J M Rhodes

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared
    Jonathan M Rhodes
    Dept of Medicine, University of Liverpool, Daulby Street, Liverpool, UK L69 3GA
    Trends Mol Med 8:10-6. 2002
  2. ncbi request reprint Surveillance for colitis-associated cancer: we cannot stop now
    J M Rhodes
    Department of Medicine, University of Liverpool, UK
    Dig Liver Dis 34:319-21. 2002
  3. doi request reprint Lectin-epithelial interactions in the human colon
    Jonathan M Rhodes
    School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool, UK
    Biochem Soc Trans 36:1482-6. 2008
  4. ncbi request reprint Lessons for inflammatory bowel disease from rheumatology
    J M Rhodes
    School of Clinical Science, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Dig Liver Dis 38:157-62. 2006
  5. pmc The role of Escherichia coli in inflammatory bowel disease
    Jonathan M Rhodes
    School of Clinical Sciences, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA
    Gut 56:610-2. 2007
  6. ncbi request reprint Clinical trial: oral prednisolone metasulfobenzoate (Predocol) vs. oral prednisolone for active ulcerative colitis
    J M Rhodes
    School of Clinical Science, University of Liverpool, Liverpool, UK
    Aliment Pharmacol Ther 27:228-40. 2008
  7. ncbi request reprint Increasing the intra-Golgi pH of cultured LS174T goblet-differentiated cells mimics the decreased mucin sulfation and increased Thomsen-Friedenreich antigen (Gal beta1-3GalNac alpha-) expression seen in colon cancer
    B J Campbell
    Glycobiology Group, Gastroenterology Research Unit, Department of Medicine, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK
    Glycobiology 11:385-93. 2001
  8. ncbi request reprint Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins
    L G Yu
    Department of Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom
    J Cell Physiol 186:282-7. 2001
  9. ncbi request reprint Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta1-3 N-acetyl-galactosamine)
    L G Yu
    Department of Medicine, University of Liverpool, UK
    Int J Cancer 73:424-31. 1997
  10. pmc Altered colonic glycoprotein expression in unaffected monozygotic twins of inflammatory bowel disease patients
    K Bodger
    School of Clinical Science, University of Liverpool, Daulby St, Liverpool L69 3GA, UK, and Orebro University Hospital, Sweden
    Gut 55:973-7. 2006

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared
    Jonathan M Rhodes
    Dept of Medicine, University of Liverpool, Daulby Street, Liverpool, UK L69 3GA
    Trends Mol Med 8:10-6. 2002
    ....
  2. ncbi request reprint Surveillance for colitis-associated cancer: we cannot stop now
    J M Rhodes
    Department of Medicine, University of Liverpool, UK
    Dig Liver Dis 34:319-21. 2002
  3. doi request reprint Lectin-epithelial interactions in the human colon
    Jonathan M Rhodes
    School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool, UK
    Biochem Soc Trans 36:1482-6. 2008
    ..This should prove a very fruitful area for future research with relevance to infectious, inflammatory and cancerous diseases of the epithelia...
  4. ncbi request reprint Lessons for inflammatory bowel disease from rheumatology
    J M Rhodes
    School of Clinical Science, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Dig Liver Dis 38:157-62. 2006
    ..very different risks of cancer in chronically inflamed colon and inflamed joints imply that cancer development requires both NFkappaB activation, to inhibit apoptosis, and the presence of agents, such as bacteria, to initiate DNA damage?..
  5. pmc The role of Escherichia coli in inflammatory bowel disease
    Jonathan M Rhodes
    School of Clinical Sciences, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA
    Gut 56:610-2. 2007
  6. ncbi request reprint Clinical trial: oral prednisolone metasulfobenzoate (Predocol) vs. oral prednisolone for active ulcerative colitis
    J M Rhodes
    School of Clinical Science, University of Liverpool, Liverpool, UK
    Aliment Pharmacol Ther 27:228-40. 2008
    ..Systemic corticosteroids are effective in ulcerative colitis but commonly cause side effects...
