L E Rhodes
Affiliation: University of Manchester
- Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markersLesley E Rhodes
Photobiology Unit, Dermatology Centre, University of Manchester, UK
Carcinogenesis 24:919-25. 2003..e. sunburn, UVR-induced p53 in skin and strand breaks in PBL, indicate protection by dietary EPA against acute UVR-induced genotoxicity; longer-term supplementation might reduce skin cancer in humans...
- Seasonal and latitudinal impact of polymorphic light eruption on quality of lifeTsui C Ling
J Invest Dermatol 126:1648-51. 2006
- Beyond sun protection factor testingL E Rhodes
University of Manchester, Hope Hospital, Manchester, UK
Int J Cosmet Sci 26:207-14. 2004....
- Prostaglandin E2 and nitric oxide mediate the acute inflammatory (erythemal) response to topical 5-aminolaevulinic acid photodynamic therapy in human skinR C C Brooke
Dermatology Centre, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, U K
Br J Dermatol 169:645-52. 2013..Topical 5-aminolaevulinic acid photodynamic therapy (5-ALA-PDT) causes a clinical inflammatory response in human skin. While histamine mediates the immediate reaction, the mediators of the prolonged erythema are unknown...
- Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinomaG Evangelou
University of Manchester, Manchester M6 6HD, UK
Br J Dermatol 166:1112-5. 2012..Topical photodynamic therapy (PDT) is a widely applied treatment for basal cell carcinoma (BCC). PDT-induced immunosuppression leading to reduced antitumour immune responses may be a factor in treatment failure...
- The role of sunlight exposure in determining the vitamin D status of the U.K. white adult populationA R Webb
School of Earth Atmospheric and Environmental Sciences, University of Manchester, Manchester M13 9PL, UK
Br J Dermatol 163:1050-5. 2010..Opinions are divided on whether the proposed optimal circulating 25-hydroxyvitamin D [25(OH)D] level (≥ 32 ng mL⁻¹) is an appropriate and feasible target at population level...
- Lifestyle factors including less cutaneous sun exposure contribute to starkly lower vitamin D levels in U.K. South Asians compared with the white populationR Kift
School of Earth, Atmospheric and Environmental Sciences, University of Manchester, Manchester, U K
Br J Dermatol 169:1272-8. 2013..Long-standing concerns over the vitamin D status of South Asian adults in the U.K. require studies using statistically valid sample sizes to measure annual variation and contributory lifestyle factors...
- Systemic photoprotection in solar urticaria with α-melanocyte-stimulating hormone analogue [Nle4-D-Phe7]-α-MSHA K Haylett
Dermatological Sciences, Inflammation Sciences Research Group, School of Translational Medicine, University of Manchester, Manchester Academic Health Sciences Centre, Salford Royal NHS Foundation Trust, Manchester M6 8HD, UK
Br J Dermatol 164:407-14. 2011..Melanin broadly reduces skin penetration by ultraviolet-visible wavelengths, thus increased melanization may protect in solar urticaria...
- Voriconazole-induced photosensitivity: photobiological assessment of a case series of 12 patientsA K Haylett
Photobiology Unit, Dermatology Centre, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Stott Lane, Manchester M6 8HD, U K
Br J Dermatol 168:179-85. 2013..The action spectrum of the photosensitivity is unknown, while an indirect retinol effect secondary to the antifungal's impact on CYP450 enzymes has been proposed to contribute to the underlying mechanism...
- Topical aminolaevulinic acid-photodynamic therapy produces an inflammatory infiltrate but reduces Langerhans cells in healthy human skin in vivoG Evangelou
Dermatological Sciences, Inflammation Sciences Research Group, School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Hospital, Manchester, UK
Br J Dermatol 165:513-9. 2011..While PDT induces direct cell death, host inflammatory and immune responses to PDT may contribute to the therapeutic effects...
- Ultraviolet-B-induced erythema is mediated by nitric oxide and prostaglandin E2 in combinationL E Rhodes
Photobiology Unit, Dermatology Center, Hope Hospital, Manchester, UK
J Invest Dermatol 117:880-5. 2001..They also show that there is prolonged synthesis of both mediators within the erythemal response and that synthesis of NO is induced by lower doses of ultraviolet B compared with that of prostaglandin E2...
