Louise N Reynard
Affiliation: University of Newcastle
- Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylationLouise N Reynard
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Hum Mol Genet 20:3450-60. 2011..The variability in DAE of rs143383 is therefore partly accounted for by differences in DNA methylation that could influence the penetrance of this allele in susceptibility to common musculoskeletal diseases...
- cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritisCatherine Bui
Musculoskeletal Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK
FASEB J 26:3000-11. 2012..In summary, the -104 CpG is demethylated in osteoarthritic cartilage, correlating with the elevated MMP13 expression and cartilage destruction, providing a highly novel link between epigenetic status and arthritic disease...
- Genetics and epigenetics of osteoarthritisLouise N Reynard
Newcastle University, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Maturitas 71:200-4. 2012....
- Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3Madhushika Ratnayake
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle, UK
BMC Med Genet 13:12. 2012..It is becoming increasingly apparent that many common complex traits are mediated by cis-acting regulatory polymorphisms that influence, in a tissue-specific manner, gene expression or transcript stability...