J Oncol 27:1105-11. 2005
    ..The pro-inflammatory effects of PIF, mediated via NF-kappaB and STAT3, are important in macrophage behaviour and may contribute to the inflammatory pro-cachectic process in the liver...
  14. ncbi request reprint Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason score
    Grant D Stewart
    Prostate Research Group, Edinburgh Cancer Research Centre, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Oncol Rep 20:1561-7. 2008
    ..However, LOX and GLUT-1 are candidate markers of hypoxia in prostate cancer and may prove useful in identifying patients with hypoxic prostate cancer. Not all hypoxia-associated molecules are relevant in prostate cancer in vivo...
  15. ncbi request reprint Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells
    Ewen M Harrison
    Tissue Injury and Repair Group, University of Edinburgh, UK
    FEBS J 273:2345-56. 2006
    ..Thus, insulin induces heme oxygenase-1 mRNA and protein expression in renal cells in a phosphatidylinositol 3-kinase/Akt and NF-E2-related factor-2-dependent manner...
  16. pmc Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling
    David C Hay
    Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    Proc Natl Acad Sci U S A 105:12301-6. 2008
    ..These studies represent an important step toward the use of hESC-derived hepatocytes in high-throughput metabolic analysis of human liver function...
  17. pmc SUMOylation of HNF4α regulates protein stability and hepatocyte function
    Wenli Zhou
    Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh Bio Quarter, 5 Little France Drive, Edinburgh EH16 4UU, UK
    J Cell Sci 125:3630-5. 2012
    ..Moreover, we believe the results will stimulate interest in the differentiation and phenotypic regulation of other somatic cell types...
  18. doi request reprint DNA strand breaks and hypoxia response inhibition mediate the radiosensitisation effect of nitric oxide donors on prostate cancer under varying oxygen conditions
    Grant D Stewart
    Prostate Research Group, Department of Urology, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK
    Biochem Pharmacol 81:203-10. 2011
    ..Neoadjuvent and concurrent use of NO-NSAIDs have the potential to improve radiotherapy treatment of prostate cancer under normoxia and hypoxia...
  19. ncbi request reprint The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes
    Nicholas M Wheelhouse
    Tissue Injury and Repair Group, Centre for Regenerative Medicine, University of Edinburgh, The Chancellor s Building, Edinburgh EH16 4SB, UK
    Int J Mol Med 18:957-61. 2006
    ..The study demonstrates that the effects of MIF upon the acute phase response are complex and can differentially modulate the production of acute phase proteins depending on the presence of other factors...
  20. doi request reprint Interaction of gonadal status with systemic inflammation and opioid use in determining nutritional status and prognosis in advanced pancreatic cancer
    Richard J E Skipworth
    Clinical and Surgical Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, UK
    Support Care Cancer 19:391-401. 2011
    ..We aimed to investigate the interaction of gonadal status with systemic inflammation and opioids in determining nutritional status and prognosis in advanced pancreatic cancer...
  21. pmc Generation of functional human hepatic endoderm from human induced pluripotent stem cells
    Gareth J Sullivan
    Medical Research Council MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK
    Hepatology 51:329-35. 2010
    ..Additionally iPSC-derived HE supported both CYP1A2 and CYP3A4 metabolism, which is essential for drug and toxicology testing...
  22. doi request reprint NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway
    Grant D Stewart
    Prostate Research Group, Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Int J Cancer 124:223-32. 2009
    ..The ability of NO-sulindac to inhibit tumour adaption to hypoxia has considerable relevance to the future management of prostate cancer with the same cellular properties as PC-3...
  23. doi request reprint The dermcidin gene in cancer: role in cachexia, carcinogenesis and tumour cell survival
    Grant D Stewart
    Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Curr Opin Clin Nutr Metab Care 11:208-13. 2008
    ..The diverse protein products of the dermcidin gene are relevant to immunity, cancer cell progression and cancer cachexia. This article evaluates recent developments/controversies around dermcidin...
  24. ncbi request reprint Frequency of the mitochondrial DNA 4977bp deletion in oesophageal mucosa during the progression of Barrett's oesophagus
    Benjamin H L Tan
    University of Edinburgh, Clinical and Surgical Sciences Surgery, Royal Infirmary, Edinburgh, UK
    Eur J Cancer 45:736-40. 2009
    ....
