R M Reynolds

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Can cortisol predict the future in obesity?
    Rebecca M Reynolds
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh, UK
    Clin Endocrinol (Oxf) 67:1-2. 2007
  2. doi request reprint Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queen s Medical Research Institute, Edinburgh, UK
    Hypertension 53:932-6. 2009
  3. doi request reprint The role of metabolic derangements and glucocorticoid excess in the aetiology of cognitive impairment in type 2 diabetes. Implications for future therapeutic strategies
    Mark W J Strachan
    Metabolic Unit, Western General Hospital, Edinburgh, UK
    Diabetes Obes Metab 11:407-14. 2009
  4. pmc Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years
    Rebecca M Reynolds
    Endocrinology Unit, BHF University Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH14 6TJ, UK
    BMJ 347:f4539. 2013
  5. pmc Association between excessive daytime sleepiness and severe hypoglycemia in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Berit Inkster
    Corresponding author Rebecca M Reynolds
    Diabetes Care 36:4157-9. 2013
  6. doi request reprint Programming effects of glucocorticoids
    Rebecca M Reynolds
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh, UK
    Clin Obstet Gynecol 56:602-9. 2013
  7. ncbi request reprint Transmitting biological effects of stress in utero: implications for mother and offspring
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK Electronic address
    Psychoneuroendocrinology 38:1843-9. 2013
  8. doi request reprint What is the evidence in humans that DNA methylation changes link events in utero and later life disease?
    Rebecca M Reynolds
    Endocrinology Unit, University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, Edinburgh, UK
    Clin Endocrinol (Oxf) 78:814-22. 2013
  9. ncbi request reprint Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis
    Rebecca M Reynolds
    Endocrinology Unit, University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Psychoneuroendocrinology 38:1271-80. 2013
  10. doi request reprint Excess maternal weight gain during pregnancy is associated with overweight/obesity in offspring at age 16 years, but maternal pre-pregnancy obesity has a greater effect
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    Evid Based Nurs 16:43-4. 2013

Detail Information

Publications50

  1. ncbi request reprint Can cortisol predict the future in obesity?
    Rebecca M Reynolds
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh, UK
    Clin Endocrinol (Oxf) 67:1-2. 2007
  2. doi request reprint Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queen s Medical Research Institute, Edinburgh, UK
    Hypertension 53:932-6. 2009
    ....
  3. doi request reprint The role of metabolic derangements and glucocorticoid excess in the aetiology of cognitive impairment in type 2 diabetes. Implications for future therapeutic strategies
    Mark W J Strachan
    Metabolic Unit, Western General Hospital, Edinburgh, UK
    Diabetes Obes Metab 11:407-14. 2009
    ..Large-scale epidemiological and intervention studies are now underway, which should enhance our understanding and management of cognitive impairment in type 2 diabetes...
  4. pmc Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years
    Rebecca M Reynolds
    Endocrinology Unit, BHF University Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH14 6TJ, UK
    BMJ 347:f4539. 2013
    ..To determine whether maternal obesity during pregnancy is associated with increased mortality from cardiovascular events in adult offspring...
  5. pmc Association between excessive daytime sleepiness and severe hypoglycemia in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Berit Inkster
    Corresponding author Rebecca M Reynolds
    Diabetes Care 36:4157-9. 2013
    ..We hypothesized that sleep disorder might increase the risk of hypoglycemia through effects on self-management and glucose regulation...
  6. doi request reprint Programming effects of glucocorticoids
    Rebecca M Reynolds
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh, UK
    Clin Obstet Gynecol 56:602-9. 2013
    ..Strategies are needed to limit antenatal glucocorticoid use to those most at risk of preterm labor and to identify those most at risk of future disease. ..
  7. ncbi request reprint Transmitting biological effects of stress in utero: implications for mother and offspring
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK Electronic address
    Psychoneuroendocrinology 38:1843-9. 2013
    ....
  8. doi request reprint What is the evidence in humans that DNA methylation changes link events in utero and later life disease?
    Rebecca M Reynolds
    Endocrinology Unit, University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, Edinburgh, UK
    Clin Endocrinol (Oxf) 78:814-22. 2013
    ..Further research in this field is needed to determine whether altered DNA methylation in target tissues can be used as a biomarker for the early identification of and intervention in individuals most at risk of later life disease...
