Gerard R Ridgway

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thickness
    Gerard R Ridgway
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neurology 79:80-4. 2012
  2. pmc The problem of low variance voxels in statistical parametric mapping; a new hat avoids a 'haircut'
    Gerard R Ridgway
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK
    Neuroimage 59:2131-41. 2012
  3. doi request reprint The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 81:756-63. 2010
  4. ncbi request reprint Increasing power to predict mild cognitive impairment conversion to Alzheimer's disease using hippocampal atrophy rate and statistical shape models
    Kelvin K Leung
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:125-32. 2010
  5. pmc Accent processing in dementia
    Julia C Hailstone
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuropsychologia 50:2233-44. 2012
  6. ncbi request reprint Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal data
    Oscar Camara
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, London WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 10:785-92. 2007
  7. ncbi request reprint Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
  8. ncbi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
  9. pmc Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 53:1070-6. 2010
  10. ncbi request reprint Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal Alzheimer's disease images
    Oscar Camara
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, UK
    Neuroimage 42:696-709. 2008

Detail Information

Publications44

  1. pmc Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thickness
    Gerard R Ridgway
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neurology 79:80-4. 2012
    ....
  2. pmc The problem of low variance voxels in statistical parametric mapping; a new hat avoids a 'haircut'
    Gerard R Ridgway
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK
    Neuroimage 59:2131-41. 2012
    ..Following theory and simulations, we propose to modify--directly and solely--the noise variance estimate, and investigate this solution on real imaging data from a range of modalities...
  3. doi request reprint The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 81:756-63. 2010
    ..They may also provide tools for assessing disease-modifying interventions. The authors investigated the progression of regional atrophy in premanifest and early HD compared with controls...
  4. ncbi request reprint Increasing power to predict mild cognitive impairment conversion to Alzheimer's disease using hippocampal atrophy rate and statistical shape models
    Kelvin K Leung
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:125-32. 2010
    ..We demonstrate increased statistical power to classify 86 MCI converters and 128 MCI stable subjects using the hippocampal atrophy rates calculated by the boundary shift integral within these ROIs...
  5. pmc Accent processing in dementia
    Julia C Hailstone
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuropsychologia 50:2233-44. 2012
    ....
  6. ncbi request reprint Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal data
    Oscar Camara
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, London WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 10:785-92. 2007
    ..Mean absolute error differences between volume changes given by the FFD-based technique and the gold standard were: sulcal CSF < 2.49%; lateral ventricles < 2.25%; brain < 0.36%; hippocampi < 1.42%...
  7. ncbi request reprint Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
    ..Reduced cortical thickness in the posterior cingulate gyrus is characteristic of AD pathology in patients with typical and atypical clinical presentations of AD, and may assist a clinical distinction of AD pathology from FTLD pathology...
  8. ncbi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
    ..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
  9. pmc Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 53:1070-6. 2010
    ..The findings suggest that the effects of GRN and MAPT mutations are expressed in partly overlapping but distinct anatomical networks that link specific molecular dysfunction with clinical phenotype...
  10. ncbi request reprint Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal Alzheimer's disease images
    Oscar Camara
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, UK
    Neuroimage 42:696-709. 2008
    ....
  11. pmc Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK Centre for Medical Image Computing, University College London, Gower Street, London, WC1E 6BT, UK
    Neuroimage 51:1345-59. 2010
    ..MAPS-HBSI required the lowest sample sizes (78 subjects) for a hypothetical trial. In conclusion, the MAPS and MAPS-HBSI methods give accurate and reliable volumes and atrophy rates across the clinical spectrum from healthy aging to AD...
  12. doi request reprint Relationship between CAG repeat length and brain volume in premanifest and early Huntington's disease
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, University College, London, UK
    J Neurol 256:203-12. 2009
    ..Overall we have demonstrated that increased CAG repeat length is associated with atrophy in extra-striatal as well as striatal regions, which has implications for the monitoring of disease-modifying therapies in the condition...
  13. pmc Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls
    Josephine Barnes
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK
    Neurobiol Aging 34:1996-2002. 2013
    ..There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages...
  14. doi request reprint Patterns of cortical thickness according to APOE genotype in Alzheimer's disease
    Leticia Gutiérrez-Galve
    Dementia Research Centre, Institute of Neurology, University College London UCL, London WC1N 3BG, UK
    Dement Geriatr Cogn Disord 28:476-85. 2009
    ..We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease)...
