J M Rhodes
Affiliation: University of Liverpool
- Inflammation and colorectal cancer: IBD-associated and sporadic cancer comparedJonathan M Rhodes
Dept of Medicine, University of Liverpool, Daulby Street, Liverpool, UK L69 3GA
Trends Mol Med 8:10-6. 2002....
- Surveillance for colitis-associated cancer: we cannot stop nowJ M Rhodes
Department of Medicine, University of Liverpool, UK
Dig Liver Dis 34:319-21. 2002
- Lectin-epithelial interactions in the human colonJonathan M Rhodes
School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool, UK
Biochem Soc Trans 36:1482-6. 2008..This should prove a very fruitful area for future research with relevance to infectious, inflammatory and cancerous diseases of the epithelia...
- Lessons for inflammatory bowel disease from rheumatologyJ M Rhodes
School of Clinical Science, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
Dig Liver Dis 38:157-62. 2006..very different risks of cancer in chronically inflamed colon and inflamed joints imply that cancer development requires both NFkappaB activation, to inhibit apoptosis, and the presence of agents, such as bacteria, to initiate DNA damage?..
- The role of Escherichia coli in inflammatory bowel diseaseJonathan M Rhodes
School of Clinical Sciences, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA
Gut 56:610-2. 2007
- Clinical trial: oral prednisolone metasulfobenzoate (Predocol) vs. oral prednisolone for active ulcerative colitisJ M Rhodes
School of Clinical Science, University of Liverpool, Liverpool, UK
Aliment Pharmacol Ther 27:228-40. 2008..Systemic corticosteroids are effective in ulcerative colitis but commonly cause side effects...
- Increasing the intra-Golgi pH of cultured LS174T goblet-differentiated cells mimics the decreased mucin sulfation and increased Thomsen-Friedenreich antigen (Gal beta1-3GalNac alpha-) expression seen in colon cancerB J Campbell
Glycobiology Group, Gastroenterology Research Unit, Department of Medicine, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK
Glycobiology 11:385-93. 2001..Intra-Golgi alkalinization affects mucin glycosylation, resulting in decreased mucin sulfation and increased expression of TF antigen, changes that mimic those seen in cancerous and premalignant human colonic epithelium...
- Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectinsL G Yu
Department of Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom
J Cell Physiol 186:282-7. 2001....
- Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta1-3 N-acetyl-galactosamine)L G Yu
Department of Medicine, University of Liverpool, UK
Int J Cancer 73:424-31. 1997....
- Altered colonic glycoprotein expression in unaffected monozygotic twins of inflammatory bowel disease patientsK Bodger
School of Clinical Science, University of Liverpool, Daulby St, Liverpool L69 3GA, UK, and Orebro University Hospital, Sweden
Gut 55:973-7. 2006..This study explores this further by assessing mucosal expression of the oncofetal carbohydrate antigen TF (galactose beta1, 3 N-acetylgalactosamine alpha-), among the same IBD twins...
- Altered glycosylation in inflammatory bowel disease: a possible role in cancer developmentB J Campbell
Glycobiology Group, Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Department of Medicine, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
Glycoconj J 18:851-8. 2001..Consequences of these changes may be relevant not only for cell-surface glycoconjugates but also for intracellular glycoconjugates...
- Pancreatic tumour marker anti-mucin antibody CAM 17.1 reacts with a sialyl blood group antigen, probably I, which is expressed throughout the human gastrointestinal tractD W Eccleston
Department of Histopathology, Walton Hospital, Liverpool, UK
Digestion 59:665-70. 1998..These studies show that CAM 17.1 binds to a sialic-acid-containing determinant of mucin, probably sialyl-I, which epitope shows wide distribution throughout the gastro-intestinal tract...
- A randomised controlled trial of high versus low long chain triglyceride whole protein feed in active Crohn's diseaseK Leiper
Gastroenterology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK
Gut 49:790-4. 2001..We performed a randomised controlled double blind trial in patients with active CD comparing two single whole protein feeds with LCT supplying 5% or 30% of the total energy...
- Agaricus bisporus (edible mushroom lectin) inhibits ocular fibroblast proliferation and collagen lattice contractionM Batterbury
Unit of Ophthalmology, St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK
Exp Eye Res 74:361-70. 2002..Further evaluation is warranted...
