T W Robbins

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Punishment induces risky decision-making in methadone-maintained opiate users but not in heroin users or healthy volunteers
    Karen D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:2115-24. 2005
  2. doi request reprint Animal models of neuropsychiatry revisited: a personal tribute to Teitelbaum
    T W Robbins
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Behav Brain Res 231:337-42. 2012
  3. doi request reprint Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry
    Trevor W Robbins
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK
    Trends Cogn Sci 16:81-91. 2012
  4. pmc Impulsive behaviour induced by both NMDA receptor antagonism and GABAA receptor activation in rat ventromedial prefrontal cortex
    Emily R Murphy
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 219:401-10. 2012
  5. pmc Incentive motivation in first-episode psychosis: a behavioural study
    Graham K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 8:34. 2008
  6. ncbi request reprint Synthesizing schizophrenia: a bottom-up, symptomatic approach
    Trevor W Robbins
    Department of Experimental Psychology, University of Cambridge, UK
    Schizophr Bull 31:854-64. 2005
  7. ncbi request reprint Chemistry of the mind: neurochemical modulation of prefrontal cortical function
    Trevor W Robbins
    Department of Experimental Psychology and Medical Research Council Centre for Behavioural and Clinical Neuroscience, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Comp Neurol 493:140-6. 2005
  8. pmc The neuropsychopharmacology of fronto-executive function: monoaminergic modulation
    T W Robbins
    Department of Experimental Psychology, and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB23EB, UK
    Annu Rev Neurosci 32:267-87. 2009
  9. ncbi request reprint Obituary: Dr Ann E. Kelley (1954-2007)
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 196:341-2. 2008
  10. ncbi request reprint A role for mesencephalic dopamine in activation: commentary on Berridge (2006)
    T W Robbins
    University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 191:433-7. 2007

Collaborators

Detail Information

Publications158 found, 100 shown here

  1. pmc Punishment induces risky decision-making in methadone-maintained opiate users but not in heroin users or healthy volunteers
    Karen D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:2115-24. 2005
    ..These findings are discussed with respect to the different mechanisms of action of heroin and methadone. Neuropsychopharmacology (2005) 30, 2115-2124. doi:10.1038/sj.npp.1300812; published online 6 July 2005...
  2. doi request reprint Animal models of neuropsychiatry revisited: a personal tribute to Teitelbaum
    T W Robbins
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Behav Brain Res 231:337-42. 2012
    ..This article illustrates these themes from examples taken from animal models of sensory neglect, drug addiction and cognitive syndromes associated with schizophrenia and other neuropsychiatric disorders...
  3. doi request reprint Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry
    Trevor W Robbins
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK
    Trends Cogn Sci 16:81-91. 2012
    ..We argue that this approach has important implications for the future classification of psychiatric disorders, genetics and therapeutics...
  4. pmc Impulsive behaviour induced by both NMDA receptor antagonism and GABAA receptor activation in rat ventromedial prefrontal cortex
    Emily R Murphy
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 219:401-10. 2012
    ..However, the mechanism underlying this effect is unclear...
  5. pmc Incentive motivation in first-episode psychosis: a behavioural study
    Graham K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 8:34. 2008
    ..It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue...
  6. ncbi request reprint Synthesizing schizophrenia: a bottom-up, symptomatic approach
    Trevor W Robbins
    Department of Experimental Psychology, University of Cambridge, UK
    Schizophr Bull 31:854-64. 2005
    ..This approach, it is argued, will enable the testing of novel drugs and the development of adequate etiological models of schizophrenia...
  7. ncbi request reprint Chemistry of the mind: neurochemical modulation of prefrontal cortical function
    Trevor W Robbins
    Department of Experimental Psychology and Medical Research Council Centre for Behavioural and Clinical Neuroscience, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Comp Neurol 493:140-6. 2005
    ..The capacity of the prefrontal cortex itself to exert top-down regulation of these ascending neurochemical systems is also discussed...
