Graham Roberts

..Managing children and teenagers with anaphylaxis is challenging due to the lack of available evidence that specific addresses these issue. The available evidence is presented and discussed...

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..Birth order has been identified as a risk factor for atopy and evidence for some candidate genes has been accumulated; however no study has yet assessed a birth order-gene interaction...

..Allergic disease has been shown to impair health-related quality of life (HRQL). The relationship between HRQL and either allergen exposure or allergic inflammation has not been previously assessed...

..The actual prevalence of latex allergy in the general United Kingdom population is unclear...

..Few studies have investigated the use of specific immunotherapy (SIT) for childhood seasonal allergic asthma...

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..This study aimed to assess the reproducibility of the NIOX MINO measurements across age, sex and lung function for both absolute and categorical exhaled nitric oxide values in two distinct groups of children and teenagers...

..Viewing asthma primarily as an epithelial disease with adoption of a chronic wound scenario also provides a route to airway wall remodeling and the varying asthma phenotypes over the life course...

..It may be clinically more useful to compare exhaled NO values with a subject's previous values than to compare them with a population based normal range...

..There are strong associations between sensitization within allergen groups as well as between allergen groups. Further studies are required to observe whether similar associations are seen with clinical allergy to these allergens...

..Prescribing auto-injectors is associated with reduced anxiety for food allergic children and their mothers, but is not associated with improved adherence with medical management or reduced risk-taking behavior...

..Many adolescents with asthma experience continued symptoms and impaired quality of life despite modern therapy. This study sought to understand their experience and to use this understanding to improve their clinical management...

..The parent-of-origin effect is important in understanding the genetic basis of childhood allergic diseases and improving our ability to identify high-risk children...

..We aimed to survey the practice in this area and look at the differences between paediatric allergists and general paediatricians, the factors influencing prescription and implementation of current guidelines...

..The co-existence of food allergy should be considered in any child with asthma. Where food allergy is confirmed, steps should be taken to avoid these foods as this may considerably improve asthma control...

..We investigated the relationships of maternal body mass index (BMI) and fat mass with childhood wheeze, and examined the influences of infant weight gain and childhood obesity...

..abstract:..

..Lupin has now been introduced into food production in the UK. There is a concern that, on account of cross-reactivity, peanut-allergic children are at high risk for lupin allergy...

..This clinical case series seeks to highlight a contemporary approach to the diagnosis of food allergy in children strategies...

..For these children, dietary avoidance alone may not be sufficient and further environmental measures may be required to limit exposure to aerosolized food...

..A single bolus of salbutamol was compared with a continuous aminophylline infusion in children with severe asthma in a randomised double blind study...

..Young children with egg, milk or multiple food allergies were at greatest risk of further reactions...

..The partial correlation showed that positive relation between mean daily eating/drinking episodes and plaque was not influenced by tooth brushing...

..More intensive management of this high-risk group of children might help to reduce future morbidity and mortality...

..CLINICAL IMPLICATIONS: In the first year of life, the rate of parentally perceived food hypersensitivity is considerably higher than objectively assessed food hypersensitivity...

..The similar pathophysiology of allergic and occupational asthma and the ability of inhaled food allergens to cause the latter raises the question as to whether aerosolized food could play a role in the pathogenesis of childhood asthma...

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