Michael J Rennie

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi Nutritional and pathophysiological modulation of body protein
    M J Rennie
    Department of Anatomy and Physiology, University of Dundee, UK
    Curr Opin Clin Nutr Metab Care 1:67-71. 1998
  2. ncbi An introduction to the use of tracers in nutrition and metabolism
    M J Rennie
    Department of Anatomy and Physiology, University of Dundee, UK
    Proc Nutr Soc 58:935-44. 1999
  3. ncbi Protein and amino acid metabolism during and after exercise and the effects of nutrition
    M J Rennie
    Department of Anatomy and Physiology, University of Dundee, Dundee DD1 4HN, Scotland
    Annu Rev Nutr 20:457-83. 2000
  4. ncbi Interaction between glutamine availability and metabolism of glycogen, tricarboxylic acid cycle intermediates and glutathione
    M J Rennie
    Department of Anatomy and Physiology, University of Dundee, Dundee DD1 4HN, Scotland, UK
    J Nutr 131:2488S-90S; discussion 2496S-7S. 2001
  5. ncbi Latency, duration and dose response relationships of amino acid effects on human muscle protein synthesis
    Michael J Rennie
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Scotland, United Kingdom
    J Nutr 132:3225S-7S. 2002
  6. ncbi A conceptual model for the corporeal body
    M J Rennie
    Division of Molecular Biology, School of Life Sciences, University of Dundee, UK
    Eur J Clin Invest 32:791-2. 2002
  7. pmc Claims for the anabolic effects of growth hormone: a case of the emperor's new clothes?
    M J Rennie
    Faculty of Life Sciences, Old Medical School, University of Dundee, Scotland, UK
    Br J Sports Med 37:100-5. 2003
  8. ncbi 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men
    Daniel J Cuthbertson
    Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Diabetes 56:2078-84. 2007
  9. doi SB431542 treatment promotes the hypertrophy of skeletal muscle fibers but decreases specific force
    Kevin I Watt
    Institute of Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, Scotland, United Kingdom
    Muscle Nerve 41:624-9. 2010
  10. ncbi Is glutamine beneficial in ischemic heart disease?
    Shihab E O Khogali
    Department of Cardiology, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Nutrition 18:123-6. 2002