  7. ncbi request reprint Increasing the intra-Golgi pH of cultured LS174T goblet-differentiated cells mimics the decreased mucin sulfation and increased Thomsen-Friedenreich antigen (Gal beta1-3GalNac alpha-) expression seen in colon cancer
    B J Campbell
    Glycobiology Group, Gastroenterology Research Unit, Department of Medicine, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK
    Glycobiology 11:385-93. 2001
    ..Intra-Golgi alkalinization affects mucin glycosylation, resulting in decreased mucin sulfation and increased expression of TF antigen, changes that mimic those seen in cancerous and premalignant human colonic epithelium...
  8. ncbi request reprint Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins
    L G Yu
    Department of Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom
    J Cell Physiol 186:282-7. 2001
    ....
  9. ncbi request reprint Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta1-3 N-acetyl-galactosamine)
    L G Yu
    Department of Medicine, University of Liverpool, UK
    Int J Cancer 73:424-31. 1997
    ....
  10. pmc Altered colonic glycoprotein expression in unaffected monozygotic twins of inflammatory bowel disease patients
    K Bodger
    School of Clinical Science, University of Liverpool, Daulby St, Liverpool L69 3GA, UK, and Orebro University Hospital, Sweden
    Gut 55:973-7. 2006
    ..This study explores this further by assessing mucosal expression of the oncofetal carbohydrate antigen TF (galactose beta1, 3 N-acetylgalactosamine alpha-), among the same IBD twins...
  11. ncbi request reprint Altered glycosylation in inflammatory bowel disease: a possible role in cancer development
    B J Campbell
    Glycobiology Group, Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Department of Medicine, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
    Glycoconj J 18:851-8. 2001
    ..Consequences of these changes may be relevant not only for cell-surface glycoconjugates but also for intracellular glycoconjugates...
  12. ncbi request reprint Pancreatic tumour marker anti-mucin antibody CAM 17.1 reacts with a sialyl blood group antigen, probably I, which is expressed throughout the human gastrointestinal tract
    D W Eccleston
    Department of Histopathology, Walton Hospital, Liverpool, UK
    Digestion 59:665-70. 1998
    ..These studies show that CAM 17.1 binds to a sialic-acid-containing determinant of mucin, probably sialyl-I, which epitope shows wide distribution throughout the gastro-intestinal tract...
  13. pmc A randomised controlled trial of high versus low long chain triglyceride whole protein feed in active Crohn's disease
    K Leiper
    Gastroenterology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK
    Gut 49:790-4. 2001
    ..We performed a randomised controlled double blind trial in patients with active CD comparing two single whole protein feeds with LCT supplying 5% or 30% of the total energy...
  14. ncbi request reprint Agaricus bisporus (edible mushroom lectin) inhibits ocular fibroblast proliferation and collagen lattice contraction
    M Batterbury
    Unit of Ophthalmology, St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK
    Exp Eye Res 74:361-70. 2002
    ..Further evaluation is warranted...
  15. ncbi request reprint Use of a biosensor to determine the binding kinetics of five lectins for Galactosyl-N-acetylgalactosamine
    J D Milton
    Gastroenterology Research Group, Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK
    Glycoconj J 18:565-9. 2001
    ..0 microM-4.5 microM]. Affinities were also calculated from the extent of binding at equlibrium and were generally similar to those calculated from the kinetic parameters indicating the true nature of these values...
  16. ncbi request reprint Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis
    K Leiper
    Gastroenterology Research Unit, Department of Medicine, University of Liverpool, Liverpool L69 3GA
    Clin Sci (Lond) 101:395-402. 2001
    ..These findings support the hypothesis that the mucosal inflammation and mucus depletion seen in ulcerative colitis could result from interaction between bacterial peptides and the mucosa...
  17. ncbi request reprint Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer
    Helen M Martin
    Department of Medicine, Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 127:80-93. 2004
    ..This study aimed to quantify and characterize mucosa-associated and intramucosal bacteria, particularly Escherichia coli, in these conditions...
  18. pmc Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis
    C Chen
    Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
    Br J Cancer 110:741-52. 2014
    ..These cytokines and chemokines in turn enhance endothelial cell activities in angiogenesis and metastasis. ..
