Helga Refsum

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults
    Helga Refsum
    Oxford Centre for Gene Function, Laboratory of Physiology, Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Clin Chem 52:129-37. 2006
  2. ncbi request reprint The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease
    Helga Refsum
    Norwegian Institute of Public Health, Oslo, Norway
    J Nutr 136:1731S-1740S. 2006
  3. doi request reprint Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study
    Anna Vogiatzoglou
    OPTIMA, Department of Pharmacology, University of Oxford, Oxford, UK
    Psychosom Med 75:20-9. 2013
  4. doi request reprint Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study
    Anna Vogiatzoglou
    OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Am J Clin Nutr 89:1078-87. 2009
  5. doi request reprint Plasma stearoyl-CoA desaturase indices: association with lifestyle, diet, and body composition
    Kathrine J Vinknes
    Department of Nutrition, Institute of Basic Medical Science, Faculty of Medicine, University of Oslo, Oslo, Norway
    Obesity (Silver Spring) 21:E294-302. 2013
  6. doi request reprint Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status
    Anna Vogiatzoglou
    OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Clin Chem 55:2198-206. 2009
  7. doi request reprint Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance
    Amany K Elshorbagy
    Department of Pharmacology, University of Oxford, UK
    Metabolism 62:509-17. 2013
  8. ncbi request reprint Folate and cobalamin status in relation to breastfeeding and weaning in healthy infants
    Gry Hay
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 88:105-14. 2008
  9. ncbi request reprint Screening for serum total homocysteine in newborn children
    Helga Refsum
    Department of Pharmacology, University of Oxford, UK
    Clin Chem 50:1769-84. 2004
  10. doi request reprint Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia
    Amany K Elshorbagy
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Nutrition 26:1201-4. 2010

Detail Information

Publications71

  1. ncbi request reprint Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults
    Helga Refsum
    Oxford Centre for Gene Function, Laboratory of Physiology, Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Clin Chem 52:129-37. 2006
    ..We developed microbiological assays (MBAs) to identify determinants and to establish reference values for cobalamin bound to transcobalamin [holotranscobalamin (holoTC)] and total TC in plasma...
  2. ncbi request reprint The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease
    Helga Refsum
    Norwegian Institute of Public Health, Oslo, Norway
    J Nutr 136:1731S-1740S. 2006
    ..Overall, the findings from HHS indicate that a raised tHcy level is associated with multiple clinical conditions, whereas a low tHcy level is associated with better physical and mental health...
  3. doi request reprint Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study
    Anna Vogiatzoglou
    OPTIMA, Department of Pharmacology, University of Oxford, Oxford, UK
    Psychosom Med 75:20-9. 2013
    ..To investigate the cross-sectional relation between metabolic markers of vitamin B(12) status and cognitive performance, and possible effect modification by the presence of depression and apolipoprotein E (ApoE) ε4...
  4. doi request reprint Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study
    Anna Vogiatzoglou
    OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Am J Clin Nutr 89:1078-87. 2009
    ..Limited information is available on the association between vitamin B-12 status and intake from different dietary sources...
  5. doi request reprint Plasma stearoyl-CoA desaturase indices: association with lifestyle, diet, and body composition
    Kathrine J Vinknes
    Department of Nutrition, Institute of Basic Medical Science, Faculty of Medicine, University of Oslo, Oslo, Norway
    Obesity (Silver Spring) 21:E294-302. 2013
    ..We examined the relations of two plasma SCD activity indices (16:1n-7/16:0, 18:1n-9/18:0) with body composition, and the association of lifestyle and dietary variables with the plasma SCD indices...
  6. doi request reprint Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status
    Anna Vogiatzoglou
    OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Clin Chem 55:2198-206. 2009
    ..However, data are sparse regarding factors, besides renal function, that may influence MMA concentrations. We searched for important determinants of plasma MMA in the general population...
  7. doi request reprint Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance
    Amany K Elshorbagy
    Department of Pharmacology, University of Oxford, UK
    Metabolism 62:509-17. 2013
    ..These effects are partly or completely reversed by cysteine supplementation. We investigated whether reversal of MR phenotypes can be achieved by other sulfur compounds, namely taurine or N-acetylcysteine (NAC)...
