Gernot Riedel

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. pmc A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats
    Anushka V Goonawardena
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Sleep Disord 2011:178469. 2011
  2. ncbi request reprint If phosphatases go up, memory goes down
    G Riedel
    University of Aberdeen, Department of Biomedical Sciences, Institute of Medical Sciences, Foresterhill, UK
    Cell Mol Life Sci 55:549-53. 1999
  3. doi request reprint Scopolamine-induced deficits in social memory in mice: reversal by donepezil
    G Riedel
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Behav Brain Res 204:217-25. 2009
  4. ncbi request reprint Function of the hippocampus in memory formation: desperately seeking resolution
    G Riedel
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Scotland
    Prog Neuropsychopharmacol Biol Psychiatry 25:835-53. 2001
  5. ncbi request reprint Glutamate receptor function in learning and memory
    Gernot Riedel
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, UK
    Behav Brain Res 140:1-47. 2003
  6. ncbi request reprint Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam
    Gernot Riedel
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Pharmacol Biochem Behav 73:391-9. 2002
  7. pmc Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice
    Gernot Riedel
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Br J Pharmacol 156:1154-66. 2009
  8. ncbi request reprint Variation of CS salience reveals group II mGluR-dependent and -independent forms of conditioning in the rat
    Gernot Riedel
    Department for Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuropharmacology 43:205-14. 2002
  9. pmc WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction
    Lianne Robinson
    School of Medical Sciences, College of Life Science and Medicine, University of Aberdeen, Foresterhill, Aberdeen, UK
    Behav Brain Res 208:584-92. 2010
  10. ncbi request reprint Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats
    Lianne Robinson
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Psychopharmacology (Berl) 198:551-63. 2008

Collaborators

Detail Information

Publications58

  1. pmc A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats
    Anushka V Goonawardena
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Sleep Disord 2011:178469. 2011
    ..Implications of endocannabinoid modulation of the sleep-wake cycle and its possible interactions with other transmitter systems are considered...
  2. ncbi request reprint If phosphatases go up, memory goes down
    G Riedel
    University of Aberdeen, Department of Biomedical Sciences, Institute of Medical Sciences, Foresterhill, UK
    Cell Mol Life Sci 55:549-53. 1999
    ..From the pharmacological as well as the transgenic analysis, it appears that especially the calcineurin/inhibitor-1 cascade plays an important role in the transition of intermediate-term into long-term memory formation...
  3. doi request reprint Scopolamine-induced deficits in social memory in mice: reversal by donepezil
    G Riedel
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Behav Brain Res 204:217-25. 2009
    ....
  4. ncbi request reprint Function of the hippocampus in memory formation: desperately seeking resolution
    G Riedel
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Scotland
    Prog Neuropsychopharmacol Biol Psychiatry 25:835-53. 2001
    ..Future work should further explore this important issue especially since long-term consolidation appears to be a necessity for permanent storage of information, and may thus engage memory mechanism that fail during ageing and dementia...
  5. ncbi request reprint Glutamate receptor function in learning and memory
    Gernot Riedel
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, UK
    Behav Brain Res 140:1-47. 2003
    ..However, memory formation appears to require mGluRs, through the modulation of consolidation and/or recall. Overall, mGluR functions seem variable and dependent on brain structure and learning task...
  6. ncbi request reprint Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam
    Gernot Riedel
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Pharmacol Biochem Behav 73:391-9. 2002
    ..Our data suggest that application of Group I antagonists to prevent neurotoxicity, combined with nootropic treatment to prevent cognitive deficits, may be a therapeutic strategy for the development of novel antineurotoxic treatments...
  7. pmc Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice
    Gernot Riedel
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Br J Pharmacol 156:1154-66. 2009
    ..Cannabinoid receptors have proven an efficient target to suppress hunger and weight gain by their pharmacological inactivation...
  8. ncbi request reprint Variation of CS salience reveals group II mGluR-dependent and -independent forms of conditioning in the rat
    Gernot Riedel
    Department for Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuropharmacology 43:205-14. 2002
    ..These results suggest that group II mGluRs modulate neural networks involved in association formation...
