G P Reynolds

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. ncbi request reprint Understanding the neurotransmitter pathology of schizophrenia: selective deficits of subtypes of cortical GABAergic neurons
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    J Neural Transm 109:881-9. 2002
  2. ncbi request reprint Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism
    Gavin P Reynolds
    Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Lancet 359:2086-7. 2002
  3. ncbi request reprint GABAergic neuronal subtypes in the human frontal cortex--development and deficits in schizophrenia
    G P Reynolds
    Department of Biomedical Science, The University of Sheffield, Western Bank, S10 2TN, Sheffield, UK
    J Chem Neuroanat 22:95-100. 2001
  4. ncbi request reprint Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain
    Gavin P Reynolds
    Department of Biomedical Science, University of Sheffield, UK
    Am J Psychiatry 160:677-9. 2003
  5. ncbi request reprint The new antipsychotics--some pharmacological aspects of their problems and potential
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
    Expert Opin Pharmacother 1:181-5. 2000
  6. ncbi request reprint Calcium binding protein markers of GABA deficits in schizophrenia--postmortem studies and animal models
    Gavin P Reynolds
    Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK
    Neurotox Res 6:57-61. 2004
  7. ncbi request reprint What is an atypical antipsychotic?
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, UK
    J Psychopharmacol 11:195-9. 1997
  8. ncbi request reprint Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Brain Res Bull 55:579-84. 2001
  9. ncbi request reprint Plasma homovanillic acid in untreated schizophrenia--relationship with symptomatology and sex
    Z J Zhang
    Department of Biomedical Science, University of Sheffield, S10 2TN, Sheffield, UK
    J Psychiatr Res 35:23-8. 2001
  10. pmc 5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases
    G P Reynolds
    Department of Biomedical Science, University of Sheffield
    Br J Pharmacol 114:993-8. 1995

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Understanding the neurotransmitter pathology of schizophrenia: selective deficits of subtypes of cortical GABAergic neurons
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    J Neural Transm 109:881-9. 2002
    ....
  2. ncbi request reprint Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism
    Gavin P Reynolds
    Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Lancet 359:2086-7. 2002
    ..0003) than in those without this allele, who were more likely to have substantial (>7%) weight gain (p=0.002). We have identified a genetic factor that is associated with antipsychotic drug-induced weight gain...
  3. ncbi request reprint GABAergic neuronal subtypes in the human frontal cortex--development and deficits in schizophrenia
    G P Reynolds
    Department of Biomedical Science, The University of Sheffield, Western Bank, S10 2TN, Sheffield, UK
    J Chem Neuroanat 22:95-100. 2001
    ..These observations support the hypothesis that GABAergic deficits in schizophrenia may stem from toxic events occurring during cortical development which selectively target immature neurons before protection by parvalbumin is conferred...
  4. ncbi request reprint Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain
    Gavin P Reynolds
    Department of Biomedical Science, University of Sheffield, UK
    Am J Psychiatry 160:677-9. 2003
    ..The authors determined whether this association held true for weight gain after clozapine treatment...
  5. ncbi request reprint The new antipsychotics--some pharmacological aspects of their problems and potential
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
    Expert Opin Pharmacother 1:181-5. 2000
    ..The newer antipsychotics show differential effects against these and other symptoms and thus their pharmacological profiles provide us with clues as to the receptor mechanisms underlying their therapeutic and side effects...
  6. ncbi request reprint Calcium binding protein markers of GABA deficits in schizophrenia--postmortem studies and animal models
    Gavin P Reynolds
    Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK
    Neurotox Res 6:57-61. 2004
    ..The temporal and aetiological relationships between glutamatergic and GABAergic deficits remains unclear, but may well relate to an initial loss/dysfunction of GABA/PV neurons that subsequently gives rise to a glutamatergic pathology...
  7. ncbi request reprint What is an atypical antipsychotic?
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, UK
    J Psychopharmacol 11:195-9. 1997
    ....
  8. ncbi request reprint Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Brain Res Bull 55:579-84. 2001
    ..In this review we discuss the evidence for altered GABAergic transmission in schizophrenia...
