Jonathan Rees

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Physiological variation in the erythemal response to ultraviolet radiation and photoadaptation
    Karen Waterston
    Systems Group, Dermatology, The University of Edinburgh, Edinburgh, Scotland, UK
    J Invest Dermatol 123:958-64. 2004
  2. pmc Dermatology undergraduate skin cancer training: a disconnect between recommendations, clinical exposure and competence
    R Benjamin Aldridge
    Department of Dermatology, University of Edinburgh, Level 1 Lauriston Building, Lauriston Place, Edinburgh, EH3 9HA, UK
    BMC Med Educ 12:27. 2012
  3. doi Understanding the evolution of human pigmentation: recent contributions from population genetics
    Jonathan L Rees
    Department of Dermatology, University of Edinburgh, Edinburgh, UK
    J Invest Dermatol 132:846-53. 2012
  4. pmc Genetic determinants of hair and eye colours in the Scottish and Danish populations
    Jonas Mengel-From
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK
    BMC Genet 10:88. 2009
  5. ncbi The fundamentals of clinical discovery
    Jonathan Rees
    University of Edinburgh, Lauriston Place, UK
    Perspect Biol Med 47:597-607. 2004
  6. ncbi Pruritus: more scratch than itch
    J L Rees
    Department of Dermatology, University of Newcastle upon Tyne, UK
    Clin Exp Dermatol 24:490-3. 1999
  7. pmc The problem with academic medicine: engineering our way into and out of the mess
    Jonathan Rees
    Department of Dermatology, University of Edinburgh, United Kingdom
    PLoS Med 2:e111. 2005
  8. ncbi Plenty new under the sun
    Jonathan Rees
    Department of Dermatology, University of Edinburgh, Edinburgh United Kingdom
    J Invest Dermatol 126:1691-2. 2006
  9. ncbi Casting light on evidence
    Jonathan L Rees
    Department of Dermatology, University of Edinburgh, Edinburgh, United Kingdom
    J Invest Dermatol 127:1570-1. 2007
  10. pmc Melanoma: what are the gaps in our knowledge
    Jonathan L Rees
    University of Edinburgh, Edinburgh, United Kingdom
    PLoS Med 5:e122. 2008

