R J Rodgers

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint Resistance of experientially-induced changes in murine plus-maze behaviour to altered retest conditions
    R J Rodgers
    Department of Psychology, University of Leeds, UK
    Behav Brain Res 86:71-7. 1997
  2. ncbi request reprint Anxiogenic profile of AM-251, a selective cannabinoid CB1 receptor antagonist, in plus-maze-naïve and plus-maze-experienced mice
    R J Rodgers
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, England, UK
    Behav Pharmacol 16:405-13. 2005
  3. ncbi request reprint Absence of anxiolytic response to chlordiazepoxide in two common background strains exposed to the elevated plus-maze: importance and implications of behavioural baseline
    R J Rodgers
    Behavioural Pharmacology Laboratory, School of Psychology University of Leeds, Leeds, UK
    Genes Brain Behav 1:242-51. 2002
  4. ncbi request reprint 'One-trial sensitization' to the anxiolytic-like effects of cannabinoid receptor antagonist SR141716A in the mouse elevated plus-maze
    R J Rodgers
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Eur J Neurosci 17:1279-86. 2003
  5. ncbi request reprint Orexins and appetite regulation
    R J Rodgers
    School of Psychology, University of Leeds, Leeds, UK
    Neuropeptides 36:303-25. 2002
  6. ncbi request reprint Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour
    R J Rodgers
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Physiol Behav 77:301-10. 2002
  7. ncbi request reprint SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats
    R J Rodgers
    School of Psychology, University of Leeds, UK
    Eur J Neurosci 13:1444-52. 2001
  8. ncbi request reprint Animal models of anxiety: an ethological perspective
    R J Rodgers
    Department of Psychology, University of Leeds, England
    Braz J Med Biol Res 30:289-304. 1997
  9. ncbi request reprint Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats
    R J Rodgers
    School of Psychology, University of Leeds, LS2 9JT, Leeds, UK
    Regul Pept 96:71-84. 2000
  10. ncbi request reprint Corticosterone response to the plus-maze: high correlation with risk assessment in rats and mice
    R J Rodgers
    Ethopharmacology Laboratory, School of Psychology, University of Leeds, UK
    Physiol Behav 68:47-53. 1999

Detail Information

Publications40

  1. ncbi request reprint Resistance of experientially-induced changes in murine plus-maze behaviour to altered retest conditions
    R J Rodgers
    Department of Psychology, University of Leeds, UK
    Behav Brain Res 86:71-7. 1997
    ..Data are discussed in relation to experientially-induced shifts in behavioural strategy and the apparent involvement of simple proximal cues (probably thigmotactic) in this enduring and adaptive form of spatial learning...
  2. ncbi request reprint Anxiogenic profile of AM-251, a selective cannabinoid CB1 receptor antagonist, in plus-maze-naïve and plus-maze-experienced mice
    R J Rodgers
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, England, UK
    Behav Pharmacol 16:405-13. 2005
    ..Data are discussed in relation to previous findings with rimonabant, the putative existence of a novel non-CB1 neuronal cannabinoid receptor and, more generally, the behavioural pharmacology of plus-maze 'trial 2'...
  3. ncbi request reprint Absence of anxiolytic response to chlordiazepoxide in two common background strains exposed to the elevated plus-maze: importance and implications of behavioural baseline
    R J Rodgers
    Behavioural Pharmacology Laboratory, School of Psychology University of Leeds, Leeds, UK
    Genes Brain Behav 1:242-51. 2002
    ..The implications of these findings for research on mutant mice are discussed...
  4. ncbi request reprint 'One-trial sensitization' to the anxiolytic-like effects of cannabinoid receptor antagonist SR141716A in the mouse elevated plus-maze
    R J Rodgers
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Eur J Neurosci 17:1279-86. 2003
    ..Data are discussed in relation to the recently described phenotypes of CB1 receptor knockout mice and, in particular, to mounting evidence for the existence of a novel SR141716A-sensitive neuronal cannabinoid receptor...
  5. ncbi request reprint Orexins and appetite regulation
    R J Rodgers
    School of Psychology, University of Leeds, Leeds, UK
    Neuropeptides 36:303-25. 2002
    ..e., finding and ingesting food without oneself becoming a meal for someone else...
  6. ncbi request reprint Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour
    R J Rodgers
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Physiol Behav 77:301-10. 2002
    ..The implications of these findings are discussed in relation to both the behavioural and pharmacological phenotyping of mutant mice...
  7. ncbi request reprint SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats
    R J Rodgers
    School of Psychology, University of Leeds, UK
    Eur J Neurosci 13:1444-52. 2001
    ..Together, these findings strongly support the view that orexin-A is involved in the regulation of feeding patterns and that this influence is mediated through the orexin-1 receptor...