  25. doi request reprint Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function
    Nathan A Stephens
    Department of Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    Clin Nutr 31:499-505. 2012
    ..This study examined the relationship between cachexia, quality of life and the mass/function/mechanical quality of lower limb skeletal muscle in gastrointestinal cancer patients...
  26. ncbi request reprint Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine
    Richard J E Skipworth
    Tissue Injury and Repair Group, University of Edinburgh, Edinburgh EH16 4SB, UK
    Int J Oncol 36:973-82. 2010
    ..Urinary proteomics using mass spectrometry can identify muscle-specific and non-muscle-specific candidate biomarkers of cancer cachexia...
  27. ncbi request reprint Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat
    Mary M Chu
    Tissue Injury and Repair Group, MRC Centre for Inflammation Research Medical School, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK
    World J Surg 31:1693-701. 2007
    ..High-fat enteral nutrition reduces the inflammatory response following hemorrhagic shock in the rat...
  28. doi request reprint Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies
    Iain J Gallagher
    Department of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Clin Cancer Res 18:2817-27. 2012
    ..The mechanisms underlying muscle wasting in patients with cancer remain poorly understood, and consequently there remains an unmet clinical need for new biomarkers and treatment strategies...
  29. doi request reprint Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism
    David C Hay
    MRC Centre for Regenerative Medicine, University of Edinburgh, Chancellor s Building, Edinburgh, EH16 4SB, UK
    Stem Cell Res 6:92-102. 2011
    ..In conclusion, our data suggest that an unbiased screening approach can identify cell culture substrate(s) that enhance the phenotypic stability of primary and stem cell-derived cell resources...
  30. ncbi request reprint Pro-inflammatory cytokine release by peripheral blood mononuclear cells from patients with advanced pancreatic cancer: relationship to acute phase response and survival
    Alastair G W Moses
    Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary, Edinburgh, EH16 4SA, UK
    Oncol Rep 21:1091-5. 2009
    ..While the elevated APPR is probably related to locally produced interleukin-6 in the liver, it seems possible that locally and systemically produced interleukin-6 influences survival...
  31. doi request reprint Cancer cachexia is associated with the IL10 -1082 gene promoter polymorphism in patients with gastroesophageal malignancy
    D A Chris Deans
    Department of Clinical and Surgical Sciences, Medical School, University of Edinburgh, Edinburgh, UK
    Am J Clin Nutr 89:1164-72. 2009
    ..The genetic predisposition of the host to local or systemic inflammation may contribute to the effect of cancer cachexia...
  32. ncbi request reprint Progenitor cell characterization and location in the developing human liver
    John D Terrace
    Centre for Regenerative Medicine, University of Edinburgh Medical School, EH16 4SB, Edinburgh, United Kingdom
    Stem Cells Dev 16:771-8. 2007
    ..Therefore, this structure may constitute a novel progenitor compartment with hemangioblast-like properties...
  33. ncbi request reprint Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia
    Grant D Stewart
    Tissue Injury and Repair Group, University of Edinburgh, UK
    Prostate 67:1308-17. 2007
    ..The aim of this work was to: (i) establish if the DCD gene confers resistance of prostate cancer cells to hypoxia and oxidative stress; (ii) identify the component of the gene transcript responsible for this effect...
  34. pmc Developing high-fidelity hepatotoxicity models from pluripotent stem cells
    Claire N Medine
    MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK
    Stem Cells Transl Med 2:505-9. 2013
    ..In conclusion, we report that pluripotent stem cell-derived hepatocytes will model toxicity predictably and in a manner comparable to current gold standard assays, representing a major advance in the field. ..
  35. ncbi request reprint Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition
    Stephen J McNally
    Tissue Injury and Repair Group, University of Edinburgh, Chancellor s Building, Little France, Edinburgh EH16 4SB, UK
    Int J Mol Med 19:165-72. 2007
    ....
  36. doi request reprint The comparison between conditioned media and serum-free media in human embryonic stem cell culture and differentiation
    Zara Hannoun
    Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, EH16 4SB, UK
    Cell Reprogram 12:133-40. 2010
    ..This data suggests that MT and SP are effective replacements for MEF-CM in hESC culture, contributing to the standardization of hESC in vitro models and ultimately their application...
  37. pmc P-selectin genotype is associated with the development of cancer cachexia
    Benjamin H L Tan
    University of Edinburgh, Clinical and Surgical Sciences Surgery, Royal Infirmary, Edinburgh, UK
    EMBO Mol Med 4:462-71. 2012
    ..P-selectin was found to be significantly upregulated in muscle in both models. Identification of P-selectin as relevant in both animal models and in cachectic cancer patients supports this as a risk factor/potential mediator in cachexia...
