Christian Roghi

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
    Christian Roghi
    Cancer Research UK Cambridge Research Institute, The Li Ka Shing Centre, UK
    FEBS J 277:3158-75. 2010
  2. ncbi Peptide aptamers as new tools to modulate clathrin-mediated internalisation--inhibition of MT1-MMP internalisation
    Rochana D Wickramasinghe
    Department of Oncology, Cambridge Research Centre, University of Cambridge, Cambridge CB2 0RE, UK
    BMC Cell Biol 11:58. 2010
  3. ncbi MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells
    Susan J Atkinson
    Department of Oncology, Cambridge University, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 398:15-22. 2006
  4. ncbi MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src
    Patricia A Eisenach
    University of Cambridge, Department of Oncology, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    J Cell Sci 123:4182-93. 2010

Collaborators

  • Patricia A Eisenach
  • Rochana D Wickramasinghe
  • Gillian Murphy
  • Susan J Atkinson
  • William R English
  • Marton Fogarasi
  • Paul Ko Ferrigno

Detail Information

Publications4

  1. ncbi Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
    Christian Roghi
    Cancer Research UK Cambridge Research Institute, The Li Ka Shing Centre, UK
    FEBS J 277:3158-75. 2010
    ..Taken together, these data suggest that GRASP55 may function as an adaptor protein coupling MT1-MMP with furin, thus leading to the activation of the zymogen...
  2. ncbi Peptide aptamers as new tools to modulate clathrin-mediated internalisation--inhibition of MT1-MMP internalisation
    Rochana D Wickramasinghe
    Department of Oncology, Cambridge Research Centre, University of Cambridge, Cambridge CB2 0RE, UK
    BMC Cell Biol 11:58. 2010
    ..Peptide aptamers are combinatorial protein reagents that bind to targets with a high specificity and a strong affinity thus providing a molecular tool kit for modulating the function of their targets in vivo...
  3. ncbi MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells
    Susan J Atkinson
    Department of Oncology, Cambridge University, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 398:15-22. 2006
    ....
  4. ncbi MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src
    Patricia A Eisenach
    University of Cambridge, Department of Oncology, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    J Cell Sci 123:4182-93. 2010
    ..The signalling cascade dependent on the MT1-MMP-VEGFR-2-Src complex activated Akt and mTOR, ultimately leading to increased VEGF-A transcription...