Karin Römisch

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Coordination of N-glycosylation and protein translocation across the endoplasmic reticulum membrane by Sss1 protein
    Wiep Scheper
    University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 278:37998-8003. 2003
  2. pmc The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB
    Elena Miranda
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Hum Mol Genet 17:1527-39. 2008
  3. ncbi request reprint Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane
    K Römisch
    University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    J Cell Sci 112:4185-91. 1999
  4. ncbi request reprint Cdc48p is UBX-linked to ER ubiquitin ligases
    Karin Römisch
    University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Hills Road, Cambridge CB2 2XY, UK
    Trends Biochem Sci 31:24-5. 2006
  5. ncbi request reprint Endoplasmic reticulum-associated degradation
    Karin Römisch
    University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, United Kingdom
    Annu Rev Cell Dev Biol 21:435-56. 2005
  6. ncbi request reprint Protein targeting from malaria parasites to host erythrocytes
    Karin Römisch
    University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Cambridge CB2 2XY, UK
    Traffic 6:706-9. 2005
  7. ncbi request reprint A cure for traffic jams: small molecule chaperones in the endoplasmic reticulum
    Karin Römisch
    University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Hills Road, Cambridge CB2 2XY, UK
    Traffic 5:815-20. 2004
  8. ncbi request reprint Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms
    Karin Römisch
    University of Cambridge, CIMR, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    J Cell Sci 116:2875-83. 2003
  9. ncbi request reprint Cell biology in the Antarctic: studying life in the freezer
    Karin Römisch
    Cambridge Institute of Medical Research and the Department of Clinical Biochemistry University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK
    Nat Cell Biol 5:3-6. 2003
  10. ncbi request reprint Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum
    Waiyan Ng
    University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Hills Road, Cambridge, CB2 2XY, UK
    J Cell Sci 120:682-91. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Coordination of N-glycosylation and protein translocation across the endoplasmic reticulum membrane by Sss1 protein
    Wiep Scheper
    University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 278:37998-8003. 2003
    ..Our data suggest that Sss1p coordinates translocation across the ER membrane and N-linked glycosylation of secretory proteins...
  2. pmc The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB
    Elena Miranda
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Hum Mol Genet 17:1527-39. 2008
    ..Moreover, mutant neuroserpin causes locomotor deficits in the fly allowing us to demonstrate a direct link between polymer accumulation and neuronal toxicity...
  3. ncbi request reprint Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane
    K Römisch
    University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    J Cell Sci 112:4185-91. 1999
    ..Retrograde transport of soluble proteins through the Sec61 channel after signal-peptide cleavage, however, must be mechanistically distinct from signal-peptide-mediated import into the ER through the same channel...
  4. ncbi request reprint Cdc48p is UBX-linked to ER ubiquitin ligases
    Karin Römisch
    University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Hills Road, Cambridge CB2 2XY, UK
    Trends Biochem Sci 31:24-5. 2006
    ..Two new papers reveal that the Ubx2 protein physically links ER-membrane-integrated ubiquitin ligases to Cdc48p, and that it is essential for degradation of substrates that are ubiquitylated at the cytoplasmic face of the ER...
  5. ncbi request reprint Endoplasmic reticulum-associated degradation
    Karin Römisch
    University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, United Kingdom
    Annu Rev Cell Dev Biol 21:435-56. 2005
    ..Export may be powered by AAA-ATPases of the proteasome 19S regulatory particle or Cdc48p/p97. Exported proteins are frequently ubiquitylated prior to degradation and are escorted to the proteasome by polyubiquitin-binding proteins...
  6. ncbi request reprint Protein targeting from malaria parasites to host erythrocytes
    Karin Römisch
    University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Cambridge CB2 2XY, UK
    Traffic 6:706-9. 2005
    ..falciparum proteins provoked a discussion on the potential mechanisms of parasite protein entry into infected erythrocytes which is summarized here...
  7. ncbi request reprint A cure for traffic jams: small molecule chaperones in the endoplasmic reticulum
    Karin Römisch
    University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Hills Road, Cambridge CB2 2XY, UK
    Traffic 5:815-20. 2004
    ..Specific ligands and cofactors such as ions, sugars, or peptides have similar effects on specific defective proteins and are beginning to be used as therapeutic agents for protein trafficking diseases...
  8. ncbi request reprint Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms
    Karin Römisch
    University of Cambridge, CIMR, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    J Cell Sci 116:2875-83. 2003
    ..Collectively, our data suggest that the limited amino-acid changes in Sec61alpha from fishes may be functionally significant and represent adaptive changes that enhance channel function in the cold...
  9. ncbi request reprint Cell biology in the Antarctic: studying life in the freezer
    Karin Römisch
    Cambridge Institute of Medical Research and the Department of Clinical Biochemistry University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK
    Nat Cell Biol 5:3-6. 2003
    ..Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional experimental organisms...
  10. ncbi request reprint Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum
    Waiyan Ng
    University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Hills Road, Cambridge, CB2 2XY, UK
    J Cell Sci 120:682-91. 2007
    ..Mutations in the ATP-binding sites of individual Rpt proteins all reduced the affinity of 19S complexes for the ER, suggesting that the 19S base in the ATP-bound conformation docks at the Sec61 channel...
  11. pmc Analysis of Sec61p and Ssh1p interactions in the ER membrane using the split-ubiquitin system
    Carol Harty
    Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK
    BMC Cell Biol 14:14. 2013
    ..Generation of fusion proteins is, however, rife with problems, and particularly in transmembrane proteins often disturbs topology, structure and function...
  12. ncbi request reprint Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum
    Elena Miranda
    Departments of Medicine and Clinical Biochemistry, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 279:28283-91. 2004
    ....
  13. pmc Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages
    Karin Römisch
    University of Cambridge, Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Cambridge, UK
    Arthritis Res Ther 8:R39. 2006
    ..This observation supports a model where the binding of the homologous GTPase domains of SRP54 and the alpha-subunit of the SRP receptor to each other regulates the release of ER signal sequences from the SRP54 M-domain...
  14. ncbi request reprint Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisis
    Tao Wang
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Hum Mol Genet 11:3097-105. 2002
    ..Furthermore, we have shown that in vitro expression of RS1 may be a useful functional assay to investigate the pathogenicity of sequence changes within the RS1 gene...