T W Robbins

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Neurobehavioural mechanisms of reward and motivation
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, UK
    Curr Opin Neurobiol 6:228-36. 1996
  2. ncbi request reprint Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Cereb Cortex 17:18-27. 2007
  3. ncbi request reprint Basal forebrain cholinergic lesions enhance conditioned approach responses to stimuli predictive of food
    M C Olmstead
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 112:611-29. 1998
  4. ncbi request reprint Effects of dopamine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, U K
    Behav Brain Res 38:243-61. 1990
  5. ncbi request reprint Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousal
    B J Cole
    Department of Experimental Psychology, University of Cambridge, U K
    Behav Brain Res 33:165-79. 1989
  6. doi request reprint Paradoxical enhancement of choice reaction time performance in patients with major depression
    H W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    J Psychopharmacol 24:471-9. 2010
  7. ncbi request reprint Impulsive choice induced in rats by lesions of the nucleus accumbens core
    R N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 292:2499-501. 2001
  8. ncbi request reprint The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement
    D M Hutcheson
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 153:464-72. 2001
  9. ncbi request reprint Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits
    A D Lawrence
    Department of Experimental Psychology, University of Cambridge, MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Brain 123:1349-64. 2000
  10. ncbi request reprint Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication
    R Swainson
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Neuropsychologia 38:596-612. 2000

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Neurobehavioural mechanisms of reward and motivation
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, UK
    Curr Opin Neurobiol 6:228-36. 1996
    ..This progress has enabled the dissection of motivational processes into components that can begin to be related to the functioning of specific limbic cortical structures that project to different compartments of the ventral striatum...
  2. ncbi request reprint Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Cereb Cortex 17:18-27. 2007
    ....
  3. ncbi request reprint Basal forebrain cholinergic lesions enhance conditioned approach responses to stimuli predictive of food
    M C Olmstead
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 112:611-29. 1998
    ..Results suggest that NBM lesions may disrupt the balance between cortical and subcortical dopamine levels, and/or produce a deficit in attentional mechanisms that is manifested as increased responding to specific stimuli...
  4. ncbi request reprint Effects of dopamine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, U K
    Behav Brain Res 38:243-61. 1990
    ....
  5. ncbi request reprint Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousal
    B J Cole
    Department of Experimental Psychology, University of Cambridge, U K
    Behav Brain Res 33:165-79. 1989
    ..They therefore complete a double dissociation of effects on accuracy and vigour of responding, supporting theories of a division of arousal-type processes...
  6. doi request reprint Paradoxical enhancement of choice reaction time performance in patients with major depression
    H W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    J Psychopharmacol 24:471-9. 2010
    ..Regardless of precise mechanism, the results do indicate that depressed patients are not invariably impaired in motivational paradigms and that their RT performance in certain situations can be superior to that of controls...
  7. ncbi request reprint Impulsive choice induced in rats by lesions of the nucleus accumbens core
    R N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 292:2499-501. 2001
    ..Thus, dysfunction of the nucleus accumbens core may be a key element in the neuropathology of impulsivity...
  8. ncbi request reprint The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement
    D M Hutcheson
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 153:464-72. 2001
    ..CONCLUSIONS: These results indicate an important role for the core of the NAcc in the acquisition of heroin-seeking behaviour under the control of drug-associated stimuli...
  9. ncbi request reprint Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits
    A D Lawrence
    Department of Experimental Psychology, University of Cambridge, MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Brain 123:1349-64. 2000
    ..The results of our investigations suggest a particular role for the striatum in context-dependent action selection, in line with current computational theories of basal ganglia function...
  10. ncbi request reprint Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication
    R Swainson
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Neuropsychologia 38:596-612. 2000
    ....
  11. ncbi request reprint Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues
    N R Selden
    Department of Experimental Psychology, University of Cambridge, U K
    Neuroscience 42:335-50. 1991
    ..These results suggest a double dissociation of the effects of amygdala and hippocampal damage on fear conditioning to explicit and contextual cues...