  9. ncbi request reprint Plasma homovanillic acid in untreated schizophrenia--relationship with symptomatology and sex
    Z J Zhang
    Department of Biomedical Science, University of Sheffield, S10 2TN, Sheffield, UK
    J Psychiatr Res 35:23-8. 2001
    ..Such neuronal deficits of developmental or degenerative origin may thus result in an elevation/disinhibition of central dopamine metabolism in schizophrenia...
  10. pmc 5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases
    G P Reynolds
    Department of Biomedical Science, University of Sheffield
    Br J Pharmacol 114:993-8. 1995
    ..The marked loss of receptors in hippocampal and cortical regions in the brains from patients with Alzheimer's disease is consistent with a role for the 5-HT4 receptor in cognitive processing...
  11. ncbi request reprint Increased density of glutamate/N-methyl-D-aspartate receptors in superior temporal cortex in schizophrenia
    S Nudmamud
    Department of Biomedical Science, The University of Sheffield, S10 2TN, Sheffield, UK
    Neurosci Lett 304:9-12. 2001
    ....
  12. ncbi request reprint Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, England, UK
    J Neurochem 72:1773-6. 1999
    ..Dopamine was decreased in the striatum in older animals, parallelling evidence for diminished dopaminergic activity in HD...
  13. ncbi request reprint Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells
    L M Reynolds
    Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK
    Neurosci Lett 309:193-6. 2001
    ....
  14. ncbi request reprint Antipsychotic drug use in neurodegenerative disease in the elderly: problems and potential from a pharmacological perspective
    G P Reynolds
    Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK
    Expert Opin Pharmacother 2:543-8. 2001
    ....
  15. ncbi request reprint Increased N-acetylaspartate in rat striatum following long-term administration of haloperidol
    M K Harte
    Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Schizophr Res 75:303-8. 2005
    ..The lack of effect in other regions indicates that the well-documented NAA deficits seen in chronically treated schizophrenia patients is not an effect of antipsychotic medication and may in fact be related to the disease process...
  16. ncbi request reprint Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response
    Gavin P Reynolds
    Department of Mental Health, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Eur Neuropsychopharmacol 15:143-51. 2005
    ..01) was apparent, again reflecting improvements in negative and general symptoms but not changes in positive symptoms...
  17. ncbi request reprint Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain
    Lindsay M Reynolds
    Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Schizophr Res 73:147-52. 2005
    ..We found significant PCP-induced deficits of NAA and NAAG only in the temporal cortex; NAAG was significantly elevated in the hippocampus. These changes closely reflect postmortem findings reported in schizophrenia...
  18. ncbi request reprint Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis
    Lucy A Templeman
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharmacogenet Genomics 15:195-200. 2005
    ..We have investigated whether these effects remain true in a Caucasian population and following longer term treatment...
  19. ncbi request reprint The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Prog Neuropsychopharmacol Biol Psychiatry 29:1021-8. 2005
    ..Such studies clearly demonstrate the potential of pharmacogenetics in optimising treatment for the individual patient...
  20. ncbi request reprint The impact of pharmacogenetics on the development and use of antipsychotic drugs
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Drug Discov Today 12:953-9. 2007
    ....
  21. doi request reprint Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia
    Olga O Yevtushenko
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Br J Psychiatry 192:424-8. 2008
    ..Obesity and metabolic syndrome are significant problems for patients taking antipsychotic drugs. Evidence is emerging of genetic risk factors...
  22. ncbi request reprint Clozapine, but not haloperidol, increases neuropeptide Y neuronal expression in the rat hypothalamus
    Shona L Kirk
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Belfast, UK
    J Psychopharmacol 20:577-9. 2006
    ..p.) for 3 weeks. Clozapine, but not haloperidol, produced an increase in NPY immunoreactivity in the ARC, suggesting that effects on NPY may be involved in increases in body weight following clozapine treatment...
  23. ncbi request reprint The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Belfast, UK
    J Psychopharmacol 20:15-8. 2006
    ..These findings demonstrate the value of pharmacogenetics in determining liability to a major side effect of antipsychotic treatment, and indicate both the molecular and physiological mechanisms underlying this side effect...
  24. ncbi request reprint Pharmacogenetics of schizophrenia
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Expert Opin Pharmacother 7:1429-40. 2006
    ....
