Anne J Ridley

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi PAK4 is activated via PI3K in HGF-stimulated epithelial cells
    Claire M Wells
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London WIW 7BS, UK
    J Cell Sci 115:3947-56. 2002
  2. ncbi Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Trends Cell Biol 16:522-9. 2006
  3. ncbi RhoB affects macrophage adhesion, integrin expression and migration
    Ann P Wheeler
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    Exp Cell Res 313:3505-16. 2007
  4. pmc The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
    Evangelia A Papakonstanti
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 26:3050-61. 2007
  5. ncbi Roles of Rho/ROCK and MLCK in TNF-alpha-induced changes in endothelial morphology and permeability
    Jenny A G McKenzie
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom
    J Cell Physiol 213:221-8. 2007
  6. ncbi Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains
    Jaime Millan
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Nat Cell Biol 8:113-23. 2006
  7. doi N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization
    Ritu Garg
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Biochem J 411:407-14. 2008
  8. ncbi Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells
    Eva Cernuda-Morollón
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    Circ Res 98:757-67. 2006
  9. ncbi Rac1 and Rac2 regulate macrophage morphology but are not essential for migration
    Ann P Wheeler
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London, W1W 7BS, UK
    J Cell Sci 119:2749-57. 2006
  10. pmc Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms
    Roy M Katso
    Ludwig Institute for Cancer Research, Royal Free and University College Hospital Medical School, London W1W 7BS, United Kingdom
    Mol Biol Cell 17:3729-44. 2006

Collaborators

Detail Information

Publications63

  1. ncbi PAK4 is activated via PI3K in HGF-stimulated epithelial cells
    Claire M Wells
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London WIW 7BS, UK
    J Cell Sci 115:3947-56. 2002
    ..These results indicate that HGF stimulates PAK4 through PI3K, and that PAK4 could contribute to HGF-induced changes in actin organisation and cell-substratum adhesion...
  2. ncbi Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Trends Cell Biol 16:522-9. 2006
    ....
  3. ncbi RhoB affects macrophage adhesion, integrin expression and migration
    Ann P Wheeler
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    Exp Cell Res 313:3505-16. 2007
    ..Since macrophages do not express RhoC, these effects of C3 transferase are due to inhibition of RhoA rather than RhoB. Our results suggest that RhoB affects cell shape and migration by regulating surface integrin levels...
  4. pmc The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
    Evangelia A Papakonstanti
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 26:3050-61. 2007
    ..This work identifies the RhoA/ROCK pathway as a major target of p110delta-mediated PI3K signalling, and establishes for the first time that PI3K controls itself, via a feedback loop involving PTEN...
  5. ncbi Roles of Rho/ROCK and MLCK in TNF-alpha-induced changes in endothelial morphology and permeability
    Jenny A G McKenzie
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom
    J Cell Physiol 213:221-8. 2007
    ..These results suggest that the gradual increase in permeability induced by TNF-alpha does not reflect contractile mechanisms mediated by Rho, ROCK, and MLCK, but involves long-term reorganization of tight junction proteins...
  6. ncbi Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains
    Jaime Millan
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Nat Cell Biol 8:113-23. 2006
    ....
  7. doi N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization
    Ritu Garg
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Biochem J 411:407-14. 2008
    ..These results indicate that dimerization via the N-terminus is critical for ROCK-I function in cells and for its regulation by RhoE...
  8. ncbi Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells
    Eva Cernuda-Morollón
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    Circ Res 98:757-67. 2006
    ..Rho GTPases are therefore candidate targets for inhibiting leukocyte transendothelial migration in heart disease and chronic inflammatory disorders...
  9. ncbi Rac1 and Rac2 regulate macrophage morphology but are not essential for migration
    Ann P Wheeler
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London, W1W 7BS, UK
    J Cell Sci 119:2749-57. 2006
    ..Together, these data show that Rac1 and Rac2 have distinct roles in regulating cell morphology, migration and invasion, but are not essential for macrophage migration or chemotaxis...