  8. pmc The neuropsychopharmacology of fronto-executive function: monoaminergic modulation
    T W Robbins
    Department of Experimental Psychology, and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB23EB, UK
    Annu Rev Neurosci 32:267-87. 2009
    ....
  9. ncbi request reprint Obituary: Dr Ann E. Kelley (1954-2007)
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 196:341-2. 2008
  10. ncbi request reprint A role for mesencephalic dopamine in activation: commentary on Berridge (2006)
    T W Robbins
    University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 191:433-7. 2007
  11. pmc Introduction. The neurobiology of drug addiction: new vistas
    T W Robbins
    Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 363:3109-11. 2008
  12. pmc Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition
    Trevor W Robbins
    Department of Experimental Psychology and University of Cambridge Behavioural and Clinical Neuroscience Institute, Downing Street, Cambridge CB2 3EB, UK
    Trends Pharmacol Sci 27:141-8. 2006
    ..We also discuss the unique functions of NMDA receptors and the fundamental role of AMPA receptors in processes that are common to some of these forms of memory, including encoding, consolidation and retrieval...
  13. ncbi request reprint Differential regulation of fronto-executive function by the monoamines and acetylcholine
    T W Robbins
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Cereb Cortex 17:i151-60. 2007
    ....
  14. pmc Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications
    T W Robbins
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Philos Trans R Soc Lond B Biol Sci 362:917-32. 2007
    ....
  15. doi request reprint Drug addiction and the memory systems of the brain
    T W Robbins
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Ann N Y Acad Sci 1141:1-21. 2008
    ..Finally, we consider the ancillary point that chronic abuse of many drugs may impact directly on neural memory systems via neuroadaptive and neurotoxic effects that lead to cognitive impairments in which memory dysfunction is prominent...
  16. ncbi request reprint Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Cereb Cortex 17:18-27. 2007
    ....
  17. ncbi request reprint Basal forebrain cholinergic lesions enhance conditioned approach responses to stimuli predictive of food
    M C Olmstead
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 112:611-29. 1998
    ..Results suggest that NBM lesions may disrupt the balance between cortical and subcortical dopamine levels, and/or produce a deficit in attentional mechanisms that is manifested as increased responding to specific stimuli...
  18. ncbi request reprint Effects of dopamine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, U K
    Behav Brain Res 38:243-61. 1990
    ....
  19. ncbi request reprint Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousal
    B J Cole
    Department of Experimental Psychology, University of Cambridge, U K
    Behav Brain Res 33:165-79. 1989
    ..They therefore complete a double dissociation of effects on accuracy and vigour of responding, supporting theories of a division of arousal-type processes...
  20. ncbi request reprint Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task
    Emma S J Robinson
    Department of Experimental Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:2398-406. 2008
    ..Our results suggest that the NAc, but not the PL or IL, is implicated in the mediation of the effects of M100907 and SB242084 on inhibitory response control during baseline 5CSRTT performance...
  21. ncbi request reprint Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity
    J W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 164:329-40. 2002
    ....
  22. ncbi request reprint Impulsive choice induced in rats by lesions of the nucleus accumbens core
    R N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 292:2499-501. 2001
    ..Thus, dysfunction of the nucleus accumbens core may be a key element in the neuropathology of impulsivity...
  23. pmc Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
    P R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain 130:2387-400. 2007
    ..Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs...
  24. doi request reprint Paradoxical enhancement of choice reaction time performance in patients with major depression
    H W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    J Psychopharmacol 24:471-9. 2010
    ..Regardless of precise mechanism, the results do indicate that depressed patients are not invariably impaired in motivational paradigms and that their RT performance in certain situations can be superior to that of controls...
  25. pmc Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
    G K Murray
    Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Mol Psychiatry 13:239, 267-76. 2008
    ..This study provides the first evidence linking abnormal mesolimbic activity, reward learning and psychosis...
  26. ncbi request reprint Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication
    R Swainson
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Neuropsychologia 38:596-612. 2000
    ....