  38. pmc Liver development, regeneration, and carcinogenesis
    Janet W C Kung
    Tissue Injury and Repair Group, Medical Research Council Centre for Regenerative Medicine, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    J Biomed Biotechnol 2010:984248. 2010
    ....
  39. doi request reprint Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks
    Alastair G Lowrie
    Tissue Injury and Repair Group, MRC Centre for Regenerative Medicine, Chancellor s Building, The University of Edinburgh Medical School, Royal Infirmary of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
    Int J Oncol 39:709-18. 2011
    ..Quantitative PCR confirmed direct upregulation of VEGFB. These data reveal PIF-CP as the key mediator of dermcidin-induced proliferation and demonstrate induction of key oncogenic pathways...
  40. doi request reprint The relevance of a hypoxic tumour microenvironment in prostate cancer
    Grant D Stewart
    Prostate Research Group, Department of Urology, University of Edinburgh, Western General Hospital, Edinburgh, UK
    BJU Int 105:8-13. 2010
    ..This review outlines the role of low-oxygen conditions in prostate cancer and the areas where further studies are required...
  41. ncbi request reprint Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury
    Stephen J McNally
    Tissue Injury and Repair Group, MRC Centre for Inflammation Research, Medical School, University of Edinburgh, Edinburgh, United Kingdom
    Transplantation 81:623-6. 2006
    ..This is the first study to demonstrate that curcumin induces HO-1 in human hepatocytes, and that the protective effects of curcumin pretreatment may have clinical potential in hepatic transplantation...
  42. ncbi request reprint Identification of possible genetic polymorphisms involved in cancer cachexia: a systematic review
    Benjamin H L Tan
    Clinical and Surgical Sciences Surgery, Royal Infirmary, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    J Genet 90:165-77. 2011
    ..The present study provides an initial framework to select genes/polymorphisms for further study in cancer cachexia, and to develop their potential as susceptibility biomarkers of developing cachexia...
  43. doi request reprint Liver tissue engineering and cell sources: issues and challenges
    Anwar A Palakkan
    Tissue Injury and Repair Group, University of Edinburgh MRC Centre for Regenerative Medicine, Edinburgh, UK
    Liver Int 33:666-76. 2013
    ..This review provides an overview of recent challenges, issues and cell sources with regard to liver tissue engineering...
  44. pmc Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues
    A G Lowrie
    Tissue Injury and Repair Group, Chancellor s Building, The University of Edinburgh Medical School, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    Br J Cancer 94:1663-71. 2006
    ..Glycosylation does not appear to be required, but the importance of asparagine residues suggests a role for the proteolysis-inducing factor core peptide domain...
  45. ncbi request reprint Absence of correlation between serum CRP levels and mitochondrial D-loop DNA mutations in gastro-oesophageal adenocarcinoma
    Benjamin H L Tan
    Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary, Edinburgh, United Kingdom
    J Cancer Res Ther 10:176-9. 2014
    ..The aim of this study was to evaluate the relationship between inflammation and accumulation of mitochondrial DNA (mtDNA) mutations in the D-loop region in carcinogenesis of gastro-oesophageal adenocarcinomas...
  46. doi request reprint The inhibitory role of stromal cell mesenchyme on human embryonic stem cell hepatocyte differentiation is overcome by Wnt3a treatment
    Judy Fletcher
    MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cloning Stem Cells 10:331-9. 2008
    ..Wnt3a pretreatment reinstated efficient hESC differentiation to hepatic endoderm. These studies represent an important step in understanding hepatocyte differentiation from hESCs and the role played by the cellular niche in vitro...
  47. pmc The adaptive response of the reticuloendothelial system to major liver resection in humans
    Martin J Schindl
    Edinburgh Liver Surgery and Transplantation Experimental Research Group eLISTER and the Department of Surgery, Royal Infirmary Edinburgh, University of Edinburgh, Edinburgh, United Kingdom
    Ann Surg 243:507-14. 2006
    ..To evaluate the contribution of the liver to total circulatory reticuloendothelial system (RES) phagocytosis capacity in patients undergoing liver resection and to compare it with values in end-stage chronic liver disease...