  12. ncbi request reprint Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set
    H S Crofts
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3DY, UK
    Cereb Cortex 11:1015-26. 2001
    ..Frontal catecholamine depletion caused an increase in distractibility while caudate dopamine loss induced greater focusing of responding...
  13. pmc Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
    G K Murray
    Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Mol Psychiatry 13:239, 267-76. 2008
    ..This study provides the first evidence linking abnormal mesolimbic activity, reward learning and psychosis...
  14. ncbi request reprint Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats
    D M Eagle
    Department of Experimental Psychology, University of Cambridge, United Kingdom
    Behav Neurosci 113:718-31. 1999
    ..Findings are discussed in relation to the roles of the dorsal and ventral striatum in reward-related behaviors...
  15. pmc Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
    P R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain 130:2387-400. 2007
    ..Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs...
  16. ncbi request reprint Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, U K
    Neuropharmacology 26:893-901. 1987
    ..Various problems of interpretation are discussed and the utility of a comparison of the different patterns of the effects of these lesions of catecholaminergic and cholinergic projections is made clear...
  17. ncbi request reprint Maternal deprivation of neonatal rats produces enduring changes in dopamine function
    F S Hall
    Department of Experimental Psychology, University of Cambridge, England
    Synapse 32:37-43. 1999
    ..Thus, behavioral responses to d-amphetamine are diminished in maternally deprived rats despite apparent increases in presynaptic dopaminergic function in the NAC...
  18. pmc Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making
    L Clark
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Brain 131:1311-22. 2008
    ..Poor decision-making in clinical populations can arise via multiple routes, with functionally dissociable effects of vmPFC and insular cortex damage...
  19. ncbi request reprint Prefrontal serotonin depletion affects reversal learning but not attentional set shifting
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:532-8. 2005
    ....
  20. pmc Contrasting effects of selective lesions of nucleus accumbens core or shell on inhibitory control and amphetamine-induced impulsive behaviour
    E R Murphy
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Eur J Neurosci 28:353-63. 2008
    ..Specifically, they suggest the shell subregion to be necessary for dopaminergic activation driving amphetamine-induced impulsive behaviour and the core subregion for the normal control of this behaviour via conditioned influences...
  21. pmc Selective prefrontal serotonin depletion impairs acquisition of a detour-reaching task
    S C Walker
    Department of Experimental Psychology, Downing Street, Cambridge CB2 3EB, UK
    Eur J Neurosci 23:3119-23. 2006
    ..This finding provides further support for the role of prefrontal serotonin in inhibitory control processes specifically in tasks sensitive to OFC dysfunction...
  22. ncbi request reprint Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity
    J W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 164:329-40. 2002
    ....
  23. ncbi request reprint Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex
    Y P Liu
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 173:175-85. 2004
    ....
  24. ncbi request reprint A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: implications for theories of executive functioning and cognitive aging. Cambridge Neuropsychological Test Automated Batte
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, U K
    J Int Neuropsychol Soc 4:474-90. 1998
    ..Finally, only limited support was found for the hypothesis that cognitive aging depends on slowed information processing...
  25. ncbi request reprint Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour
    R D Rogers
    Departments of Experimental Psychology and Psychiatry, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 146:482-91. 1999
    ..However, little research has addressed the specific cognitive consequences of changed monoaminergic function that might contribute to the production of impulsive behaviour...
  26. doi request reprint Methylphenidate-induced impulsivity: pharmacological antagonism by beta-adrenoreceptor blockade
    J A Milstein
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    J Psychopharmacol 24:309-21. 2010
    ..The other antagonists had no effect on methylphenidate-induced impulsivity. Taken together, these studies provide evidence for a modulatory role of beta-adrenoreceptors on methylphenidate-induced impulsive responding...
  27. doi request reprint Drug addiction and the memory systems of the brain
    T W Robbins
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Ann N Y Acad Sci 1141:1-21. 2008
    ..Finally, we consider the ancillary point that chronic abuse of many drugs may impact directly on neural memory systems via neuroadaptive and neurotoxic effects that lead to cognitive impairments in which memory dysfunction is prominent...