  8. ncbi request reprint Folate and cobalamin status in relation to breastfeeding and weaning in healthy infants
    Gry Hay
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 88:105-14. 2008
    ..Folate and cobalamin status changes markedly during infancy...
  9. ncbi request reprint Screening for serum total homocysteine in newborn children
    Helga Refsum
    Department of Pharmacology, University of Oxford, UK
    Clin Chem 50:1769-84. 2004
    ..Newborn screening for total homocysteine (tHcy) in blood may identify babies with vitamin B12 (B12) deficiency or homocystinuria, but data on the causes of increased tHcy in screening samples are sparse...
  10. doi request reprint Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia
    Amany K Elshorbagy
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Nutrition 26:1201-4. 2010
    ..We investigated the serum sulfur amino acid profile of male Fischer-344 rats fed a methionine-restricted diet for 3 mo...
  11. doi request reprint Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
    Celeste A de Jager
    OPTIMA, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Int J Geriatr Psychiatry 27:592-600. 2012
    ..Here we report the effect of B vitamins on cognitive and clinical decline (secondary outcomes) in the same study...
  12. doi request reprint MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circulation 119:2507-15. 2009
    ..We sought to distinguish the effects of plasma versus vascular tissue 5-MTHF and homocysteine on vascular redox and endothelial nitric oxide bioavailability in human vessels...
  13. doi request reprint Vitamin B-12 and cognition in the elderly
    A David Smith
    Oxford Project to Investigate Memory and Ageing, The Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 89:707S-11S. 2009
    ..Pending the outcome of better trials, it is suggested that the elderly in particular should be encouraged to maintain a good, rather than just an adequate, vitamin B-12 status by dietary means...
  14. doi request reprint Cognitive performance among the elderly in relation to the intake of plant foods. The Hordaland Health Study
    Eha Nurk
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
    Br J Nutr 104:1190-201. 2010
    ..The only negative cognitive association was with increased intake of white bread. In the elderly, a diet rich in plant foods is associated with better performance in several cognitive abilities in a dose-dependent manner...
  15. ncbi request reprint Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism?
    Amany K Elshorbagy
    Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, United Kingdom
    Am J Clin Nutr 88:738-46. 2008
    ....
  16. ncbi request reprint Facts and recommendations about total homocysteine determinations: an expert opinion
    Helga Refsum
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Clin Chem 50:3-32. 2004
    ....
  17. ncbi request reprint Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study
    Eha Nurk
    Department of Pharmacology, University of Oxford, UK
    Am J Clin Nutr 86:1470-8. 2007
    ..Increasing evidence suggests that cognitive impairment and dementia in older subjects might be influenced by a diet including seafood...
  18. ncbi request reprint Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study
    Eha Nurk
    Department of Pharmacology, Oxford Project to Investigate Memory and Ageing OPTIMA, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    Ann Neurol 58:847-57. 2005
    ....
  19. pmc Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment
    Gwenaelle Douaud
    Functional Magnetic Resonance Imaging of the Brain FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 110:9523-8. 2013
    ..Further B-vitamin supplementation trials focusing on elderly subjets with high homocysteine levels are warranted to see if progression to dementia can be prevented...
  20. doi request reprint Associations between plasma polyunsaturated fatty acids, plasma stearoyl-CoA desaturase indices and body fat
    Kathrine J Vinknes
    Department of Nutrition, Institute of Basic Medical Science, Faculty of Medicine, University of Oslo, Oslo, Norway
    Obesity (Silver Spring) 21:E512-9. 2013
    ..Both n-3 and n-6 polyunsaturated fatty acids (PUFA) regulate expression of the SCD enzymes. Whether higher plasma PUFA were associated with lower SCD indices in humans was examined...
  21. pmc The association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents
    Amany K Elshorbagy
    Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e44166. 2012
    ..Plasma total cysteine (tCys) independently relates to fat mass in adults. Dietary cyst(e)ine promotes adiposity and decreases glucose tolerance in some rodent models, but alleviates insulin resistance in others...
  22. pmc Dietary cystine level affects metabolic rate and glycaemic control in adult mice
    Amany K Elshorbagy
    Department of Pharmacology, University of Oxford, UK
    J Nutr Biochem 23:332-40. 2012
    ..Overall, high cystine intake promotes adiposity and an adverse metabolic phenotype in mice, indicating that the positive association of plasma tCys with obesity in humans may be causal...