  27. pmc Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:6950-9. 2008
    ....
  28. doi request reprint The effects of modafinil on mood and cognition in Huntington's disease
    Andrew D Blackwell
    Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 199:29-36. 2008
    ..We examined whether modafinil induced similar effects in individuals with Huntington's disease (HD)...
  29. ncbi request reprint Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits
    A D Lawrence
    Department of Experimental Psychology, University of Cambridge, MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Brain 123:1349-64. 2000
    ..The results of our investigations suggest a particular role for the striatum in context-dependent action selection, in line with current computational theories of basal ganglia function...
  30. ncbi request reprint The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement
    D M Hutcheson
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 153:464-72. 2001
    ..CONCLUSIONS: These results indicate an important role for the core of the NAcc in the acquisition of heroin-seeking behaviour under the control of drug-associated stimuli...
  31. pmc Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
    K D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:612-23. 2005
    ..We sought to investigate this possibility using functional neuroimaging...
  32. pmc Differential roles of dopamine D1 and D2 receptors in the nucleus accumbens in attentional performance on the five-choice serial reaction time task
    Marie Astrid Pezze
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:273-83. 2007
    ..The data are discussed in terms of the different functions of NAC dopamine receptors in the processing of information from its different cortico-limbic inputs...
  33. ncbi request reprint Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Cambridge, United Kingdom
    Biol Psychiatry 55:1031-40. 2004
    ..We examined whether modafinil induced similar improvements in adults with attention-deficit/hyperactivity disorder...
  34. pmc Selective depletion of cortical noradrenaline by anti-dopamine beta-hydroxylase-saporin impairs attentional function and enhances the effects of guanfacine in the rat
    Jean A Milstein
    Department of Experimental Psychology, University of Cambridge Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 190:51-63. 2007
    ..This study employed a novel immunotoxin, anti-dopamine-beta hydroylase (DbetaH)-saporin, to make relatively selective lesions of the noradrenergic projections to the prefrontal cortex (PFC) in rats trained to perform the 5CSRT...
  35. ncbi request reprint Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set
    H S Crofts
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3DY, UK
    Cereb Cortex 11:1015-26. 2001
    ..Frontal catecholamine depletion caused an increase in distractibility while caudate dopamine loss induced greater focusing of responding...
  36. ncbi request reprint Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues
    N R Selden
    Department of Experimental Psychology, University of Cambridge, U K
    Neuroscience 42:335-50. 1991
    ..These results suggest a double dissociation of the effects of amygdala and hippocampal damage on fear conditioning to explicit and contextual cues...
  37. ncbi request reprint Lesions to the subthalamic nucleus decrease impulsive choice but impair autoshaping in rats: the importance of the basal ganglia in Pavlovian conditioning and impulse control
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, UK
    Eur J Neurosci 21:3107-16. 2005
    ..These data bear a striking similarity to those observed after lesions of the orbitofrontal cortex and are suggestive of an important role for corticosubthalamic connections in complex cognitive behaviour...
  38. ncbi request reprint Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function
    J A Parkinson
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Behav Brain Res 137:149-63. 2002
    ..This difference in lesion-induced impairment implies that mesoaccumbens dopamine may play differential roles in the learning and performance of preparatory Pavlovian conditioning...
  39. ncbi request reprint Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, U K
    Neuropharmacology 26:893-901. 1987
    ..Various problems of interpretation are discussed and the utility of a comparison of the different patterns of the effects of these lesions of catecholaminergic and cholinergic projections is made clear...
  40. ncbi request reprint Prefrontal serotonin depletion affects reversal learning but not attentional set shifting
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:532-8. 2005
    ....
  41. ncbi request reprint Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats
    D M Eagle
    Department of Experimental Psychology, University of Cambridge, United Kingdom
    Behav Neurosci 113:718-31. 1999
    ..Findings are discussed in relation to the roles of the dorsal and ventral striatum in reward-related behaviors...
  42. ncbi request reprint Cognitive inflexibility after prefrontal serotonin depletion
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Science 304:878-80. 2004
    ....