  9. pmc WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction
    Lianne Robinson
    School of Medical Sciences, College of Life Science and Medicine, University of Aberdeen, Foresterhill, Aberdeen, UK
    Behav Brain Res 208:584-92. 2010
    ..Collectively, these data suggest that in this spatial reference memory task WIN-2 causes a reduction in cholinergic activation, possibly through a non-CB(1)-like mechanism, which affects long-term but not short-term spatial memory...
  10. ncbi request reprint Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats
    Lianne Robinson
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Psychopharmacology (Berl) 198:551-63. 2008
    ..As exogenous cannabinoid agonists impair memory formation, could it be that antagonists have opposing effects and act as memory-enhancing drugs?..
  11. pmc Cannabinoid and cholinergic systems interact during performance of a short-term memory task in the rat
    Anushka V Goonawardena
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Learn Mem 17:502-11. 2010
    ..Whether deficits are due to reduced nicotinic or muscarinic receptor activation, or both, awaits further analysis...
  12. ncbi request reprint Age-dependent changes in hippocampal synaptic transmission and plasticity in the PLB1Triple Alzheimer mouse
    David J Koss
    School of Medical Sciences College of Life Sciences and Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Cell Mol Life Sci 70:2585-601. 2013
    ....
  13. doi request reprint Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine
    Serena Deiana
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, Scotland
    Psychopharmacology (Berl) 202:53-65. 2009
    ..Cholinergic enhancers ameliorate AD symptoms and represent the main current therapy for AD. MTC (Methylthioninium chloride), an antioxidant with metabolism-enhancing properties may be a novel candidate with pro-cognitive capacities...
  14. ncbi request reprint Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts
    Paola Fadda
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Behav Brain Res 168:307-11. 2006
    ..These data suggest that reversal of working memory deficits by CBD-rich extracts are specific to the cannabinoid system and do not compensate for acutely induced cholinergic or glutamatergic receptor hypoactivity...
  15. ncbi request reprint The seed extract of Cassia obtusifolia offers neuroprotection to mouse hippocampal cultures
    Benjamin D Drever
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Aberdeen, Scotland, UK
    J Pharmacol Sci 107:380-92. 2008
    ..2 pg/ml). Collectively, these results are important for the therapeutic use of COE in the treatment of neurodegenerative disorders...
  16. ncbi request reprint Bi-directional alterations of LTP after acute homocysteine exposure
    Louisa A Christie
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD Scotland, UK
    Behav Brain Res 205:559-63. 2009
    ..By comparison, NMDA unidirectionally reduced LTP, whereas l-cysteine led to facilitated LTP. Such HCY-induced alterations in neuronal communication may contribute to cognitive failure in dementia...
  17. ncbi request reprint Intracellular Ca2+ stores modulate SOCCs and NMDA receptors via tyrosine kinases in rat hippocampal neurons
    David J Koss
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cell Calcium 46:39-48. 2009
    ..This study provides first evidence for tyrosine based phospho-regulation of SOCCs and NMDA signalling in neurons...
  18. ncbi request reprint Visual acuity in the water maze: sensitivity to muscarinic receptor blockade in rats and mice
    Lianne Robinson
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Behav Brain Res 151:277-86. 2004
    ..The effect of scopolamine on spatial reference memory in mice was not tested in this study. These data suggest that it may be possible to dissociate drug-induced effects on memory from changes in sensory perception...
  19. doi request reprint In vitro modelling of Alzheimer's disease: degeneration and cell death induced by viral delivery of amyloid and tau
    Sandra Stoppelkamp
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD Scotland, UK
    Exp Neurol 229:226-37. 2011
    ..Overall, these cellular models offer advantages for mechanistic studies and target identification in AD and related disorders...
  20. ncbi request reprint Modulation of hippocampal calcium signalling and plasticity by serine/threonine protein phosphatases
    David J Koss
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    J Neurochem 102:1009-23. 2007
    ..This study highlights novel signalling effects of prolonged inhibition of protein phosphatases and suggests reduced post-synaptic signalling as a major mechanism for basal synaptic transmission and long-term potentiation impairments...