  10. pmc Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms
    Roy M Katso
    Ludwig Institute for Cancer Research, Royal Free and University College Hospital Medical School, London W1W 7BS, United Kingdom
    Mol Biol Cell 17:3729-44. 2006
    ..Taken together, these findings suggest that PI3KC2beta regulates the migration and survival of human tumor cells by distinct molecular mechanisms...
  11. pmc RhoE function is regulated by ROCK I-mediated phosphorylation
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    EMBO J 24:1170-80. 2005
    ..This is the first demonstration of an endogenous Rho family member being phosphorylated in vivo and indicates that phosphorylation is an important mechanism to control the stability and function of this GTPase-deficient Rho protein...
  12. pmc RhoE binds to ROCK I and inhibits downstream signaling
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom
    Mol Cell Biol 23:4219-29. 2003
    ..These data suggest that RhoE induces stress fiber disassembly by directly binding ROCK I and inhibiting it from phosphorylating downstream targets...
  13. ncbi An in vitro model to study the role of endothelial rho GTPases during leukocyte transendothelial migration
    Jaime Millan
    Ludwig Institute for Cancer Research, University College London, UK
    Methods Enzymol 406:643-55. 2006
    ..Finally, we describe how to image and quantitate leukocyte TEM by digital time-lapse microscopy...
  14. ncbi Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering
    Aleksandar Ivetic
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS United Kingdom
    J Biol Chem 279:33263-72. 2004
    ..These results suggest that ERM proteins are required for microvillar positioning of L-selectin and that this is important both for leukocyte tethering and L-selectin shedding...
  15. pmc PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics
    Stephen D Smith
    Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
    J Cell Sci 121:3729-36. 2008
    ..Together, these data indicate that PAK1 signals via ERK1/2 to regulate lamellipodial stability...
  16. ncbi Inhibition of ROCK by RhoE
    Kirsi Riento
    Ludwig Institute for Cancer Research, University College London, UK
    Methods Enzymol 406:533-41. 2006
    ..RhoE itself is phosphorylated by ROCK I, and this may enhance RhoE regulation of ROCK I function. This chapter describes the method used for studying ROCK inhibition by RhoE...
  17. ncbi Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization
    Claire M Wells
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London W1W 7BS, UK
    Exp Cell Res 310:303-10. 2005
    ..Our results suggest that the migration speed of macrophages is regulated independently of spread area or membrane ruffling and that Vav1 is selectively required to maintain a normal migration speed...
  18. pmc RhoE inhibits cell cycle progression and Ras-induced transformation
    Priam Villalonga
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House St, London W1W 7BS, United Kingdom
    Mol Cell Biol 24:7829-40. 2004
    ..RhoE also inhibited Ras- and Raf-induced fibroblast transformation. These results indicate that RhoE inhibits cell cycle progression upstream of the pRb checkpoint...
  19. ncbi p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation
    Clemens M Franz
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    J Biol Chem 279:6588-94. 2004
    ..We therefore propose that binding of p120ctn to microtubules is inversely related to its ability to regulate Rho GTPases...
  20. ncbi Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin
    Jenny A G McKenzie
    Ludwig Institute for Cancer Research, Royal Free and University College, School of Medicine, 91 Riding Street, London WIW 7BS, UK
    FEBS Lett 580:2388-94. 2006
    ..These data identify CKI epsilon as a novel occludin kinase that may be important for the regulation of occludin...
  21. ncbi Cell migration in development and disease
    Clemens M Franz
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom
    Dev Cell 2:153-8. 2002
    ..A recent meeting at the Max Delbrück Center in Berlin, Germany provided a forum to discuss the molecular mechanisms of cell migration in a broad range of contexts including chemotaxis, development, immunity, and cancer...
  22. ncbi Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells
    Paul W Thompson
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom
    J Immunol 169:1007-13. 2002
    ..These results indicate that in endothelial cells, ICAM-1, but not ICAM-2, rapidly stimulates signaling responses involving RhoA...