  43. ncbi request reprint Maternal deprivation of neonatal rats produces enduring changes in dopamine function
    F S Hall
    Department of Experimental Psychology, University of Cambridge, England
    Synapse 32:37-43. 1999
    ..Thus, behavioral responses to d-amphetamine are diminished in maternally deprived rats despite apparent increases in presynaptic dopaminergic function in the NAC...
  44. ncbi request reprint Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex
    Y P Liu
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 173:175-85. 2004
    ....
  45. pmc Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats
    Andrea Bari
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Psychopharmacology (Berl) 205:273-83. 2009
    ..While there is relative consensus regarding the anatomical substrates of behavioral inhibition, the neurochemical imbalance responsible for the deficits in stopping displayed by impulsive individuals is still a matter of debate...
  46. pmc Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens
    Morgane Besson
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 35:560-9. 2010
    ..Such divergent roles may have relevance for the etiology and treatment of clinical disorders of behavioral control, including attention-deficit hyperactivity disorder and drug addiction...
  47. ncbi request reprint Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Biol Psychiatry 62:977-84. 2007
    ..Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential. Studies have yet to assess whether atomoxetine improves cognition following a single oral dose in ADHD...
  48. doi request reprint Animal models of neuropsychiatric disorders
    A B P Fernando
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Annu Rev Clin Psychol 7:39-61. 2011
    ....
  49. ncbi request reprint Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour
    R D Rogers
    Departments of Experimental Psychology and Psychiatry, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 146:482-91. 1999
    ..However, little research has addressed the specific cognitive consequences of changed monoaminergic function that might contribute to the production of impulsive behaviour...
  50. ncbi request reprint Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers
    P J Brasted
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Res Bull 46:487-93. 1998
    ..Rather, the pattern of reaction time deficit after striatal lesions depends critically on the apparatus used and the precise response requirements for each task...
  51. ncbi request reprint Lesions of the pedunculopontine tegmental nucleus increase sucrose consumption but do not affect discrimination or contrast effects
    M C Olmstead
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 113:732-43. 1999
    ..Somewhat surprisingly, lesions increased sucrose intake when rats were food-restricted. These results suggest that PPTg lesions do not disrupt primary motivation or the ability to evaluate and respond to changes in reward strength...
  52. ncbi request reprint A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: implications for theories of executive functioning and cognitive aging. Cambridge Neuropsychological Test Automated Batte
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, U K
    J Int Neuropsychol Soc 4:474-90. 1998
    ..Finally, only limited support was found for the hypothesis that cognitive aging depends on slowed information processing...
  53. ncbi request reprint Diazepam produces disinhibitory cognitive effects in male volunteers
    J B Deakin
    University of Cambridge School of Clinical Medicine, Department of Psychiatry, Addenbrooke s Hospital, Box 189, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 173:88-97. 2004
    ..Diazepam has well known amnestic and sedative effects but effects on fronto-executive function remain largely uninvestigated, especially on neuropsychologically validated tests of risk taking and orbitofrontal cortex function...
  54. doi request reprint Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'
    E S J Robinson
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, Cambridge, UK
    Behav Brain Res 196:310-6. 2009
    ..We thus suggest that an inability to bridge delays to future rewards and reward-related stimuli is a candidate behavioural endophenotype that pre-disposes to clinical psychopathology...
  55. ncbi request reprint Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial reaction time task
    J McGaughy
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:1905-13. 2002
    ..These data provide the first direct evidence for a relationship between selective damage in the basal forebrain with decreased cortical ACh efflux and impaired attentional function...
  56. doi request reprint Methylphenidate-induced impulsivity: pharmacological antagonism by beta-adrenoreceptor blockade
    J A Milstein
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    J Psychopharmacol 24:309-21. 2010
    ..The other antagonists had no effect on methylphenidate-induced impulsivity. Taken together, these studies provide evidence for a modulatory role of beta-adrenoreceptors on methylphenidate-induced impulsive responding...
