A G Renehan

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. doi request reprint Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    Andrew G Renehan
    Department of Surgery, School of Cancer Studies, University of Manchester, UK
    Lancet 371:569-78. 2008
  2. pmc Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer
    M M Seenath
    Clinical and Experimental Pharmacology, Paterson Institute of Cancer Research, Manchester, UK
    Br J Cancer 99:459-63. 2008
  3. pmc A specific cadherin phenotype may characterise the disseminating yet non-metastatic behaviour of pseudomyxoma peritonei
    R Bibi
    Cancer Research UK Immunology Group, Paterson Institute for Cancer Research, Manchester, UK
    Br J Cancer 95:1258-64. 2006
  4. pmc Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer
    A Greystoke
    Clinical and Experimental Pharmacology CEP Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Br J Cancer 107:1518-24. 2012
  5. doi request reprint Body mass index at different adult ages, weight change, and colorectal cancer risk in the National Institutes of Health-AARP Cohort
    Andrew G Renehan
    Department of Surgery, the Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom
    Am J Epidemiol 176:1130-40. 2012
  6. doi request reprint Diabetes and cancer (2): evaluating the impact of diabetes on mortality in patients with cancer
    A G Renehan
    Department of Surgery, School of Cancer and enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, the Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
    Diabetologia 55:1619-32. 2012
  7. doi request reprint Growth hormone receptor polymorphism and growth hormone therapy response in children: a Bayesian meta-analysis
    Andrew G Renehan
    School of Cancer andEnabling Sciences, University of Manchester, United Kingdom
    Am J Epidemiol 175:867-77. 2012
  8. ncbi request reprint Patterns of local disease failure and outcome after salvage surgery in patients with anal cancer
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Br J Surg 92:605-14. 2005
  9. ncbi request reprint Colorectal cancer prevention: choosing the most effective population strategy using bio-mathematical approaches
    A G Renehan
    Department of Surgery, Academic Division of Cancer Studies, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    Colorectal Dis 9:393-6. 2007
  10. ncbi request reprint Insulin and Cancer: Report of the Proceedings of the First International Workshop, October 27-28, 2007, Düsseldorf, Germany
    Andrew G Renehan
    Department of Surgery, School of Cancer Studies, University of Manchester, Manchester, UK
    Pediatr Endocrinol Rev 5:810-6. 2008

Detail Information

Publications45

  1. doi request reprint Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    Andrew G Renehan
    Department of Surgery, School of Cancer Studies, University of Manchester, UK
    Lancet 371:569-78. 2008
    ..We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups...
  2. pmc Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer
    M M Seenath
    Clinical and Experimental Pharmacology, Paterson Institute of Cancer Research, Manchester, UK
    Br J Cancer 99:459-63. 2008
    ..04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain...
  3. pmc A specific cadherin phenotype may characterise the disseminating yet non-metastatic behaviour of pseudomyxoma peritonei
    R Bibi
    Cancer Research UK Immunology Group, Paterson Institute for Cancer Research, Manchester, UK
    Br J Cancer 95:1258-64. 2006
    ....
  4. pmc Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer
    A Greystoke
    Clinical and Experimental Pharmacology CEP Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Br J Cancer 107:1518-24. 2012
    ..Having validated these ELISAs, we assessed their utility in colorectal cancer (CRC)...
  5. doi request reprint Body mass index at different adult ages, weight change, and colorectal cancer risk in the National Institutes of Health-AARP Cohort
    Andrew G Renehan
    Department of Surgery, the Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom
    Am J Epidemiol 176:1130-40. 2012
    ..16, 1.56, respectively). For women, relations throughout were weaker than those observed for men. These findings suggest that weight gains during early to middle adulthood have important influences on colon cancer risk, especially in men...
  6. doi request reprint Diabetes and cancer (2): evaluating the impact of diabetes on mortality in patients with cancer
    A G Renehan
    Department of Surgery, School of Cancer and enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, the Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
    Diabetologia 55:1619-32. 2012
    ....