Collaborators

Detail Information

Publications39

  1. ncbi Physiological variation in the erythemal response to ultraviolet radiation and photoadaptation
    Karen Waterston
    Systems Group, Dermatology, The University of Edinburgh, Edinburgh, Scotland, UK
    J Invest Dermatol 123:958-64. 2004
    ....
  2. pmc Dermatology undergraduate skin cancer training: a disconnect between recommendations, clinical exposure and competence
    R Benjamin Aldridge
    Department of Dermatology, University of Edinburgh, Level 1 Lauriston Building, Lauriston Place, Edinburgh, EH3 9HA, UK
    BMC Med Educ 12:27. 2012
    ..We set out to determine students' competence at skin lesion diagnosis and to quantify their clinical exposure to examples of such lesions during their dermatology attachment...
  3. doi Understanding the evolution of human pigmentation: recent contributions from population genetics
    Jonathan L Rees
    Department of Dermatology, University of Edinburgh, Edinburgh, UK
    J Invest Dermatol 132:846-53. 2012
    ..Future larger studies are likely to provide more details of this process and may provide evidence for exactly which mechanistic pathways have mediated selection...
  4. pmc Genetic determinants of hair and eye colours in the Scottish and Danish populations
    Jonas Mengel-From
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK
    BMC Genet 10:88. 2009
    ..Many of the genes found were previously known as underlying mutant mouse phenotypes or human genetic disease, but others, previously unsuspected as pigmentation genes, have also been discovered...
  5. ncbi The fundamentals of clinical discovery
    Jonathan Rees
    University of Edinburgh, Lauriston Place, UK
    Perspect Biol Med 47:597-607. 2004
    ..I suggest that much medical research is best viewed as a form of engineering rather than science, and that the knowledge base and research funding for the amelioration of disease needs to be much more broadly based than at present...
  6. ncbi Pruritus: more scratch than itch
    J L Rees
    Department of Dermatology, University of Newcastle upon Tyne, UK
    Clin Exp Dermatol 24:490-3. 1999
    ..Recent advances in two areas that may prove relevant are discussed: new technological improvements in movement meters and compatible software; and some recently described animal models...
  7. pmc The problem with academic medicine: engineering our way into and out of the mess
    Jonathan Rees
    Department of Dermatology, University of Edinburgh, United Kingdom
    PLoS Med 2:e111. 2005
  8. ncbi Plenty new under the sun
    Jonathan Rees
    Department of Dermatology, University of Edinburgh, Edinburgh United Kingdom
    J Invest Dermatol 126:1691-2. 2006
    ..What remains unclear are the mechanisms linking gene variation with sun sensitivity or tumor risk. In particular, it remains unclear whether pigmentary effects of the MC1R can account for all of the increase in cancer risk...
  9. ncbi Casting light on evidence
    Jonathan L Rees
    Department of Dermatology, University of Edinburgh, Edinburgh, United Kingdom
    J Invest Dermatol 127:1570-1. 2007
    ..Nor should they. In a new RCT, Kirke and colleagues have compared the therapeutic effects of different types of UVB radiation on clearance of psoriasis. Their study is unlikely to be the last word on this topic...
  10. pmc Melanoma: what are the gaps in our knowledge
    Jonathan L Rees
    University of Edinburgh, Edinburgh, United Kingdom
    PLoS Med 5:e122. 2008
  11. doi Evidence and the industrialization of medicine
    J L Rees
    Department of Dermatology, University of Edinburgh, Edinburgh, UK
    Clin Exp Dermatol 33:390-3. 2008
    ..How we can formally combine evidence from different traditions is, despite the claims of the evidence-based medicine movement, as yet unresolved...
  12. doi Vexed by red-headed conundrums
    Jonathan L Rees
    Department of Dermatology, University of Edinburgh, Edinburgh, UK
    J Invest Dermatol 130:1771-3. 2010
    ..describe their use of mouse transgenics to demonstrate that the MC1R signaling pathway influences cancer risk via mechanisms in addition to pigmentation...
  13. pmc The genetics of sun sensitivity in humans
    Jonathan L Rees
    Systems Group, Dermatology, University of Edinburgh, Edinburgh, United Kingdom
    Am J Hum Genet 75:739-51. 2004
    ..Thus, a single locus, identified within a Mendelian framework, can contribute significantly to human pigmentary variation...
  14. ncbi Clinical science: time for a new contract
    Jonathan Rees
    University of Edinburgh
    Clin Med 2:423-5. 2002
    ..If academic medicine is to continue to be attractive to the brightest and most interesting minds institutional change is unavoidable...
  15. ncbi The melanocortin 1 receptor (MC1R): more than just red hair
    J L Rees
    University of Edinburgh, Royal Infirmary, United Kingdom
    Pigment Cell Res 13:135-40. 2000
    ..Whether this conclusion is as a result of weakness in the statistical testing procedures applied, or whether it will be seen in other pigment genes will be of great interest for studies of human skin colour evolution...
  16. ncbi Post-genome integrative biology: so that's what they call clinical science
    J Rees
    University of Edinburgh, Royal Infirmary
    Clin Med 1:393-400. 2001
    ..We need to think more about disease and less about genes; more in the clinic and less in the laboratory...
  17. ncbi Trials, evidence, and the management of patients with psoriasis
    Jonathan L Rees
    University of Edinburgh, United Kingdom
    J Am Acad Dermatol 48:135-43. 2003
  18. ncbi Complex disease and the new clinical sciences
    Jonathan Rees
    Systems Group, Department of Dermatology, University of Edinburgh, The Lauriston Building, Lauriston Place, Edinburgh EH3 9YW, UK
    Science 296:698-700. 2002
    ..At the same time, clinical discovery and patient-oriented research have become less common. Here, I suggest that these developments are interdependent, each representing the flip side of an inaccurate view of how clinical advance occurs...
  19. ncbi The photoadaptive response to ultraviolet exposure in human skin using ultraviolet spectrophotometry
    Alison Hennessy
    Department of Dermatology, University of Edinburgh, Edinburgh EH3 9HA, UK
    Photodermatol Photoimmunol Photomed 21:229-33. 2005