  28. ncbi request reprint Differential regulation of fronto-executive function by the monoamines and acetylcholine
    T W Robbins
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Cereb Cortex 17:i151-60. 2007
    ....
  29. ncbi request reprint Spatial and non-spatial working memory at different stages of Parkinson's disease
    A M Owen
    Department of Psychiatry, University of Cambridge, UK
    Neuropsychologia 35:519-32. 1997
    ....
  30. ncbi request reprint Cognitive inflexibility after prefrontal serotonin depletion
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Science 304:878-80. 2004
    ....
  31. ncbi request reprint Lesions of the pedunculopontine tegmental nucleus increase sucrose consumption but do not affect discrimination or contrast effects
    M C Olmstead
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 113:732-43. 1999
    ..Somewhat surprisingly, lesions increased sucrose intake when rats were food-restricted. These results suggest that PPTg lesions do not disrupt primary motivation or the ability to evaluate and respond to changes in reward strength...
  32. ncbi request reprint D-Amphetamine remediates attentional performance in rats with dorsal prefrontal lesions
    Y Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge CB23EB, UK
    Behav Brain Res 158:97-107. 2005
    ....
  33. doi request reprint Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia
    H W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Psychol Med 40:433-40. 2010
    ....
  34. pmc Reinforcement and reversal learning in first-episode psychosis
    G K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Schizophr Bull 34:848-55. 2008
    ..Abnormalities in reinforcement learning and reversal learning have been reported in psychosis, possibly secondary to subcortical dopamine abnormalities...
  35. ncbi request reprint Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers
    P J Brasted
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Res Bull 46:487-93. 1998
    ..Rather, the pattern of reaction time deficit after striatal lesions depends critically on the apparatus used and the precise response requirements for each task...
  36. pmc Noradrenergic versus dopaminergic modulation of impulsivity, attention and monitoring behaviour in rats performing the stop-signal task: possible relevance to ADHD
    A Bari
    Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 230:89-111. 2013
    ....
  37. ncbi request reprint Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands
    R Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Cereb Cortex 11:1136-43. 2001
    ..Hence, DA-ergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of DA function in underlying cortico-striatal circuitry...
  38. pmc Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
    K D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:612-23. 2005
    ..We sought to investigate this possibility using functional neuroimaging...
  39. ncbi request reprint The role of withdrawal in heroin addiction: enhances reward or promotes avoidance?
    D M Hutcheson
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Nat Neurosci 4:943-7. 2001
    ..In support of this hypothesis, we show here that previous experience with heroin in withdrawal is necessary for subsequent heroin-seeking behavior to be enhanced when dependent rats once again experience withdrawal...
  40. ncbi request reprint Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity
    Y Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Behav Brain Res 146:105-19. 2003
    ..Furthermore, these data provide new insights into the functional organization of the rodent frontal cortex with a particular emphasis on localization of function...
  41. ncbi request reprint Lesions of the medial and lateral striatum in the rat produce differential deficits in attentional performance
    R D Rogers
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 115:799-811. 2001
    ..These data suggest that the medial and lateral striatum have contrasting roles in the control of instrumental responding related to the primary sources of their cortical innervation...
  42. ncbi request reprint Dissociable contributions of the orbitofrontal and lateral prefrontal cortex of the marmoset to performance on a detour reaching task
    J D Wallis
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Eur J Neurosci 13:1797-808. 2001
    ....
  43. ncbi request reprint Improved short-term spatial memory but impaired reversal learning following the dopamine D(2) agonist bromocriptine in human volunteers
    M A Mehta
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, UK
    Psychopharmacology (Berl) 159:10-20. 2001
    ..Studies in humans of cognitive effects of dopaminergic drugs have largely focused on tasks of working memory, with a few studies also examining executive function...
  44. pmc Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers
    U Muller
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neuropharmacology 64:490-5. 2013
    ....
  45. ncbi request reprint Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
    L Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, and Department of Medical Genetics, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 182:570-8. 2005
    ..Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear...
