Affiliation: University of Dundee
- Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1aAmy R Cameron
Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
Aging Cell 7:69-77. 2008..Further investigation in these two areas might provide insight into how age-related metabolic disease may be deferred...
- Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulinSiobhan Anton
Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland DD1 9SY, UK
Cell Signal 19:378-83. 2007..Our results suggest that agents acting in the manner of EGCG may be useful antidiabetic agents...
- Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusionGraham Rena
MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
EMBO J 21:2263-71. 2002..The cluster of phosphorylation sites at Ser319, Ser322, Ser325 and Ser329 appears to accelerate nuclear export by controlling the interaction of FKHR with the Ran-containing protein complex that mediates this process...
- D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1aGraham Rena
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
EMBO Rep 5:60-5. 2004..D4476 is much more potent and specific than IC261 or CKI-7, and is therefore the most useful CK1 inhibitor currently available for identifying physiological substrates of CK1...
- The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1aAmy R Cameron
Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
Biochem J 443:57-64. 2012..Further investigation of this signalling response might illuminate novel pharmacological strategies for the treatment of age-related diseases...
- Cellular responses to the metal-binding properties of metforminLisa Logie
Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
Diabetes 61:1423-33. 2012..Together, these results suggest that cellular effects of biguanides depend on their metal-binding properties. This link may illuminate a better understanding of the molecular mechanisms enabling antihyperglycemic drug action...
- Molecular mechanism of action of metformin: old or new insights?Graham Rena
Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
Diabetologia 56:1898-906. 2013..In this review we summarise the recent research developments on the molecular action of metformin. ..
- Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activitySatish Patel
Division of Cellular Signalling, School of Life Sciences, Wellcome Trust Biocentre Medical Sciences Institute Complex, Dow Street, University of Dundee, Dundee DD1 5EH, United Kingdom
J Biol Chem 277:9889-95. 2002..Therefore, although the insulin-responsive sequence of the G6Pase gene promoter is related to that of the IGFBP-1 promoter, the signaling pathways that mediate suppression of these genes are distinct...