  19. pmc Management of inflammatory bowel disease
    M Nayar
    Department of Medicine, University of Liverpool, Liverpool, UK
    Postgrad Med J 80:206-13. 2004
    ..High dosages of corticosteroids may provide symptomatic relief in Crohn's disease but do not affect the long term natural history of the disease, and management strategies should avoid using steroids whenever possible...
  20. ncbi request reprint Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44
    R Singh
    Department of Medicine, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
    Glycobiology 11:587-92. 2001
    ....
  21. ncbi request reprint Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine
    Sreedhar Subramanian
    Division of Gastroenterology, University School of Clinical Science, Liverpool, UK
    Inflamm Bowel Dis 14:162-75. 2008
    ..Mucosally adherent E. coli are found in inflammatory bowel disease (IBD) and colon cancer. They promote release of the proinflammatory cytokine interleukin-8 (IL-8). We explored mechanisms for this release and its inhibition by drugs...
  22. ncbi request reprint Peanut lectin stimulates proliferation of colon cancer cells by interaction with glycosylated CD44v6 isoforms and consequential activation of c-Met and MAPK: functional implications for disease-associated glycosylation changes
    Ravinder Singh
    Division of Gastroenterology, School of Clinical Science, Nuffield Building, Crown Street, University of Liverpool, Liverpool, L69 3BX, UK
    Glycobiology 16:594-601. 2006
    ..It provides a mechanism by which dietary, microbial, or endogenous galactose-binding lectins could affect epithelial proliferation in the cancerous and precancerous colon...
  23. ncbi request reprint Host-bacteria interaction in inflammatory bowel disease
    Paul Knight
    School of Clinical Sciences, University of Liverpool, Nuffield Building, Crown Street, Liverpool L693BX, UK
    Br Med Bull 88:95-113. 2008
    ..Inflammatory bowel disease (IBD) results from complex interactions between: host genome, immune system, mucosa, bacteria, and environment...
  24. pmc Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers
    Carol L Roberts
    Gastroenterology Research Unit, University School of Clinical Sciences, Crown Street, Liverpool, UK
    Gut 59:1331-9. 2010
    ..We have assessed the effect of soluble non-starch polysaccharide (NSP) and food emulsifiers on translocation of Escherichia coli across M-cells...
  25. doi request reprint A subset of mucosa-associated Escherichia coli isolates from patients with colon cancer, but not Crohn's disease, share pathogenicity islands with urinary pathogenic E. coli
    Christina Bronowski
    Division of Medical Microbiology, School of Infection and Host Defence, University of Liverpool, Liverpool, UK
    Microbiology 154:571-83. 2008
    ..This enabled us to identify a group of isolates from colon cancer (30-40 %) carrying multiple genes previously categorized as UPEC-specific and implicated in virulence...
  26. pmc Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics
    Sreedhar Subramanian
    Division of Gastroenterology, School of Clinical Science, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom
    Antimicrob Agents Chemother 52:427-34. 2008
    ..Colonic mucosa-associated E. coli, particularly CD isolates, replicate within macrophages. Clinical trials are indicated to assess the efficacy of a combination antibiotic therapy targeting intramacrophage E. coli...
  27. doi request reprint Clinical trial: randomized study of clarithromycin versus placebo in active Crohn's disease
    K Leiper
    Department of Gastroenterology, Royal Liverpool and Broadgreen University Hospitals, Liverpool, UK
    Aliment Pharmacol Ther 27:1233-9. 2008
    ..Crohn's disease is characterized by defective innate immune responses to intestinal bacteria. Clarithromycin is a broad-spectrum antibiotic that has good penetration into macrophages...
  28. pmc Detection of sulfated glycoproteins in intestinal metaplasia: a comparison of traditional mucin staining with immunohistochemistry for the sulfo-Lewis(a) carbohydrate epitope
    K Bodger
    Department of Medicine, University of Liverpool, Liverpool L9 7AL, UK
    J Clin Pathol 56:703-8. 2003
    ..Incompletely differentiated sulfomucin rich gastric IM (type III) may have increased malignant potential. The types of sulfated oligosaccharide structures present in IM, BO, and colon have not been fully characterised...
