Christopher W G Redman

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Immunology of pre-eclampsia
    Christopher W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Am J Reprod Immunol 63:534-43. 2010
  2. doi request reprint IFPA Senior Award Lecture: Making sense of pre-eclampsia - Two placental causes of preeclampsia?
    C W Redman
    The John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom Electronic address
    Placenta 35:S20-5. 2014
  3. doi request reprint Placental stress and pre-eclampsia: a revised view
    C W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Placenta 30:S38-42. 2009
  4. pmc The endoplasmic reticulum stress of placental impoverishment
    Christopher W G Redman
    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Am J Pathol 173:311-4. 2008
  5. doi request reprint Circulating microparticles in normal pregnancy and pre-eclampsia
    C W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Placenta 29:S73-7. 2008
  6. ncbi request reprint Microparticles and immunomodulation in pregnancy and pre-eclampsia
    C W G Redman
    University of Oxford, Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Reprod Immunol 76:61-7. 2007
  7. ncbi request reprint Latest advances in understanding preeclampsia
    Christopher W Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 308:1592-4. 2005
  8. ncbi request reprint NK cells and human pregnancy--an inflammatory view
    Ian L Sargent
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK, OX3 9DU
    Trends Immunol 27:399-404. 2006
  9. pmc RhoE is regulated by cyclic AMP and promotes fusion of human BeWo choriocarcinoma cells
    Gavin P Collett
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e30453. 2012
  10. ncbi request reprint Membrane trafficking of CD98 and its ligand galectin 3 in BeWo cells--implication for placental cell fusion
    Paola Dalton
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    FEBS J 274:2715-27. 2007

