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Philip J Reeves
Affiliation: University of Essex
Opefi C, Tranter D, Smith S, Reeves P. Construction of stable mammalian cell lines for inducible expression of G protein-coupled receptors. Methods Enzymol. 2015;556:283-305 pubmed publisher
..Finally, we describe methods for the growth of these cells lines in scalable suspension culture for the preparation of milligram amounts of recombinant protein. ..
Sanchez Reyes O, Cooke A, Tranter D, Rashid D, Eilers M, Reeves P, et al. G Protein-Coupled Receptors Contain Two Conserved Packing Clusters. Biophys J. 2017;112:2315-2326 pubmed publisher
..g., positions 1.46 and 2.47) are more tolerant to mutation but affect the overall stability of the protein. These findings reveal a common structural scaffold of GPCRs that is important for receptor folding and activation. ..
Athanasiou D, Aguilà M, Bellingham J, Li W, McCulley C, Reeves P, et al. The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy. Prog Retin Eye Res. 2018;62:1-23 pubmed publisher
..The understanding of the disease mechanisms associated with rhodopsin RP and the development of targeted therapies offer the potential of treatment for this currently untreatable neurodegeneration. ..