Collaborators

Detail Information

Publications42

  1. ncbi Nutritional and pathophysiological modulation of body protein
    M J Rennie
    Department of Anatomy and Physiology, University of Dundee, UK
    Curr Opin Clin Nutr Metab Care 1:67-71. 1998
    ..It also deals with organ-specific protein metabolism of the splanchnic region, particularly the gut, liver and kidney...
  2. ncbi An introduction to the use of tracers in nutrition and metabolism
    M J Rennie
    Department of Anatomy and Physiology, University of Dundee, UK
    Proc Nutr Soc 58:935-44. 1999
    ..The examples given are from a variety of sources, including the work of the author, but the principles underlying the techniques are universally applicable to all metabolic investigations using tracers...
  3. ncbi Protein and amino acid metabolism during and after exercise and the effects of nutrition
    M J Rennie
    Department of Anatomy and Physiology, University of Dundee, Dundee DD1 4HN, Scotland
    Annu Rev Nutr 20:457-83. 2000
    ..There is no evidence that habitual exercise increases protein requirements; indeed protein metabolism may become more efficient as a result of training...
  4. ncbi Interaction between glutamine availability and metabolism of glycogen, tricarboxylic acid cycle intermediates and glutathione
    M J Rennie
    Department of Anatomy and Physiology, University of Dundee, Dundee DD1 4HN, Scotland, UK
    J Nutr 131:2488S-90S; discussion 2496S-7S. 2001
    ..This ability appears to be connected to the ability to sustain intracardiac ATP, phosphocreatine and glutathione...
  5. ncbi Latency, duration and dose response relationships of amino acid effects on human muscle protein synthesis
    Michael J Rennie
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Scotland, United Kingdom
    J Nutr 132:3225S-7S. 2002
    ..The maximal capacity for storage of amino acids as muscle protein probably sets an upper value on the extent to which amino acids can be stored after a single meal...
  6. ncbi A conceptual model for the corporeal body
    M J Rennie
    Division of Molecular Biology, School of Life Sciences, University of Dundee, UK
    Eur J Clin Invest 32:791-2. 2002
  7. pmc Claims for the anabolic effects of growth hormone: a case of the emperor's new clothes?
    M J Rennie
    Faculty of Life Sciences, Old Medical School, University of Dundee, Scotland, UK
    Br J Sports Med 37:100-5. 2003
    ..The overexaggeration of the effects of growth hormone in muscle building is effectively promoting its abuse and thereby encouraging athletes and elderly men to expose themselves to increased risk of disease for little benefit...
  8. ncbi 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men
    Daniel J Cuthbertson
    Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Diabetes 56:2078-84. 2007
    ..3 +/- 0.6 to 10 +/- 0.6 mg x kg(-1) x min(-1) (P < 0.05). In healthy people, AICAR acutely stimulates muscle 2DG uptake with a minor effect on whole-body glucose disposal...
  9. doi SB431542 treatment promotes the hypertrophy of skeletal muscle fibers but decreases specific force
    Kevin I Watt
    Institute of Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, Scotland, United Kingdom
    Muscle Nerve 41:624-9. 2010
    ..SB431542 can initially antagonize myostatin signaling, but long-term unexpected signaling effects occur. Muscle fibers hypertrophy, but their specific force decreases compared to control...
  10. ncbi Is glutamine beneficial in ischemic heart disease?
    Shihab E O Khogali
    Department of Cardiology, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Nutrition 18:123-6. 2002
    ..We also explored the potential cardioprotective effects of glutamine in patients with chronic stable angina...
  11. ncbi Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
    Daniel Cuthbertson
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland
    FASEB J 19:422-4. 2005
    ..Countermeasures to maximize muscle maintenance should target these deficits...
  12. ncbi Control of the size of the human muscle mass
    Michael J Rennie
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, DD1 4HN, Scotland, United Kingdom
    Annu Rev Physiol 66:799-828. 2004
    ....
  13. ncbi Human bone collagen synthesis is a rapid, nutritionally modulated process
    John A Babraj
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland
    J Bone Miner Res 20:930-7. 2005
    ..Surprisingly, postabsorptive bone collagen synthesis is not sluggish, being approximately 0.07%/h more rapid than that of muscle protein, and capable of being stimulated within 4 h of intravenous feeding by 66 +/- 13%...
  14. pmc Connecting the dots for mechanochemical transduction in muscle
    Michael J Rennie
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    J Physiol 553:1. 2003
    ....
  15. ncbi Branched-chain amino acids as fuels and anabolic signals in human muscle
    Michael J Rennie
    Medical Sciences, University of Aberdeen, Aberdeen AB24 3FX, UK
    J Nutr 136:264S-8S. 2006
    ..However, at insulin of <5 microU/mL, AAs appear to stimulate MPS without increasing mTOR signaling. Further increasing availability of insulin to postprandial values increases signaling activity, but has no further effect on MPS...
  16. ncbi Muscle protein metabolism during hemodialysis
    Julien Bohe
    JE2411 and Medical Intensive Care Unit, Lyon Sud University Hospital, Pierre Benite, France
    J Ren Nutr 16:3-16. 2006
    ..We concentrate on the discussion of muscle protein metabolism because muscle is the predominant site of protein storage, and its integrity is mandatory for the maintenance of a good quality of life...
  17. pmc How nutrition and exercise maintain the human musculoskeletal mass
    Henning Wackerhage
    School of Medical Sciences, University of Aberdeen, UK
    J Anat 208:451-8. 2006
    ..Current evidence suggests that one of the major problems with loss of muscle during ageing is an inability of the tissue to respond adequately to increased availability of nutrients...
  18. ncbi Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle
    Louise Deldicque
    Place Pierre de Coubertin 1, B 1348 Louvain la Neuve, Belgium
    J Appl Physiol (1985) 104:371-8. 2008
    ..05); calpain 1 mRNA increased 70% 72 h postexercise (P < 0.05) and at no other time. In conclusion, 5 days of creatine supplementation do not enhance anabolic signaling but increase the expression of certain targeted genes...
  19. ncbi Maintenance of the musculoskeletal mass by control of protein turnover: the concept of anabolic resistance and its relevance to the transplant recipient
    Michael J Rennie
    School of Biomedical Sciences, University of Nottingham Graduate Entry Medical School, Derby City General Hospital
    Ann Transplant 10:31-4. 2005
    ..These predictions should be tested by examining longitudinal effects of different modes of exercise and nutritional regimens on rehabilitation of muscle in transplant patients...
  20. pmc Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle
    Sarah B Wilkinson
