Research Topics
| P RedgraveSummaryAffiliation: University of Sheffield Country: UK Publications
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Detail Information
Publications
Functional properties of the basal ganglia's re-entrant loop architecture: selection and reinforcementP Redgrave
Neuroscience Research Unit, Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
Neuroscience 198:138-51. 2011..We suggest that this mechanism may be better suited to ensure the prioritisation of inputs associated with reward...
The short-latency dopamine signal: a role in discovering novel actions?Peter Redgrave
Neuroscience Research Unit, Department of Psychology, University of Sheffield, Sheffield, S10 2TP, UK
Nat Rev Neurosci 7:967-75. 2006....- What is reinforced by phasic dopamine signals?Peter Redgrave
Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK
Brain Res Rev 58:322-39. 2008..Furthermore, DA-promoted repetition of preceding actions/movements should enable the system to converge on those aspects of context and behavioural output that lead to the discovery of novel actions... - Brainstem interactions with the basal gangliaPeter Redgrave
Department of Psychology, University of Sheffield, Sheffield, S10 2TP, UK
Parkinsonism Relat Disord 13:S301-5. 2007..The potential functions of the basal ganglia network are then considered together along with resulting insights that may help our understanding of Parkinson's disease and other basal ganglia-related disorders... 
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's diseasePeter Redgrave
Neuroscience Research Unit, Department of Psychology, University of Sheffield, UK
Nat Rev Neurosci 11:760-72. 2010..Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action...- Nociceptive neurones in rat superior colliculus. II. Effects of lesions to the contralateral descending output pathway on nocifensive behavioursP Redgrave
Department of Psychology, University of Sheffield, UK
Exp Brain Res 109:197-208. 1996..These data suggest that, under certain behavioural circumstances, nociceptive information from the SC is integral to the elaboration of orienting and approach movements of the head and mouth elicited by persistent noxious stimuli... - Nociceptive neurones in rat superior colliculus. I. Antidromic activation from the contralateral predorsal bundleP Redgrave
Department of Psychology, University of Sheffield, UK
Exp Brain Res 109:185-96. 1996..Nociceptive neurones could, therefore, effect orientation responses to noxious stimuli via similar output pathways that low-threshold neurones utilize to initiate orientation to innocuous stimuli... - Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortexJ Berwick
Department of Psychology, University of Sheffield, Sheffield S10 2TN, UK
J Neurophysiol 99:787-98. 2008..quot; These data confirm hemodynamics are capable of providing accurate "single-condition" maps of neural activity... - Neurovascular coupling investigated with two-dimensional optical imaging spectroscopy in rat whisker barrel cortexJ Berwick
Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TP, UK
Eur J Neurosci 22:1655-66. 2005..There was also a consistent increase in Hbr from arterial regions after whisker stimulation... - Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular couplingLuke Boorman
Department of Psychology, University of Sheffield, Sheffield S10 2TN, United Kingdom
J Neurosci 30:4285-94. 2010..Since a similar type of neural suppression in surround regions was associated with a negative BOLD signal, the increased levels of suppression in positive BOLD regions could importantly moderate the size of the observed BOLD response... - How visual stimuli activate dopaminergic neurons at short latencyEleanor Dommett
Department of Psychology, University of Sheffield, Sheffield, S10 2TP, UK
Science 307:1476-9. 2005..As the primary source of visual afferents, the limited processing capacities of the colliculus may constrain the visual information content of phasic DA responses... - Nociceptive responses of midbrain dopaminergic neurones are modulated by the superior colliculus in the ratV Coizet
Department of Psychology, University of Sheffield, UK
Neuroscience 139:1479-93. 2006..However, the superior colliculus is unlikely to be the primary source of nociceptive sensory input to the ventral midbrain... - Phasic activation of substantia nigra and the ventral tegmental area by chemical stimulation of the superior colliculus: an electrophysiological investigation in the ratVeronique Coizet
Department of Psychology, University of Sheffield, Sheffield, S10 2TP, UK
Eur J Neurosci 17:28-40. 2003..These data suggest that the SC is in a position to play an important role in discriminating the appropriate stimulus qualities required to activate DA cells at short latency... - A computational model of action selection in the basal ganglia. II. Analysis and simulation of behaviourK Gurney
Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
Biol Cybern 84:411-23. 2001..Third, the behaviour of the model as a signal selection mechanism has parallels with some kinds of action selection observed in animals under various levels of dopaminergic modulation... - Covariant maturation of nocifensive oral behaviour and c-fos expression in rat superior colliculusJ G McHaffie
Department of Psychology, University of Sheffield S10 2TP, UK
Neuroscience 109:597-607. 2002.... - Adverse drug effects following oseltamivir mass treatment and prophylaxis in a school outbreak of 2009 pandemic influenza A(H1N1) in June 2009, Sheffield, United KingdomM Strong
School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom
Euro Surveill 15:pii/19565. 2010.... - Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activityJ E Mayhew
Artificial Intelligence Vision Research Unit, University of Sheffield, United Kingdom
Neuroimage 4:183-93. 1996.... - A robot model of the basal ganglia: behavior and intrinsic processingTony J Prescott
Adaptive Behavior Research Group, Department of Psychology, University of Sheffield, Sheffield, Western Bank, South Yorkshire, Sheffield S10 2TN, UK
Neural Netw 19:31-61. 2006..The model is shown to cast light on recent neurobiological findings concerning behavioral switching and sequencing... - The hemodynamic impulse response to a single neural eventJohn Martindale
Psychology Department, University of Sheffield, Western Bank Sheffield, UK