  7. doi request reprint Growth hormone receptor polymorphism and growth hormone therapy response in children: a Bayesian meta-analysis
    Andrew G Renehan
    School of Cancer andEnabling Sciences, University of Manchester, United Kingdom
    Am J Epidemiol 175:867-77. 2012
    ....
  8. ncbi request reprint Patterns of local disease failure and outcome after salvage surgery in patients with anal cancer
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Br J Surg 92:605-14. 2005
    ..Salvage surgery for anal cancer is usually reserved for local disease failure, but issues relating to the prediction of local failure and surgical outcome are ill defined...
  9. ncbi request reprint Colorectal cancer prevention: choosing the most effective population strategy using bio-mathematical approaches
    A G Renehan
    Department of Surgery, Academic Division of Cancer Studies, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    Colorectal Dis 9:393-6. 2007
    ..Examples are discussed of the potential population effects of an agent that modulates cell kinetics, such as aspirin, vs one that merely reduces mutational rates...
  10. ncbi request reprint Insulin and Cancer: Report of the Proceedings of the First International Workshop, October 27-28, 2007, Düsseldorf, Germany
    Andrew G Renehan
    Department of Surgery, School of Cancer Studies, University of Manchester, Manchester, UK
    Pediatr Endocrinol Rev 5:810-6. 2008
  11. ncbi request reprint The effects of sex steroid replacement therapy on an expanded panel of IGF-related peptides
    Andrew G Renehan
    Department of Surgery, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Growth Horm IGF Res 17:210-9. 2007
    ..The aim of this study was to clarify these relationships, as circulating IGF-related peptides are potential surrogates of predisposition to common chronic diseases...
  12. ncbi request reprint Obesity and cancer: pathophysiological and biological mechanisms
    Andrew G Renehan
    Department of Surgery, School of Cancer and Imaging Sciences, University of Manchester, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester, UK
    Arch Physiol Biochem 114:71-83. 2008
    ....
  13. doi request reprint Acromegaly, growth hormone and cancer risk
    Andrew G Renehan
    School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
    Best Pract Res Clin Endocrinol Metab 22:639-57. 2008
    ..This emphasizes the need for patient selection balanced against the known morbidity of untreated GH deficiency...
  14. doi request reprint Incident cancer burden attributable to excess body mass index in 30 European countries
    Andrew G Renehan
    Department of Surgery, School of Cancer, Enabling Sciences and Technology, University of Manchester, Manchester Academic Health Science Centre, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Int J Cancer 126:692-702. 2010
    ..The estimates reported here provide a baseline for future modelling, and underline the need for research into interventions to control weight in the context of endometrial, breast and colorectal cancer...
  15. doi request reprint Foreword: Implementing cancer prevention in Europe
    Andrew G Renehan
    Department of Surgery, the Christie NHS Foundation Trust, School of Cancer and enabling Sciences, University of Manchester, UK
    Eur J Cancer 46:2523-4. 2010
    ..The Special Issue is supported by focused evidence-based case studies of how these processes might be best taken forward...
  16. doi request reprint Interpreting the epidemiological evidence linking obesity and cancer: A framework for population-attributable risk estimations in Europe
    Andrew G Renehan
    Department of Surgery, the Christie NHS Foundation Trust, School of Cancer and enabling Sciences, University of Manchester, UK
    Eur J Cancer 46:2581-92. 2010
    ..Overall, this framework gives conservative estimates for PAR - nonetheless, the numbers of avoidable cancers across Europe through avoidance of excess weight are substantial...
  17. doi request reprint Insulin analogues and cancer risk: the emergence of second-generation studies
    A G Renehan
    School of Cancer and enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, the Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
    Diabetologia 55:7-9. 2012
    ..A list of preferred qualities for pharmaco-epidemiological studies is presented...
  18. ncbi request reprint Paradoxical elevations in serum IGF-II and IGF binding protein-2 in acromegaly: insights into the regulation of these peptides
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 55:469-75. 2001
    ..This study compared serum IGF-II and IGFBP-2 distributions between acromegalics and a large normal adult population to explore possible determinants...