  15. ncbi request reprint Improved maximum a posteriori cortical segmentation by iterative relaxation of priors
    Manuel Jorge Cardoso
    Centre for Medical Image Computing, University College London, UK
    Med Image Comput Comput Assist Interv 12:441-9. 2009
    ....
  16. pmc Brain MAPS: an automated, accurate and robust brain extraction technique using a template library
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 55:1091-108. 2011
    ..In conclusion, MAPS had relatively high accuracy and low variability compared to HWA, BET and BSE in MR scans with and without atrophy...
  17. pmc Impairments of auditory scene analysis in Alzheimer's disease
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Brain 135:190-200. 2012
    ..This work suggests a basis for understanding a class of clinical symptoms in Alzheimer's disease and for delineating cognitive mechanisms that mediate auditory scene analysis both in health and in neurodegenerative disease...
  18. pmc Progressive logopenic/phonological aphasia: erosion of the language network
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
    Neuroimage 49:984-93. 2010
    ....
  19. doi request reprint A comparison of voxel and surface based cortical thickness estimation methods
    Matthew J Clarkson
    Centre for Medical Image Computing, The Engineering Front Building, University College London, London WC1E 6BT, UK
    Neuroimage 57:856-65. 2011
    ..Finally we assessed longitudinal performance and concluded that currently FreeSurfer provides the most plausible measure of change over time, with further work required for voxel based methods...
  20. doi request reprint Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neurobiol Aging 32:1466-76. 2011
    ..These distinct patterns of atrophy may have diagnostic utility. In a clinical context, a relatively spared medial temporal lobe in the presence of posterior parietal atrophy may imply PCA, and should not discount AD...
  21. ncbi request reprint Basic visual function and cortical thickness patterns in posterior cortical atrophy
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 21:2122-32. 2011
    ..However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation...
  22. ncbi request reprint Profiles of white matter tract pathology in frontotemporal dementia
    Colin J Mahoney
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Hum Brain Mapp 35:4163-79. 2014
    ..Hum Brain Mapp 35:4163-4179, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. ..
  23. doi request reprint Global gray matter changes in posterior cortical atrophy: a serial imaging study
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Alzheimers Dement 8:502-12. 2012
    ..However, differential longitudinal atrophy patterns are not well understood...
  24. pmc The importance of group-wise registration in tract based spatial statistics study of neurodegeneration: a simulation study in Alzheimer's disease
    Shiva Keihaninejad
    Dementia Research Centre, University College London Institute of Neurology, London, United Kingdom
    PLoS ONE 7:e45996. 2012
    ..Using a group-wise average atlas as the reference outperformed other references in the TBSS pipeline in all evaluations...
  25. pmc White matter tract signatures of the progressive aphasias
    Colin J Mahoney
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:1687-99. 2013
    ..These WM signatures of PPA syndromes illustrate the selective vulnerability of brain language networks in these diseases and might have some pathologic specificity...
  26. pmc MIRIAD--Public release of a multiple time point Alzheimer's MR imaging dataset
    Ian B Malone
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Neuroimage 70:33-6. 2013
    ....
  27. doi request reprint Issues with threshold masking in voxel-based morphometry of atrophied brains
    Gerard R Ridgway
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, London, UK
    Neuroimage 44:99-111. 2009
    ..We investigate the issues related to mask construction, and recommend the use of alternative strategies which greatly decrease this danger of false negatives...
  28. doi request reprint Head size, age and gender adjustment in MRI studies: a necessary nuisance?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 53:1244-55. 2010
    ..Division of all volumes by head size is unlikely to be adequate owing to their non-proportional relationship...
  29. pmc Nonverbal sound processing in semantic dementia: a functional MRI study
    Johanna C Goll
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 61:170-80. 2012
    ..The breakdown of these mechanisms constitutes a network-level functional signature of this neurodegenerative disease...
  30. pmc LoAd: a locally adaptive cortical segmentation algorithm
    M Jorge Cardoso
    Centre for Medical Image Computing CMIC, University College London, London, UK
    Neuroimage 56:1386-97. 2011
    ....
  31. ncbi request reprint Fast free-form deformation using graphics processing units
    Marc Modat
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, London, UK
    Comput Methods Programs Biomed 98:278-84. 2010
    ..This technology could be of significant utility in time-critical applications such as image-guided interventions, or in the processing of large data sets...