  29. pmc Dietary lectins can stimulate pancreatic growth in the rat
    Angela Kelsall
    Foetal and Infant Toxico Pathology, University of Liverpool, Liverpool L69 7ZA, UK
    Int J Exp Pathol 83:203-8. 2002
    ..In conclusion, long-term feeding of low doses of lectin can influence pancreatic growth, and this trophic action may have potential adverse implications for the development of pancreatic cancer in humans...
  30. ncbi request reprint Microbial mannan inhibits bacterial killing by macrophages: a possible pathogenic mechanism for Crohn's disease
    Chiedzo M Mpofu
    Division of Gastroenterology, School of Clinical Science, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 133:1487-98. 2007
    ..Crohn's disease (CD) is mimicked by inherited phagocyte disorders and is associated with circulating antibodies against yeast mannan (anti-Saccharomyces cerevisiae antibody; ASCA). We speculated that mannans might impair phagocyte function...
  31. ncbi request reprint Diet and colorectal cancer: an investigation of the lectin/galactose hypothesis
    Richard C Evans
    Department of Medicine, University of Liverpool, England
    Gastroenterology 122:1784-92. 2002
    ..This study tests the hypothesis that galactose, which is variably plentiful in fruit and vegetable but not cereal fibers, might prevent cancer by binding and inhibiting such lectins...
  32. doi request reprint Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis
    Keith Leiper
    Department of Gastroenterology, University of Liverpool, Liverpool, UK
    Gut 60:1520-6. 2011
    ..To assess the safety and efficacy of the B lymphocyte (anti-CD20) antibody, rituximab, in the treatment of steroid-resistant moderately active ulcerative colitis (UC)...
  33. ncbi request reprint Review article: minimizing tuberculosis during anti-tumour necrosis factor-alpha treatment of inflammatory bowel disease
    V S Theis
    University Hospital Aintree, Department of Gastroenterology, UK
    Aliment Pharmacol Ther 27:19-30. 2008
    ..Tumour necrosis factor (TNF)-alpha inhibitors are a major advance in the management of inflammatory bowel disease but increase the risk for tuberculosis (TB)...
  34. pmc Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis
    Qicheng Zhao
    Gastroenterology Research Unit, School of Clinical Sciences, Centre for Glycobiology, University of Liverpool, Liverpool L69 3GE, UK
    Mol Cancer 9:154. 2010
    ....
  35. pmc Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface
    Qicheng Zhao
    Gastroenterology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Cancer Res 69:6799-806. 2009
    ..This provides insight into the molecular regulation of metastasis and has important implications for the development of novel therapeutic strategies for prevention of metastasis...
  36. ncbi request reprint An N-terminal truncated form of Orp150 is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import
    Lu Gang Yu
    Department of Medicine, The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, University of Liverpool, Liverpool L69, United Kingdom
    J Biol Chem 277:24538-45. 2002
    ..This cytoplasmic form of Orp150 expresses the lectin carbohydrate ligand (sialyl-2,3-galactosyl-beta1,3-N-acetylgalactosamine-alpha) and is shown to be essential for nuclear localization sequence-dependent nuclear protein import...
  37. ncbi request reprint Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion
    Lu Gang Yu
    Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, School of Clinical Science, University of Liverpool, UK
    J Biol Chem 282:773-81. 2007
    ..This suggests a critical role for circulating galectin-3 in cancer metastasis and highlights the functional importance of altered cell surface glycosylation in cancer progression...
  38. ncbi request reprint Effect of systemic corticosteroid therapy on risk for intra-abdominal or pelvic abscess in non-operated Crohn's disease
    Anurag Agrawal
    Department of Gastroenterology, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Clin Gastroenterol Hepatol 3:1215-20. 2005
    ..Systemic corticosteroid therapy increases risk of postoperative sepsis in Crohn's disease. This study investigates its effect on risk for sepsis in non-operated patients...
  39. ncbi request reprint A case-control study of drinking water and dairy products in Crohn's Disease--further investigation of the possible role of Mycobacterium avium paratuberculosis
    Ibrahim Abubakar
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
    Am J Epidemiol 165:776-83. 2007
    ..The observed association with meat and the negative association with pasteurized milk need further study...