Angela C Roberts

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Autonomic arousal in an appetitive context in primates: a behavioural and neural analysis
    Katrin Braesicke
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Eur J Neurosci 21:1733-40. 2005
  2. pmc Selective prefrontal serotonin depletion impairs acquisition of a detour-reaching task
    S C Walker
    Department of Experimental Psychology, Downing Street, Cambridge CB2 3EB, UK
    Eur J Neurosci 23:3119-23. 2006
  3. doi The importance of serotonin for orbitofrontal function
    Angela C Roberts
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 69:1185-91. 2011
  4. ncbi Synergistic and regulatory effects of orbitofrontal cortex on amygdala-dependent appetitive behavior
    A C Roberts
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Ann N Y Acad Sci 1121:297-319. 2007
  5. ncbi Forebrain connectivity of the prefrontal cortex in the marmoset monkey (Callithrix jacchus): an anterograde and retrograde tract-tracing study
    Angela C Roberts
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    J Comp Neurol 502:86-112. 2007
  6. ncbi Primate orbitofrontal cortex and adaptive behaviour
    A C Roberts
    Department of Anatomy, University of Cambridge, Cambridge, UK
    Trends Cogn Sci 10:83-90. 2006
  7. ncbi Cognitive inflexibility after prefrontal serotonin depletion
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Science 304:878-80. 2004
  8. pmc Differential contributions of the primate ventrolateral prefrontal and orbitofrontal cortex to serial reversal learning
    Rafal Rygula
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 30:14552-9. 2010
  9. doi Contribution of the amygdala, but not orbitofrontal or medial prefrontal cortices, to the expression of flavour preferences in marmoset monkeys
    Carmen Agustín-Pavón
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Eur J Neurosci 34:1006-17. 2011
  10. pmc Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus
    Hannah F Clarke
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:4290-7. 2011