  48. pmc Specific binding of an antigen-antibody complex to apoptotic human neutrophils
    Simon P Hart
    Medical Research Council Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh, Scotland
    Am J Pathol 162:1011-8. 2003
    ..This report is the first to provide evidence that antigen-antibody complexes bind specifically to apoptotic neutrophils and implicates apoptosis-associated changes in Fc gamma receptor function...
  49. ncbi request reprint Optimization of the paired enzyme assay for heme oxygenase activity
    Stephen J McNally
    Tissue Injury and Repair Group, MRC Centre for Inflammation Research, Medical School 6th Floor, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Anal Biochem 332:398-400. 2004
  50. ncbi request reprint Laser Doppler anemometry measurements of the shear stresses on ultrasonic contrast agent microbubbles attached to agar
    Mairead B Butler
    Department of Medical Physics, University of Edinburgh, Edinburgh EH16 4SB, UK
    Ultrasound Med Biol 31:545-52. 2005
    ..The bubbles were found to remain attached to the agar for shear stresses of up to 3.4 Pa. This compares with mean physiological arterial shear stresses of less than 1.5 Pa for pulsatile flow...
  51. ncbi request reprint Serum from patients with fulminant hepatic failure causes hepatocyte detachment and apoptosis by a beta(1)-integrin pathway
    Philip N Newsome
    Department of Hepatology, University of Edinburgh, Edinburgh, UK
    Hepatology 40:636-45. 2004
    ..This finding has important implications in the future of cellular transplantation for liver and other organ diseases...
  52. ncbi request reprint TNF-alpha induced DNA damage in primary murine hepatocytes
    Nicholas M Wheelhouse
    Division of Pathology, College of Medicine and Veterinary Medicine, Teviot Place, University of Edinburgh, Edinburgh EH8 9AG, Scotland, UK
    Int J Mol Med 12:889-94. 2003
    ..We believe that this study indicates a possible putative role for TNF-alpha in the early stages of malignant transformation of hepatocytes...
  53. doi request reprint Probing microbubble targeting with atomic force microscopy
    V Sboros
    Medical Physics, School of Clinical Sciences and Community Health, University of Edinburgh, Edinburgh, UK
    Colloids Surf B Biointerfaces 80:12-7. 2010
    ..In conclusion, the capability of single microbubbles to target cell lines was shown to be feasible with AFM...
  54. ncbi request reprint Proteolysis-inducing factor regulates hepatic gene expression via the transcription factors NF-(kappa)B and STAT3
    T M Watchorn
    Molecular Immunology Group, Department of Clinical and Surgical Sciences, Edinburgh University, U K
    FASEB J 15:562-4. 2001
    ..The expression of PIF peaks during the embryonic period E8 to E9, a stage that is crucial in the development of skeletal muscle and liver and during which both NF-kB and STAT3 activation can also be observed...
  55. ncbi request reprint Nanomechanical probing of microbubbles using the atomic force microscope
    V Sboros
    Medical Physics, School of Clinical Sciences and Community Health, University of Edinburgh, Edinburgh, UK
    Ultrasonics 46:349-54. 2007
    ..The nanointerrogation of MBs using AFM provides new insight into their mechanical properties, and should be of assistance to MB design and manufacture...
  56. pmc Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines
    G D Stewart
    Tissue Injury and Repair Group, Clinical and Surgical Sciences Surgery, University of Edinburgh, Edinburgh EH16 4SB, UK
    Br J Cancer 99:126-32. 2008
    ..The relationship of these findings to dermcidin protein levels and cell survival remains to be determined...
  57. ncbi request reprint Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer
    S J Wigmore
    Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, EH3 9YW, UK
    Int J Oncol 21:881-6. 2002
    ..In conclusion, human pancreatic cancer cell lines elaborate pro-inflammatory cytokines which have the potential to mediate elements of the systemic inflammatory response...
  58. ncbi request reprint Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia
    M D Barber
    University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW, UK
    Nutr Cancer 40:118-24. 2001
    ..This may account for the reversal of weight loss in patients consuming this supplement...
  59. ncbi request reprint Biomarkers for cancer cachexia: is there also a genetic component to cachexia?
    B H L Tan
    Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, The University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Support Care Cancer 16:229-34. 2008
    ..Cancer cachexia is a severe debilitating disorder, which causes significant morbidity and mortality. In clinical practice, cachexia is often not treated until a late stage, when therapeutic options are limited...
  60. ncbi request reprint Manufacture and acoustical characterisation of a high-frequency contrast agent for targeting applications
    C M Moran
    Medical Physics, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Ultrasound Med Biol 32:421-8. 2006
    ..Maximum mean backscatter power was measured for sonicated liposomal dispersions with 60% by weight of phosphatidylethanolamine. Moreover, this dispersion had greater mean backscatter power than sheep blood at 40 MHz...
  61. pmc Snail family transcription factors are implicated in thyroid carcinogenesis
    Robert G Hardy
    Tissue Injury and Repair Group, Centre for Regenerative Medicine, University of Edinburgh, Division of Clinical and Surgical Sciences, Room FU501, Chancellors Bldg, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Am J Pathol 171:1037-46. 2007
    ..In conclusion, SNAI1 and SNAI2 are ectopically expressed in thyroid carcinomas, and aberrant expression in mice is associated with papillary carcinoma development...
  62. doi request reprint Proteomic analysis of urinary upper gastrointestinal cancer markers
    Holger Husi
    School of Clinical Sciences and Community Health, University of Edinburgh, UK
    Proteomics Clin Appl 5:289-99. 2011
    ..We have investigated the use of human urine as a non-invasive medium to screen for molecular biomarkers of carcinomas of the upper gastrointestinal (uGI) tract using SELDI-TOF-MS...
  63. ncbi request reprint The role of heat shock protein 90 in modulating ischemia-reperfusion injury in the kidney
    Stephen O'Neill
    MRC Centre for Inflammation Research, Tissue Injury and Repair Group, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    Expert Opin Investig Drugs 21:1535-48. 2012
    ..Ischemia-reperfusion injury (IRI) is an unavoidable consequence of the transplantation procedure and is responsible for delayed graft function and poorer long-term outcomes...
  64. ncbi request reprint Hepatic progenitor cells in human fetal liver express the oval cell marker Thy-1
    Neil M Masson
    Tissue Injury and Repair Group, Department of Clinical and Surgical Sciences Surgery, University of Edinburgh Medical School, Edinburgh, EH16 4SB, UK
    Am J Physiol Gastrointest Liver Physiol 291:G45-54. 2006
    ..These cells expressed several lineage markers, including coexpression of biliary and hepatocellular proteins and mRNA. These data suggest that Thy-1 is a marker of liver stem cells in human fetal liver...
  65. ncbi request reprint Eicosapentaenoic acid modulates the immune response but has no effect on a mimic of antigen-specific responses
    M D Barber
    Tissue Injury and Repair Group, University of Edinburgh MRC Centre for Inflammation Research, Medical School, Edinburgh, United Kingdom
    Nutrition 21:588-93. 2005
    ..In the present study we assessed the effect of high-purity EPA provided as a novel diester with propane-1,3-diol, which was delivered orally within the normal dietary fat content...
  66. pmc Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing
    Alixe H M Kilgour
    Centre for Cognitive Ageing and Cognitive Epidemiology, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e84057. 2013
    ....
  67. pmc Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia
    Nathan A Stephens
    Department of Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, EH16 4SB, UK
    Genome Med 2:1. 2010
    ..Our genomics analysis also supports the view that the available preclinical models do not accurately reflect the molecular characteristics of human muscle from cancer cachexia patients...
  68. ncbi request reprint Early stress protein gene expression in a human model of ischemic preconditioning
    Anisha Patel
    Tissue Injury and Repair Group, MRC Centre for Inflammation Research, Medical School, University of Edinburgh, Edinburgh EH8 9AG, UK
    Transplantation 78:1479-87. 2004
    ..In conclusion, expression of the cytoprotective protein HO-1 is significantly up-regulated in the liver within minutes of PHC. It is likely that HO-1 contributes to the early protective effects of ischemic preconditioning...
  69. ncbi request reprint Firefly luciferase terminally degraded by mild heat exposure: implications for reporter assays
    Ewen M Harrison
    Tissue Injury and Repair Group, University of Edinburgh, Chancellor s Building, Little France Crescent, UK
    J Immunol Methods 310:182-5. 2006
    ..This vastly underappreciated effect is worthy of further emphasis and luciferase reporter vectors should be used with caution in protocols that involve exposure to temperatures outside the physiological range...