  21. pmc Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice
    Lianne Robinson
    School of Medical Science, College of Life Science and Medicine, University of Aberdeen, Aberdeen, AB25 2ZD Scotland, UK
    Behav Brain Res 250:148-56. 2013
    ..Alterations in the time-course of habituation may indicate deficiencies in cognitive processing. ..
  22. pmc Recruitment of hippocampal neurons to encode behavioral events in the rat: alterations in cognitive demand and cannabinoid exposure
    Anushka V Goonawardena
    Department of Physiology and Pharmacology, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina, USA
    Hippocampus 20:1083-94. 2010
    ..These cannabinoid-induced alterations in hippocampal neuronal activity may explain the observed deficits in DNMS performance...
  23. doi request reprint Involvement of the cholinergic system in conditioning and perceptual memory
    Lianne Robinson
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Behav Brain Res 221:443-65. 2011
    ....
  24. ncbi request reprint Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1
    Sanbing Shen
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom
    J Neurosci 28:10893-904. 2008
    ..These abnormalities in Disc1(tr) transgenic mice are consistent with findings in severe schizophrenia...
  25. pmc Cannabinoids alter spontaneous firing, bursting, and cell synchrony of hippocampal principal cells
    Anushka V Goonawardena
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Hippocampus 21:520-31. 2011
    ....
  26. pmc Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1
    Bettina Platt
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 6:e27068. 2011
    ..PLB1(Triple) mice progress from a mild (MCI-like) state to a more comprehensive AD-relevant phenotype, which are accessible using translational tools such as wireless EEG and microPET/CT...
  27. ncbi request reprint Effects of delta9-THC and WIN-55,212-2 on place preference in the water maze in rats
    Lianne Robinson
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Psychopharmacology (Berl) 166:40-50. 2003
    ..It therefore seems advisable to assess the reinforcing properties of the drugs in the same behavioural model used for learning experiments...
  28. doi request reprint Culturing conditions determine neuronal and glial excitability
    Sandra Stoppelkamp
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, UK
    J Neurosci Methods 194:132-8. 2010
    ..Especially for investigations of toxicity and neuroprotection mixed cultures may be more physiologically relevant over isolated cultures as they comprise aspects of mutual influences between glia and neurones...
  29. doi request reprint The cholinergic system and hippocampal plasticity
    Benjamin D Drever
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Behav Brain Res 221:505-14. 2011
    ..The present review examines these multiple roles of acetylcholine in hippocampal plasticity...
  30. doi request reprint The cholinergic system and spatial learning
    Serena Deiana
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Behav Brain Res 221:389-411. 2011
    ..Unresolved and contradictory results are highlighted and discussed...
  31. pmc Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus
    Anushka V Goonawardena
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 271157 1083, USA
    Neuropharmacology 61:1016-25. 2011
    ..They also highlight a specific window of memory processing, i.e. encoding, which is sensitive to cannabinoid modulation...
  32. doi request reprint Store-operated Ca2+ entry in hippocampal neurons: Regulation by protein tyrosine phosphatase PTP1B
    David J Koss
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cell Calcium 53:125-38. 2013
    ..These data suggest tyrosine phosphorylation gating SOCE, and implicate PTP1B as a key regulatory enzyme. The involvement of PTP1B in SOCE and its relation to SOCC components and mechanism of regulation are discussed...
  33. doi request reprint FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease
    Bettina Platt
    School of Medical Sciences, Institute of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Biochem Soc Trans 39:874-80. 2011
    ..The present paper reviews the results obtained so far in rodent AD models, and summarizes advantages and disadvantages of such procedures...
  34. ncbi request reprint Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats
    Paola Fadda
    Department of Biomedical Science, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuropharmacology 47:1170-9. 2004
    ..It appears that spatial working/short-term memory is not sensitive to CBD-rich extracts and that potentiation and antagonism of Delta(9)-THC-induced spatial memory deficits is dependent on the ratio between CBD and Delta(9)-THC...