  9. ncbi request reprint Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis
    Rebecca M Reynolds
    Endocrinology Unit, University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Psychoneuroendocrinology 38:1271-80. 2013
    ..This study highlights a clear gender difference in HPA activity under non-stressful natural conditions. This finding may be relevant for research into sex-specific stress-related diseases with a typical onset in late adolescence...
  10. doi request reprint Excess maternal weight gain during pregnancy is associated with overweight/obesity in offspring at age 16 years, but maternal pre-pregnancy obesity has a greater effect
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    Evid Based Nurs 16:43-4. 2013
    ..Studies need to identify women at highest risk of excess GWG plus potential benefits of intense dietary and lifestyle counselling...
  11. doi request reprint Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis--2012 Curt Richter Award Winner
    Rebecca M Reynolds
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Psychoneuroendocrinology 38:1-11. 2013
    ..Such findings open novel avenues for further exploration of the contribution of glucocorticoids to later life disease...
  12. pmc Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study
    Rebecca M Reynolds
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Eur J Endocrinol 166:861-8. 2012
    ..The aim was to assess the characteristics of people with type 2 diabetes prescribed glucocorticoids in a real-world setting and to quantify resulting adverse effects...
  13. doi request reprint Leptin levels and depressive symptoms in people with type 2 diabetes: the edinburgh type 2 diabetes study
    Javier Labad
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK
    Psychosom Med 74:39-45. 2012
    ..We sought to assess whether leptin is related to depressive symptoms in people with Type 2 diabetes...
  14. doi request reprint A role for kisspeptins in pregnancy: facts and speculations
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Sciences, Jennifer Brown Research Laboratory, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Reproduction 138:1-7. 2009
    ..Here, we review the literature regarding the role and physiological significance of kisspeptin in pregnancy and highlight some of the key questions that require addressing...
  15. doi request reprint Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 95:1602-8. 2010
    ..People with type 2 diabetes are at increased cardiovascular disease risk and thus are suitable to study associations of plasma cortisol with cardiovascular risk...
  16. doi request reprint Maternal BMI, parity, and pregnancy weight gain: influences on offspring adiposity in young adulthood
    R M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 95:5365-9. 2010
    ..The prevalence of obesity among women of childbearing age is increasing. Emerging evidence suggests that this has long-term adverse influences on offspring health...
  17. doi request reprint Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease
    R M Reynolds
    Centre for Cardiovascular Sciences, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland, UK
    QJM 102:469-75. 2009
    ..This may be due to different sampling conditions, reflecting basal cortisol levels, vs. responsiveness of HPA axis activity, which may have diverse influences on the pathogenesis of atherosclerosis...
  18. doi request reprint Corticosteroid-mediated programming and the pathogenesis of obesity and diabetes
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Steroid Biochem Mol Biol 122:3-9. 2010
    ..This activation of the HPA axis is also associated with increased risk of development of diabetes and obesity in later life...
  19. ncbi request reprint Hyponatraemia for the clinical endocrinologist
    Rebecca M Reynolds
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Clin Endocrinol (Oxf) 63:366-74. 2005
  20. ncbi request reprint Differences in cortisol concentrations in South Asian and European men living in the United Kingdom
    Rebecca M Reynolds
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Clin Endocrinol (Oxf) 64:530-4. 2006
    ..The aim of the study was to examine ethnic differences in cortisol levels and to compare the relationships between cortisol levels and cardiovascular risk factors in men from different ethnic groups...
  21. ncbi request reprint Assessing the HPA axis in patients with pituitary disease: a UK survey
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Sciences, University of Edinburgh, Queen s Medical Research Institute, Little France Crescent, Edinburgh EH16 4TJ, UK
    Clin Endocrinol (Oxf) 64:82-5. 2006
    ....
  22. ncbi request reprint Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women
    R M Reynolds
    Endocrinology Unit, University of Edinburgh, Queens Medical Research Institute, EH16 4TJ Edinburgh, UK
    Calcif Tissue Int 77:134-8. 2005
    ..These data provide evidence that circulating endogenous glucocorticoids influence the rate of involutional bone loss in healthy individuals...