  57. pmc Contrasting effects of selective lesions of nucleus accumbens core or shell on inhibitory control and amphetamine-induced impulsive behaviour
    E R Murphy
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Eur J Neurosci 28:353-63. 2008
    ..Specifically, they suggest the shell subregion to be necessary for dopaminergic activation driving amphetamine-induced impulsive behaviour and the core subregion for the normal control of this behaviour via conditioned influences...
  58. pmc Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making
    L Clark
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Brain 131:1311-22. 2008
    ..Poor decision-making in clinical populations can arise via multiple routes, with functionally dissociable effects of vmPFC and insular cortex damage...
  59. pmc Selective prefrontal serotonin depletion impairs acquisition of a detour-reaching task
    S C Walker
    Department of Experimental Psychology, Downing Street, Cambridge CB2 3EB, UK
    Eur J Neurosci 23:3119-23. 2006
    ..This finding provides further support for the role of prefrontal serotonin in inhibitory control processes specifically in tasks sensitive to OFC dysfunction...
  60. doi request reprint Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex
    Susannah C Walker
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    J Neurosci 29:6033-41. 2009
    ..However, 5-HT does not appear to be implicated in this response inhibitory capacity...
  61. ncbi request reprint Prefrontal cortical-ventral striatal interactions involved in affective modulation of attentional performance: implications for corticostriatal circuit function
    Anastasia Christakou
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:773-80. 2004
    ..This distinction provides an insight into the functional specialization of corticostriatal circuits in similar behavioral contexts...
  62. ncbi request reprint Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex
    Y Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom CB2 3EB
    J Neurosci 23:8771-80. 2003
    ..In contrast, the ILC lesion had no effect on response inhibitory control in either of these settings. The findings are discussed in the context of dissociable executive functions in ventral sectors of the rat prefrontal cortex...
  63. pmc Methylphenidate ('Ritalin') can ameliorate abnormal risk-taking behavior in the frontal variant of frontotemporal dementia
    Shibley Rahman
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Neuropsychopharmacology 31:651-8. 2006
    ..The results are discussed in terms of the 'somatic marker' hypothesis of impaired decision-making following orbitofrontal dysfunction...
  64. ncbi request reprint Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:669-82. 2005
    ..These data suggest a significant role for 5-HT : DA interactions within the NAC in the control of impulsivity, and in the mechanism by which amphetamine decreases impulsive choice...
  65. pmc Comparison of the conditioned reinforcing properties of a safety signal and appetitive stimulus: effects of d-amphetamine and anxiolytics
    A B P Fernando
    Department of Psychology, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 227:195-208. 2013
    ..Such responding should also be sensitive to the rate-increasing effects of d-amphetamine and to the anxiolytics 8-OH-DPAT and diazepam...
  66. ncbi request reprint Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity
    Y Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Behav Brain Res 146:105-19. 2003
    ..Furthermore, these data provide new insights into the functional organization of the rodent frontal cortex with a particular emphasis on localization of function...
  67. ncbi request reprint D-Amphetamine remediates attentional performance in rats with dorsal prefrontal lesions
    Y Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge CB23EB, UK
    Behav Brain Res 158:97-107. 2005
    ....
  68. ncbi request reprint Asymmetric frontal activation during episodic memory: the effects of stimulus type on encoding and retrieval
    A C Lee
    Department of Experimental Psychology, Cambridge, UK
    Neuropsychologia 38:677-92. 2000
    ..These results suggest that encoding and retrieval may actually involve similar regions of the lateral prefrontal cortex when all factors relating to the type of stimulus material (i.e. modality), are appropriately controlled...
  69. doi request reprint Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia
    H W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Psychol Med 40:433-40. 2010
    ....
  70. ncbi request reprint Impaired dimensional selection but intact use of reward feedback during visual discrimination learning in Parkinson's disease
    R Swainson
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychologia 44:1290-304. 2006
    ....