- Use of a biosensor to determine the binding kinetics of five lectins for Galactosyl-N-acetylgalactosamineJ D Milton
Gastroenterology Research Group, Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK
Glycoconj J 18:565-9. 2001..0 microM-4.5 microM]. Affinities were also calculated from the extent of binding at equlibrium and were generally similar to those calculated from the kinetic parameters indicating the true nature of these values...
- Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitisK Leiper
Gastroenterology Research Unit, Department of Medicine, University of Liverpool, Liverpool L69 3GA
Clin Sci (Lond) 101:395-402. 2001..These findings support the hypothesis that the mucosal inflammation and mucus depletion seen in ulcerative colitis could result from interaction between bacterial peptides and the mucosa...
- Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancerHelen M Martin
Department of Medicine, Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, University of Liverpool, Liverpool, United Kingdom
Gastroenterology 127:80-93. 2004..This study aimed to quantify and characterize mucosa-associated and intramucosal bacteria, particularly Escherichia coli, in these conditions...
- Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasisC Chen
Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Br J Cancer 110:741-52. 2014..These cytokines and chemokines in turn enhance endothelial cell activities in angiogenesis and metastasis. ..
- Management of inflammatory bowel diseaseM Nayar
Department of Medicine, University of Liverpool, Liverpool, UK
Postgrad Med J 80:206-13. 2004..High dosages of corticosteroids may provide symptomatic relief in Crohn's disease but do not affect the long term natural history of the disease, and management strategies should avoid using steroids whenever possible...
- Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44R Singh
Department of Medicine, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
Glycobiology 11:587-92. 2001....
- Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamineSreedhar Subramanian
Division of Gastroenterology, University School of Clinical Science, Liverpool, UK
Inflamm Bowel Dis 14:162-75. 2008..Mucosally adherent E. coli are found in inflammatory bowel disease (IBD) and colon cancer. They promote release of the proinflammatory cytokine interleukin-8 (IL-8). We explored mechanisms for this release and its inhibition by drugs...
- Peanut lectin stimulates proliferation of colon cancer cells by interaction with glycosylated CD44v6 isoforms and consequential activation of c-Met and MAPK: functional implications for disease-associated glycosylation changesRavinder Singh
Division of Gastroenterology, School of Clinical Science, Nuffield Building, Crown Street, University of Liverpool, Liverpool, L69 3BX, UK
Glycobiology 16:594-601. 2006..It provides a mechanism by which dietary, microbial, or endogenous galactose-binding lectins could affect epithelial proliferation in the cancerous and precancerous colon...
- Host-bacteria interaction in inflammatory bowel diseasePaul Knight
School of Clinical Sciences, University of Liverpool, Nuffield Building, Crown Street, Liverpool L693BX, UK
Br Med Bull 88:95-113. 2008..Inflammatory bowel disease (IBD) results from complex interactions between: host genome, immune system, mucosa, bacteria, and environment...
- Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiersCarol L Roberts
Gastroenterology Research Unit, University School of Clinical Sciences, Crown Street, Liverpool, UK
Gut 59:1331-9. 2010..We have assessed the effect of soluble non-starch polysaccharide (NSP) and food emulsifiers on translocation of Escherichia coli across M-cells...
- A subset of mucosa-associated Escherichia coli isolates from patients with colon cancer, but not Crohn's disease, share pathogenicity islands with urinary pathogenic E. coliChristina Bronowski
Division of Medical Microbiology, School of Infection and Host Defence, University of Liverpool, Liverpool, UK
Microbiology 154:571-83. 2008..This enabled us to identify a group of isolates from colon cancer (30-40 %) carrying multiple genes previously categorized as UPEC-specific and implicated in virulence...
- Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to AntibioticsSreedhar Subramanian
Division of Gastroenterology, School of Clinical Science, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom
Antimicrob Agents Chemother 52:427-34. 2008..Colonic mucosa-associated E. coli, particularly CD isolates, replicate within macrophages. Clinical trials are indicated to assess the efficacy of a combination antibiotic therapy targeting intramacrophage E. coli...
- Clinical trial: randomized study of clarithromycin versus placebo in active Crohn's diseaseK Leiper
Department of Gastroenterology, Royal Liverpool and Broadgreen University Hospitals, Liverpool, UK
Aliment Pharmacol Ther 27:1233-9. 2008..Crohn's disease is characterized by defective innate immune responses to intestinal bacteria. Clarithromycin is a broad-spectrum antibiotic that has good penetration into macrophages...