  46. ncbi request reprint Impaired dimensional selection but intact use of reward feedback during visual discrimination learning in Parkinson's disease
    R Swainson
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychologia 44:1290-304. 2006
    ....
  47. ncbi request reprint Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
    B J Everitt
    Department of Experimental Psychology, University of Cambridge, United Kingdom
    Ann N Y Acad Sci 877:412-38. 1999
    ....
  48. pmc Differential contributions of dopamine and serotonin to orbitofrontal cortex function in the marmoset
    S C Walker
    Department of Experimental Psychology, University of Cambridge, UK
    Cereb Cortex 19:889-98. 2009
    ....
  49. ncbi request reprint Rule-abstraction deficits following a basal ganglia lesion
    R Swainson
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neurocase 7:433-43. 2001
    ..These data provide evidence for the dissociability of cognitive functions within the basal ganglia...
  50. ncbi request reprint The neuropsychological basis of addictive behaviour
    B J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Brain Res Brain Res Rev 36:129-38. 2001
    ....
  51. ncbi request reprint Selective deficits in attentional performance on the 5-choice serial reaction time task following pedunculopontine tegmental nucleus lesions
    W L Inglis
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Behav Brain Res 123:117-31. 2001
    ..The PPTg may control attentional processes through its direct projections to the forebrain cholinergic system or, indirectly, through activation of thalamocortical projections...
  52. ncbi request reprint Neural systems underlying arousal and attention. Implications for drug abuse
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, UK
    Ann N Y Acad Sci 846:222-37. 1998
    ....
  53. ncbi request reprint Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection
    C Baunez
    Department of Experimental Psychology, University of Cambridge, CB2 3EB Cambridge, UK
    Eur J Neurosci 13:1609-16. 2001
    ..Together, these results suggest that the STN plays an important role in response preparatory processes, including response selection and inhibitory control processes...
  54. ncbi request reprint The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats
    H L Alderson
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 153:455-63. 2001
    ..v. heroin, may mediate processes that are of special importance during the acquisition of instrumental behaviour...
  55. ncbi request reprint The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins
    J McGaughy
    Department of Experimental Psychology, University of Cambridge, CB2 3EB, Cambridge, UK
    Behav Brain Res 115:251-63. 2000
    ..Additionally, the conceptual and methodological cost and benefits of the methods of infusion used to produce lesions with these immunotoxins is assessed...
  56. ncbi request reprint Neuroscience. Boosting working memory
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 290:2275-6. 2000
    ..In a Perspective, Robbins et al. discuss new findings (Furey et al.) with fMRI that reveal how working memory is enhanced by the drug physostigmine, which increases cholinergic function in the brain...
  57. ncbi request reprint Asymmetric frontal activation during episodic memory: the effects of stimulus type on encoding and retrieval
    A C Lee
    Department of Experimental Psychology, Cambridge, UK
    Neuropsychologia 38:677-92. 2000
    ..These results suggest that encoding and retrieval may actually involve similar regions of the lateral prefrontal cortex when all factors relating to the type of stimulus material (i.e. modality), are appropriately controlled...
  58. ncbi request reprint Effects of excitotoxic lesions of the rat prefrontal cortex on CREB regulation and presynaptic markers of dopamine and amino acid function in the nucleus accumbens
    J W Dalley
    Department of Experimental Psychology, University of Cambridge, UK
    Eur J Neurosci 11:1265-74. 1999
    ....
  59. ncbi request reprint Discrimination, reversal, and shift learning in Huntington's disease: mechanisms of impaired response selection
    A D Lawrence
    Department of Experimental Psychology, University of Cambridge, UK
    Neuropsychologia 37:1359-74. 1999
    ....
  60. pmc Comparison of the conditioned reinforcing properties of a safety signal and appetitive stimulus: effects of d-amphetamine and anxiolytics
    A B P Fernando
    Department of Psychology, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 227:195-208. 2013
    ..Such responding should also be sensitive to the rate-increasing effects of d-amphetamine and to the anxiolytics 8-OH-DPAT and diazepam...