  71. pmc Reinforcement and reversal learning in first-episode psychosis
    G K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Schizophr Bull 34:848-55. 2008
    ..Abnormalities in reinforcement learning and reversal learning have been reported in psychosis, possibly secondary to subcortical dopamine abnormalities...
  72. ncbi request reprint Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat
    L S Wilkinson
    The Babraham Institute, Department of Neurobiology, Cambridge, UK
    Eur J Neurosci 10:1019-26. 1998
    ....
  73. ncbi request reprint Spatial and non-spatial working memory at different stages of Parkinson's disease
    A M Owen
    Department of Psychiatry, University of Cambridge, UK
    Neuropsychologia 35:519-32. 1997
    ....
  74. ncbi request reprint Multidimensional scaling of integrated neurocognitive function and schizophrenia as a disconnexion disorder
    D E Welchew
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Neuroimage 17:1227-39. 2002
    ..However, there was significantly greater variability of interregional configurations within the group of patients with schizophrenia. The implications for schizophrenia as a disconnexion disorder are discussed...
  75. ncbi request reprint Task-set switching deficits in early-stage Huntington's disease: implications for basal ganglia function
    Adam R Aron
    University of Cambridge, UK
    J Cogn Neurosci 15:629-42. 2003
    ....
  76. ncbi request reprint Differential effects of nucleus accumbens core, shell, or dorsal striatal inactivations on the persistence, reacquisition, or reinstatement of responding for a drug-paired conditioned reinforcer
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:1413-25. 2008
    ..These results are discussed with reference to the neural systems involved in different aspects of responding maintained by drug-paired conditioned reinforcers...
  77. doi request reprint Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific
    Vasileios Boulougouris
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 30:930-8. 2010
    ..These data also bear on the issue of whether 5-HT(2C) receptor antagonism within the OFC might help elucidate the biological substrate of obsessive-compulsive disorder, offering the potential for therapeutic application...
  78. ncbi request reprint Sulpiride alleviates the attentional impairments of rats with medial prefrontal cortex lesions
    Filippo Passetti
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Behav Brain Res 138:59-69. 2003
    ..These results extend previous findings of attentional impairments in rats with mPFC lesions and are compatible with recent hypotheses concerning the role of dopaminergic dysregulation in the pathogenesis of schizophrenia...
  79. ncbi request reprint Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 22:6247-53. 2002
    ..These data indicate a possible involvement of the dopaminergic innervation of the dorsal striatum in well established, or habitual, cocaine-seeking behavior...
  80. doi request reprint Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D(2/3) receptor antagonist sulpiride
    Marie A Pezze
    Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge CB23EB, UK
    Psychopharmacology (Berl) 202:307-13. 2009
    ..The prefrontal cortex (PFC) and nucleus accumbens (NAC) are key brain loci considered to mediate many of the cognitive deficits associated with schizophrenia and related disorders...
  81. ncbi request reprint Functional disconnection of the medial prefrontal cortex and subthalamic nucleus in attentional performance: evidence for corticosubthalamic interaction
    Yogita Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 23:5477-85. 2003
    ..This study provides direct evidence that performance in tasks that require optimal attentional and executive control relies on a corticosubthalamic interaction within the neural circuitry of the basal ganglia...
  82. ncbi request reprint Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers
    Mitul A Mehta
    Department of Psychiatry, Level E4, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 176:331-42. 2004
    ..These include working memory and set-shifting deficits. Theories of DA function have predicted that distraction or impaired switching may be important determinants of such deficits...
  83. ncbi request reprint Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex
    Yogita Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 29:1628-36. 2004
    ..These data provide the first demonstration that dopamine D1 receptor stimulation sufficient to improve attentional accuracy, can also disrupt, and facilitate short-term working memory performance in a delay-dependent manner...
  84. pmc Cholinergic modulation of visual attention and working memory: dissociable effects of basal forebrain 192-IgG-saporin lesions and intraprefrontal infusions of scopolamine
    Yogita Chudasama
    Cambridge University, Department of Experimental Psychology, Cambridge CB2 3EB, UK
    Learn Mem 11:78-86. 2004
    ..Together, these findings implicate the nBM cortical cholinergic system in both attentional and mnemonic processing...
