Kirsi Riento

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Rocks: multifunctional kinases in cell behaviour
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Nat Rev Mol Cell Biol 4:446-56. 2003
  2. pmc RhoE function is regulated by ROCK I-mediated phosphorylation
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    EMBO J 24:1170-80. 2005
  3. ncbi Inhibition of ROCK by RhoE
    Kirsi Riento
    Ludwig Institute for Cancer Research, University College London, UK
    Methods Enzymol 406:533-41. 2006
  4. doi N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization
    Ritu Garg
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Biochem J 411:407-14. 2008
  5. pmc RhoE inhibits cell cycle progression and Ras-induced transformation
    Priam Villalonga
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House St, London W1W 7BS, United Kingdom
    Mol Cell Biol 24:7829-40. 2004
  6. ncbi Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin
    Jenny A G McKenzie
    Ludwig Institute for Cancer Research, Royal Free and University College, School of Medicine, 91 Riding Street, London WIW 7BS, UK
    FEBS Lett 580:2388-94. 2006
  7. pmc RhoE binds to ROCK I and inhibits downstream signaling
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom
    Mol Cell Biol 23:4219-29. 2003

Collaborators

Detail Information

Publications7

  1. ncbi Rocks: multifunctional kinases in cell behaviour
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Nat Rev Mol Cell Biol 4:446-56. 2003
    ..Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states...
  2. pmc RhoE function is regulated by ROCK I-mediated phosphorylation
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    EMBO J 24:1170-80. 2005
    ..This is the first demonstration of an endogenous Rho family member being phosphorylated in vivo and indicates that phosphorylation is an important mechanism to control the stability and function of this GTPase-deficient Rho protein...
  3. ncbi Inhibition of ROCK by RhoE
    Kirsi Riento
    Ludwig Institute for Cancer Research, University College London, UK
    Methods Enzymol 406:533-41. 2006
    ..RhoE itself is phosphorylated by ROCK I, and this may enhance RhoE regulation of ROCK I function. This chapter describes the method used for studying ROCK inhibition by RhoE...
  4. doi N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization
    Ritu Garg
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Biochem J 411:407-14. 2008
    ..These results indicate that dimerization via the N-terminus is critical for ROCK-I function in cells and for its regulation by RhoE...
  5. pmc RhoE inhibits cell cycle progression and Ras-induced transformation
    Priam Villalonga
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House St, London W1W 7BS, United Kingdom
    Mol Cell Biol 24:7829-40. 2004
    ..RhoE also inhibited Ras- and Raf-induced fibroblast transformation. These results indicate that RhoE inhibits cell cycle progression upstream of the pRb checkpoint...
  6. ncbi Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin
    Jenny A G McKenzie
    Ludwig Institute for Cancer Research, Royal Free and University College, School of Medicine, 91 Riding Street, London WIW 7BS, UK
    FEBS Lett 580:2388-94. 2006
    ..These data identify CKI epsilon as a novel occludin kinase that may be important for the regulation of occludin...
  7. pmc RhoE binds to ROCK I and inhibits downstream signaling
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom
    Mol Cell Biol 23:4219-29. 2003
    ..These data suggest that RhoE induces stress fiber disassembly by directly binding ROCK I and inhibiting it from phosphorylating downstream targets...