  23. doi request reprint Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:996-9. 2008
    ..The results also indicate that COMT activity may influence a broader range of biochemical pathways than hitherto appreciated...
  24. doi request reprint Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies
    Amany K Elshorbagy
    Department of Pharmacology, University of Oxford, Oxford, UK
    Curr Opin Clin Nutr Metab Care 15:49-57. 2012
    ..Animal and cellular experiments support the concept that cysteine may be obesogenic. Here we review experimental and epidemiologic findings linking cysteine and related compounds with fat regulation and obesity...
  25. ncbi request reprint Screening for vitamin B-12 and folate deficiency in older persons
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 77:1241-7. 2003
    ..Folate deficiency also results in elevated tHcy. Measurement of these metabolites can be used to screen for functional vitamin B-12 or folate deficiency...
  26. ncbi request reprint Is folic acid good for everyone?
    A David Smith
    Oxford Project to Investigate Memory and Ageing, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 87:517-33. 2008
    ..Only then can authorities develop the right strategies for the population as a whole...
  27. pmc Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial
    A David Smith
    Oxford Project to Investigate Memory and Ageing, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e12244. 2010
    ..Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia. Plasma concentrations of homocysteine can be lowered by dietary administration of B vitamins...
  28. doi request reprint Midlife vascular risk factors and their association with dementia deaths: results from a Norwegian prospective study followed up for 35 years
    Bjørn Heine Strand
    Norwegian Institute of Public Health, Marcus Thranes gt 6, 0473 Oslo, Norway
    J Neurol Sci 324:124-30. 2013
    ..To better understand the mechanisms involved in the associations between midlife underweight, diabetes, and elevated cholesterol level and late-life dementia death, these links need to be further investigated...
  29. pmc Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase
    Amany K Elshorbagy
    Department of Pharmacology, University of Oxford, Oxford, UK
    J Lipid Res 52:104-12. 2011
    ..FM/BW% and serum leptin were modestly decreased. Our results indicate that anti-obesity effects of MR are caused by low cysteine and that dietary sulfur amino acid composition contributes to SCD1 regulation...
  30. doi request reprint The association of plasma cysteine and gamma-glutamyltransferase with BMI and obesity
    Amany K Elshorbagy
    Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
    Obesity (Silver Spring) 17:1435-40. 2009
    ..We also suggest that the association of serum GGT with BMI and obesity is unrelated to the role of GGT in cysteine turnover. The potential link between cysteine and fat metabolism should be further evaluated...
  31. doi request reprint Cysteine, homocysteine and bone mineral density: a role for body composition?
    Amany K Elshorbagy
    Department of Physiology, Le Gros Clarke Building, Anatomy and Genetics, Oxford University, UK
    Bone 44:954-8. 2009
    ..Plasma total cysteine (tCys) and homocysteine (tHcy) are associated with body composition, which in turn affects bone mineral density (BMD)...
  32. ncbi request reprint Plasma creatinine as a determinant of plasma total homocysteine concentrations in the Hordaland Homocysteine Study: use of statistical modeling to determine reference limits
    Amany K Elshorbagy
    Oxford Centre for Gene Function, Department of Physiology, Anatomy and Genetics, Oxford University, UK
    Clin Biochem 40:1209-18. 2007
    ..We established population-based reference limits for plasma total homocysteine (tHcy) according to creatinine...
  33. ncbi request reprint Plasma concentration of folate as a biomarker for the intake of fruit and vegetables: the Hordaland Homocysteine Study
    Asgeir Brevik
    Department of Nutrition, School of Medicine, University of Oslo, Oslo, Norway
    Am J Clin Nutr 81:434-9. 2005
    ..Nutritional biomarkers may be used to assess dietary exposure without the errors commonly associated with self-reported dietary data...
  34. ncbi request reprint Birth prevalence of homocystinuria
    Helga Refsum
    Department of Pharmacology, University of Oxford, United Kingdom
    J Pediatr 144:830-2. 2004
    ..Our results suggest that homocystinuria is more common than previously reported. Newborn screening for homocystinuria through mutation detection should be further considered...