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    J Physiol 586:3701-17. 2008
    ....
  21. pmc Why muscle stops building when it's working
    Michael J Rennie
    The University of Nottingham Medical School, Derby City General Hospital, UK
    J Physiol 569:3. 2005
  22. ncbi No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle
    Benjamin F Miller
    Institute of Sports Medicine, Copenhagen
    Am J Physiol Endocrinol Metab 290:E163-E168. 2006
    ..Therefore, there is no effect of menstrual cycle phase, at rest or in response to an acute bout of exercise, on myofibrillar protein synthesis and muscle collagen synthesis in women...
  23. ncbi Creatine supplementation has no effect on human muscle protein turnover at rest in the postabsorptive or fed states
    Magali Louis
    Universite Catholique de Louvain, Universite Libre de Bruxelles, Brussels 1200, Belgium
    Am J Physiol Endocrinol Metab 284:E764-70. 2003
    ..026), but creatine had no effect on turnover in the postabsorptive or fed states. Thus any increase in muscle mass accompanying creatine supplementation must be associated with increased physical activity...
  24. ncbi No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise
    Magali Louis
    Universite Catholique de Louvain, France
    Am J Physiol Endocrinol Metab 285:E1089-94. 2003
    ..01). Exercise increased the synthetic rates of myofibrillar and sarcoplasmic proteins by two- to threefold (P < 0.05), and leg phenylalanine balance became more positive, but creatine was without any anabolic effect...
  25. pmc Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study
    Julien Bohe
    Division of Metabolism, Department of Surgery, University of Texas Medical Branch, Shriners Burns Hospital, Galveston, TX 77550, USA
    J Physiol 552:315-24. 2003
    ..We propose that the stimulation of protein synthesis depends on the sensing of the concentration of extracellular, rather than intramuscular EAAs...
  26. ncbi Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions
    Daniel R Moore
    Dept of Kinesiology, Exercise Metabolism Research Group, McMaster Univ, 1280 Main St W, Hamilton, ON, Canada L8S 4K1
    Am J Physiol Endocrinol Metab 288:E1153-9. 2005
    ..Therefore, a more rapid rise in MPS after maximal LC could translate into greater protein accretion and muscle hypertrophy during chronic resistance training utilizing maximal LC...
  27. ncbi Body maintenance and repair: how food and exercise keep the musculoskeletal system in good shape
    Michael J Rennie
    University of Nottingham, School of Biomedical Sciences, Graduate Entry Medical School, Derby City General Hospital, Uttoxeter Road, Derby DE22 3DT, UK
    Exp Physiol 90:427-36. 2005
    ....
  28. ncbi Increased IGF mRNA in human skeletal muscle after creatine supplementation
    Louise Deldicque
    Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain la Neuve, Belgium
    Med Sci Sports Exerc 37:731-6. 2005
    ....
  29. pmc Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise
    Benjamin F Miller
    Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Denmark
    J Physiol 567:1021-33. 2005
    ..The similar time course of changes of protein synthetic rates in different cell types supports the idea of coordinated musculotendinous adaptation...
  30. pmc Protein synthesis a low priority for exercising muscle
    Philip J Atherton
    University of Nottingham Medical School at Derby, Derby City General Hospital, Derby DE22 3DT, UK
    J Physiol 573:288-9. 2006
  31. doi Reliability of results and interpretation of measures of 3-methylhistidine in muscle interstitium as marker of muscle proteolysis
    Michael J Rennie
    J Appl Physiol 105:1380-1; author reply 1382-3. 2008
  32. ncbi Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 93:1797-805. 2002
    ....
  33. doi Decrease in Akt/PKB signalling in human skeletal muscle by resistance exercise
    Louise Deldicque
    Department of Physical Education and Rehabilitation, Universite Catholique de Louvain, Place Pierre de Coubertin 1, Louvain la Neuve, Belgium
    Eur J Appl Physiol 104:57-65. 2008
    ..The present results indicate that high-intensity resistance exercise in the fasted state inhibits Akt/PKB and 4E-BP1 whilst concomitantly augmenting MAPK signalling and p70(s6k) on Thr421/Ser424...
  34. pmc Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women
    Gordon I Smith
    School of Medicine, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 3:e1875. 2008
    ..05) in both sexes. Thus, there is sexual dimorphism in MPS and its control in older adults; a greater basal rate of MPS, operating over most of the day may partially explain the slower loss of muscle in older women...
  35. pmc A role for leucine in rejuvenating the anabolic effects of food in old rats
    Michael J Rennie
    The University of Nottingham Medical School at Derby, Derby City General Hospital, UK
    J Physiol 569:357. 2005
  36. pmc Letter to the Editor on the Journal Club article by Barker and Traber
    Michael J Rennie
    J Physiol 586:307-8; author reply 309-10. 2008
  37. pmc The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse
    Maarten D de Boer
    Instititute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager ST7 2HL, UK
    J Physiol 585:241-51. 2007
    ....
  38. ncbi New approaches and recent results concerning human-tissue collagen synthesis
    Ken Smith
    School of Biomedical Sciences, University of Nottingham at Derby Graduate Entry Medical School, Derby, UK
    Curr Opin Clin Nutr Metab Care 10:582-90. 2007
    ..Recent application of stable isotope tracer techniques to measure human collagen synthesis has provided some insights into the role of nutrition and exercise on collagen turnover in the extracellular matrix of the musculoskeletal system...
  39. ncbi Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle
    Anne Marie Winther Petersen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 293:E843-8. 2007
    ..We conclude that smoking impairs the muscle protein synthesis process and increases the expression of genes associated with impaired muscle maintenance; smoking therefore likely increases the risk of sarcopenia...
  40. ncbi Swings and roundabouts for muscle gain and loss: differences between sexes?
    Bettina Mittendorfer
    J Appl Physiol 100:375-6. 2006
  41. ncbi Tendon collagen synthesis at rest and after exercise in women
    Benjamin F Miller
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    J Appl Physiol (1985) 102:541-6. 2007
    ..It is concluded that both in the resting state and after exercise, tendon collagen FSR is lower in women than in men, which may contribute to a lower rate of tissue repair after exercise...
  42. ncbi Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32
    Matthew C Kostek
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Physiol Genomics 31:42-52. 2007
    ..The molecular differences might contribute to mechanisms underlying the physiological adaptations seen with training using the two modes of exercise...