  25. ncbi request reprint Effect of 5-HT1A receptor gene polymorphism on negative and depressive symptom response to antipsychotic treatment of drug-naive psychotic patients
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Rd, Belfast BT9 7BL UK
    Am J Psychiatry 163:1826-9. 2006
    ..The authors sought to determine whether this polymorphism influences symptom response to antipsychotic drug treatment...
  26. ncbi request reprint 5-HT2C receptor gene polymorphisms associated with antipsychotic drug action alter promoter activity
    Matthew J Hill
    Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James Hospital, James Street, Dublin, D8, Ireland
    Brain Res 1149:14-7. 2007
    ..Both -759C/T and -697G/C polymorphic sites are likely to play a role in basal promoter activity. Resistance to weight gain may, in part, be mediated by the consequences of reduced 5-HT(2C) receptor expression...
  27. ncbi request reprint Schizophrenia, antipsychotics and metabolic disease
    Gavin P Reynolds
    J Psychopharmacol 21:355-6. 2007
  28. ncbi request reprint Chronic haloperidol or clozapine treatment does not alter parvalbumin immunoreactivity in the rat frontal cortex or hippocampus
    Marie Cahir
    Department of Mental Health, The Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Rd, Belfast, BT9 7BL, UK
    Neurosci Lett 373:57-60. 2005
    ....
  29. ncbi request reprint Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
    Clare L Beasley
    Department of Biomedical Science, University of Sheffield, United Kingdom
    Biol Psychiatry 52:708-15. 2002
    ..The calcium-binding proteins parvalbumin, calbindin, and calretinin can be used as markers for specific subpopulations of cortical GABAergic interneurons...
  30. ncbi request reprint A selective reduction in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia patients
    ZhiJun Zhang
    Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, China
    Chin Med J (Engl) 115:819-23. 2002
    ..To determine the relative densities of the GABAergic subpopulation defined by calcium-binding proteins and to further study the importance of changes in GABAergic interneurons on neuropathology in the hippocampus in schizophrenia cases...
  31. ncbi request reprint The increased activity of plasma manganese superoxide dismutase in tardive dyskinesia is unrelated to the Ala-9Val polymorphism
    ZhiJun Zhang
    Department of Psychiatry, Nanjing Brain Hospital and Nanjing Medical University, PR China
    J Psychiatr Res 36:317-24. 2002
    ..We conclude that while we have further evidence of a disturbance in the mechanisms regulating oxidative free radicals in TD, this effect is not under the control of the genetic polymorphism investigated here...
  32. ncbi request reprint Weight gain, antipsychotic drug treatment and pharmacogenomics
    Gavin P Reynolds
    Pharmacogenomics 3:567-70. 2002
  33. ncbi request reprint [Association of antipsychotic agent-induced weight gain with a polymorphism of the promotor region of the 5-HT2C receptor gene]
    ZhiJun Zhang
    Psychiatry Department and Clinical Science Center, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China
    Zhonghua Yi Xue Za Zhi 82:1097-101. 2002
    ..To determine whether 5-hydroxytryptamine 2C (5-HT2C) receptor gene 759C/T polymorphism influences the weight gain following antipsychotic agents (APS) treatment in patient with schizophrenia...
  34. ncbi request reprint A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia
    Zhi Jun Zhang
    Department of Biomedical Science, University of Sheffield, Western Bank, UK
    Schizophr Res 55:1-10. 2002
    ..The findings provide further evidence to support a profound and selective abnormality of a sub-population of GABAergic neurons in the hippocampus in schizophrenia...
  35. ncbi request reprint N-acetylaspartate and N-Acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder: a postmortem study
    Sutisa Nudmamud
    Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    Biol Psychiatry 53:1138-41. 2003
    ..Several magnetic resonance spectroscopy studies have found evidence of N-acetylaspartate deficits in schizophrenia...
  36. ncbi request reprint Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia
    Zhi Jun Zhang
    Department of Psychiatry, Nanjing Brain Hospital and Nanjing Medical University, Nanjing, People s Republic of China
    Psychiatr Genet 13:187-92. 2003
    ....