  70. doi request reprint Molecular profile of organ culture-stored corneal epithelium: LGR5 is a potential new phenotypic marker of residual human corneal limbal epithelial stem cells
    Joanna Brzeszczynska
    Tissue Injury and Repair Group, University of Edinburgh MRC Centre for Regenerative Medicine, Edinburgh, Scotland, UK
    Int J Mol Med 29:871-6. 2012
    ..However, the existence of CK10 together with co-expressed α-actin and vimentin suggests that the corneas investigated were under oxidative stress and showed evidence of squamous metaplasia...
  71. ncbi request reprint Effect of interleukin-2 on peripheral blood mononuclear cell cytokine production and the hepatic acute phase protein response
    S J Wigmore
    University Department of Surgery, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, United Kingdom
    Clin Immunol 104:174-82. 2002
    ..These findings suggest that in this model IL-2 may modulate PBMC-induced acute phase protein production through an IL-6 and TNF-independent pathway...
  72. pmc Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle
    Neil Johns
    Department of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 9:e83618. 2014
    ..One impediment towards the effective treatment of cachexia is a validated classification system...
  73. doi request reprint LSCluster, a large-scale sequence clustering and aligning software for use in partial identity mapping and splice-variant analysis
    Holger Husi
    Biomarkers and Systems Medicine Group, University of Glasgow, Glasgow, UK
    J Proteomics 84:185-9. 2013
    ..The software (current version 2.0) is freely available through the PADB (Proteomic Analysis DataBase) initiative at www.PADB.org...
  74. pmc Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro
    P B Lai
    Lister Research Laboratories, Department of Surgery, University of Edinburgh, Royal Infirmary, UK
    Br J Cancer 74:1375-83. 1996
    ..Therefore, we conclude that EPA mediates its effect on the pancreatic cancer cell line MIA PaCa-2, at least in part, via cell cycle arrest and the induction of apoptosis...
  75. ncbi request reprint Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis
    J J Powell
    University Department of Surgical and Clinical Sciences, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Surgery 129:633-40. 2001
    ..However, a predetermined imbalance between IL-1beta and its antagonist IL-1RA would appear to exist in patients with severe acute pancreatitis, although the genetic basis for this altered relationship could not be determined...
  76. ncbi request reprint Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines
    S J Wigmore
    University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh, EH3 9YW, UK
    Int J Oncol 18:467-73. 2001
    ..Furthermore, they demonstrate the complexity of tumour cell cytokine production and highlight the difficulties in developing effective therapeutic biological response strategies...
  77. pmc A polymorphism of the interleukin-1 beta gene influences survival in pancreatic cancer
    M D Barber
    University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh, EH3 9YW, Scotland, UK
    Br J Cancer 83:1443-7. 2000
    ..This may reflect the role of IL-1b in inducing an acute phase protein response and cachexia in cancer or may be related to changes in tumour phenotype...
  78. pmc Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines
    J S Falconer
    University Department of Surgery, Royal Infirmary, Edinburgh, UK
    Br J Cancer 69:826-32. 1994
    ....
  79. ncbi request reprint Insertion of SMRV-H viral DNA at the c-myc gene locus of a BL cell line and presence in established cell lines
    P G Middleton
    LRF Lab, Medical School, Newcastle upon Tyne, UK
    Int J Cancer 52:451-4. 1992
    ..New insertions of the genome were produced spontaneously in these cells. The origins of the type-D retrovirus and its implications for workers in the field are discussed...
  80. ncbi request reprint Leptin and its relation to weight loss, ob gene expression and the acute-phase response in surgical patients
    A G Moses
    Department of Clinical and Surgical Sciences (Surgery, University of Edinburgh, Edinburgh, UK
    Br J Surg 88:588-93. 2001
    ..Omental fat may have more influence on plasma leptin than subcutaneous fat. Accelerated weight loss in patients with cancer with an ongoing inflammatory response could be mediated in part by inappropriately high plasma levels of leptin...
  81. pmc The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer
    M D Barber
    University Department of Surgery, Royal Infirmary, Edinburgh EH3 9YW, UK
    Br J Cancer 90:1129-32. 2004
    ..05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer...
  82. ncbi request reprint Interferon-gamma polymorphisms correlate with duration of survival in pancreatic cancer
    M A T Halma
    Tissue Injury and Repair Group, Centre for Inflammation Research, College of Medicine and Veterinary Medicine, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom
    Hum Immunol 65:1405-8. 2004
    ..We therefore propose that the presence of allele 2 may be a useful marker for patient outcome...
