Research Topics
Genomes and GenesSpecies | K RazaSummaryAffiliation: University of Birmingham Country: UK Publications
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Publications
Timing the therapeutic window of opportunity in early rheumatoid arthritis: proposal for definitions of disease duration in clinical trialsKarim Raza
Division of Immunity and Infection, Rheumatology Research Group, University of Birmingham, Birmingham B15 2TT, UK
Ann Rheum Dis 71:1921-3. 2012....
Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse eventsParesh Jobanputra
Department of Rheumatology, Selly Oak Hospital, University Hospital Birmingham NHS Foundation Trust, Raddlebarn Road, Birmingham, B29 6JD, UK
BMC Musculoskelet Disord 9:48. 2008..We report an investigation from a local surveillance for serious adverse drug reactions associated with disease modifying anti-rheumatic drugs that was triggered by the occurrence of liver failure in two of our patients...- The relationship between the presence of anti-cyclic citrullinated peptide antibodies and clinical phenotype in very early rheumatoid arthritisMohammed Z Cader
MRC Centre for Immune Regulation, School of Immunity and Infection, The University of Birmingham, Birmingham, UK
BMC Musculoskelet Disord 11:187. 2010..The aim of this study was to establish whether the clinical phenotypes of anti-CCP positive and negative disease are distinct at the earliest clinically apparent phase of disease... 
Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammationRowan S Hardy
Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham Medical School, Birmingham, UK
Arthritis Res Ther 8:R108. 2006....- Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expressionLeigh D Church
Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Arthritis Res Ther 12:R184. 2010.... - Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalphaGreg Parsonage
Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
Arthritis Res Ther 10:R47. 2008..We therefore tested the hypothesis that synovial fibroblasts bridge the biological responses that connect TH17 cells to neutrophils by producing neutrophil survival factors following their activation with IL-17... - Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritisKarim Raza
MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
Arthritis Res Ther 8:R120. 2006..g. IL-2, IL-4, IL-15 GMCSF, GCSF). It is likely that this process contributes to an accumulation of leukocytes in the early rheumatoid lesion and is involved in the development of the microenvironment required for persistent RA... - Treating very early rheumatoid arthritisKarim Raza
Rheumatology Research Group, Division of Immunity and Infection, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK
Best Pract Res Clin Rheumatol 20:849-63. 2006..The rationale for, and approaches to, treatment within this very early window are discussed... - The Michael Mason prize: early rheumatoid arthritis--the window narrowsKarim Raza
School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK
Rheumatology (Oxford) 49:406-10. 2010..Effective public engagement, to reduce this delay, is the key to translate advances in the fields of pathology, prognostication and therapy into benefit for patients with new onset RA... - Predicting the development of RA in patients with early undifferentiated arthritisKarim Raza
Rheumatology Research Group, Division of Immunity and Infection, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
Best Pract Res Clin Rheumatol 23:25-36. 2009.... - The influence of ethnicity on the extent of, and reasons underlying, delay in general practitioner consultation in patients with RAKanta Kumar
Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, UK
Rheumatology (Oxford) 49:1005-12. 2010..The influence of ethnicity on delay in assessment has not been addressed. We studied the extent of delay in patients of South Asian origin compared with other patients and the reasons underlying this delay... - The 11beta-hydroxysteroid dehydrogenase enzymes--arbiters of the effects of glucocorticoids in synovium and boneKarim Raza
MRC Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
Rheumatology (Oxford) 49:2016-23. 2010..This article reviews recent findings in this area that highlight the role of these enzymes in rheumatic diseases... - Delays in assessment of patients with rheumatoid arthritis: variations across EuropeKarim Raza
Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Ann Rheum Dis 70:1822-5. 2011..The first 3 months after symptom onset represent an important therapeutic window for rheumatoid arthritis (RA). This study investigates the extent and causes of delay in assessment of patients with RA in eight European countries... 