  37. ncbi request reprint Effects of antipsychotics on fat deposition and changes in leptin and insulin levels. Magnetic resonance imaging study of previously untreated people with schizophrenia
    Zhi Jun Zhang
    Department of Psychiatry Nanjing Brain Hospital and Nanjing Medical University, Nanjing, China
    Br J Psychiatry 184:58-62. 2004
    ..Weight gain is a common consequence of antipsychotic drug treatment and can lead to further morbidity...
  38. ncbi request reprint Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation
    Michael K Harte
    Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    Biol Psychiatry 56:296-9. 2004
    ..Magnetic resonance spectroscopy studies have shown reductions of cortical and hippocampal NAA in schizophrenia, and a recent postmortem study has demonstrated a regionally selective temporal cortex deficit...
  39. ncbi request reprint Receptor mechanisms in the treatment of schizophrenia
    Gavin P Reynolds
    Department of Mental Health, Queen s University Belfast, Belfast, UK
    J Psychopharmacol 18:340-5. 2004
    ..Some drugs, notably the D2 partial agonists, can provide antipsychotic effects without the emergence of several of the seproblematic side-effects, which bodes well for future treatment...
  40. ncbi request reprint The role of dopamine in motor symptoms in the R6/2 transgenic mouse model of Huntington's disease
    Miriam A Hickey
    Department of Pharmacology, University of Cambridge, UK
    J Neurochem 81:46-59. 2002
    ..These results suggest that dysfunctional DA neurotransmission contributes to phenotype development in R6/2 mice and thus also may be important in symptom progression in HD...
  41. ncbi request reprint The atypical antipsychotic olanzapine enhances ingestive behaviour in the rat: a preliminary study
    Zoe Thornton-Jones
    School of Pharmacy, University of Bradford, UK
    J Psychopharmacol 16:35-7. 2002
    ....
  42. ncbi request reprint Acute and chronic tryptophan depletion differentially regulate central 5-HT1A and 5-HT 2A receptor binding in the rat
    Marie Cahir
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla, 97 Lisburn Road, Northern Ireland, UK
    Psychopharmacology (Berl) 190:497-506. 2007
    ..Tryptophan depletion is used to reduce central serotonergic function and to investigate its role in psychiatric illness. Despite widespread clinical use, its effects on serotonin (5-HT) receptors have not been well characterized...
  43. ncbi request reprint The effect of chronic antipsychotic treatment on sexual behaviour, hormones and organ size in the male rat
    Xiangrong Zhang
    The Department of Psychiatry and Clinical Science Centre, Nanjing Brain Hospital, and Nanjing Medical University, Nanjing, PR China
    J Psychopharmacol 21:428-34. 2007
    ..These findings contribute to our understanding of antispsychotic drug-induced male sexual dysfunction...
  44. ncbi request reprint The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders
    Sutisa Nudmamud-Thanoi
    Division of Psychiatry and Neuroscience, Queen s University Belfast, White Medical Building, Belfast BT97BL, UK
    Neurosci Lett 372:173-7. 2004
    ..The findings in affective disorders are interesting in respect of reports of cortical NMDA receptor deficits in suicide victims, although antidepressant drug treatment may contribute to these changes...
  45. ncbi request reprint An in vitro model of inflammatory neurodegeneration and its neuroprotection
    Kirsten Messmer
    University of Sheffield, Department of Biomedical Science, Western Bank, Sheffield S10 2TN, UK
    Neurosci Lett 388:39-44. 2005
    ..This co-culture of neuronal cells and activated THP-1 provides a useful model for the study of inflammatory mechanisms resulting in neuronal cell death...
  46. ncbi request reprint Ziprasidone suppresses olanzapine-induced increases in ingestive behaviour in the rat
    Shona L Kirk
    Bradford School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK
    Eur J Pharmacol 505:253-4. 2004
    ..The results suggest that ziprasidone suppresses the significant increases in food intake produced by olanzapine, indicating that it has an intrinsic protective mechanism against drug-induced increases in food intake...
  47. ncbi request reprint Actions of antipsychotic drugs on pancreatic beta-cell function: contrasting effects of clozapine and haloperidol
    Leonard Best
    Department of Medicine, University of Manchester, Oxford Road, Manchester M13 9WL, UK
    J Psychopharmacol 19:597-601. 2005
    ..These findings may relate to the increased incidence of diabetes associated with clozapine treatment...