  83. pmc Elevated tumour interleukin-1beta is associated with systemic inflammation: A marker of reduced survival in gastro-oesophageal cancer
    D A C Deans
    Tissue Injury and Repair Group, Department of Clinical and Surgical Sciences, MRC Centre for Inflammation Research, The Chancellor s Building, Edinburgh University, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Br J Cancer 95:1568-75. 2006
    ..05 and P = 0.03, respectively). Tumour chronic inflammatory infiltrate and tumour tissue IL-1beta overexpression are potential independent factors influencing systemic inflammation in oesophagogastric cancer patients...
  84. ncbi request reprint Modulation of the liver export protein synthetic response to feeding by an n-3 fatty-acid-enriched nutritional supplement is associated with anabolism in cachectic cancer patients
    Matthew D Barber
    Department of Clinical and Surgical Sciences Surgery, The University of Edinburgh, Royal Infirmary, Edinburgh EH16 4SA, Scotland, U K
    Clin Sci (Lond) 106:359-64. 2004
    ..7 compared with 14.6 g/day; P = 0.01). Modulation of hepatic export protein synthesis with feeding may have contributed to the net whole-body anabolism observed with administration of the n -3 fatty-acid-enriched oral supplement...
  85. ncbi request reprint Nitric oxide donating nonsteroidal anti-inflammatory drugs induce apoptosis in human prostate cancer cell systems and human prostatic stroma via caspase-3
    Justine Sarah Royle
    Department of Urology, Western General Hospital, Prostate Research Group, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    J Urol 172:338-44. 2004
    ..NO is a powerful biological messenger with multiple cellular effects. We established the effects of 2 of these new drugs in prostate cell systems...
  86. ncbi request reprint Is there a human homologue to the murine proteolysis-inducing factor?
    Barbara M Wieland
    Departments of Oncology and Chemistry, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 13:4984-92. 2007
    ..We aimed to establish the clinical significance of PIF in cancer patients and to elucidate its structural features...
  87. doi request reprint The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle
    Guo Hua Qiu
    Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore
    J Hepatol 48:433-41. 2008
    ..The 35 genes mapped to the AP20 subregion of this locus were screened for their expression to identify candidate tumor suppressor genes. DLEC1 was selected for further characterization in primary hepatocellular carcinomas and cell lines...
  88. ncbi request reprint Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans
    Richard J Simpson
    Biomedicine and Sport and Exercise Science Research Group, School of Life Sciences, Napier University, Edinburgh, United Kingdom
    Res Sports Med 15:157-74. 2007
    ..No differences were found between the intensive and downhill protocols. In conclusion, apoptosis of circulating lymphocytes does not appear to contribute to exercise-induced lymphocytopenia...
  89. ncbi request reprint Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma
    Guo Hua Qiu
    Department of Physiology, Faculty of Medicine, National University of Singapore, Block MD9, 2 Medical Drive, Singapore 117597, Singapore
    J Hepatol 46:655-63. 2007
    ..hDAB2IP is a candidate tumor suppressor gene. We studied the expression of its two variants, hDAB2IPA and hDAB2IPB, in normal tissues, and the expression and methylation status of hDAB2IPA in hepatocellular carcinomas (HCC) and cell lines...
  90. ncbi request reprint Febrile-range temperature but not heat shock augments the acute phase response to interleukin-6 in human hepatoma cells
    Stephen J Wigmore
    Liver Research Group, University of Birmingham, Institute of Biomedical Research 5th Floor, Wolfson Drive, Birmingham B15 2TT, UK
    Am J Physiol Gastrointest Liver Physiol 290:G903-11. 2006
    ..The mechanism of this action appears to be transcriptionally regulated in the case of ACT, but in the case of transferrin, it may be mediated by another process such as posttranslational modification...
  91. ncbi request reprint Immune alterations, lipid peroxidation, and muscle damage following a hill race
    Richard J Simpson
    Biomedicine and Sport and Exercise Science Research Group, School of Life Sciences, Napier University, 10 Colinton Rd, Edinburgh EH10 5DT, UK
    Can J Appl Physiol 30:196-211. 2005
    ..Future studies should examine the link between muscle damage, oxidative stress, and the acute phase response following hill races of longer duration with larger eccentric components...
  92. doi request reprint Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo
    David C Hay
    Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Rd, London W12ONN, UK
    Stem Cells 26:894-902. 2008
    ..Our results have provided evidence that hESCs can be differentiated efficiently in vitro to functional hepatocytes, which may be useful as an in vitro system for toxicity screening in drug discovery...