    ..The purpose of this study was to estimate independently these changes occurring in the epidermis following repeated exposure to UV in two groups with differing degrees of constitutive pigmentation...
  20. ncbi DNA repair gene polymorphisms and genetic predisposition to cutaneous melanoma
    Joanne E Povey
    Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Carcinogenesis 28:1087-93. 2007
    ..88, P = 0.005). The products of the two NER genes, ERCC1 and XPF, where associations with melanoma were found, act together in a rate-limiting step in the repair pathway...
  21. ncbi Itching for progress
    J Rees
    Dermatology, University of Edinburgh, Edinburgh, UK
    Clin Exp Dermatol 30:471-3. 2005
    ....
  22. ncbi Depth data improves skin lesion segmentation
    Xiang Li
    School of Informatics, University of Edinburgh, UK
    Med Image Comput Comput Assist Interv 12:1100-7. 2009
    ..The experiments show that our proposed method integrating chromatic and geometric information produces segmentation results for pigmented lesions close to dermatologists and more consistent and accurate results for non-pigmented lesions...
  23. ncbi P for probability and p for p53
    Jonathan Rees
    Department of Dermatology, University of Edinburgh, Edinburgh, UK
    J Invest Dermatol 121:xii-xiii. 2003
  24. ncbi Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation
    Alison Hennessy
    Department of Dermatology, University of Edinburgh, UK
    Pigment Cell Res 18:220-3. 2005
    ..Although our numbers are small, our results extend previous work in man, and lead us to speculate that factors other than the amount of pheomelanin may be important in determining UVR susceptibility in persons with red hair...
  25. ncbi Variation in skin thickness may explain some of the within-person variation in ultraviolet radiation-induced erythema at different body sites
    Karen Waterston
    J Invest Dermatol 124:1078. 2005
  26. ncbi Quantitative measures of the effect of the melanocortin 1 receptor on human pigmentary status
    Lisa Naysmith
    Systems Group, Dermatology, University of Edinburgh, Edinburgh, UK
    J Invest Dermatol 122:423-8. 2004
    ....
  27. ncbi Genetics of hair and skin color
    Jonathan L Rees
    Systems Group, Dermatology, University of Edinburgh, Lauriston Buildings, Lauriston Place, Edinburgh, EH3 9YW, United Kingdom
    Annu Rev Genet 37:67-90. 2003
    ..It is argued that given advances in model systems, increases in technical facility, and the lower cost of genotype assessment, the lack of standardized phenotype assessment is now a major limit on advance...
  28. ncbi Impact of homozygosity of R151C variant of MC1r in human hair follicle melanocytes
    St├ęphane F Commo
    J Invest Dermatol 128:1319-22. 2008
  29. ncbi The relationship between constitutive pigmentation and sensitivity to ultraviolet radiation induced erythema is dose-dependent
    Thomas Ha
    Department of Dermatology, University of Edinburgh, Edinburgh, UK
    Pigment Cell Res 16:477-9. 2003
    ..14 and 0.17 respectively. The proportion of variation explained is also greater at higher UVR challenge doses. Studies relating UVR sensitivity and pigmentation need to take account of the dose of UVR administered...
  30. ncbi Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair
    Aneta Ringholm
    Department of Neuroscience, Division of Pharmacology, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 123:917-23. 2004
    ..The results provide important pharmacological characterization of common MC1 receptor variants in various world populations...
  31. ncbi Red hair--a desirable mutation?
    Thomas Ha
    Department of Dermatology, University of Edinburgh, Edinburgh, UK
    J Cosmet Dermatol 1:62-5. 2002
    ..This paper reviews the path of discovery of the MC1R in control of animal coat colour, the subsequent role of MC1R in human physiology and possibly wider role of MC1R in human skin carcinogenesis and human development through history...
  32. ncbi Phenotypic expression of melanocortin-1 receptor mutations in Black Jamaicans
    Colin A McKenzie
    Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica
    J Invest Dermatol 121:207-8. 2003
  33. ncbi The time course of photoadaptation and pigmentation studied using a novel method to distinguish pigmentation from erythema
    Carol Oh
    Systems Group, Dermatology, University of Edinburgh, Edinburgh, UK
    J Invest Dermatol 123:965-72. 2004
    ..For comparison we also document overall photoadaptation and relate changes in pigmentation to the overall changes in photoadaptation...
  34. ncbi Time course of ultraviolet B-induced erythema in people with red hair harbouring homozygous melanocortin 1 receptor mutations
    Thomas K K Ha
    Systems Group, Dermatology, University of Edinburgh, Edinburgh, UK
    Exp Dermatol 12:514-7. 2003
    ..We could detect no consistent differences in ultraviolet radiation-induced erythema between the groups studied. The pharmacological mechanisms underpinning such prolonged inflammatory responses merit further investigation...
  35. ncbi Ultraviolet radiation sensitivity in vitiligo and adjacent normal skin
    Carol Oh
    Acta Derm Venereol 86:380. 2006
  36. ncbi The usefulness of 4-amino-3-hydroxyphenylalanine as a specific marker of pheomelanin
    Kazumasa Wakamatsu
    Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 15:225-32. 2002
    ..Thus, we conclude that 'specific AHP' is a more specific marker of pheomelanin than is 'total AHP'...
  37. ncbi No association between p53 codon 72 polymorphisms and erythemal response
    Claire Manson
    J Invest Dermatol 122:1334-5. 2004
  38. ncbi The development of an objective method for measuring scratch in children with atopic dermatitis suitable for clinical use
    Kenneth Benjamin
    Systems Group, Department of Dermatology, The University of Edinburgh, Lauriston, UK
    J Am Acad Dermatol 50:33-40. 2004
    ..Accelerometers provide a useful and practical way of assessing scratching at night in the patient's own home and could be used as an objective measure of disease activity both in clinical trials and in everyday clinical practice...
  39. ncbi Two cultures?
    Jonathan L Rees
    Department of Dermatology, University of Edinburgh, United Kingdom
    J Am Acad Dermatol 46:313-6. 2002