  61. doi request reprint Animal models of neuropsychiatry revisited: a personal tribute to Teitelbaum
    T W Robbins
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Behav Brain Res 231:337-42. 2012
    ..This article illustrates these themes from examples taken from animal models of sensory neglect, drug addiction and cognitive syndromes associated with schizophrenia and other neuropsychiatric disorders...
  62. ncbi request reprint Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function
    A Christakou
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 115:812-25. 2001
    ....
  63. ncbi request reprint Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks
    R Swainson
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Dement Geriatr Cogn Disord 12:265-80. 2001
    ..QD patients' performance correlated with the degree of subsequent global cognitive decline. Elements of contextual and cued recall may account for the task's sensitivity and specificity for AD...
  64. ncbi request reprint Mechanisms of cognitive set flexibility in Parkinson's disease
    R Cools
    Department of Experimental Psychology, Cambridge Centre for Brain Repair, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
    Brain 124:2503-12. 2001
    ..Finally, the impairment in task-set switching was only apparent when competing information was present, i.e. when the load on selection mechanisms was increased...
  65. ncbi request reprint A role for mesencephalic dopamine in activation: commentary on Berridge (2006)
    T W Robbins
    University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 191:433-7. 2007
  66. ncbi request reprint Lesions of the medial prefrontal cortex or nucleus accumbens core do not impair inhibitory control in rats performing a stop-signal reaction time task
    D M Eagle
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
    Behav Brain Res 146:131-44. 2003
    ..These results are discussed with respect to the fronto-striatal circuitry involved in the mediation of behavioural inhibition...
  67. ncbi request reprint Decision making deficits in patients with first-episode and chronic schizophrenia
    S B Hutton
    Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Campus St Dunstan s Rd London W6 8RF, UK
    Schizophr Res 55:249-57. 2002
    ..These results contribute to increasing evidence of orbitofrontal dysfunction in schizophrenia, and suggest that disease progression or the effects of long term antipsychotic medication may influence performance on this task...
  68. ncbi request reprint Evolution of cognitive dysfunction in an incident Parkinson's disease cohort
    C H Williams-Gray
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Brain 130:1787-98. 2007
    ..Furthermore, given that these predictors of dementia are readily measurable within just a few minutes in a clinical setting, our work may ultimately have practical implications in terms of guiding prognosis in individual patients...
  69. ncbi request reprint Diazepam produces disinhibitory cognitive effects in male volunteers
    J B Deakin
    University of Cambridge School of Clinical Medicine, Department of Psychiatry, Addenbrooke s Hospital, Box 189, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 173:88-97. 2004
    ..Diazepam has well known amnestic and sedative effects but effects on fronto-executive function remain largely uninvestigated, especially on neuropsychologically validated tests of risk taking and orbitofrontal cortex function...
  70. ncbi request reprint Decision-making cognition in mania and depression
    F C Murphy
    Department of Psychiatry, University of Cambridge
    Psychol Med 31:679-93. 2001
    ..Viewed in the context of other recent studies, these findings are consistent with a role for the ventromedial prefrontal cortex in mediating mood-cognition relationships...
  71. ncbi request reprint Acute dietary tryptophan depletion impairs maintenance of "affective set" and delayed visual recognition in healthy volunteers
    J S Rubinsztein
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
    Psychopharmacology (Berl) 154:319-26. 2001
    ..The novel finding of impairment on a delayed visual pattern recognition task confirms and extends previous studies where selective effects on memory and learning have been found following acute tryptophan depletion...
  72. ncbi request reprint Obituary: Dr Ann E. Kelley (1954-2007)
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 196:341-2. 2008
  73. ncbi request reprint Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and d-amphetamine
    D M Eagle
    Department of Experimental Psychology, University of Cambridge, Cambridge, England, United Kingdom
    Behav Neurosci 117:1302-17. 2003
    ..Medial striatal lesions also significantly slowed stop-signal reaction time. Subsequent treatment with d-amphetamine removed (0.3 mg/kg) or exacerbated (1.0 mg/kg) this deficit...