J Cereb Blood Flow Metab 23:546-55. 2003..The model provided an excellent fit to the empirical data. The implications of these results for modeling schemes and for physiologic systems coupling neural and hemodynamic activity are discussed... - Altered neurovascular coupling during information-processing statesMyles Jones
The Centre for Signal Processing in Neuroimaging and Systems Neuroscience, Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TP, UK
Eur J Neurosci 27:2758-72. 2008..These data suggest that there may be differences in stimulus-evoked neural activity and accompanying haemodynamics during different information-processing states... - Nonlinear coupling of neural activity and CBF in rodent barrel cortexMyles Jones
Neural Imaging Research Unit, Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TP, UK
Neuroimage 22:956-65. 2004..These results show that care must be exercised when interpreting imaging data elicited by particularly strong or weak stimuli and that hemodynamic changes may better reflect the input to a region rather than its spiking output... - Collateralization of the tectonigral projection with other major output pathways of superior colliculus in the ratVeronique Coizet
Neuroscience Research Unit, Department of Psychology, University of Sheffield, Sheffield, S10 2TP, UK
J Comp Neurol 500:1034-49. 2007.... - A computational model of action selection in the basal ganglia. I. A new functional anatomyK Gurney
Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
Biol Cybern 84:401-10. 2001..The model contrasts with the prevailing functional segregation of basal ganglia into 'direct' and 'indirect' pathways... - Integration of neural responses originating from different regions of the cortical somatosensory mapJ Berwick
Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TP, UK
Brain Res 1030:284-93. 2004..Furthermore, the longer latency of the inhibition following stimulation of the contralateral forepaw suggests the possible involvement of extracortical circuitry... - Differential expression of fos-like immunoreactivity in the descending projections of superior colliculus after electrical stimulation in the ratS M King
Department of Psychology, University of Sheffield, UK
Behav Brain Res 78:131-45. 1996..However, given the total lack of expression in a pathway which is known to be activated, it also provides further evidence that c-fos cannot simply be used as a high resolution neuronal activity marker for mapping functional pathways... - Hemodynamic response in the unanesthetized rat: intrinsic optical imaging and spectroscopy of the barrel cortexJason Berwick
Department of Psychology and Artificial Intelligence Vision Research Unit, University of Sheffield, Western Bank, Sheffield, UK
J Cereb Blood Flow Metab 22:670-9. 2002..This work represents a step in the development of an experimental model that can be used to investigate fundamental neurologic processes in the awake-behaving rodent... - A direct projection from superior colliculus to substantia nigra for detecting salient visual eventsEliane Comoli
Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
Nat Neurosci 6:974-80. 2003..We conclude that it is within this afferent sensory circuitry that the critical perceptual discriminations that identify stimuli as both unpredicted and biologically salient are made... - Computational models of the basal ganglia: from robots to membranesKevin Gurney
Adaptive Behaviour Research Group, Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
Trends Neurosci 27:453-9. 2004..We identify distinct modelling strategies that can deliver important and complementary insights into the nature of problems the basal ganglia have evolved to solve, and describe methods that are used to solve them... - Testing computational hypotheses of brain systems function: a case study with the basal gangliaK N Gurney
Adaptive Behaviour Research Group, Department of Psychology, University of Sheffield, S10 2TP, UK
Network 15:263-90. 2004..The realistically constrained models show a selection benefit, while control models show a decrement in selection ability. These results, taken together, provide further validation of our selection hypothesis of basal ganglia function... - N-methyl D-aspartate (NMDA) evoked changes in blood pressure and heart rate from the rat superior colliculusK A Keay
Department of Psychology, University of Sheffield, U K
Exp Brain Res 80:148-56. 1990..The question of whether the rostromedial SC might represent an early link in the circuitry responsible for organizing defensive movements and appropriate physiological changes to potentially dangerous overhead stimuli is considered... - Optical imaging spectroscopy in the unanaesthetised ratChris Martin
Artificial Intelligence Vision Research Unit, Department of Psychology, University of Sheffield, Western Bank, S10 2TP, Sheffield, UK
J Neurosci Methods 120:25-34. 2002..This preparation may make possible the investigation of the haemodynamic correlates of a broad range of neurological processes in the awake, behaving rodent... - Short-latency visual input to the subthalamic nucleus is provided by the midbrain superior colliculusVeronique Coizet
Department of Psychology, University of Sheffield, Sheffield S10 2TP, United Kingdom
J Neurosci 29:5701-9. 2009.... - Empirically inspired simulated electro-mechanical model of the rat mystacial follicle-sinus complexBen Mitchinson
Adaptive Behaviour Research Group, Department of Psychology, The University of Sheffield, Sheffield S10 2TP, UK
Proc Biol Sci 271:2509-16. 2004..The agreement was good enough to suggest that the model captures many of the key features of the peripheral whisker system in the rat... - Subcortical loops through the basal gangliaJohn G McHaffie
Wake Forest University School of Medicine, Department of Neurobiology and Anatomy, Medical Center Boulevard, Winston-Salem NC 27157-1010, USA
Trends Neurosci 28:401-7. 2005.... - Anatomical evidence for an anticonvulsant relay in the rat ventromedial medullaSafa Shehab
Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, UAE
Eur J Neurosci 22:1431-44. 2005.... - Pharmacological evidence for an anticonvulsant relay in the rat ventromedial medullaSafa Shehab
Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, UAE
Eur J Neurosci 26:2585-94. 2007..Together these data establish the final functional link connecting brainstem anticonvulsant circuitry with reticulospinal systems controlling hindlimb musculature... - Dopamine neurones form a discrete plexus with melanopsin cells in normal and degenerating retinaAnthony A Vugler
Division of Cellular Therapy, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
Exp Neurol 205:26-35. 2007....