- Detection of sulfated glycoproteins in intestinal metaplasia: a comparison of traditional mucin staining with immunohistochemistry for the sulfo-Lewis(a) carbohydrate epitopeK Bodger
Department of Medicine, University of Liverpool, Liverpool L9 7AL, UK
J Clin Pathol 56:703-8. 2003..Incompletely differentiated sulfomucin rich gastric IM (type III) may have increased malignant potential. The types of sulfated oligosaccharide structures present in IM, BO, and colon have not been fully characterised...
- Dietary lectins can stimulate pancreatic growth in the ratAngela Kelsall
Foetal and Infant Toxico Pathology, University of Liverpool, Liverpool L69 7ZA, UK
Int J Exp Pathol 83:203-8. 2002..In conclusion, long-term feeding of low doses of lectin can influence pancreatic growth, and this trophic action may have potential adverse implications for the development of pancreatic cancer in humans...
- Microbial mannan inhibits bacterial killing by macrophages: a possible pathogenic mechanism for Crohn's diseaseChiedzo M Mpofu
Division of Gastroenterology, School of Clinical Science, University of Liverpool, Liverpool, United Kingdom
Gastroenterology 133:1487-98. 2007..Crohn's disease (CD) is mimicked by inherited phagocyte disorders and is associated with circulating antibodies against yeast mannan (anti-Saccharomyces cerevisiae antibody; ASCA). We speculated that mannans might impair phagocyte function...
- Diet and colorectal cancer: an investigation of the lectin/galactose hypothesisRichard C Evans
Department of Medicine, University of Liverpool, England
Gastroenterology 122:1784-92. 2002..This study tests the hypothesis that galactose, which is variably plentiful in fruit and vegetable but not cereal fibers, might prevent cancer by binding and inhibiting such lectins...
- Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitisKeith Leiper
Department of Gastroenterology, University of Liverpool, Liverpool, UK
Gut 60:1520-6. 2011..To assess the safety and efficacy of the B lymphocyte (anti-CD20) antibody, rituximab, in the treatment of steroid-resistant moderately active ulcerative colitis (UC)...
- Review article: minimizing tuberculosis during anti-tumour necrosis factor-alpha treatment of inflammatory bowel diseaseV S Theis
University Hospital Aintree, Department of Gastroenterology, UK
Aliment Pharmacol Ther 27:19-30. 2008..Tumour necrosis factor (TNF)-alpha inhibitors are a major advance in the management of inflammatory bowel disease but increase the risk for tuberculosis (TB)...
- Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikisQicheng Zhao
Gastroenterology Research Unit, School of Clinical Sciences, Centre for Glycobiology, University of Liverpool, Liverpool L69 3GE, UK
Mol Cancer 9:154. 2010....
- Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surfaceQicheng Zhao
Gastroenterology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
Cancer Res 69:6799-806. 2009..This provides insight into the molecular regulation of metastasis and has important implications for the development of novel therapeutic strategies for prevention of metastasis...
- An N-terminal truncated form of Orp150 is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein importLu Gang Yu
Department of Medicine, The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, University of Liverpool, Liverpool L69, United Kingdom
J Biol Chem 277:24538-45. 2002..This cytoplasmic form of Orp150 expresses the lectin carbohydrate ligand (sialyl-2,3-galactosyl-beta1,3-N-acetylgalactosamine-alpha) and is shown to be essential for nuclear localization sequence-dependent nuclear protein import...
- Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesionLu Gang Yu
Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, School of Clinical Science, University of Liverpool, UK
J Biol Chem 282:773-81. 2007..This suggests a critical role for circulating galectin-3 in cancer metastasis and highlights the functional importance of altered cell surface glycosylation in cancer progression...
- Effect of systemic corticosteroid therapy on risk for intra-abdominal or pelvic abscess in non-operated Crohn's diseaseAnurag Agrawal
Department of Gastroenterology, Royal Liverpool University Hospital, Liverpool, United Kingdom
Clin Gastroenterol Hepatol 3:1215-20. 2005..Systemic corticosteroid therapy increases risk of postoperative sepsis in Crohn's disease. This study investigates its effect on risk for sepsis in non-operated patients...
- A case-control study of drinking water and dairy products in Crohn's Disease--further investigation of the possible role of Mycobacterium avium paratuberculosisIbrahim Abubakar
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
Am J Epidemiol 165:776-83. 2007..The observed association with meat and the negative association with pasteurized milk need further study...