  35. doi request reprint S-adenosylmethionine is associated with fat mass and truncal adiposity in older adults
    Amany K Elshorbagy
    Department of Pharmacology, University of Oxford, Oxford, UK
    J Nutr 143:1982-8. 2013
    ..Prospective studies are needed to investigate the interactions among dietary energy and animal protein content, SAM concentrations, and change in body weight and cardiometabolic risk. ..
  36. ncbi request reprint Detection of single-nucleotide polymorphisms by PCR with universal energy transfer-labeled primers: application to folate- and cobalamin-related genes
    Donald R Warden
    Department of Pharmacology, University of Oxford, Oxford, UK
    Clin Chem 51:1713-6. 2005
  37. ncbi request reprint Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life
    Gry Hay
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 86:64-73. 2007
    ..Adequate iron status at birth may prevent iron deficiency in early childhood...
  38. ncbi request reprint Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease
    Cheerag Shirodaria
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Circulation 115:2262-70. 2007
    ..We compared the effects of folic acid on human vessels using pharmacological high-dose versus low-dose treatment, equivalent to dietary folate fortification...
  39. ncbi request reprint 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circulation 114:1193-201. 2006
    ..We hypothesized that 5-MTHF would improve endothelial function by decreasing superoxide and peroxynitrite production and by improving eNOS coupling, mediated by BH4 availability...
  40. ncbi request reprint Plasma total homocysteine and hospitalizations for cardiovascular disease: the Hordaland Homocysteine Study
    Eha Nurk
    Department of Public Health and Primary Health Care, University of Bergen, Armauer Hansen s Building, N 5021 Bergen, Norway
    Arch Intern Med 162:1374-81. 2002
    ..Elevated total plasma homocysteine (tHcy) level is a risk factor for occlusive disease in the coronary, cerebral, and peripheral vessels and is related to several lifestyle factors associated with cardiovascular disease (CVD)...
  41. ncbi request reprint Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention
    Øyvind Bleie
    Institute of Medicine, University of Bergen, Haukeland University Hospital, N 5021 Bergen, Norway
    Am J Clin Nutr 80:641-8. 2004
    ....
  42. ncbi request reprint Is folic acid the answer?
    Helga Refsum
    Am J Clin Nutr 80:241-2. 2004
  43. ncbi request reprint Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study
    Eha Nurk
    Department of Public Health and Primary Health Care, University of Bergen, Norway
    Am J Clin Nutr 79:812-9. 2004
    ..Elevated plasma concentrations of total homocysteine (tHcy) are a risk factor for cardiovascular disease. tHcy is a marker of folate and cobalamin deficiencies and is also related to several lifestyle factors...
  44. ncbi request reprint Hematological parameters and cobalamin status in infants born to smoking mothers
    Anne Lise Bjørke Monsen
    Department of Pediatrics, University of Bergen, Bergen, Norway
    Biol Neonate 85:249-55. 2004
    ..At 6 weeks, maternal smoking significantly predicted the methylmalonic acid and total homocysteine levels, suggesting an influence from smoking on the cobalamin function in these infants...
  45. ncbi request reprint Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation
    Pal I Holm
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, N 5021 Bergen, Norway
    Arterioscler Thromb Vasc Biol 24:301-7. 2004
    ..Betaine is a substrate in the betaine-homocysteine methyltransferase reaction, converting homocysteine to methionine. There are only sparse data on plasma betaine as a determinant of the plasma total homocysteine (tHcy) concentration...
  46. ncbi request reprint Plasma total cysteine, mortality, and cardiovascular disease hospitalizations: the Hordaland Homocysteine Study
    Lina El-Khairy
    LOCUS for Homocysteine and Related Vitamins, Department of Public Health and Primary Care Health, University of Bergen, N 5021 Bergen, Norway
    Clin Chem 49:895-900. 2003
    ....
  47. ncbi request reprint Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years
    Anne Lise Bjørke Monsen
    Department of Pediatrics, University of Bergen, N 5021 Bergen, Norway
    Clin Chem 49:2067-75. 2003
    ..Recent data indicate that cobalamin and folate status, including the metabolic markers methylmalonic acid (MMA) and total homocysteine (tHcy), undergo marked changes during childhood, particularly during the first year...
