Louise N Reynard

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
    Louise N Reynard
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Hum Mol Genet 20:3450-60. 2011
  2. pmc The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383
    Catherine M Syddall
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 9:e1003557. 2013
  3. pmc Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues
    Emma V A Raine
    Newcastle University, Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    BMC Musculoskelet Disord 14:85. 2013
  4. doi request reprint cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis
    Catherine Bui
    Musculoskeletal Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK
    FASEB J 26:3000-11. 2012
  5. pmc The genetics and functional analysis of primary osteoarthritis susceptibility
    Louise N Reynard
    Newcastle University, Institute of Cellular Medicine, Newcastle upon Tyne, UK
    Expert Rev Mol Med 15:e2. 2013
  6. doi request reprint Genetics and epigenetics of osteoarthritis
    Louise N Reynard
    Newcastle University, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Maturitas 71:200-4. 2012
  7. pmc Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3
    Madhushika Ratnayake
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle, UK
    BMC Med Genet 13:12. 2012

Collaborators

Detail Information

Publications7

  1. doi request reprint Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
    Louise N Reynard
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Hum Mol Genet 20:3450-60. 2011
    ..The variability in DAE of rs143383 is therefore partly accounted for by differences in DNA methylation that could influence the penetrance of this allele in susceptibility to common musculoskeletal diseases...
  2. pmc The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383
    Catherine M Syddall
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 9:e1003557. 2013
    ..In conclusion, we have identified four trans-acting factors that are binding to GDF5, three of which are modulating GDF5 expression via the OA susceptibility locus rs143383. ..
  3. pmc Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues
    Emma V A Raine
    Newcastle University, Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    BMC Musculoskelet Disord 14:85. 2013
    ..We were keen therefore to assess whether the effect that rs1676486 has on COL11A1 expression in LDH is also observed in OA and whether the rs2615977 association to OA also marked AEI...
  4. doi request reprint cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis
    Catherine Bui
    Musculoskeletal Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK
    FASEB J 26:3000-11. 2012
    ..In summary, the -104 CpG is demethylated in osteoarthritic cartilage, correlating with the elevated MMP13 expression and cartilage destruction, providing a highly novel link between epigenetic status and arthritic disease...
  5. pmc The genetics and functional analysis of primary osteoarthritis susceptibility
    Louise N Reynard
    Newcastle University, Institute of Cellular Medicine, Newcastle upon Tyne, UK
    Expert Rev Mol Med 15:e2. 2013
    ..Epigenetic mechanisms such as DNA methylation also influence OA risk, and integration of genetic, transcriptomic and epigenetic data will allow us to use the genetic discoveries for informed development of new OA biological treatments...
  6. doi request reprint Genetics and epigenetics of osteoarthritis
    Louise N Reynard
    Newcastle University, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Maturitas 71:200-4. 2012
    ....
  7. pmc Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3
    Madhushika Ratnayake
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle, UK
    BMC Med Genet 13:12. 2012
    ..It is becoming increasingly apparent that many common complex traits are mediated by cis-acting regulatory polymorphisms that influence, in a tissue-specific manner, gene expression or transcript stability...