Tom G Richardson
Affiliation: University of Bristol
Hatcher C, Relton C, Gaunt T, Richardson T. Leveraging brain cortex-derived molecular data to elucidate epigenetic and transcriptomic drivers of complex traits and disease. Transl Psychiatry. 2019;9:105 pubmed publisher
..Our study should prove valuable in helping future studies prioritize candidate genes and epigenetic mechanisms for in-depth functional follow-up analyses. ..
Taylor K, Davey Smith G, Relton C, Gaunt T, Richardson T. Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization. Genome Med. 2019;11:6 pubmed publisher
..Future studies which continue to uncover quantitative trait loci for molecular traits across various tissue and cell types will further improve our capability to understand and prevent disease. ..
Erzurumluoglu A, Baird D, Richardson T, Timpson N, Rodriguez S. Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications. Genes (Basel). 2018;9: pubmed publisher
..Further studies using other traits, phenome-wide association studies (PheWAS), other haplogroups and/or autosomal SNPs are required to test the generalisability and utility of this approach. ..
Richardson T, Zheng J, Davey Smith G, Timpson N, Gaunt T, Relton C, et al
. Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk. Am J Hum Genet. 2017;101:590-602 pubmed publisher
..Integrating our results with expression quantitative trait loci data, we provide evidence that variation at these regulatory regions is likely to also influence gene expression levels at these loci. ..
Richardson T, Thomas E, Sessions R, Lawlor D, Tavare J, Day I. Structural and population-based evaluations of TBC1D1 p.Arg125Trp. PLoS ONE. 2013;8:e63897 pubmed publisher
..06, P?=?0.80). Our analysis suggests that R125W in TBC1D1 plays a role in the binding of an effector protein, but we find no evidence that the R125W variant is related to mean BMI or odds of obesity in a general population sample. ..