Collaborators

Detail Information

Publications33

  1. ncbi Autonomic arousal in an appetitive context in primates: a behavioural and neural analysis
    Katrin Braesicke
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Eur J Neurosci 21:1733-40. 2005
    ..Together these data serve as an important step towards understanding the role of autonomic arousal in emotion and its neural underpinnings...
  2. pmc Selective prefrontal serotonin depletion impairs acquisition of a detour-reaching task
    S C Walker
    Department of Experimental Psychology, Downing Street, Cambridge CB2 3EB, UK
    Eur J Neurosci 23:3119-23. 2006
    ..This finding provides further support for the role of prefrontal serotonin in inhibitory control processes specifically in tasks sensitive to OFC dysfunction...
  3. doi The importance of serotonin for orbitofrontal function
    Angela C Roberts
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 69:1185-91. 2011
    ....
  4. ncbi Synergistic and regulatory effects of orbitofrontal cortex on amygdala-dependent appetitive behavior
    A C Roberts
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Ann N Y Acad Sci 1121:297-319. 2007
    ..It will be argued that, overall, the OFC plays a critical role in the context-dependent regulation of positive affective responding governed by external cues, in keeping with a role in executive control...
  5. ncbi Forebrain connectivity of the prefrontal cortex in the marmoset monkey (Callithrix jacchus): an anterograde and retrograde tract-tracing study
    Angela C Roberts
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    J Comp Neurol 502:86-112. 2007
    ..In addition it had extensive connections with limbic regions including the amygdala, parahippocampal cortex, cingulate, and retrosplenial cortex...
  6. ncbi Primate orbitofrontal cortex and adaptive behaviour
    A C Roberts
    Department of Anatomy, University of Cambridge, Cambridge, UK
    Trends Cogn Sci 10:83-90. 2006
    ....
  7. ncbi Cognitive inflexibility after prefrontal serotonin depletion
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Science 304:878-80. 2004
    ....
  8. pmc Differential contributions of the primate ventrolateral prefrontal and orbitofrontal cortex to serial reversal learning
    Rafal Rygula
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 30:14552-9. 2010
    ..Together, these data demonstrate the heterogeneous but interrelated involvement of primate OFC and VLPFC in the performance of serial reversal learning...
  9. doi Contribution of the amygdala, but not orbitofrontal or medial prefrontal cortices, to the expression of flavour preferences in marmoset monkeys
    Carmen Agustín-Pavón
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Eur J Neurosci 34:1006-17. 2011
    ..The most parsimonious explanation is that the amygdala contributes to the expression of food preferences based on learnt cues but not those based on an innate preference for sweetness...
  10. pmc Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus
    Hannah F Clarke
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:4290-7. 2011
    ....
  11. doi Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex
    Hannah F Clarke
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB23EB, United Kingdom
    J Neurosci 28:10972-82. 2008
    ....
  12. doi Autonomic, behavioral, and neural analyses of mild conditioned negative affect in marmosets
    Yevheniia Mikheenko
    Department of Physiology, University of Cambridge, United Kingdom
    Behav Neurosci 124:192-203. 2010
    ..Future studies will determine the role of the prefrontal cortex in the regulation of these negative emotional responses, to provide insights into the neuropathology of affective disorders...
  13. doi Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion
    Carmen Agustín-Pavón
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 72:266-72. 2012
    ....
  14. doi Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex
    Susannah C Walker
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    J Neurosci 29:6033-41. 2009
    ..However, 5-HT does not appear to be implicated in this response inhibitory capacity...
  15. pmc Dissociable roles for lateral orbitofrontal cortex and lateral prefrontal cortex during preference driven reversal learning
    Adam Hampshire
    Medical Research Council Cognition and Brain Sciences Unit, Chaucer Road, Cambridge, UK
    Neuroimage 59:4102-12. 2012
    ..These results accord well with the hypothesis that distinct components of adaptable behaviour are supported by anatomically distinct components of the executive system...
  16. ncbi Lesions of the orbitofrontal but not medial prefrontal cortex disrupt conditioned reinforcement in primates
    Andrew Pears
    Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, United Kingdom
    J Neurosci 23:11189-201. 2003
    ..Together, these findings demonstrate the critical and specific involvement of the orbitofrontal cortex but not the medial PFC in conditioned reinforcement...
  17. doi Preference judgements involve a network of structures within frontal, cingulate and insula cortices
    Amir M Chaudhry
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB23DY, UK
    Eur J Neurosci 29:1047-55. 2009
    ....
  18. doi Opposing effects of 5,7-DHT infusions into the orbitofrontal cortex and amygdala on flexible responding
    M S Man
    Department of Physiology, University of Cambridge, Cambridge CB2 3DY, UK
    Cereb Cortex 20:1668-75. 2010
    ..These opposing behavioral effects of serotonin manipulations in the same experimental context may be understood in terms of the top-down regulatory control of the amygdala by the OFC...
  19. ncbi Dissociable contributions of the orbitofrontal and lateral prefrontal cortex of the marmoset to performance on a detour reaching task
    J D Wallis
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Eur J Neurosci 13:1797-808. 2001
    ....
  20. ncbi Neural contributions to the motivational control of appetite in humans
    Elanor C Hinton
    Section of Developmental Psychiatry, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, CB2 2AH, UK
    Eur J Neurosci 20:1411-8. 2004
    ..The findings of this study have implications for research into the underlying mechanisms of eating disorders...
  21. pmc Differential contributions of dopamine and serotonin to orbitofrontal cortex function in the marmoset
    S C Walker
    Department of Experimental Psychology, University of Cambridge, UK
    Cereb Cortex 19:889-98. 2009
    ....
  22. doi The role of the orbitofrontal cortex and medial striatum in the regulation of prepotent responses to food rewards
    M S Man
    Department of Physiology, Development and Neuroscience, University of Cambridge, UK
    Cereb Cortex 19:899-906. 2009
    ..These findings identify the critical contribution of the OFC and MS in the regulation of responding by affective cues...
  23. ncbi Inhibitory control and affective processing in the prefrontal cortex: neuropsychological studies in the common marmoset
    A C Roberts
    Department of Anatomy, University of Cambridge, Downing Site, Cambridge CB2 3DY, UK
    Cereb Cortex 10:252-62. 2000
    ....
  24. ncbi The role of the primate amygdala in conditioned reinforcement
    J A Parkinson
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 21:7770-80. 2001
    ....
  25. ncbi Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set
    H S Crofts
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3DY, UK
    Cereb Cortex 11:1015-26. 2001
    ..Frontal catecholamine depletion caused an increase in distractibility while caudate dopamine loss induced greater focusing of responding...
  26. ncbi Acquisition of instrumental conditioned reinforcement is resistant to the devaluation of the unconditioned stimulus
    J A Parkinson
    University of Cambridge, Cambridge, UK
    Q J Exp Psychol B 58:19-30. 2005
    ....
  27. ncbi Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Cereb Cortex 17:18-27. 2007
    ....
  28. ncbi Differential regulation of fronto-executive function by the monoamines and acetylcholine
    T W Robbins
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Cereb Cortex 17:i151-60. 2007
    ....
  29. pmc Uncoupling of behavioral and autonomic responses after lesions of the primate orbitofrontal cortex
    Y L Reekie
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 105:9787-92. 2008
    ....
  30. ncbi Perseveration and strategy in a novel spatial self-ordered sequencing task for nonhuman primates: effects of excitotoxic lesions and dopamine depletions of the prefrontal cortex
    P Collins
    University of Cambridge Department of Experimental Psychology Cambridge UK Downing Street CB2 3EB
    J Cogn Neurosci 10:332-54. 1998
    ....
  31. doi Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates
    Mei See Man
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    Int J Neuropsychopharmacol 15:91-105. 2012
    ..They provide insight into the neurochemical mechanisms underlying the regulation of positive emotional responses, advancing our understanding of the neural basis of pathologically dysregulated emotion. ..
  32. ncbi Dissociable contributions of the human amygdala and orbitofrontal cortex to incentive motivation and goal selection
    F Sergio Arana
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 23:9632-8. 2003
    ....
  33. ncbi Serotoninergic regulation of emotional and behavioural control processes
    Roshan Cools
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Trends Cogn Sci 12:31-40. 2008
    ..We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects...