Research Topics
Genomes and Genes | Karin RömischSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Coordination of N-glycosylation and protein translocation across the endoplasmic reticulum membrane by Sss1 proteinWiep Scheper
University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, United Kingdom
J Biol Chem 278:37998-8003. 2003..Our data suggest that Sss1p coordinates translocation across the ER membrane and N-linked glycosylation of secretory proteins...
The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIBElena Miranda
Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
Hum Mol Genet 17:1527-39. 2008..Moreover, mutant neuroserpin causes locomotor deficits in the fly allowing us to demonstrate a direct link between polymer accumulation and neuronal toxicity...- Surfing the Sec61 channel: bidirectional protein translocation across the ER membraneK Römisch
University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
J Cell Sci 112:4185-91. 1999..Retrograde transport of soluble proteins through the Sec61 channel after signal-peptide cleavage, however, must be mechanistically distinct from signal-peptide-mediated import into the ER through the same channel... - Cdc48p is UBX-linked to ER ubiquitin ligasesKarin Römisch
University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Hills Road, Cambridge CB2 2XY, UK
Trends Biochem Sci 31:24-5. 2006..Two new papers reveal that the Ubx2 protein physically links ER-membrane-integrated ubiquitin ligases to Cdc48p, and that it is essential for degradation of substrates that are ubiquitylated at the cytoplasmic face of the ER... - Endoplasmic reticulum-associated degradationKarin Römisch
University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, United Kingdom
Annu Rev Cell Dev Biol 21:435-56. 2005..Export may be powered by AAA-ATPases of the proteasome 19S regulatory particle or Cdc48p/p97. Exported proteins are frequently ubiquitylated prior to degradation and are escorted to the proteasome by polyubiquitin-binding proteins... - Protein targeting from malaria parasites to host erythrocytesKarin Römisch
University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Cambridge CB2 2XY, UK
Traffic 6:706-9. 2005..falciparum proteins provoked a discussion on the potential mechanisms of parasite protein entry into infected erythrocytes which is summarized here... - A cure for traffic jams: small molecule chaperones in the endoplasmic reticulumKarin Römisch
University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Hills Road, Cambridge CB2 2XY, UK
Traffic 5:815-20. 2004..Specific ligands and cofactors such as ions, sugars, or peptides have similar effects on specific defective proteins and are beginning to be used as therapeutic agents for protein trafficking diseases... - Protein translocation across the endoplasmic reticulum membrane in cold-adapted organismsKarin Römisch
University of Cambridge, CIMR, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
J Cell Sci 116:2875-83. 2003..Collectively, our data suggest that the limited amino-acid changes in Sec61alpha from fishes may be functionally significant and represent adaptive changes that enhance channel function in the cold... - Cell biology in the Antarctic: studying life in the freezerKarin Römisch
Cambridge Institute of Medical Research and the Department of Clinical Biochemistry University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK
Nat Cell Biol 5:3-6. 2003..Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional experimental organisms... - Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulumWaiyan Ng
University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Hills Road, Cambridge, CB2 2XY, UK
J Cell Sci 120:682-91. 2007..Mutations in the ATP-binding sites of individual Rpt proteins all reduced the affinity of 19S complexes for the ER, suggesting that the 19S base in the ATP-bound conformation docks at the Sec61 channel... - Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulumElena Miranda
Departments of Medicine and Clinical Biochemistry, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Hills Road, Cambridge CB2 2XY, United Kingdom
J Biol Chem 279:28283-91. 2004.... - Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stagesKarin Römisch
University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Cambridge, UK
Arthritis Res Ther 8:R39. 2006..This observation supports a model where the binding of the homologous GTPase domains of SRP54 and the alpha-subunit of the SRP receptor to each other regulates the release of ER signal sequences from the SRP54 M-domain... - Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisisTao Wang
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
Hum Mol Genet 11:3097-105. 2002..Furthermore, we have shown that in vitro expression of RS1 may be a useful functional assay to investigate the pathogenicity of sequence changes within the RS1 gene...