- Influence of oral antioxidants on ultraviolet radiation-induced skin damage in humansK Swindells
Photobiology Unit, Dermatology Centre, University of Manchester School of Medicine and Hope Hospital, Manchester, UK
Photodermatol Photoimmunol Photomed 20:297-304. 2004....
- Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'?E A Langan
Photobiology Unit, Dermatological Sciences, Epithelial Sciences Research Group, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, U K
Br J Dermatol 163:451-5. 2010..The photoprotective and other biological effects of α-MSH analogues await full determination...
- The impact of photosensitivity disorders on aspects of lifestyleR Stafford
Photobiology Unit, Dermatological Sciences, Epithelial Sciences Research Group, School of Translational Medicine, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Hospital, University of Manchester, Manchester, M6 8HD, UK
Br J Dermatol 163:817-22. 2010..No previous studies have directly compared lifestyle attributes between photosensitive and healthy individuals...
- The potential of omega-3 fatty acids in the prevention of non-melanoma skin cancerHomer S Black
Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA
Cancer Detect Prev 30:224-32. 2006..Supplementary omega-3 FA significantly reduces the level of pro-inflammatory and immunosuppressive PGE(2) levels in Ultraviolet B-irradiated human skin...
- Influence of eicosapentaenoic acid, an omega-3 fatty acid, on ultraviolet-B generation of prostaglandin-E2 and proinflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 in human skin in vivoHassan Shahbakhti
Photobiology Unit, Dermatology Centre, University of Manchester, Manchester M6 8HD, UK
Photochem Photobiol 80:231-5. 2004..Hence, in healthy skin in vivo, there was no evidence that reduction of the sunburn response by EPA is mediated by the proinflammatory cytokines examined; abrogation of UV-B-generated PGE(2) may play a role...
- Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblastsAmy Storey
Department of Medicine, University of Liverpool, Liverpool, UK
J Invest Dermatol 124:248-55. 2005..001). Hence both n-3 PUFA inhibit production of UVB- and TNF-alpha-induced IL-8 in skin cells; this may be important in the photoprotective and other anti-inflammatory effects conferred by these agents...
- Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinomaLesley E Rhodes
Photobiology Unit, Department of Dermatology, University of Manchester, Salford Royal Foundation Hospital, Manchester M6 8HD, England
Arch Dermatol 143:1131-6. 2007..To compare 5-year lesion recurrence rates in primary nodular basal cell carcinoma treated with topical methyl aminolevulinate photodynamic therapy (PDT) or simple excision surgery...
- Effects of oral vitamin E and beta-carotene supplementation on ultraviolet radiation-induced oxidative stress in human skinFrank McArdle
Department of Medicine, University of Liverpool, Liverpool, United Kingdom
Am J Clin Nutr 80:1270-5. 2004..Ultraviolet radiation (UVR) generates reactive oxygen species in skin that can play a role in skin damage, but reports about the photoprotective properties of oral antioxidant supplements are conflicting...
- Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory responseRebecca C C Brooke
Photobiology Unit, Dermatological Sciences, University of Manchester, Salford Royal Hospital, Manchester, UK
J Invest Dermatol 126:2296-301. 2006..Thus, two discrete acute inflammatory responses to topical ALA-PDT occur in human skin; histamine mediates the immediate response, but does not appear involved in the delayed phototoxicity...
- Preventive oncologyLesley E Rhodes
Lancet 363:1736-7. 2004
- Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trialLesley E Rhodes
Department of Dermatology, Royal Liverpool University Hospital, Liverpool, England
Arch Dermatol 140:17-23. 2004..Photodynamic therapy (PDT) is increasingly used as a noninvasive treatment for nodular basal cell carcinoma (BCC), without a sound evidence base...
- Conjugated linoleic acids modulate UVR-induced IL-8 and PGE2 in human skin cells: potential of CLA isomers in nutritional photoprotectionAmy Storey
Department of Medicine, University of Liverpool, Liverpool, UK
Carcinogenesis 28:1329-33. 2007..05). Hence, CLA isomers differentially modulate UVB effects on skin cells in vitro. CLA-containing foods have potential in photoprotection; the cutaneous effects of individual isomers warrant clinical study...