  23. ncbi Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages
    Yann Leverrier
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London W1W 7BS, United Kingdom
    J Biol Chem 278:38437-42. 2003
    ..Our findings demonstrate that p110beta is the major class I catalytic isoform required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by primary macrophages...
  24. ncbi Rocks: multifunctional kinases in cell behaviour
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Nat Rev Mol Cell Biol 4:446-56. 2003
    ..Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states...
  25. ncbi Rho GTPases and the regulation of endothelial permeability
    Beata Wojciak-Stothard
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine Branch, 91 Riding House Street, London W1W 7BS, UK
    Vascul Pharmacol 39:187-99. 2002
    ..We also discuss strategies for targeting Rho GTPase signalling in therapies for diseases involving altered endothelial permeability...
  26. pmc Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases
    Beata Wojciak-Stothard
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House St, London W1W 7BS, UK
    J Cell Biol 161:429-39. 2003
    ..Our results show that endothelial cells reorient in response to shear stress by a two-step process involving Rho-induced depolarization, followed by Rho/Rac-mediated polarization and migration in the direction of flow...
  27. ncbi Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein
    Giles O C Cory
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, Courtauld Building, 91 Riding House Street, London W1W 7BS, United Kingdom
    J Biol Chem 277:45115-21. 2002
    ..We propose that phosphorylation of Tyr(291) directly regulates WASp function...
  28. ncbi Mammalian cell microinjection assay to study the function of Rho family guanosine triphosphatases
    Ritu Garg
    Ludwig Institute for Cancer Research, University College London, UK
    Methods Mol Biol 332:257-67. 2006
    ..Here, we describe the procedure for microinjecting cells with purified recombinant proteins or with expression vectors encoding proteins, and for analyzing the cells after injection...
  29. ncbi Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration
    Claire M Wells
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London WIW 7BS, UK
    J Cell Sci 117:1259-68. 2004
    ..However, Rac1-deficient macrophages show normal migration and chemotaxis. Thus in macrophages Rac1 is primarily responsible for regulating cell morphology, contributes to membrane ruffling, but is not required for migration...
  30. ncbi Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP
    Giles O C Cory
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, Courtauld Building, 91 Riding House Street, London W1W 7BS, United Kingdom
    Mol Cell 11:1229-39. 2003
    ..We propose that constitutive VCA domain phosphorylation is required for optimal stimulation of the Arp2/3 complex by WASP...
  31. pmc Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes
    Aleksandar Ivetic
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    Immunology 112:165-76. 2004
    ..This review discusses recent findings on ERM protein function in leucocytes and how these may be integrated with Rho GTPase signalling...
  32. ncbi CSF-1 and PI 3-kinase regulate podosome distribution and assembly in macrophages
    Ann P Wheeler
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, United Kingdom
    Cell Motil Cytoskeleton 63:132-40. 2006
    ..Our results indicate that CSF-1 acts via PI 3-kinase to enhance podosome assembly and that this is linked to macrophage polarization...
  33. ncbi Pulling back to move forward
    Anne J Ridley
    Ludwig Institute for Cancer Research and Department of Biochemistry and Molecular Biology, University College London, 91 Riding House Street, London W1W 7BS, United Kingdom
    Cell 116:357-8. 2004
    ..Giannone and coworkers (this issue of Cell) describe how cells periodically pull back on these protrusions in order to sense and respond to the rigidity of their environment...
  34. pmc Rho GTPases and leucocyte-induced endothelial remodelling
    Jaime Millan
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Biochem J 385:329-37. 2005
    ..In this review, we discuss recent findings on leucocyte-induced alterations to endothelial cells, and the roles of Rho GTPases in these responses...
  35. ncbi Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
    Ann P Wheeler
    Laboratory of Cellular Molecular Biology, Ludwig Institute for Cancer Research, London W1W 7BS, United Kingdom
    Exp Cell Res 301:43-9. 2004
    ..In cancer cells, the expression and activity of RhoA, B, and C is altered in different ways. Together, this evidence suggests that although the 3 isoforms of Rho are structurally highly homologous, they have different cellular functions...
