J D Reeves
Affiliation: University College London
- Primary human immunodeficiency virus type 2 (HIV-2) isolates infect CD4-negative cells via CCR5 and CXCR4: comparison with HIV-1 and simian immunodeficiency virus and relevance to cell tropism in vivoJ D Reeves
The Wohl Virion Centre, Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, United Kingdom
J Virol 73:7795-804. 1999..Our study, however, emphasizes that primary HIV-2 strains carry the potential to infect CD4(-) cells expressing CCR5 or CXCR4 in vivo...
- A broad range of chemokine receptors are used by primary isolates of human immunodeficiency virus type 2 as coreceptors with CD4A McKnight
Section of Virology, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
J Virol 72:4065-71. 1998..These data therefore indicate that another factor(s) influences the ability of HIV-2 to replicate in human cell types that express the appropriate receptors for virus entry...
- Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligandsG Simmons
Wohl Virion Centre, Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, UK
Immunol Rev 177:112-26. 2000..One compound, aminooxypentane or AOP-RANTES, was a particularly potent inhibitor of HIV infection on PBMCs, macrophages and CCR5+ cell lines and demonstrated the great promise of therapeutic strategies aimed at CCR5...
- Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 TatS Ghezzi
AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
Biochem Biophys Res Commun 270:992-6. 2000..This could favour spreading of R5 viruses, a condition observed in vivo immediately after transmission and in the early asymptomatic phase of infection...
- Effect of mutations in the V3 loop of HIV-1 gp120 on infectivity and susceptibility to proteolytic cleavageT F Schulz
Chester Beatty Laboratories, Institute of Cancer Research, London, UK
AIDS Res Hum Retroviruses 9:159-66. 1993..Therefore, one would have to postulate the involvement of several cellular proteinases, or proteases with multiple specificities, in V3-based viral tropism...
- Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokinesC Boshoff
Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK
Science 278:290-4. 1997..vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma...
- DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functionsS Pohlmann
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Virol 75:10523-6. 2001..Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface...