Margaret S Robinson
Affiliation: University of Cambridge
Davies A, Itzhak D, Edgar J, Archuleta T, Hirst J, Jackson L, et al
. AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A. Nat Commun. 2018;9:3958 pubmed publisher
..Our study uncovers ATG9A trafficking as a ubiquitous function of the AP-4 pathway. Furthermore, it provides a potential molecular pathomechanism of AP-4 deficiency, through dysregulated spatial control of autophagy. ..
Hirst J, Schlacht A, Norcott J, Traynor D, Bloomfield G, Antrobus R, et al
. Characterization of TSET, an ancient and widespread membrane trafficking complex. elife. 2014;3:e02866 pubmed publisher
..Thus, we have uncovered the machinery for an ancient and widespread pathway, which provides new insights into early eukaryotic evolution.DOI: http://dx.doi.org/10.7554/eLife.02866.001. ..
Dacks J, Robinson M. Outerwear through the ages: evolutionary cell biology of vesicle coats. Curr Opin Cell Biol. 2017;47:108-116 pubmed publisher
Navarro Negredo P, Edgar J, Wrobel A, Zaccai N, Antrobus R, Owen D, et al
. Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting. J Cell Biol. 2017;216:2927-2943 pubmed publisher
..In contrast, these mutants failed to rescue Nef-induced down-regulation of MHC class I, suggesting a possible mechanism for attacking the virus while sparing the host cell. ..
Sahu B, Manna P, Edgar J, Antrobus R, Mahata S, Bartolomucci A, et al
. Role of clathrin in dense core vesicle biogenesis. Mol Biol Cell. 2017;28:2676-2685 pubmed publisher
..Taken together, our data indicate that clathrin has a function in DCV biogenesis beyond its established role in removing unwanted proteins from the immature vesicle. ..
Navarro Negredo P, Edgar J, Manna P, Antrobus R, Robinson M. The WDR11 complex facilitates the tethering of AP-1-derived vesicles. Nat Commun. 2018;9:596 pubmed publisher
..We propose that the complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles that were generated using AP-1. ..