Research Topics
| Glenn C RodrigoSummaryAffiliation: University of Leicester Country: UK Publications
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Detail Information
Publications
Role of mitochondrial re-energization and Ca2+ influx in reperfusion injury of metabolically inhibited cardiac myocytesGlenn C Rodrigo
Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
Cardiovasc Res 67:291-300. 2005..We used isolated myocytes to investigate the role of mitochondrial re-energization and Ca2+ influx during reperfusion on hypercontracture, loss of Ca2+ homeostasis and contractile function...
Ischemic preconditioning of the whole heart confers protection on subsequently isolated ventricular myocytesGlenn C Rodrigo
Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester, UK
Am J Physiol Heart Circ Physiol 294:H524-31. 2008..The model should allow future studies in isolated cells of the protective mechanisms induced by true ischemia...
Diazoxide causes early activation of cardiac sarcolemmal KATP channels during metabolic inhibition by an indirect mechanismGlenn C Rodrigo
Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
Cardiovasc Res 61:570-9. 2004..Protection is coupled with early action potential failure, due to early activation of sarcoKATP channels during metabolic inhibition (MI), which is likely to involve an indirect effect of diazoxide...
Inotropic response of cardiac ventricular myocytes to beta-adrenergic stimulation with isoproterenol exhibits diurnal variation: involvement of nitric oxideHelen E Collins
Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester LE3 9QP, United Kingdom
Circ Res 106:1244-52. 2010..Although >10% of cardiac gene expression displays diurnal variations, little is known of their impact on excitation-contraction coupling...
Phenylephrine preconditioning involves modulation of cardiac sarcolemmal K(ATP) current by PKC delta, AMPK and p38 MAPKHelen E Turrell
Department of Cell Physiology and Pharmacology, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK
J Mol Cell Cardiol 51:370-80. 2011..The increase in sarcK(ATP) current induced by phenylephrine preconditioning requires PKCĪ“, AMPK and p38 and may contribute to the observed improvement in contractile recovery...
