J D Reeves

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Primary human immunodeficiency virus type 2 (HIV-2) isolates infect CD4-negative cells via CCR5 and CXCR4: comparison with HIV-1 and simian immunodeficiency virus and relevance to cell tropism in vivo
    J D Reeves
    The Wohl Virion Centre, Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, United Kingdom
    J Virol 73:7795-804. 1999
  2. ncbi A broad range of chemokine receptors are used by primary isolates of human immunodeficiency virus type 2 as coreceptors with CD4
    A McKnight
    Section of Virology, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Virol 72:4065-71. 1998
  3. ncbi Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands
    G Simmons
    Wohl Virion Centre, Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, UK
    Immunol Rev 177:112-26. 2000
  4. ncbi Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 Tat
    S Ghezzi
    AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    Biochem Biophys Res Commun 270:992-6. 2000
  5. ncbi Effect of mutations in the V3 loop of HIV-1 gp120 on infectivity and susceptibility to proteolytic cleavage
    T F Schulz
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    AIDS Res Hum Retroviruses 9:159-66. 1993
  6. ncbi Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines
    C Boshoff
    Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK
    Science 278:290-4. 1997
  7. ncbi DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions
    S Pohlmann
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 75:10523-6. 2001

Collaborators

  • A E Proudfoot
  • G Simmons
  • M T Dittmar
  • K Ariyoshi
  • John Moore
  • F Kirchhoff
  • R A Weiss
  • S Pohlmann
  • S Ghezzi
  • A McKnight
  • C Boshoff
  • F Baribaud
  • K Hiebenthal-Millow
  • G J Leslie
  • T G Edwards
  • T Macfarlan
  • R W Doms
  • G Vallanti
  • D M Noonan
  • R Benelli
  • M G Aluigi
  • M Morini
  • A Albini
  • E Vicenzi
  • M Cota
  • G Poli
  • S Hibbitts
  • P R Clapham
  • H Whittle
  • D Whitby
  • J Moniz-Periera
  • E Aarons
  • P W Gray
  • M A Siani
  • P D Collins
  • Y Endo
  • Y Chang
  • T Sasaki
  • V L Schweickart
  • Y Takeuchi
  • T J Williams
  • P S Moore
  • T F Schulz
  • K A Page
  • P Stephens
  • C Tailor
  • G Clements
  • S Ortlepp
  • J G Hoad

Detail Information

Publications7

  1. ncbi Primary human immunodeficiency virus type 2 (HIV-2) isolates infect CD4-negative cells via CCR5 and CXCR4: comparison with HIV-1 and simian immunodeficiency virus and relevance to cell tropism in vivo
    J D Reeves
    The Wohl Virion Centre, Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, United Kingdom
    J Virol 73:7795-804. 1999
    ..Our study, however, emphasizes that primary HIV-2 strains carry the potential to infect CD4(-) cells expressing CCR5 or CXCR4 in vivo...
  2. ncbi A broad range of chemokine receptors are used by primary isolates of human immunodeficiency virus type 2 as coreceptors with CD4
    A McKnight
    Section of Virology, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Virol 72:4065-71. 1998
    ..These data therefore indicate that another factor(s) influences the ability of HIV-2 to replicate in human cell types that express the appropriate receptors for virus entry...
  3. ncbi Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands
    G Simmons
    Wohl Virion Centre, Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, UK
    Immunol Rev 177:112-26. 2000
    ..One compound, aminooxypentane or AOP-RANTES, was a particularly potent inhibitor of HIV infection on PBMCs, macrophages and CCR5+ cell lines and demonstrated the great promise of therapeutic strategies aimed at CCR5...
  4. ncbi Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 Tat
    S Ghezzi
    AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    Biochem Biophys Res Commun 270:992-6. 2000
    ..This could favour spreading of R5 viruses, a condition observed in vivo immediately after transmission and in the early asymptomatic phase of infection...
  5. ncbi Effect of mutations in the V3 loop of HIV-1 gp120 on infectivity and susceptibility to proteolytic cleavage
    T F Schulz
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    AIDS Res Hum Retroviruses 9:159-66. 1993
    ..Therefore, one would have to postulate the involvement of several cellular proteinases, or proteases with multiple specificities, in V3-based viral tropism...
  6. ncbi Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines
    C Boshoff
    Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK
    Science 278:290-4. 1997
    ..vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma...
  7. ncbi DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions
    S Pohlmann
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 75:10523-6. 2001
    ..Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface...