Paul R Riley

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi Vascularizing the heart
    Paul R Riley
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Cardiovasc Res 91:260-8. 2011
  2. doi Thymosin beta4 induces epicardium-derived neovascularization in the adult heart
    Paul R Riley
    UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Biochem Soc Trans 37:1218-20. 2009
  3. doi Essential role for thymosin β4 in regulating vascular smooth muscle cell development and vessel wall stability
    Alex Rossdeutsch
    Molecular Medicine Unit, UCL Institute of Child Health, UCL, London, UK
    Circ Res 111:e89-102. 2012
  4. pmc Prox1 maintains muscle structure and growth in the developing heart
    Catherine A Risebro
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Development 136:495-505. 2009
  5. doi Thymosin beta4 facilitates epicardial neovascularization of the injured adult heart
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London, UK
    Ann N Y Acad Sci 1194:97-104. 2010
  6. ncbi Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Nature 445:177-82. 2007
  7. pmc Identification of Thymosin β4 as an effector of Hand1-mediated vascular development
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Nat Commun 1:46. 2010
  8. ncbi Nucleolar release of Hand1 acts as a molecular switch to determine cell fate
    David M J Martindill
    Molecular Medicine Unit, UCL Institute of Child Health, London, WC1N 1EH, UK
    Nat Cell Biol 9:1131-41. 2007
  9. ncbi Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London, WC1N 1EH, UK
    Ann N Y Acad Sci 1112:171-88. 2007
  10. ncbi Harnessing the potential of adult cardiac stem cells: lessons from haematopoiesis, the embryo and the niche
    Gemma M Balmer
    Molecular Medicine Unit, UCL Institute of Child Health, University College London, UK
    J Cardiovasc Transl Res 5:631-40. 2012