  35. doi request reprint EEG, activity, and sleep architecture in a transgenic AβPPswe/PSEN1A246E Alzheimer's disease mouse
    Amar Jyoti
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    J Alzheimers Dis 22:873-87. 2010
    ..Though not fully recapitulating the profile of AD patients, this suggests activity and EEG recordings as sensitive and translational biomarkers in murine models...
  36. ncbi request reprint No spatial working memory deficit in beta-amyloid-exposed rats. A longitudinal study
    Eva von Linstow Roloff
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Prog Neuropsychopharmacol Biol Psychiatry 26:955-70. 2002
    ..These data suggest that intra-hippocampal beta A1-40 administration alters cholinergic transmission, but these alterations may be mild and thus do not lead to obvious working memory deficits in a DMTP task in well-trained animals...
  37. doi request reprint 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease
    Elisa Calamai
    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    Chem Commun (Camb) 49:792-4. 2013
    ..The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator...
  38. ncbi request reprint Memantine acts as a cholinergic stimulant in the mouse hippocampus
    Benjamin D Drever
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD Scotland, UK
    J Alzheimers Dis 12:319-33. 2007
    ..These interactions with the cholinergic system are likely to contribute to memantine's therapeutic potential...
  39. doi request reprint The cholinergic system, EEG and sleep
    Bettina Platt
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Behav Brain Res 221:499-504. 2011
    ..With novel technologies and computational tools now becoming available, advanced mechanistic insights may be gained and new avenues explored for diagnostics and therapeutics...
  40. pmc Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory
    Andrew J Murray
    Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK
    Nat Neurosci 14:297-9. 2011
    ..We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory...
  41. pmc The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats
    L Robinson
    Department of Biomedical Sciences, Institute for Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Br J Pharmacol 151:688-700. 2007
    ..We therefore assessed the effects of the synthetic cannabinoid HU210 on memory and hippocampal activity...
  42. pmc Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome
    Lianne Robinson
    School of Medical Sciences, University of Aberdeen, Forresterhill, Aberdeen, AB25 2ZD, UK
    Brain 135:2699-710. 2012
    ..Our findings sustain the view that MeCP2 does not play a pivotal role in brain development, but may instead be required to maintain full neurological function once development is complete...
  43. ncbi request reprint Sleep and hippocampus: do we search for the right things?
    Jurij Brankack
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    Prog Neuropsychopharmacol Biol Psychiatry 33:806-12. 2009
    ..In this review, we attempt to reconcile some of the seemingly antagonistic theories of sleep function in a succinct and unbiased manner and develop an eclectic view of its role in learning and memory...
  44. ncbi request reprint Fear conditioning-induced time- and subregion-specific increase in expression of mGlu5 receptor protein in rat hippocampus
    G Riedel
    Department of Biomedical Sciences, Institute for Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuropharmacology 39:1943-51. 2000
    ..They support the notion that mGluRs in CA3 may play a part in short-term, and those in CA1 may play a part in long-term consolidation of memory...
  45. ncbi request reprint Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence
    B Platt
    Biomedical Sciences, Aberdeen University, Scotland, Aberdeen, UK
    Brain Res Bull 55:257-67. 2001
    ....
  46. ncbi request reprint Functions of cannabinoid receptors in the hippocampus
    S N Davies
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Neuropharmacology 42:993-1007. 2002
    ....
  47. pmc Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes
    Kaja Plucińska
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom
    J Neurosci 34:10710-28. 2014
    ....
  48. doi request reprint Mapping changes in mouse brain metabolism with PET/CT
    Andy Welch
    School of Medicine and Dentistry, University of Aberdeen, Aberdeen, United Kingdom and
    J Nucl Med 54:1946-53. 2013
    ..In particular, we considered the effects of scan length, image registration methods, image quantification methods, and smoothing during statistical parametric mapping (SPM)...