  23. ncbi request reprint The utility of three different methods for measuring urinary 18-hydroxycortisol in the differential diagnosis of suspected primary hyperaldosteronism
    R M Reynolds
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 152:903-7. 2005
    ..We have evaluated three urine 18-OHF methods using a panel of urine samples from patients with hypertension...
  24. ncbi request reprint Is there a gender difference in the associations of birthweight and adult hypothalamic-pituitary-adrenal axis activity?
    Rebecca M Reynolds
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 152:249-53. 2005
    ..In animal models females are more sensitive than males to HPA axis programming, but whether gender influences susceptibility in humans is unknown...
  25. ncbi request reprint Human insulin resistance: the role of glucocorticoids
    Rebecca M Reynolds
    University of Edinburgh, Department of Medical Sciences, Western General Hospital, Edinburgh, UK
    Diabetes Obes Metab 5:5-12. 2003
  26. ncbi request reprint Elevated plasma cortisol in glucose-intolerant men: differences in responses to glucose and habituation to venepuncture
    R M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, SO16 6YD Southampton, United Kingdom
    J Clin Endocrinol Metab 86:1149-53. 2001
    ..18), who showed a lack of habituation to repeated plasma measurements. These data support the hypothesis that alterations in central regulation of the hypothalamic-pituitary-adrenal axis may be important in glucose intolerance...
  27. ncbi request reprint Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors
    R M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 86:245-50. 2001
    ..This may be an important mechanism underpinning the effects of events in early life on later cardiovascular disease...
  28. pmc Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes Care 33:714-20. 2010
    ..We aimed to determine whether fasting cortisol levels are associated with cognitive ability and estimated lifetime cognitive change in an elderly population with type 2 diabetes...
  29. ncbi request reprint Reproducibility of the low dose dexamethasone suppression test: comparison between direct plasma and salivary cortisol assays
    R M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, UK
    Clin Endocrinol (Oxf) 49:307-10. 1998
    ..Little is known about the reproducibility of this test, or whether the test can be combined with analysis of salivary cortisol which would offer a significant advantage over plasma in population studies...
  30. ncbi request reprint Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, UK
    Hypertension 35:1301-6. 2000
    ..These results show that low birth weight is associated with raised fasting plasma cortisol concentrations. Increased activity of the hypothalamic-pituitary-adrenal axis may link low birth weight with raised blood pressure in adult life...
  31. doi request reprint Prevalence and markers of advanced liver disease in type 2 diabetes
    R M Williamson
    Metabolic Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    QJM 105:425-32. 2012
    ..We examined the prevalence of advanced liver disease in people with type 2 diabetes and analysed the effectiveness of liver function tests (LFTs) as a screening tool...
  32. doi request reprint Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    J Labad
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Diabetologia 53:467-71. 2010
    ..The aim of the study was to identify risk factors for depression and anxiety in a well-characterised cohort of individuals with type 2 diabetes mellitus...
  33. doi request reprint Increased maternal BMI is associated with an increased risk of minor complications during pregnancy with consequent cost implications
    F C Denison
    Centre for Reproductive Biology, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    BJOG 116:1467-72. 2009
    ..To investigate the effect of maternal body mass index (BMI) on minor complications, associated additional medication use during pregnancy and the consequent cost implications...
  34. doi request reprint Prevalence of abnormal plasma liver enzymes in older people with Type 2 diabetes
    J R Morling
    Centre for Population Health Sciences, The University of Edinburgh, Edinburgh, UK
    Diabet Med 29:488-91. 2012
    ..To determine the prevalence and distribution of abnormal plasma liver enzymes in a representative sample of older adults with Type 2 diabetes...
  35. doi request reprint Placental structure and inflammation in pregnancies associated with obesity
    K A Roberts
    University of Edinburgh, Queens Medical Research Institute, Little France Crescent, Edinburgh, UK
    Placenta 32:247-54. 2011
    ..The aim of this study was to characterise the maternal and placental inflammatory status and investigate associated changes in placental structure in obese women...