Collaborators

Detail Information

Publications27

  1. doi request reprint Immunology of pre-eclampsia
    Christopher W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Am J Reprod Immunol 63:534-43. 2010
    ..For the first time, the pathogenesis of pre-eclampsia can be related to defined immune mechanisms that are appropriate to the fetomaternal frontier. Now, the challenge is to prove the detail...
  2. doi request reprint IFPA Senior Award Lecture: Making sense of pre-eclampsia - Two placental causes of preeclampsia?
    C W Redman
    The John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom Electronic address
    Placenta 35:S20-5. 2014
    ..It also implies that all pregnant women may be destined to get pre-eclampsia but spontaneous or induced delivery averts this outcome in most instances. ..
  3. doi request reprint Placental stress and pre-eclampsia: a revised view
    C W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Placenta 30:S38-42. 2009
    ..These may also contribute to the final inflammatory syndrome. We propose a modified version of the two-stage model for pre-eclampsia...
  4. pmc The endoplasmic reticulum stress of placental impoverishment
    Christopher W G Redman
    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Am J Pathol 173:311-4. 2008
  5. doi request reprint Circulating microparticles in normal pregnancy and pre-eclampsia
    C W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Placenta 29:S73-7. 2008
    ..However inhibitory activity has also been ascribed to trophoblast derived exosomes. In vitro, they down-regulate T cell activity, a T cell change that has been repeatedly observed, ex vivo, during normal pregnancy...
  6. ncbi request reprint Microparticles and immunomodulation in pregnancy and pre-eclampsia
    C W G Redman
    University of Oxford, Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Reprod Immunol 76:61-7. 2007
    ..Deletion of activate T cells which express Fas ligand by Fas-expressing exosomes derived from trophoblast may contribute to immunoregulation necessary for normal pregnancy...
  7. ncbi request reprint Latest advances in understanding preeclampsia
    Christopher W Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 308:1592-4. 2005
    ..This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings...
  8. ncbi request reprint NK cells and human pregnancy--an inflammatory view
    Ian L Sargent
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK, OX3 9DU
    Trends Immunol 27:399-404. 2006
    ..We suggest novel ways in which the trophoblast might stimulate the maternal systemic inflammatory response, and how dysfunctional NK-cell activation could result in the maternal syndrome of pre-eclampsia...
  9. pmc RhoE is regulated by cyclic AMP and promotes fusion of human BeWo choriocarcinoma cells
    Gavin P Collett
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e30453. 2012
    ....
  10. ncbi request reprint Membrane trafficking of CD98 and its ligand galectin 3 in BeWo cells--implication for placental cell fusion
    Paola Dalton
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    FEBS J 274:2715-27. 2007
    ....
  11. ncbi request reprint Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line
    Paola Dalton
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Biochim Biophys Acta 1768:401-10. 2007
    ..The results thus suggest that the function of CD98 in cell fusion is distinct from its role in cellular nutrient delivery...
  12. pmc Detection of soluble ST2 in human follicular fluid and luteinized granulosa cells
    Jennifer H Southcombe
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e74385. 2013
    ..01). These embryos were transferred to the patient and levels of FF sST2 compared between successful and unsuccessful ICSI cycles. However unlike G-CSF, sST2 levels cannot be used to predict cycle outcome...
  13. doi request reprint Multicolor flow cytometry and nanoparticle tracking analysis of extracellular vesicles in the plasma of normal pregnant and pre-eclamptic women
    Rebecca A Dragovic
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3 Women s Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Biol Reprod 89:151. 2013
    ..In general, EVs were elevated in pregnancy plasma apart from platelet EVs, which were reduced. These studies did not show any differences in EVs between NormP and PE, probably because late-onset PE was studied. ..
  14. pmc Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
    Rebecca A Dragovic
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Nanomedicine 7:780-8. 2011
    ..By combining NTA with fluorescence measurement we have demonstrated that vesicles can be labeled with specific antibody-conjugated quantum dots, allowing their phenotype to be determined...
  15. ncbi request reprint Preeclampsia and the systemic inflammatory response
    Christopher W G Redman
    Department of Obstetric Medicine, University of Oxford, Oxford, UK
    Semin Nephrol 24:565-70. 2004
    ..The clinical implications of these concepts are discussed...
  16. ncbi request reprint Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells
    Angela M Borzychowski
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 35:3054-63. 2005
    ..001 and p <0.01, respectively) and pre-eclamptic women (p <0.05). These results confirm that immunoregulation occurs in pregnancy, but suggest a dominant role of the innate rather than the adaptive immune system...
  17. pmc Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity
    Chris Gardiner
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3, Women s Centre, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 6:e26313. 2011
    ..It is caused by the placenta, which sheds increased amounts of syncytiotrophoblast microvesicles (STBM) into the maternal circulation. We hypothesized that STBM could contribute to the haemostatic activation observed in pre-eclampsia...
  18. pmc Downregulation of caveolin-1 enhances fusion of human BeWo choriocarcinoma cells
    Gavin P Collett
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e10529. 2010
    ..Caveolin-1 has been shown to be expressed in human villous cytotrophoblast and to be downregulated during fusion into syncytiotrophoblast but it is unclear whether it plays a role in this process...
  19. pmc ST2 and IL-33 in pregnancy and pre-eclampsia
    Ingrid Granne
    Oxford Fertility Unit, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e24463. 2011
    ..These results suggest that sST2 may play a significant role in pregnancies complicated by pre-eclampsia and increased sST2 could contribute to the type 1 bias seen in this disorder...
  20. ncbi request reprint Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia
    Yoshiki Kudo
    Department of Human Anatomy and Genetics, University of Oxford, United Kingdom
    Am J Obstet Gynecol 188:719-26. 2003
    ..Therefore, we studied tryptophan metabolism in pregnant women, with or without preeclampsia, as well as expression and function of placental indoleamine 2,3-dioxygenase...
  21. ncbi request reprint Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles
    Sarah J Germain
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 178:5949-56. 2007
    ..Circulating STBMs bind to monocytes and stimulate the production of inflammatory cytokines. It is concluded that they are potential contributors to altered systemic inflammatory responsiveness in pregnancy and pre-eclampsia...
  22. ncbi request reprint Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom
    Margaret P Rayman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom
    Am J Obstet Gynecol 189:1343-9. 2003
    ....
  23. ncbi request reprint Preeclampsia with abnormal liver function tests is associated with cholestasis in a subgroup of cases
    Dimitrios G Goulis
    Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, London, UK
    Hypertens Pregnancy 23:19-27. 2004
    ..To investigate whether women with preeclampsia and abnormal liver function tests have raised serum bile acids...
  24. doi request reprint Detection and identification of novel metabolomic biomarkers in preeclampsia
    Louise C Kenny
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Reprod Sci 15:591-7. 2008
    ..The identity of these metabolites provides new insights into the pathology of this condition and raises the possibility of the development of a predictive test...
  25. doi request reprint Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system
    Warwick B Dunn
    Manchester Centre for Integrative Systems Biology, School of Chemistry, The Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 871:288-98. 2008
    ..The data were used to indicate possible biomarkers of pre-eclampsia and showed both the instruments and XCMS to be applicable to the reproducible and valid detection of disease biomarkers present in serum...
  26. pmc Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
    ..In light of our findings, reproductive success may have been a factor in the evolution and maintenance of human HLA-C and KIR polymorphisms...
  27. ncbi request reprint Abnormal iron parameters in the pregnancy syndrome preeclampsia
    Margaret P Rayman
    School of Biomedical and Life Sciences, University of Surrey, Guildford, United Kongdom
    Am J Obstet Gynecol 187:412-8. 2002
    ..Our purpose was to investigate iron status parameters in preeclampsia with a view to exploring their possible contribution to the etiology...