  49. ncbi request reprint Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behavi
    Serena Deiana
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Psychopharmacology (Berl) 219:859-73. 2012
    ..Other constituents of Cannabis sativa, the hemp plant, however, remain relatively unexplored in vivo. These include cannabidiol (CBD), cannabidivarine (CBDV), Δ(9)-tetrahydrocannabivarin (Δ(9)-THCV) and cannabigerol (CBG)...
  50. ncbi request reprint Enhanced hippocampal long-term potentiation in rats after chronic exposure to homocysteine
    Louisa A Christie
    School of Medical Sciences, College of Life Sciences and Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Neurosci Lett 373:119-24. 2005
    ..These changes may reflect the suggested (excito-)toxicity of HCY and its putative contribution to neurodegenerative disease...
  51. pmc A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones
    David J Koss
    School of Medical Sciences, College of Life Sciences and Medicine, Institute of Medical Science, The University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    BMC Pharmacol 7:1. 2007
    ..Using electrophysiology, calcium imaging and 1,6-diphenyl-1,3,5-hexatriene imaging, the pore forming properties of poly-APS and four related synthetic oligomers have been tested on primary cultured rat hippocampal neurones...
  52. ncbi request reprint Long-term study of chronic oral aluminum exposure and spatial working memory in rats
    Eva von Linstow Roloff
    Department of Biomedical Sciences, Institute for Medical Sciences, University of Aberdeen, Fostererhill, Scotland
    Behav Neurosci 116:351-6. 2002
    ..This testing protocol may enable between- and within-subject long-term assessment of spatial working memory before and after drug treatment and may prove useful in animal models of progressive cognitive decline...
  53. ncbi request reprint Dissociation of cholinergic function in spatial and procedural learning in rats
    E von Linstow Roloff
    School of Medical Sciences, College of Life Science and Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Neuroscience 146:875-89. 2007
    ..Apart from the well-known contribution to sensorimotor and procedural learning, our findings provide compelling evidence for an important role of muscarinic acetylcholine receptor signaling in spatial episodic-like memory...
  54. ncbi request reprint Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity
    S A Algaidi
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Exp Neurol 197:8-21. 2006
    ..Overall, it is concluded that healthy adult rats are able to cope with continuous exposure to HCY. While HCY affects growth and neuronal excitability, this does not precipitate into an immediate impairment of cognitive function...
  55. ncbi request reprint Comparison of automated home-cage monitoring systems: Emphasis on feeding behaviour, activity and spatial learning following pharmacological interventions
    Lianne Robinson
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK Electronic address
    J Neurosci Methods 234:13-25. 2014
    ..Different automated systems have been developed to facilitate long-term and continuous assessment of behaviours including locomotor activity, feeding behaviour and circadian activity...
  56. pmc Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation
    Pierre Trifilieff
    Laboratoire de Neurosciences Cognitives, Centre National de la Recherche Scientifique, CNRS UMR 5106, Universite de Bordeaux I, 33605 Talence, France
    Learn Mem 13:349-58. 2006
    ..These data provide compelling evidence that CA1 serves different forms of memory by expressing differential cellular mechanisms that are dependent on the training regime...
  57. ncbi request reprint Altered cellular distribution of phospho-tau proteins coincides with impaired retrograde axonal transport in neurons of aged rats
    Grazyna Niewiadomska
    Department of Neurophysiology, Nencki Institute, Warsaw, Poland
    Ann N Y Acad Sci 1048:287-95. 2005
    ..Since a somatic localization of phospho-Tau is indicative of cytoskeletal breakdown, we suggest that failure of axonal trafficking may be responsible for the lack of trophic support in aged cholinergic neurons of the basal forebrain...
  58. ncbi request reprint Syntheses and energy transfer in multiporphyrinic arrays self-assembled with hydrogen-bonding recognition groups and comparison with covalent steroidal models
    Teodor Silviu Balaban
    Karlsruhe Institute of Technology, Forschungszentrum Karlsruhe, Institute for Nanotechnology, Postfach 3640, 76021 Karlsruhe, Germany
    Chemistry 13:8411-27. 2007
    ..This study predicts that it is indeed possible to build large supramolecular antennas and the component design and supramolecular dynamics are essential features that dictate EET rates and efficiencies...