  19. ncbi request reprint Obesity and cancer risk: the role of the insulin-IGF axis
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Trends Endocrinol Metab 17:328-36. 2006
    ..As the prevalence of EBW increases to epidemic proportions, untangling the links between EBW and the insulin-IGF axis and its wider molecular interactions will become increasingly important in the development of preventive strategies...
  20. ncbi request reprint Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Endocr Relat Cancer 13:273-8. 2006
    ..The reasons are complex and include differences in study design, lack of standardisation between assays, and variations in IGFBP-3 proteolytic activity--these are discussed in this commentary...
  21. ncbi request reprint Preventing cancer, cardiovascular disease, and diabetes
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    Lancet 365:1449-51. 2005
  22. pmc Impact on survival of intensive follow up after curative resection for colorectal cancer: systematic review and meta-analysis of randomised trials
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester M20 4BX
    BMJ 324:813. 2002
    ..To review the evidence from clinical trials of follow up of patients after curative resection for colorectal cancer...
  23. ncbi request reprint High-risk colorectal adenomas and serum insulin-like growth factors
    A G Renehan
    Department of Surgery, Cancer Research Campaign Department of Epithelial Biology, Paterson Institute for Cancer Research, Manchester, UK
    Br J Surg 88:107-13. 2001
    ..This study investigated the hypothesis that circulating levels of insulin-like growth factor (IGF) I and its main binding protein (IGFBP-3) predict for the presence of colorectal adenomas, surrogate markers of colorectal cancer risk...
  24. pmc Cost effectiveness analysis of intensive versus conventional follow up after curative resection for colorectal cancer
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Withington, Manchester M20 4BX
    BMJ 328:81. 2004
    ..To determine the cost effectiveness of intensive follow up compared with conventional follow up in patients with colorectal cancer...
  25. ncbi request reprint Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Lancet 363:1346-53. 2004
    ..Circulating concentrations of IGF-I might be associated with an increased risk of cancer, whereas IGFBP-3 concentrations could be associated with a decreased cancer risk...
  26. pmc The effect of cigarette smoking use and cessation on serum insulin-like growth factors
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Br J Cancer 91:1525-31. 2004
    ..For male former vs never smokers, there were no differences in mean IGF-I and IGFBP-3 concentrations, suggesting that smoking cessation is associated with normalisation of peptide concentrations...
  27. pmc Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Br J Cancer 92:430-3. 2005
    ....
  28. ncbi request reprint The prevalence and characteristics of colorectal neoplasia in acromegaly
    A G Renehan
    Department of Surgery, Christie Hospital National Health Service Trust, Manchester, United Kingdom
    J Clin Endocrinol Metab 85:3417-24. 2000
    ..This study has failed to demonstrate an increased prevalence of neoplasia in acromegalic patients compared with the expected prevalence in the general population and questions the need for an aggressive colonoscopic screening policy...
  29. ncbi request reprint Determination of large bowel length and loop complexity in patients with acromegaly undergoing screening colonoscopy
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 62:323-30. 2005
    ..In turn, large bowel dimensions may be increased in these patients, factors that predict for increased risk of serious complications such as perforation...
  30. ncbi request reprint Acromegaly and colorectal cancer: a comprehensive review of epidemiology, biological mechanisms, and clinical implications
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Horm Metab Res 35:712-25. 2003
    ..From a clinical perspective, it seems reasonable to consider a once-only colonoscopic screening at approximately age 55 years, but potential risks and benefits should be balanced...
  31. ncbi request reprint Determination of IGF-I, IGF-II, IGFBP-2, and IGFBP-3 levels in serum and plasma: comparisons using the Bland-Altman method
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Growth Horm IGF Res 13:341-6. 2003
    ..These findings emphasize the need to standardize methods of collecting blood samples in future epidemiological studies and trials...