  8. ncbi request reprint Animal models of anxiety: an ethological perspective
    R J Rodgers
    Department of Psychology, University of Leeds, England
    Braz J Med Biol Res 30:289-304. 1997
    ..On the basis of this review, it is suggested that other models of anxiety may well benefit from greater attention to behavioural detail...
  9. ncbi request reprint Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats
    R J Rodgers
    School of Psychology, University of Leeds, LS2 9JT, Leeds, UK
    Regul Pept 96:71-84. 2000
    ..Further studies will be required to confirm the identity of the specific orexin receptors (i.e. OX(1) or OX(2)) involved in mediating the dose-dependent behavioural effects reported...
  10. ncbi request reprint Corticosterone response to the plus-maze: high correlation with risk assessment in rats and mice
    R J Rodgers
    Ethopharmacology Laboratory, School of Psychology, University of Leeds, UK
    Physiol Behav 68:47-53. 1999
    ..Findings are discussed in relation to the functional significance of risk assessment in potentially dangerous situations and the potential involvement of glucocorticoids in this process. All rights reserved...
  11. ncbi request reprint Anxiety, defence and the elevated plus-maze
    R J Rodgers
    Department of Psychology, University of Leeds, UK
    Neurosci Biobehav Rev 21:801-10. 1997
    ..More attention to behaviour and somewhat less emphasis on test simplicity and convenience would seem to be warranted...
  12. ncbi request reprint Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S
    Y Ishii
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, LS2 9JT, UK
    Behav Brain Res 160:11-24. 2005
    ..However, unlike the immediate short-circuiting of the satiety sequence induced by CCK-8S, the slower response to SB-334867 implies a more indirect mechanism of action...
  13. ncbi request reprint Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
    Behav Brain Res 157:331-41. 2005
    ....
  14. doi request reprint Endogenous opioids and cannabinoids: system interactions in the regulation of appetite, grooming and scratching
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS29JT, UK
    Physiol Behav 94:422-31. 2008
    ....
  15. ncbi request reprint Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Physiol Behav 81:129-40. 2004
    ..Overall, the divergent profiles obtained with equianorectic doses of LiCl and SB-334867 provide convincing evidence for the behavioural selectivity of SB-334867-induced anorexia...
  16. ncbi request reprint Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male rats
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Psychopharmacology (Berl) 195:27-39. 2007
    ..Although the CB1 receptor antagonist/inverse agonist rimonabant acutely suppresses food intake in rodents, the behavioural specificity of this effect remains unclear...
  17. doi request reprint Sibutramine & naloxone: infra-additive interaction in the regulation of appetite?
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Behav Brain Res 207:174-81. 2010
    ..g. rimonabant, bupropion), would not support naloxone-sibutramine polytherapy in the clinical management of obesity...
  18. doi request reprint Effects of acute low-dose combined treatment with naloxone and AM 251 on food intake, feeding behaviour and weight gain in rats
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Pharmacol Biochem Behav 91:358-66. 2009
    ..g. 'neutral' CB1 receptor antagonists), current data constitute further proof of concept regarding the anorectic efficacy, selectivity and added value of low-dose polytherapy with opioid and CB1 receptor antagonists...
  19. doi request reprint Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats
    F L Wright
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Psychopharmacology (Berl) 226:415-31. 2013
    ..Previous research suggests that the acute anorectic effect of cannabinoid CB1 receptor antagonist/inverse agonists may be secondary to response competition from the compulsive scratching and grooming syndrome characteristic of these agents...
  20. ncbi request reprint Behaviourally-selective hypophagic effects of naloxone in non-deprived male rats presented with palatable food
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    Behav Brain Res 187:417-27. 2008
    ....
  21. doi request reprint Sibutramine-induced anorexia: potent, dose-dependent and behaviourally-selective profile in male rats
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Behav Brain Res 198:359-65. 2009
    ..Current data support the conclusion that the acute anorectic and weight loss efficacy of sibutramine in adult male rats is not secondary to behavioural disruption but, instead, is due largely to an acceleration in behavioural satiety...
  22. doi request reprint Effects of acute low-dose combined treatment with rimonabant and sibutramine on appetite and weight gain in rats
    A J Tallett
    Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Pharmacol Biochem Behav 97:92-100. 2010
    ....
  23. doi request reprint Strain- and model-dependent effects of chlordiazepoxide, L-838,417 and zolpidem on anxiety-like behaviours in laboratory mice
    L S Mathiasen
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, Leeds University, Leeds LS2 9JT, Leeds, UK
    Pharmacol Biochem Behav 90:19-36. 2008
    ....
  24. doi request reprint Night and day: diurnal differences in the behavioural satiety sequence in male rats
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Physiol Behav 97:125-30. 2009
    ..The potential contribution of diurnal differences in rate of eating is discussed as are the implications of these findings for future studies on the neurobiology of feeding behaviour...