  32. pmc The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study
    David M Cash
    From the Dementia Research Centre D M C, Y L, N S R, K M K, T Y, I B M, M N R, S O, N C F and Wellcome Trust Centre for Neuroimaging G R R, UCL Institute of Neurology, London, UK Washington University School of Medicine T L S B, N J C, D S M, C X, R J B, J C M, St Louis, MO Mayo Clinic C R J, Rochester, MN Imaging Genetics Center P M T, Laboratory of Neuroimaging, Department of Neurology and Psychiatry, UCLA School of Medicine, Los Angeles, CA Indiana University School of Medicine B F G, A J S, Indianapolis Mental Health Research Institute C L M, The University of Melbourne, Victoria, Australia Mary S Easton Center for Alzheimer s Disease J M R, UCLA Department of Neurology, Los Angeles, CA Butler Hospital S P S, Providence, RI Neuroscience Research Australia P R S, Sydney and the Center for Alzheimer Research and Treatment R A S, Japan
    Neurology 81:1425-33. 2013
    ..To assess regional patterns of gray and white matter atrophy in familial Alzheimer disease (FAD) mutation carriers...
  33. pmc Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease
    Natalie S Ryan
    Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosugery, Queen Square, London WC1N 3BG, UK
    Brain 136:1399-414. 2013
    ..It may be owing to their dense connectivity that imaging changes are seen first in the thalamus and striatum, which then progress to involve other regions in a vulnerable neuronal network...
  34. doi request reprint Defective emotion recognition in early HD is neuropsychologically and anatomically generic
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, University College London, UK
    Neuropsychologia 46:2152-60. 2008
    ..Even in early HD there is a wide-ranging impairment in recognition of negative emotions denoting 'threat'. Our findings implicate a generic fronto-subcortical network in the pathogenesis of these emotion recognition deficits...
  35. pmc Voice processing in dementia: a neuropsychological and neuroanatomical analysis
    Julia C Hailstone
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 134:2535-47. 2011
    ..The right anterior temporal lobe is likely to have a critical role in the recognition of voices and other modalities of person knowledge...
  36. pmc Comparing the similarity and spatial structure of neural representations: a pattern-component model
    Jorn Diedrichsen
    Institute of Cognitive Neuroscience, University College London, London, UK
    Neuroimage 55:1665-78. 2011
    ..Thus, the new model provides a theoretical and analytical framework to study the structure of distributed neural representations...
  37. doi request reprint Algorithms, atrophy and Alzheimer's disease: cautionary tales for clinical trials
    Nick C Fox
    The Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 57:15-8. 2011
    ..In the absence of a "gold standard", we discuss a number of steps against which methodologies designed to quantify atrophy from serial scans can be assessed...
  38. doi request reprint Ten simple rules for reporting voxel-based morphometry studies
    Gerard R Ridgway
    Centre for Medical Image Computing, University College London, UK
    Neuroimage 40:1429-35. 2008
    ..This editorial suggests core principles that should be followed and information that should be included when reporting a VBM study in order to make it transparent, replicable and useful...
  39. doi request reprint Consistent multi-time-point brain atrophy estimation from the boundary shift integral
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 59:3995-4005. 2012
    ..Either improved interpolation or symmetric registration alone can greatly reduce this bias, and our proposed method combining both aspects shows no significant bias in any of the four experiments...
  40. pmc Patterns of longitudinal brain atrophy in the logopenic variant of primary progressive aphasia
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK Electronic address
    Brain Lang 127:121-6. 2013
    ....
  41. ncbi request reprint Phenomenological model of diffuse global and regional atrophy using finite-element methods
    Oscar Camara
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, Department of Computer Science, University College London, London WCEI 6BT, UK
    IEEE Trans Med Imaging 25:1417-30. 2006
    ..Results confirm the potential of the proposed methodology...
  42. pmc Set-level threshold-free tests on the intrinsic volumes of SPMs
    Gareth R Barnes
    The Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 68:133-40. 2013
    ..We also demonstrate the application to real data and illustrate the comparison of the expected and observed Euler characteristics over the complete threshold range...
  43. ncbi request reprint The role of polarity in antonym and synonym conceptual knowledge: evidence from stroke aphasia and multidimensional ratings of abstract words
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK
    Neuropsychologia 50:2636-44. 2012
    ....
  44. pmc Abstract conceptual feature ratings: the role of emotion, magnitude, and other cognitive domains in the organization of abstract conceptual knowledge
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London London, UK Stroke Unit, Northwick Park Hospital Harrow, London, UK
    Front Hum Neurosci 7:186. 2013
    ....