  32. pmc Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, M20 4BX
    Br J Cancer 83:1344-50. 2000
    ..We conclude that the serum IGF-II and IGFBP-2 profiles may provide insights into underlying biological mechanisms, and that serum IGFBP-2 may have an adjunct role in cancer surveillance in patients with colorectal cancer...
  33. doi request reprint Treatments and outcomes of peritoneal surface tumors through a centralized national service (United kingdom)
    S Rout
    Peritoneal Tumour Service, Department of Surgery, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Dis Colon Rectum 52:1705-14. 2009
    ..To better define treatment pathways, five-year results in patients referred to one of two centralized national treatment centers in the United Kingdom were analyzed...
  34. pmc A phase II study evaluating the use of concurrent mitomycin C and capecitabine in patients with advanced unresectable pseudomyxoma peritonei
    A L Farquharson
    Peritoneal Tumour Service, Department of Surgery, Christie Hospital NHS Foundation Trust, Manchester, UK
    Br J Cancer 99:591-6. 2008
    ..This is the first trial to demonstrate an apparent benefit of systemic chemotherapy in patients with advanced unresectable PMP...
  35. ncbi request reprint Gender and age influence the relationship between serum GH and IGF-I in patients with acromegaly
    C Parkinson
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Clin Endocrinol (Oxf) 57:59-64. 2002
    ....
  36. doi request reprint Classification of and cytoreductive surgery for low-grade appendiceal mucinous neoplasms
    J R McDonald
    Peritoneal Tumour Service, Christie NHS Foundation Trust, Manchester, UK
    Br J Surg 99:987-92. 2012
    ..The role of cytoreductive surgery for these relatively early lesions is unclear...
  37. doi request reprint Biological mechanisms linking obesity and cancer risk: new perspectives
    Darren L Roberts
    Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, the Christie NHS Foundation Trust, Manchester, UK
    Annu Rev Med 61:301-16. 2010
    ....
  38. pmc Clinico-pathological and treatment-related factors influencing survival in parotid cancer
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Br J Cancer 80:1296-300. 1999
    ..Post-operative RT contributes significantly to locoregional control and probably confers some survival advantage in high-risk patients...
  39. ncbi request reprint The relevance of apoptosis for cellular homeostasis and tumorigenesis in the intestine
    A G Renehan
    EpiStem Ltd, Manchester, United Kingdom
    Can J Gastroenterol 15:166-76. 2001
    ..The importance of understanding the molecular biology of apoptotic pathways in cancer therapy and future directions are also addressed...
  40. doi request reprint Body mass index, hormone replacement therapy, and endometrial cancer risk: a meta-analysis
    Emma J Crosbie
    Gynaecology Oncology Research Group, School of Cancer and enabling Sciences, University of Manchester, Manchester, UK
    Cancer Epidemiol Biomarkers Prev 19:3119-30. 2010
    ..Body mass index (BMI) is a risk factor for endometrial cancer. We quantified the risk and investigated whether the association differed by use of hormone replacement therapy (HRT), menopausal status, and histologic type...
  41. ncbi request reprint Acromegaly and colorectal cancer: risk assessment should be based on population-based studies
    Andrew G Renehan
    J Clin Endocrinol Metab 87:1909; author reply 1909. 2002
  42. ncbi request reprint IGF-I, IGF binding protein-3 and breast cancer risk: comparison of 3 meta-analyses
    Andrew G Renehan
    Int J Cancer 115:1006-7; author reply 1008. 2005
  43. ncbi request reprint Physical activity before and after diagnosis of colorectal cancer: disease risk, clinical outcomes, response pathways and biomarkers
    David J Harriss
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Liverpool, UK
    Sports Med 37:947-60. 2007
    ..Research evidence is, however, limited as to whether these markers are beneficially affected by physical activity, either before or after diagnosis of colorectal cancer...
  44. pmc Diabetes, insulin therapy, and colorectal cancer
    Andrew G Renehan
    BMJ 330:551-2. 2005