  36. ncbi Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
    ....
  37. ncbi Snails, Swiss, and serum: the solution for Rac 'n' Rho
    Anne J Ridley
    Laboratory of Cellular Molecular Biology, Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, United Kingdom
    Cell 116:S23-5, 2 p following S25. 2004
  38. ncbi Rho proteins and cancer
    Anne J Ridley
    Department of Biochemistry and Molecular Biology, Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, University College London, London, UK
    Breast Cancer Res Treat 84:13-9. 2004
    ..However, there is little evidence so far from animal studies to define if and how Rho proteins contribute to cancer cell proliferation, survival, invasion and metastasis...
  39. pmc RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress
    Pat P Ongusaha
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Curr Biol 16:2466-72. 2006
    ..Thus, RhoE is anticipated to function by regulating ROCK I signaling to control the balance between cell survival and cell death in response to genotoxic stress...
  40. doi Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
    Mariona Graupera
    Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nature 453:662-6. 2008
    ..These results provide the first in vivo evidence for p110-isoform selectivity in endothelial PI3K signalling during angiogenesis...
  41. ncbi Cell motility: braking WAVEs
    Giles O C Cory
    Nature 418:732-3. 2002
  42. ncbi Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases
    Claire A Swetman
    Department of Immunology and Molecular Pathology, University College London, London, GB
    Eur J Immunol 32:2074-83. 2002
    ..DC therefore coordinate adhesion and protrusion to perform a specialized process of cellular morphogenesis, which differentiates these cells from all other cells of the immune system and may contribute to their distinctive function...
  43. pmc Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins
    Lars Peter Erwig
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 103:12825-30. 2006
    ..These observations have direct implications for the clearance of dying cells and the roles played by different phagocytes in antigen digestion and presentation...
  44. ncbi RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific
    Karine Bailly
    Vascular Biology and Pharmacology Unit, Institute of Child Health, University College London, UK
    Circ Res 94:1383-91. 2004
    ..These data show that acute hypoxia induces RhoA activation only in PASMCs from young animals, whereas chronic hypoxia selectively downregulates RhoA activity in outer medial PASMCs leading to an altered phenotype...
  45. ncbi beta1-Integrins determine the dendritic morphology which enhances DC-SIGN-mediated particle capture by dendritic cells
    Claire A Swetman Andersen
    Department of Immunology and Molecular Pathology, University College London, Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK
    Int Immunol 18:1295-303. 2006
    ..The unusual combination of a dendritic morphology and high motility is likely to play a major role in the efficient function of DCs as sentinels of the immune system...
  46. ncbi IQGAP1 promotes cell motility and invasion
    Jennifer M Mataraza
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School Boston, Massachusetts 02115, USA
    J Biol Chem 278:41237-45. 2003
    ..Moreover, invasion mediated by constitutively active Cdc42 was attenuated by IQGAP1DeltaGRD. Thus, IQGAP1 has a fundamental role in cell motility and invasion...
  47. ncbi Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1
    Ceniz Zihni
    KCL School of Medicine and Dentistry, Rayne Institute, Kings College London, 123 Coldharbour Lane, London SE5 9NU, UK
    J Biol Chem 281:7317-23. 2006
    ..Our findings suggest that PSKs form a subgroup of sterile 20 (STE20)-like kinases that regulate different cytoskeletal processes...
  48. ncbi Mammalian Rho GTPases: new insights into their functions from in vivo studies
    Sarah J Heasman
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London, UK
    Nat Rev Mol Cell Biol 9:690-701. 2008
    ..The recent availability of knockout mice for several members of the Rho family reveals new information about their roles in signalling to the cytoskeleton and in development...
  49. ncbi Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration
    Cornelia Weiss-Haljiti
    Serono Pharmaceutical Research Institute, Serono International S A, 14 Chemin des Aulx, CH 1228 Plan les Ouates, Geneva, Switzerland
    J Biol Chem 279:43273-84. 2004
    ..Our results thus demonstrate a chemokine-specific signaling pathway in which Gi and PI3Kgamma coordinate to drive Rac1 and PAK2 activation that eventually controls the chemotactic response...