  48. ncbi request reprint Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study
    Ingvar Bjelland
    Department of Public Health and Primary Health Care, LOCUS for Homocysteine and Related Vitamins, University of Bergen, Norway
    Arch Gen Psychiatry 60:618-26. 2003
    ..This study examined the associations between folate, total homocysteine, vitamin B12, and the methylenetetrahydrofolate reductase 677C-->T polymorphism, and anxiety and depression in a large population-based study...
  49. ncbi request reprint Plasma total cysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study
    Lina El-Khairy
    LOCUS for Homocysteine and Related Vitamins and the Department of Pharmacology, University of Bergen, Norway
    Am J Clin Nutr 77:467-72. 2003
    ..Total homocysteine (tHcy) is associated with pregnancy complications and adverse pregnancy outcomes. The associations of plasma total cysteine (tCys) with such outcomes have not been investigated in large populations...
  50. ncbi request reprint Predictors of change in plasma total cysteine: longitudinal findings from the Hordaland homocysteine study
    Lina El-Khairy
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, N 5021 Bergen, Norway
    Clin Chem 49:113-20. 2003
    ..Changes and predictors of change in tCys concentrations over a mean follow-up time of 6.0 (5.2-7.2) years were assessed in this study...
  51. ncbi request reprint Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: the European Concerted Action Project
    Raymond Meleady
    Department of Cardiology, Adelaide Meath Hospital, Incorporating the National Children s Hospital, Tallaght, Dublin, Ireland
    Am J Clin Nutr 77:63-70. 2003
    ..5.1.20) enzyme have elevated plasma concentrations of the cardiovascular disease risk factor homocysteine, particularly if folate depleted...
  52. ncbi request reprint Maternal total homocysteine concentration and neonatal size in India
    Chittaranjan S Yajnik
    King Edward Memorial Hospital, Pune, India
    Asia Pac J Clin Nutr 14:179-81. 2005
    ..We conclude that maternal vitamin B12 deficiency reflected in plasma tHcy concentration contributes to small size of Indian babies...
  53. ncbi request reprint Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study
    Clara Gram Gjesdal
    Department of Public Health and Primary Health Care, Institute of Medicine, University of Bergen, and Department of Rheumatology, Haukeland University Hospital, Norway
    Arch Intern Med 166:88-94. 2006
    ..We examined the association of hip BMD with levels of plasma tHcy, folate, and vitamin B12 and the methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C polymorphisms...
  54. ncbi request reprint Homocysteine, B vitamins, and cardiovascular disease
    Helga Refsum
    N Engl J Med 355:207; author reply 209-11. 2006
  55. ncbi request reprint Folate, but not vitamin B-12 status, predicts respiratory morbidity in north Indian children
    Tor A Strand
    Centre for International Health, University of Bergen, Bergen, Norway
    Am J Clin Nutr 86:139-44. 2007
    ..Vitamin deficiencies are often part of malnutrition, which predisposes to acute lower respiratory tract infections...
  56. ncbi request reprint Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study
    Charles H Halsted
    Genome and Biomedical Sciences Facility, University of California Davis, Davis, CA 95616, USA
    Am J Clin Nutr 86:514-21. 2007
    ..Previous studies provided conflicting results on the effect of the GCPII 1561C-->T polymorphism on folate and total homocysteine (tHcy) concentrations...
  57. ncbi request reprint Plasma folate concentration and cognitive performance: Rotterdam Scan Study
    Lonneke M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands
    Am J Clin Nutr 86:728-34. 2007
    ..Evidence is increasing for beneficial and independent effects of folate on cognitive function, but the underlying biologic mechanism is as yet unknown...
  58. ncbi request reprint Cobalamin and folate status in infants and young children in a low-to-middle income community in India
    Sunita Taneja
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
    Am J Clin Nutr 86:1302-9. 2007
    ..Population-based data on the prevalence of cobalamin and folate deficiency in India are lacking...
  59. ncbi request reprint Effect of vitamin B12 treatment on haptocorrin
    Anne L Mørkbak
    Department of Clinical Biochemistry, Aarhus Sygehus, Denmark
    Clin Chem 52:1104-11. 2006
    ..Haptocorrin (HC) carries the major part of circulating cobalamin, but whether HC is altered on treatment with vitamin B12 remains unknown...
  60. ncbi request reprint Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study
    Svetlana V Konstantinova
    Section of Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien, 31, Bergen, Norway
    Br J Nutr 98:201-10. 2007
    ..In conclusion, food items rich in B-vitamins and with a low content of fat and sugar were related to lower tHcy levels. Eggs, chicken, non-processed meat, fish and milk were inversely associated with tHcy...