  85. pmc Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers
    U Muller
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neuropharmacology 64:490-5. 2013
    ....
  86. ncbi request reprint Selective deficits in attentional performance on the 5-choice serial reaction time task following pedunculopontine tegmental nucleus lesions
    W L Inglis
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Behav Brain Res 123:117-31. 2001
    ..The PPTg may control attentional processes through its direct projections to the forebrain cholinergic system or, indirectly, through activation of thalamocortical projections...
  87. ncbi request reprint Lesions of the medial and lateral striatum in the rat produce differential deficits in attentional performance
    R D Rogers
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 115:799-811. 2001
    ..These data suggest that the medial and lateral striatum have contrasting roles in the control of instrumental responding related to the primary sources of their cortical innervation...
  88. ncbi request reprint Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands
    R Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Cereb Cortex 11:1136-43. 2001
    ..Hence, DA-ergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of DA function in underlying cortico-striatal circuitry...
  89. ncbi request reprint The role of withdrawal in heroin addiction: enhances reward or promotes avoidance?
    D M Hutcheson
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Nat Neurosci 4:943-7. 2001
    ..In support of this hypothesis, we show here that previous experience with heroin in withdrawal is necessary for subsequent heroin-seeking behavior to be enhanced when dependent rats once again experience withdrawal...
  90. ncbi request reprint The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 163:362-80. 2002
    ..The developmental history and application of the 5-choice serial reaction time task (5CSRTT) for measuring effects of drugs and other manipulations on attentional performance (and stimulus control) in rats is reviewed...
  91. ncbi request reprint Dissociable contributions of the orbitofrontal and lateral prefrontal cortex of the marmoset to performance on a detour reaching task
    J D Wallis
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Eur J Neurosci 13:1797-808. 2001
    ....
  92. ncbi request reprint Neural systems underlying arousal and attention. Implications for drug abuse
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, UK
    Ann N Y Acad Sci 846:222-37. 1998
    ....
  93. ncbi request reprint Improved short-term spatial memory but impaired reversal learning following the dopamine D(2) agonist bromocriptine in human volunteers
    M A Mehta
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, UK
    Psychopharmacology (Berl) 159:10-20. 2001
    ..Studies in humans of cognitive effects of dopaminergic drugs have largely focused on tasks of working memory, with a few studies also examining executive function...
  94. ncbi request reprint Redefining the functional organization of working memory processes within human lateral prefrontal cortex
    A M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Eur J Neurosci 11:567-74. 1999
    ....
  95. ncbi request reprint Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
    L Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, and Department of Medical Genetics, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 182:570-8. 2005
    ..Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear...
  96. pmc Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion
    Jonathan P Roiser
    Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK, and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    Neuropsychopharmacology 31:2264-72. 2006
    ....
  97. ncbi request reprint Cognitive enhancing effects of modafinil in healthy volunteers
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Psychopharmacology (Berl) 165:260-9. 2003
    ....
  98. pmc Profile of executive and memory function associated with amphetamine and opiate dependence
    Karen D Ersche
    Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychopharmacology 31:1036-47. 2006
    ..Impairment persists after several years of drug abstinence and may reflect neuropathology in frontal and temporal cortices...
  99. ncbi request reprint Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 24:1129-35. 2004
    ....
  100. ncbi request reprint Executive function in Tourette's syndrome and obsessive-compulsive disorder
    Laura H Watkins
    MRC Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Psychol Med 35:571-82. 2005
    ....
  101. ncbi request reprint Mechanisms of cognitive set flexibility in Parkinson's disease
    R Cools
    Department of Experimental Psychology, Cambridge Centre for Brain Repair, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
    Brain 124:2503-12. 2001
    ..Finally, the impairment in task-set switching was only apparent when competing information was present, i.e. when the load on selection mechanisms was increased...