Suppression of inflammation in primary systemic vasculitis restores vascular endothelial function: lessons for atherosclerotic disease?K Raza
Department of Rheumatology, University of Birmingham, Birmingham, UK
Circulation 102:1470-2. 2000..Our hypothesis that vasculitis results in arteriosclerosis by causing vascular endothelial dysfunction was tested in patients with primary systemic necrotizing vasculitis (SNV)...- Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell originKarim Raza
MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
Arthritis Res Ther 7:R784-95. 2005..The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA... - Ultrasound guidance allows accurate needle placement and aspiration from small joints in patients with early inflammatory arthritisK Raza
MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham B15 2TT, UK
Rheumatology (Oxford) 42:976-9. 2003..To compare the accuracy of palpation-guided and high frequency ultrasound-guided needle placement in small joints and to develop a technique to obtain synovial fluid from these joints for diagnosis and research... - Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritisKarim Raza
MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
J Rheumatol 32:231-8. 2005..To study the prognostic value of antibodies to cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF), alone and in combination, in patients with very early synovitis... - Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophilsAndrew Filer
MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Arthritis Rheum 54:2096-108. 2006..The findings also provide a potential explanation for site-specific differences in the pattern of T cell and neutrophil accumulation observed in chronic inflammatory diseases... - Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluidS H Wong
Rheumatology Research Group, MRC Centre for Immune Regulation, Institute of Biomedical Research, Birmingham University, Birmingham, UK
Rheumatology (Oxford) 48:39-44. 2009..This study set out to determine whether lactoferrin can delay neutrophil apoptosis and could act as a survival factor for neutrophils in SF... - Beliefs about medicines in patients with rheumatoid arthritis and systemic lupus erythematosus: a comparison between patients of South Asian and White British originK Kumar
Rheumatology Research Group, Division of Immunity and Infection, The University of Birmingham, Birmingham B15 2TT, UK
Rheumatology (Oxford) 47:690-7. 2008..To assess whether patients with RA and SLE who are of South Asian origin have different beliefs about medicines in general, and about DMARDs in particular, compared with patients of White British/Irish origin... - Delay in presentation to primary care physicians is the main reason why patients with rheumatoid arthritis are seen late by rheumatologistsK Kumar
Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, The University of Birmingham, Birmingham B15 2TT, UK
Rheumatology (Oxford) 46:1438-40. 2007..To study the delay from the time of symptom onset to assessment by a Rheumatologist in patients with rheumatoid arthritis (RA) and to determine the contributions of patient and physician dependent factors to this delay... - Infliximab leads to a rapid but transient improvement in endothelial function in patients with primary systemic vasculitisK Raza
Rheumatology Research Group, Division of Immunity and Infection, The Medical School, The University of Birmingham, and Department of Rheumatology, City Hospital, UK
Ann Rheum Dis 65:946-8. 2006..CONCLUSION: The rapid but transient improvement in EDV after TNFalpha inhibition suggests that TNFalpha may have a direct role in the impairment of endothelial function... - Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone lossK Kaur
Endocrinology, School of Clinical and Experimental Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
Ann Rheum Dis 69:1185-90. 2010..During inflammatory arthritis synovium and bone are exposed to both these factors. This study hypothesised that glucocorticoids magnify the effects of inflammatory cytokines on local glucocorticoid production in both synovium and bone... - Diffuse endothelial dysfunction is common to ANCA associated systemic vasculitis and polyarteritis nodosaA D Filer
Department of Rheumatology, University of Birmingham, UK
Ann Rheum Dis 62:162-7. 2003..It has previously been shown that such endothelial cell dysfunction (ECD) occurring in the brachial artery can complicate primary systemic necrotising vasculitis (SNV)... - 'I just thought it was normal aches and pains': a qualitative study of decision-making processes in patients with early rheumatoid arthritisJ Sheppard
Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, UK
Rheumatology (Oxford) 47:1577-82. 2008..However, many patients delay for prolonged periods before seeking medical advice. This study explores factors influencing the decision to seek medical advice in RA patients... - Local and systemic glucocorticoid metabolism in inflammatory arthritisR Hardy
Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
Ann Rheum Dis 67:1204-10. 2008..Isolated, primary synovial fibroblasts generate active glucocorticoids through expression of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). This enzyme produces cortisol from inactive cortisone (and prednisolone from prednisone)... - 'It's like taking poison to kill poison but I have to get better': a qualitative study of beliefs about medicines in Rheumatoid arthritis and Systemic lupus erythematosus patients of South Asian originK Kumar
School of Immunity and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK
Lupus 20:837-44. 2011..Beliefs about the causes of disease had an important impact on the way some patients viewed medicines for RA and SLE. This will have implications for educational programmes designed to promote patient involvement in disease management... - The role of chemokines in leucocyte-stromal interactions in rheumatoid arthritisAndrew Filer
Rheumatology Research Group, MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
Front Biosci 13:2674-85. 2008..However an intriguing role of stromal cells has been demonstrated in the inappropriate expression of constitutive, housekeeping chemokines, which contribute to the persistence of inflammation by actively blocking its resolution... - Impaired endothelial function in systemic lupus erythematosusM K Piper
Department of Rheumatology, University of Birmingham, UK