  61. ncbi request reprint Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study
    Clara Gram Gjesdal
    Department of Public Helath and Primary Health Care, University of Bergen, Bergen, Norway
    J Bone Miner Res 22:747-56. 2007
    ..High levels of homocysteine and low levels of folate predicted fracture, whereas vitamin B12 and genotypes were not related to fracture risk. High homocysteine may be a modifiable risk factor for hip fracture...
  62. doi request reprint Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen, Norway
    JAMA 300:795-804. 2008
    ..Observational studies have reported associations between circulating total homocysteine concentration and risk of cardiovascular disease. Oral administration of folic acid and vitamin B(12) can lower plasma total homocysteine levels...
  63. ncbi request reprint Oral vitamin B12 supplementation reduces plasma total homocysteine concentration in women in India
    Chittaranjan S Yajnik
    Diabetes Unit, King Edward Memorial Hospital, Moodliar Road, Pune, India
    Asia Pac J Clin Nutr 16:103-9. 2007
    ..People in India have a high prevalence of low vitamin B12 status and high plasma total homocysteine (tHcy) concentrations...
  64. ncbi request reprint Are we ready for mandatory fortification with vitamin B-12?
    Helga Refsum
    Am J Clin Nutr 88:253-4. 2008
  65. ncbi request reprint Vitamin B12 deficiency and hyperhomocysteinemia in rural and urban Indians
    C S Yajnik
    Diabetes Unit, King Edward Memorial Hospital and Research Centre, Pune, India
    J Assoc Physicians India 54:775-82. 2006
    ..Low vitamin B12 concentration in South Asian Indians is common, but the exact prevalence is not known...
  66. ncbi request reprint Homocysteine levels in men and women of different ethnic and cultural background living in England
    Francesco P Cappuccio
    Department of General Practice and Primary Care, St George s Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Atherosclerosis 164:95-102. 2002
    ..They are in part accounted for by their vegetarianism. These differences in tHcy are large enough to be important contributors to the risk of vascular disease and may be preventable by simple targeted population strategies...
  67. ncbi request reprint Holo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study
    Ebba Nexo
    Department of Clinical Biochemistry, AKH, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Chem 48:1768-71. 2002
    ..We examined the effect of oral vitamin B(12) treatment on fluctuations in plasma total cobalamin and its binding proteins transcobalamin (TC) and haptocorrin (HC)...
  68. ncbi request reprint Variation in plasma cystathionine and its relation to changes in plasma concentrations of homocysteine and methionine in healthy subjects during a 24-h observation period
    Anne B Guttormsen
    Department of Anaesthesia and Intensive Care and the Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway
    Am J Clin Nutr 79:76-9. 2004
    ..Plasma cystathionine measurement may be a useful complement to total homocysteine measurement in the assessment of B vitamin status. Information on the within-person variation in cystathionine is currently sparse...
  69. ncbi request reprint Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study
    Eha Nurk
    LOCUS for Homosysteine and Related Vitamins, Department of Public Health and Primary Health Care, University of Bergen, Norway
    Am J Med 117:26-31. 2004
    ..We studied whether two polymorphisms in the MTHFR gene (677C-->T and 1298A-->C) are associated with pregnancy complications, adverse outcomes, and birth defects...
  70. ncbi request reprint Uracil in human DNA from subjects with normal and impaired folate status as determined by high-performance liquid chromatography-tandem mass spectrometry
    Jicun Ren
    College of Chemistry and Chemical Engineering, Shanghai Jiaotong University, People s Republic of China
    Anal Chem 74:295-9. 2002
    ..Our data show that the uracil levels in human DNA isolated from peripheral white blood cells did not differ between subjects with folate deficiency and subjects with normal red cell folate levels...
  71. ncbi request reprint Dietary fat and plasma total homocysteine concentrations in 2 adult age groups: the Hordaland Homocysteine Study
    Paula Berstad
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    Am J Clin Nutr 85:1598-605. 2007
    ..The intake of n-3 (formerly called omega-3) fatty acids (FAs) may be inversely associated with plasma total homocysteine (tHcy) concentrations, but the epidemiologic data are sparse...