  25. ncbi request reprint Effects of systematic variation in presatiation and fasting on the behavioural satiety sequence in male rats
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Physiol Behav 79:227-38. 2003
    ..e., a delay) in the BSS, confirming the greater sensitivity of this measure relative to food intake per se. The potential utility of these reference profiles is discussed in relation to drug-induced changes in food intake and the BSS...
  26. doi request reprint Orexin-1 receptor antagonism fails to reduce anxiety-like behaviour in either plus-maze-naïve or plus-maze-experienced mice
    R J Rodgers
    Behavioural Neuroscience Laboratory Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Behav Brain Res 243:213-9. 2013
    ..This unique pattern of activity suggests that orexin receptor antagonists may have therapeutic value in those clinical anxiety disorders characterised by intense emotional arousal...
  27. ncbi request reprint Palatability, food intake and the behavioural satiety sequence in male rats
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, LS2 9JT, Leeds, UK
    Physiol Behav 80:37-47. 2003
    ..Data are discussed in relation to the specific behavioural signature to quinine-induced anorexia and its potential utility in identifying appetite suppressants that may modify intake via changes in taste sensitivity and/or palatability...
  28. ncbi request reprint Prior test experience compromises the anxiolytic efficacy of chlordiazepoxide in the mouse light/dark exploration test
    A Holmes
    Ethopharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Behav Brain Res 122:159-67. 2001
    ....
  29. doi request reprint Behavioural satiety sequence (BSS): separating wheat from chaff in the behavioural pharmacology of appetite
    R J Rodgers
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Pharmacol Biochem Behav 97:3-14. 2010
    ..In sum, as BSS analysis offers a reliable means of differentiating the wheat (primary anorectics) from the chaff (secondary anorectics), it should form an integral part of early phase testing in any anti-obesity drug screening programme...
  30. ncbi request reprint Anxiolytic effects of valproate and diazepam in mice are differentially sensitive to picrotoxin antagonism
    A Dalvi
    Ethopharmacology Laboratory, School of Psychology, University of Leeds, Leeds, LS2 9JT, UK
    Pharmacol Biochem Behav 68:23-32. 2001
    ..Further studies will be required to assess the generality of present findings to other mouse strains, species and behavioural paradigms...
  31. ncbi request reprint Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes
    R J Rodgers
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
    Psychopharmacology (Berl) 187:345-55. 2006
    ..Although resistant to conventional anxiolytics, this behavioural phenotype may involve stress-induced release of endogenous opioids...
  32. ncbi request reprint The NK1 receptor antagonist NKP608 lacks anxiolytic-like activity in Swiss-Webster mice exposed to the elevated plus-maze
    R J Rodgers
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Behav Brain Res 154:183-92. 2004
    ..These new data are also discussed in relation to the general difficulty of relating the behavioural profiles of NK(1) receptor antagonists to their potency at NK(1) receptors...
  33. ncbi request reprint More haste, considerably less speed
    R J Rodgers
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK
    J Psychopharmacol 21:141-3. 2007
  34. doi request reprint Trait differences in response to chronic nicotine and nicotine withdrawal in rats
    K Z Kolokotroni
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
    Psychopharmacology (Berl) 231:567-80. 2014
    ....
  35. doi request reprint Effects of chronic nicotine, nicotine withdrawal and subsequent nicotine challenges on behavioural inhibition in rats
    K Z Kolokotroni
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
    Psychopharmacology (Berl) 219:453-68. 2012
    ..Although several theories propose impulsivity as a key component of addiction, the precise nature of this relationship remains unclear...
  36. ncbi request reprint Animal models of 'anxiety': where next?
    R J Rodgers
    Ethopharmacology Laboratory, School of Psychology, University of Leeds, UK
    Behav Pharmacol 8:477-96; discussion 497-504. 1997
    ....
  37. doi request reprint Acute behavioural effects of bupropion and naltrexone, alone and in combination, in non-deprived male rats presented with palatable mash
    F L Wright
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
    Psychopharmacology (Berl) 228:291-307. 2013
    ..Although bupropion and naltrexone (alone and in combination) reduce food consumption in rodents and humans, their effects on behaviour during feeding tests have not been thoroughly investigated...
  38. ncbi request reprint PYY3-36 as an anti-obesity drug target
    M M Boggiano
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294 1170, USA
    Obes Rev 6:307-22. 2005
    ..We review the studies that are in the public domain which support or challenge PYY3-36 as a potential anti-obesity target...
  39. ncbi request reprint Physiology: does gut hormone PYY3-36 decrease food intake in rodents?
    M Tschop
    Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA
    Nature 430:1 p following 165; discussion 2 p following 165. 2004
    ..The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36...
  40. ncbi request reprint Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination
    N R Mirza
    Department of In Vivo Pharmacology, Neurosearch A S, 93 Pederstrupvej, DK 2750 Ballerup, Denmark
    J Pharmacol Exp Ther 316:1291-9. 2006
    ....