Collaborators

Detail Information

Publications27

  1. doi Vascularizing the heart
    Paul R Riley
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Cardiovasc Res 91:260-8. 2011
    ..Finally, we will extrapolate directly from development to address adult maintenance of the coronaries, vascular homeostasis and remodelling in response to pathology, aligned with the potential for revascularizing the injured adult heart...
  2. doi Thymosin beta4 induces epicardium-derived neovascularization in the adult heart
    Paul R Riley
    UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Biochem Soc Trans 37:1218-20. 2009
    ....
  3. doi Essential role for thymosin β4 in regulating vascular smooth muscle cell development and vessel wall stability
    Alex Rossdeutsch
    Molecular Medicine Unit, UCL Institute of Child Health, UCL, London, UK
    Circ Res 111:e89-102. 2012
    ..There is currently a lack of insight into developmental insults that may define the molecular and cellular characteristics of initiating and perpetrating factors in adult aneurismal disease...
  4. pmc Prox1 maintains muscle structure and growth in the developing heart
    Catherine A Risebro
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Development 136:495-505. 2009
    ....
  5. doi Thymosin beta4 facilitates epicardial neovascularization of the injured adult heart
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London, UK
    Ann N Y Acad Sci 1194:97-104. 2010
    ..As such, we identify Tbeta4 as a facilitator of cardiac neovascularization and highlight adult EPDCs as resident progenitors which, when instructed by Tbeta4, have the capacity to sustain the myocardium after ischemic damage...
  6. ncbi Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Nature 445:177-82. 2007
    ....
  7. pmc Identification of Thymosin β4 as an effector of Hand1-mediated vascular development
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Nat Commun 1:46. 2010
    ..Thus, we identify an in vivo downstream target of Hand1 and reveal impaired yolk sac vasculogenesis as a primary cause of early embryonic lethality following loss of this critical bHLH factor...
  8. ncbi Nucleolar release of Hand1 acts as a molecular switch to determine cell fate
    David M J Martindill
    Molecular Medicine Unit, UCL Institute of Child Health, London, WC1N 1EH, UK
    Nat Cell Biol 9:1131-41. 2007
    ..This study defines a novel cellular mechanism for regulating Hand1 that is a crucial step in the stem-cell differentiation pathway...
  9. ncbi Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London, WC1N 1EH, UK
    Ann N Y Acad Sci 1112:171-88. 2007
    ..regenerx.com), therefore, insight into the repair mechanism(s) induced by Tbeta-4 is an essential step toward harnessing therapeutic survival, migration, and repair properties of the peptide in the context of acute myocardial damage...
  10. ncbi Harnessing the potential of adult cardiac stem cells: lessons from haematopoiesis, the embryo and the niche
    Gemma M Balmer
    Molecular Medicine Unit, UCL Institute of Child Health, University College London, UK
    J Cardiovasc Transl Res 5:631-40. 2012
    ....
  11. doi The epicardium as a candidate for heart regeneration
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Future Cardiol 8:53-69. 2012
    ..myocardial infarction injury signaling reactivates the adult epicardium; understanding the timing and magnitude of these signals will enlighten strategies for myocardial repair...
  12. ncbi A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis
    Nicola Smart
    Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Mech Dev 119:S65-71. 2002
    ..0-E10.5) and Hand1 homozygous-mutant embryos (E8.0) confirmed co-expression of the putative targets with Hand1 in the heart and their aberrant expression in a Hand1-null background...
  13. pmc De novo cardiomyocytes from within the activated adult heart after injury
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Nature 474:640-4. 2011
    ....
  14. ncbi Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart
    Catherine A Risebro
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Development 133:4595-606. 2006
    ....
  15. ncbi Thymosin β4 protein therapy for cardiac repair
    Karina N Dubé
    Molecular Medicine Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Curr Pharm Des 18:799-806. 2012
    ....
  16. ncbi Formation of the ventricles
    Catherine A Risebro
    UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    ScientificWorldJournal 6:1862-80. 2006
    ....
  17. doi Resident cardiac progenitor cells: at the heart of regeneration
    Sveva Bollini
    Molecular Medicine Unit, University College London Institute of Child Health, London, UK
    J Mol Cell Cardiol 50:296-303. 2011
    ..This review will focus on current research into the biology of CPCs and their regenerative potential. This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited"...
  18. pmc Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2
    Alison A Hill
    Molecular Medicine Unit, Institute of Child Health, 30 Guilford St, London WC1N 1EH, United Kingdom
    Mol Cell Biol 24:9835-47. 2004
    ....
  19. pmc Coronary vessel development and insight towards neovascular therapy
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London, UK
    Int J Exp Pathol 90:262-83. 2009
    ..Thus, an understanding of the mechanisms of embryonic coronary vasculogenesis and angiogenesis may prove invaluable in developing novel strategies for cardiovascular regeneration and therapeutic coronary angiogenesis...
  20. ncbi Thymosin beta4 and angiogenesis: modes of action and therapeutic potential
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Angiogenesis 10:229-41. 2007
    ....
  21. ncbi Thymosin beta4 and Ac-SDKP: tools to mend a broken heart
    Alex Rossdeutsch
    UCL Institute of Child Health, London, UK
    J Mol Med (Berl) 86:29-35. 2008
    ..This review focuses on the reported mechanisms of action through which Thymosin beta4 might accomplish this effect and the clinical prospects for its use as a therapeutic agent...
  22. ncbi Cell cycle switch to endocycle: the nucleolus lends a hand
    David M J Martindill
    Molecular Medicine Unit, UCL Institute of Child Health, London, United Kingdom
    Cell Cycle 7:17-23. 2008
    ..In this brief discussion we examine the wider implications of these findings and address some of the unanswered questions that remain...
  23. ncbi A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis
    Nicola Smart
    Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Gene Expr Patterns 2:61-7. 2002
    ..0-E10.5) and Hand1 homozygous-mutant embryos (E8.0) confirmed co-expression of the putative targets with Hand1 in the heart and their aberrant expression in a Hand1-null background...
  24. doi Derivation of epicardium-derived progenitor cells (EPDCs) from adult epicardium
    Nicola Smart
    UCL Institute of Child Health, London, United Kingdom
    Curr Protoc Stem Cell Biol . 2009
    ....
  25. doi The stem cell movement
    Nicola Smart
    University College London Institute of Child Health, United Kingdom
    Circ Res 102:1155-68. 2008
    ....
  26. doi Epicardium-derived cells: a new source of regenerative capacity
    Joaquim M Vieira
    Molecular Medicine Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
    Heart 97:15-9. 2011
    ..Due to its fundamental role in heart development, the epicardium emerges as an obvious candidate. Here, recent findings are reviewed that show adult epicardium-derived cells as a new source of regenerative capacity for heart repair...
  27. ncbi Maternal diet programs embryonic kidney gene expression
    Simon J M Welham
    Nephro Urology, Institute of Child Health, University College London, London, United Kingdom
    Physiol Genomics 22:48-56. 2005
    ..The human implication is that the maternal diet ingested between conception and 5- 6-wk gestation contributes to the variation in glomerular numbers that are known to occur between healthy and hypertensive populations...