  36. ncbi request reprint Predicting cardiovascular risk factors from plasma cortisol measured during oral glucose tolerance tests
    Rebecca M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton, UK
    Metabolism 52:524-7. 2003
    ..However, the altered HPA response to feeding does not appear to be primarily responsible for HPA activation in subjects with the metabolic syndrome...
  37. pmc Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Riccardo E Marioni
    Centre for Population Health Sciences, University of Edinburgh, Scotland, UK
    Diabetes 59:710-3. 2010
    ....
  38. pmc Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Jie Ding
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Diabetes 59:2883-9. 2010
    ..A considerable homology exists between the retinal and cerebral microcirculations; a hypothesized association between diabetic retinopathy (DR) and cognitive decline was examined in older people with type 2 diabetes...
  39. pmc Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice
    Alison D McNeilly
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Hepatol 52:705-11. 2010
    ..We investigated whether this was mediated through bile acids acting to impair steroid clearance by inhibiting glucocorticoid metabolism by 5beta-reductase...
  40. doi request reprint The relationship between type 2 diabetes and dementia
    Mark W J Strachan
    Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh EH42XU, UK
    Br Med Bull 88:131-46. 2008
    ..The prevalence of type 2 diabetes and dementia are set to rise inexorably over the next 30-40 years. There are now substantial data to suggest that type 2 diabetes is associated with an increased risk of dementia...
  41. doi request reprint Impact of maternal obesity on offspring obesity and cardiometabolic disease risk
    Amanda J Drake
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 6TJ, UK
    Reproduction 140:387-98. 2010
    ..The ultimate aim is to identify potential targets, which may be amenable to prevention or early intervention in order to improve the health of this and future generations...
  42. doi request reprint Low serum cortisol predicts early death after acute myocardial infarction
    Rebecca M Reynolds
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Crit Care Med 38:973-5. 2010
    ..Low serum cortisol concentrations have been associated with adverse prognosis in critical illness of diverse etiology...
  43. ncbi request reprint Stress responsiveness in adult life: influence of mother's diet in late pregnancy
    Rebecca M Reynolds
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    J Clin Endocrinol Metab 92:2208-10. 2007
    ..Because raised fasting cortisol concentrations probably reflect a greater response to the stress of fasting and venesection, we suspected that this diet may have led to increased stress responsiveness in the adult offspring...
  44. doi request reprint Glucocorticoids turn over slowly in human adipose tissue in vivo
    Katherine A Hughes
    Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 95:4696-702. 2010
    ..In other organs, transport can be regulated in a steroid- and tissue-specific manner. Moreover, 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) generates additional cortisol within adipose...
  45. pmc Disorders of sodium balance
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Sciences, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ
    BMJ 332:702-5. 2006
  46. ncbi request reprint Changing trends in incidence and mortality of thyroid cancer in Scotland
    Rebecca M Reynolds
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Clin Endocrinol (Oxf) 62:156-62. 2005
    ..The incidence of thyroid cancer is increasing in several countries. The aim was to investigate trends in the incidence and mortality of thyroid cancer in Scotland, where thyroid cancer is relatively uncommon, between 1960 and 2002...
  47. doi request reprint Decreased serum levels of kisspeptin in early pregnancy are associated with intra-uterine growth restriction and pre-eclampsia
    R Anne Armstrong
    Centre for Reproductive Biology, Department of Reproductive and Developmental Sciences, Queen s Medical Research Institute, University of Edinburgh, UK
    Prenat Diagn 29:982-5. 2009
    ..To investigate whether pregnancies with development of subsequent pre-eclampsia and intra-uterine growth restriction are associated with altered levels of kisspeptin in maternal serum in the second trimester...
  48. ncbi request reprint Second primary cancers in thyroid cancer patients: a multinational record linkage study
    Thekkepat C Sandeep
    Metabolic Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Clin Endocrinol Metab 91:1819-25. 2006
    ..Thyroid cancer can also arise as a second primary neoplasm after other cancers...
  49. pmc Home blood glucose monitoring in type 2 diabetes
    Rebecca M Reynolds
    BMJ 329:754-5. 2004
  50. ncbi request reprint Skeletal muscle glucocorticoid receptor density and insulin resistance
    Rebecca M Reynolds
    JAMA 287:2505-6. 2002