Research Topics
Genomes and GenesSpecies | Jason RiceSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
Critical components of a DNA fusion vaccine able to induce protective cytotoxic T cells against a single epitope of a tumor antigenJason Rice
Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospitals Trust, Southampton, United Kingdom
J Immunol 169:3908-13. 2002..These data demonstrate the power of epitope-specific CTL against tumor cells and illustrate a strategy for priming immunity via a dual component DNA vaccine...
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoireJason Rice
Molecular Immunology Group, Cancer Sciences Division, University of Southampton School of Medicine, Southampton, UK
Eur J Immunol 38:2118-30. 2008..These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8(+) T cell responses from a residual tolerized repertoire...
A DNA vaccine strategy for effective antibody induction to pathogen-derived antigensJason Rice
Division of Cancer Sciences, Genetic Vaccines Group, University of Southampton Medical School, Southampton, UK
Methods Mol Biol 799:405-19. 2012..Finally, we provide a safe and effective protocol for delivery of DNA vaccines, based on intramuscular injection followed by electroporation...- DNA fusion vaccines induce epitope-specific cytotoxic CD8(+) T cells against human leukemia-associated minor histocompatibility antigensJason Rice
Molecular Immunology Group, Southampton University Hospitals Trust, Southampton, Hampshire, United Kingdom
Cancer Res 66:5436-42. 2006..These safe epitope-specific vaccines offer a potential strategy to prime HA-1- or HA-2-specific CTL in transplant donors before adoptive transfer... - DNA fusion vaccines induce targeted epitope-specific CTLs against minor histocompatibility antigens from a normal or tolerized repertoireJason Rice
Molecular Immunology Group, Southampton University Hospitals Trust, Southampton, Hampshire, United Kingdom
J Immunol 173:4492-9. 2004..For patients, vaccination could activate a potentially less tolerized repertoire against similar Ags that may be overexpressed by tumor cells, for focused immune attack... - Electroporation as a "prime/boost" strategy for naked DNA vaccination against a tumor antigenSarah Buchan
Molecular Immunology Group, Southampton University Hospitals Trust, Southampton, United Kingdom
J Immunol 174:6292-8. 2005..Therefore, boosting may not require viral vectors, but simply a physical change in delivery, facilitating application to the cancer clinic... - DNA fusion gene vaccines against cancer: from the laboratory to the clinicFreda K Stevenson
Molecular Immunology Group, Tenovus Laboratory, Cancer Sciences Division, Southampton University Hospitals, Southampton, UK
Immunol Rev 199:156-80. 2004..Vaccination strategies against cancer and against microbes are sharing knowledge and technology for mutual benefit... - A DNA fusion vaccine induces bactericidal antibodies to a peptide epitope from the PorA porin of Neisseria meningitidisDelin Zhu
Genetic Vaccine Group, Cancer Sciences Division, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
Infect Immun 76:334-8. 2008..These data provide proof of principle for a DNA fusion plasmid strategy as a novel approach to preparing vaccines based on defined, protective epitopes... - DNA vaccines: precision tools for activating effective immunity against cancerJason Rice
Genetic Vaccine Group, Cancer Sciences Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
Nat Rev Cancer 8:108-20. 2008..Recently, novel delivery systems, especially electroporation, have overcome this translational block. Here, we assess the development, current performance and potential of DNA vaccines for the treatment of cancer... - Optimizing cancer immunotherapy trials: back to basicsFreda K Stevenson
Molecular Immunology Group, Cancer Sciences Division, Southampton University Hospitals Trust, Southampton, UK
Eur J Immunol 36:1070-3. 2006..These twin problems of engagement of T-cell help and delivery of adequate antigen can now be addressed by applying immunological logic to cancer vaccines... - DNA vaccines against cancer come of ageFreda K Stevenson
Cancer Sciences Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
Curr Opin Immunol 22:264-70. 2010..Prolongation of remission is the goal and an activated immune system should achieve this... - DNA vaccines to attack cancerFreda K Stevenson
Molecular Immunology Group, Tenovus Laboratory, Cancer Sciences Division, Southampton University Hospitals Trust, Southampton SO16 6YD, UK
Proc Natl Acad Sci U S A 101:14646-52. 2004..Physical methods including electroporation provide increased expression without introducing additional competing antigens. A wide range of cancers can be targeted, and objective assays of response will determine efficacy... - DNA fusion gene vaccines induce cytotoxic T-cell attack on naturally processed peptides of human prostate-specific membrane antigenGisella E Vittes
University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
Eur J Immunol 41:2447-56. 2011..The preclinical model provides a powerful tool for generating CD8(+) T cells able to predict whether target cells can process and present peptides, essential for planning peptide vaccine-based clinical trials... - A gamma-herpesvirus immune evasion gene allows tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitopeJason Rice
Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospitals Trust, Southampton, GB
Eur J Immunol 32:3481-7. 2002..They may have relevance for escape of human virus-associated malignancies, and raise the question of whether analogous molecules might contribute to the failure of CTL to eliminate tumors... - Tumor vaccinesFreda K Stevenson
Molecular Immunology Group, Tenovus Laboratory, Cancer Sciences Division Southampton University Hospitals Trust, Southampton SO16 6YD, United Kingdom
Adv Immunol 82:49-103. 2004 - DNA vaccination induces WT1-specific T-cell responses with potential clinical relevanceCoralie Chaise
INSERM U 841, Institut Mondor de Recherche Biomédicale IMRB, Departement d Immunologie, Dermatologie et Oncologie, Creteil, France
Blood 112:2956-64. 2008.... - Priming protective CD8 T cell immunity by DNA vaccines encoding chimeric, stress protein-capturing tumor-associated antigenReinhold Schirmbeck
Department of Internal Medicine I, University of Ulm, Ulm, Germany
J Immunol 177:1534-42. 2006..A vaccination strategy based on delivering antigenic, hsp-associated TAA fragments can thus prime protective CD8 T cell immunity even if these TAA are of low intrinsic immunogenicity... - Public T cell receptor beta-chains are not advantaged during positive selectionAnna L Furmanski
Department of Immunology, Hammersmith Hospital, Imperial College London, London, United Kingdom
J Immunol 180:1029-39. 2008..Therefore, the establishment and maintenance of public beta-chains in the periphery is predominantly controlled by post-thymic events through modification of the primary, thymus-derived TCR repertoire...