  50. doi Rho GTPases in cancer cell biology
    Francisco M Vega
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    FEBS Lett 582:2093-101. 2008
    ..Here, we discuss how Rho GTPases could contribute to different steps of cancer progression, including proliferation, survival, invasion and metastasis...
  51. pmc T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice
    Sarah J Jarmin
    Department of Immunology, Division of Medicine, Imperial College London, Hammersmith Campus, London, United Kingdom
    J Clin Invest 118:1154-64. 2008
    ..These observations suggest that pharmacological targeting of p110delta activity is a viable strategy for the therapy of T cell-mediated pathology...
  52. ncbi Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing
    Ceniz Zihni
    Kings College London, Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, United Kingdom
    J Biol Chem 282:6484-93. 2007
    ....
  53. ncbi Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G protein
    Halina Garavini
    BBSRC Bloomsbury Centre for Structural Biology and School of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX
    Biochemistry 41:6303-10. 2002
    ..By superposition of the RhoE structure on structures of Rho family proteins in complex with binding partners, we make predictions on RhoE interactions with these partners...
  54. doi Getting invasive with GEP100 and Arf6
    Ferran Valderrama
    Nat Cell Biol 10:16-8. 2008
  55. pmc Implantation of the human embryo requires Rac1-dependent endometrial stromal cell migration
    Seema Grewal
    Nuffield Department of Obstetrics and Gynecology, University of Oxford, Level 3, Women s Centre, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 105:16189-94. 2008
    ..These results reveal embryo-induced and localized endometrial responses that may govern implantation of the human embryo...
  56. ncbi SnapShot: Rho family GTPases
    Francisco M Vega
    Randall Division of Cell and Molecular Biophysics, King s College London, London, UK
    Cell 129:1430. 2007
  57. ncbi Rho GTPases and cell cycle control
    Priam Villalonga
    Ludwig Institute for Cancer Research and Department of Biochemistry and Molecular Biology, University College London, London, UK
    Growth Factors 24:159-64. 2006
    ....
  58. ncbi Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis
    Henri J Huttunen
    Program of Molecular Neurobiology, Institute of Biotechnology, and Department of Biosciences, University of Helsinki, Helsinki FIN 00014, Finland
    Cancer Res 62:4805-11. 2002
    ..Taken together, these results suggest that amphoterin binds to RAGE through a COOH-terminal motif that can be used as an efficient inhibitor to block invasive migration of tumor cells...
  59. ncbi Focus on membrane dynamics
    Mark A McNiven
    Trends Cell Biol 16:485-6. 2006
  60. ncbi The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability
    Costas Mitsopoulos
    Department of Academic Surgery, GKT School of Medicine and Dentistry, Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, United Kingdom
    J Biol Chem 278:18085-91. 2003
    ..These results demonstrate that PSK interacts with microtubules and affects their organization and stability independently of PSK kinase activity...
  61. ncbi Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis
    Miao Tzu Huang
    Imperial College, BHF Cardiovascular Sciences Unit, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Blood 106:1636-43. 2005
    ..Our findings identify a novel pathway regulating angiogenesis through ICAM-2 and a novel mechanism for Rac activation during angiogenesis...
  62. ncbi Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1
    Gareth E Jones
    Randall Centre, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Exp Cell Res 290:120-31. 2003
    ..These results indicate that the initial actin reorganization induced by either a GPCR or tyrosine kinase receptor agonist is not dependent on PI3Kgamma, whereas PI3Kgamma is needed for optimal migration of macrophages to either agonist...
  63. ncbi Analysis of cell migration using the Dunn chemotaxis chamber and time-lapse microscopy
    Claire M Wells
    Randall Centre, King s College London, London, UK
    Methods Mol Biol 294:31-41. 2005
    ..This is a particularly useful protocol as it can be adapted to study bone marrow-derived macrophages isolated from genetically modified mice and thus study the requirement for a specific protein in cell migration and chemotaxis...