Lupus 16:84-8. 2007..There was no relationship between endothelial function and the development of damage in any organ system, including the cardiovascular system during patient follow-up. Patients with SLE have impaired endothelial Lupus (2007) 16, 84-88... - Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitisAndrew Filer
Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, Institute for Biomedical Research, The University of Birmingham, Birmingham B15 2TT, UK
Ann Rheum Dis 70:500-7. 2011..This study evaluated musculoskeletal ultrasound, a sensitive tool for the detection of synovitis and erosions, as a predictor of outcome in very early synovitis... - Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathwaysAndrew Filer
University of Birmingham, Division of Immunity and Infection, Birmingham, UK
Arthritis Rheum 60:1604-14. 2009..This study was undertaken to investigate the hypothesis that galectin 3 induces proinflammatory effects in RA by modulating the pattern of cytokine and chemokine production in synovial fibroblasts... - Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signalingS John Curnow
Department of Rheumatology, Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, Medical School, The University of Birmingham, UK
J Immunol 173:5290-7. 2004..However, combinations of IL-6 and soluble IL-6R were highly effective inhibitors of T cell apoptosis, suggesting that the trans-signaling pathway is likely to be a key mediator of T cell apoptosis inhibition mediated by uveitis AqH... - Experience with a Punjabi, Urdu and Hindi rheumatology telephone helplineKanta Kumar
Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
Musculoskeletal Care 7:210-8. 2009.... - Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosisDagmar Scheel-Toellner
MRC Centre of Immune Regulation, Division of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Apoptosis 13:109-17. 2008..We conclude that these two intracellular pools of Bcl-2 are regulated through different mechanisms and only the cytokine-mediated regulation of the mitochondrial pool is relevant to the control of the initiation of apoptosis... - Breaking communication barriers for RA patients of South Asian origin: the use of a bilingual educational audio CD and linguistically appropriate peer support and educationKanta Kumar
Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
Musculoskeletal Care 9:11-8. 2011..Patient education resources are required to address language barriers, poor literacy and (potentially discordant) cultural beliefs. We have investigated a novel strategy to meet this need... - Endothelial cells, fibroblasts and vasculitisChristopher D Buckley
Department of Rheumatology, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK
Rheumatology (Oxford) 44:860-3. 2005..It may also underlie the accelerated atherosclerosis seen in other immune-mediated rheumatic diseases, such as rheumatoid arthritis... - A regional audit of the prevention and treatment of corticosteroid-induced osteoporosis in patients with rheumatic diseases in the West MidlandsN Erb
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, The Guest Hospital, Tipton Road, Dudley, West Midlands DY1 4SE, UK
Rheumatology (Oxford) 41:1021-4. 2002..The Committee plan to re-audit in 2 yr... - The role of endothelial cell dysfunction in the cardiovascular mortality of RAP A Bacon
University of Birmingham, Faculty of Medicine, Department of Rheumatology and Cardiology, Edgbaston, Birmingham B15 2TT, United Kingdom
Int Rev Immunol 21:1-17. 2002.... - 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3Louisa E Jeffery
Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
J Immunol 183:5458-67. 2009..Our results suggest that 1,25(OH)(2)D(3) and IL-2 have direct synergistic effects on activated T cells, acting as potent anti-inflammatory agents and physiologic inducers of adaptive regulatory T cells... - Targeting stromal cells in chronic inflammationAndrew Filer
Rheumatology Research Group, MRC Center for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
Discov Med 7:20-6. 2007..Therapeutic manipulation of the stromal microenvironment has been particularly effective in treating cancer and is likely to provide novel therapies to achieve improved control of chronic inflammatory disease... - Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid jointLakhvir K Assi
Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Arthritis Rheum 56:1776-86. 2007..This study was undertaken to investigate the expression of BLyS and regulation of BLyS release from the surface of neutrophils infiltrating the rheumatoid joint... - The assessment of T-cell apoptosis in synovial fluidKarim Raza
MRC Centre for Immune Regulation, Institute for Biomedical Research Building, University of Birmingham, UK
Methods Mol Med 136:117-38. 2007..The choice of assay depends, in part, on the phase of apoptosis under investigation and this review puts this into context by introducing these phases and their regulation... - The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosisD Scheel-Toellner
MRC Centre for Immune Regulation, Birmingham University Medical School, Birmingham B15 2TT, UK
Biochem Biophys Res Commun 297:876-9. 2002..We conclude that formation of the DISC occurs in lipid rafts and that these membrane microdomains are required for efficient Fas signalling and apoptosis... - Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohortMohammed Z Cader
Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
Ann Rheum Dis 70:949-55. 2011..This study therefore assesses the performance of these new criteria in patients with early synovitis... - Reversing myocardial microvascular disease in a patient with rheumatoid arthritisKarim Raza
MRC Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, UK
J Rheumatol 32:754-6. 2005..This may be an important determinant of cardiovascular outcome in RA, and this case indicated that it can be reversed with immunosuppression... - Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: moving toward individualized treatment decision-makingAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 58:2241-7. 2008..Recently, a prediction rule was developed to estimate the chance of progression to RA in individual patients presenting with UA. This study investigates the accuracy of this prediction rule in independent cohorts of patients with UA... - Annexin-1 modulates T-cell activation and differentiationFulvio D'Acquisto
William Harvey Research Institute, Bart s and The London, Queen Mary School of Medicine and Dentistry, UK
Blood 109:1095-102. 2007....