  74. pmc Introduction. The neurobiology of drug addiction: new vistas
    T W Robbins
    Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 363:3109-11. 2008
  75. ncbi request reprint The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers
    F C Murphy
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Psychopharmacology (Berl) 163:42-53. 2002
    ....
  76. pmc Subdissociative dose ketamine produces a deficit in manipulation but not maintenance of the contents of working memory
    Rebekah A E Honey
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 28:2037-44. 2003
    ..The specificity of this ketamine effect suggests that the earliest effect of NMDA receptor blockade is in higher order control of executive function rather than in more basic maintenance processes...
  77. ncbi request reprint Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance
    F C Murphy
    Department of Psychiatry, University of Cambridge
    Psychol Med 33:455-67. 2003
    ..The present research sought to determine whether the inability of depressed patients to utilize performance feedback advantageously is equally true for accurate and misleading feedback...
  78. ncbi request reprint Individual differences in prefrontal cortical activation on the Tower of London planning task: implication for effortful processing
    F Cazalis
    INSERM U 483, 9 quai Saint Bernard, 75005, Paris, France
    Eur J Neurosci 17:2219-25. 2003
    ....
  79. pmc Inhibition of subliminally primed responses is mediated by the caudate and thalamus: evidence from functional MRI and Huntington's disease
    A R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK
    Brain 126:713-23. 2003
    ....
  80. ncbi request reprint The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 163:362-80. 2002
    ..The developmental history and application of the 5-choice serial reaction time task (5CSRTT) for measuring effects of drugs and other manipulations on attentional performance (and stimulus control) in rats is reviewed...
  81. ncbi request reprint Neurocognitive deficits in decision-making and planning of patients with DSM-III-R borderline personality disorder
    E Bazanis
    Department of Psychiatry, University of Cambridge
    Psychol Med 32:1395-405. 2002
    ..Such investigations may improve our understanding of the possible role of brain dysfunction in BPD and improve the characterization of the psychological difficulties associated with this disorder...
  82. ncbi request reprint Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function
    J A Parkinson
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Behav Brain Res 137:149-63. 2002
    ..This difference in lesion-induced impairment implies that mesoaccumbens dopamine may play differential roles in the learning and performance of preparatory Pavlovian conditioning...
  83. ncbi request reprint Multidimensional scaling of integrated neurocognitive function and schizophrenia as a disconnexion disorder
    D E Welchew
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Neuroimage 17:1227-39. 2002
    ..However, there was significantly greater variability of interregional configurations within the group of patients with schizophrenia. The implications for schizophrenia as a disconnexion disorder are discussed...
  84. pmc Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications
    T W Robbins
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Philos Trans R Soc Lond B Biol Sci 362:917-32. 2007
    ....
  85. ncbi request reprint Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls
    J H Barnett
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Mol Psychiatry 12:502-9. 2007
    ..There was no evidence of publication bias. We conclude that there is small but significant relationship between Val(158)Met genotype and executive function in healthy individuals but not in schizophrenia...
  86. ncbi request reprint The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning
    L Clark
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Brain Cogn 55:41-53. 2004
    ..Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning...
  87. ncbi request reprint Impaired spatial working memory in adults with attention-deficit/hyperactivity disorder: comparisons with performance in adults with borderline personality disorder and in control subjects
    J H Dowson
    Cambridge University Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK
    Acta Psychiatr Scand 110:45-54. 2004
    ....
  88. ncbi request reprint Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial reaction time task
    J McGaughy
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:1905-13. 2002
    ..These data provide the first direct evidence for a relationship between selective damage in the basal forebrain with decreased cortical ACh efflux and impaired attentional function...
  89. ncbi request reprint Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting ability
    C Pantelis
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Parkville and Sunshine Hospital, St Albans, Victoria, Australia
    Psychol Med 34:693-703. 2004
    ..Few studies have assessed their relationship with neuropsychological deficits. We hypothesized that these syndromes may represent behavioural manifestations of frontal-subcortical impairments, previously described in schizophrenia...
  90. pmc Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
    S J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge, CB2 2PY, UK
    J Neurol Neurosurg Psychiatry 76:343-8. 2005
    ..To investigate the heterogeneity of idiopathic Parkinson's disease (PD) in a data driven manner among a cohort of patients in the early clinical stages of the disease meeting established diagnostic criteria...
  91. ncbi request reprint The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers
    S R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, P O Box 189, Cambridge CB2 2QQ, UK
    Neurosci Biobehav Rev 29:399-419. 2005
    ..This has direct implications not only for OCD but also for putative obsessive-compulsive spectrum conditions including attention deficit hyperactivity disorder, Tourette's syndrome, and trichotillomania (compulsive hair pulling)...
  92. ncbi request reprint Plasma level-dependent effects of methylphenidate on task-related functional magnetic resonance imaging signal changes
    Ulrich Muller
    MRC Behavioural and Clinical Neuroscience Centre, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:624-33. 2005
    ..Understanding of its cognition-enhancing effects and the neurobiological mechanisms involved, especially in elderly people, is currently incomplete...
  93. pmc Lateralisation of striatal function: evidence from 18F-dopa PET in Parkinson's disease
    A L Cheesman
    Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Neurol Neurosurg Psychiatry 76:1204-10. 2005
    ..This study aimed to investigate the contribution of the dopaminergic system to performance on two executive tasks using (18)F-6-fluorodopa positron emission tomography ((18)F-dopa PET) in PD subjects with early cognitive changes...
  94. ncbi request reprint Decision-making in mania: a PET study
    J S Rubinsztein
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Brain 124:2550-63. 2001
    ....
  95. ncbi request reprint Characteristic neurocognitive profile associated with adult attention-deficit/hyperactivity disorder
    A McLean
    Department of Psychiatry, School of Clinical Medicine, University of Cambridge
    Psychol Med 34:681-92. 2004
    ..The current study examined cognitive function in adults diagnosed with ADHD employing well-validated neuropsychological tasks...
  96. ncbi request reprint Psychopharmacological approaches to modulating attention in the five-choice serial reaction time task: implications for schizophrenia
    Y Chudasama
    National Institute of Mental Health, Building 49, Room 1B80, Convent Drive, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 174:86-98. 2004
    ..In schizophrenia, attentional disturbance is a core feature which may not only accompany the disorder, but may precede the onset of psychiatric symptoms...
  97. ncbi request reprint Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: locomotion, cocaine self-administration, and prepulse inhibition of startle
    S B Caine
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 115:880-94. 2001
    ....
  98. pmc Saccadic latency distributions in Parkinson's disease and the effects of L-dopa
    A W Michell
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, CB2 2PY, Cambridge, UK
    Exp Brain Res 174:7-18. 2006
    ....
  99. ncbi request reprint Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans
    Y Chudasama
    Laboratory of Neuropsychology, National Institute of Mental Health, Convent Drive, Building 49, Room 1B80, Bethesda, MD 20892, USA
    Biol Psychol 73:19-38. 2006
    ....
  100. ncbi request reprint The specificity of clinical characteristics in adults with attention-deficit/hyperactivity disorder: a comparison with patients with borderline personality disorder
    J H Dowson
    Department of Psychiatry, Box 189, Addenbrooke s Hospital, Cambridge University, Cambridge CB2 2QQ, UK
    Eur Psychiatry 19:72-8. 2004
    ..The results provide further validation for the ADSA scales and support a previous claim that 'long-term consistencies', i.e., related to task and goal persistence, is 'the centrepiece behavioural issue' for adults with ADHD...
  101. ncbi request reprint Limbic-striatal memory systems and drug addiction
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Neurobiol Learn Mem 78:625-36. 2002
    ..These systems include separate and overlapping influences from the amygdala, hippocampus, and cingulate and medial prefrontal cortex on drug-seeking as well as drug-taking behavior, including the propensity to relapse...