K Raza

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis
    Rowan Hardy
    Arthritis Res Ther 14:R226. 2012
  2. doi request reprint Timing the therapeutic window of opportunity in early rheumatoid arthritis: proposal for definitions of disease duration in clinical trials
    Karim Raza
    Division of Immunity and Infection, Rheumatology Research Group, University of Birmingham, Birmingham B15 2TT, UK
    Ann Rheum Dis 71:1921-3. 2012
  3. pmc Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events
    Paresh Jobanputra
    Department of Rheumatology, Selly Oak Hospital, University Hospital Birmingham NHS Foundation Trust, Raddlebarn Road, Birmingham, B29 6JD, UK
    BMC Musculoskelet Disord 9:48. 2008
  4. pmc The relationship between the presence of anti-cyclic citrullinated peptide antibodies and clinical phenotype in very early rheumatoid arthritis
    Mohammed Z Cader
    MRC Centre for Immune Regulation, School of Immunity and Infection, The University of Birmingham, Birmingham, UK
    BMC Musculoskelet Disord 11:187. 2010
  5. pmc Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation
    Rowan S Hardy
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham Medical School, Birmingham, UK
    Arthritis Res Ther 8:R108. 2006
  6. pmc Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression
    Leigh D Church
    Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Arthritis Res Ther 12:R184. 2010
  7. pmc Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha
    Greg Parsonage
    Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
    Arthritis Res Ther 10:R47. 2008
  8. ncbi request reprint Suppression of inflammation in primary systemic vasculitis restores vascular endothelial function: lessons for atherosclerotic disease?
    K Raza
    Department of Rheumatology, University of Birmingham, Birmingham, UK
    Circulation 102:1470-2. 2000
  9. pmc Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis
    Karim Raza
    MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
    Arthritis Res Ther 8:R120. 2006
  10. pmc Treating very early rheumatoid arthritis
    Karim Raza
    Rheumatology Research Group, Division of Immunity and Infection, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK
    Best Pract Res Clin Rheumatol 20:849-63. 2006

Collaborators

Detail Information

Publications49

  1. pmc Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis
    Rowan Hardy
    Arthritis Res Ther 14:R226. 2012
    ..Consequently, the links between synovial inflammation, altered Wnt signalling and bone remodelling are not direct but are dependent on local activation of endogenous glucocorticoids...
  2. doi request reprint Timing the therapeutic window of opportunity in early rheumatoid arthritis: proposal for definitions of disease duration in clinical trials
    Karim Raza
    Division of Immunity and Infection, Rheumatology Research Group, University of Birmingham, Birmingham B15 2TT, UK
    Ann Rheum Dis 71:1921-3. 2012
    ....
  3. pmc Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events
    Paresh Jobanputra
    Department of Rheumatology, Selly Oak Hospital, University Hospital Birmingham NHS Foundation Trust, Raddlebarn Road, Birmingham, B29 6JD, UK
    BMC Musculoskelet Disord 9:48. 2008
    ..We report an investigation from a local surveillance for serious adverse drug reactions associated with disease modifying anti-rheumatic drugs that was triggered by the occurrence of liver failure in two of our patients...
  4. pmc The relationship between the presence of anti-cyclic citrullinated peptide antibodies and clinical phenotype in very early rheumatoid arthritis
    Mohammed Z Cader
    MRC Centre for Immune Regulation, School of Immunity and Infection, The University of Birmingham, Birmingham, UK
    BMC Musculoskelet Disord 11:187. 2010
    ..The aim of this study was to establish whether the clinical phenotypes of anti-CCP positive and negative disease are distinct at the earliest clinically apparent phase of disease...
  5. pmc Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation
    Rowan S Hardy
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham Medical School, Birmingham, UK
    Arthritis Res Ther 8:R108. 2006
    ....
  6. pmc Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression
    Leigh D Church
    Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Arthritis Res Ther 12:R184. 2010
    ....
  7. pmc Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha
    Greg Parsonage
    Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
    Arthritis Res Ther 10:R47. 2008
    ..We therefore tested the hypothesis that synovial fibroblasts bridge the biological responses that connect TH17 cells to neutrophils by producing neutrophil survival factors following their activation with IL-17...
  8. ncbi request reprint Suppression of inflammation in primary systemic vasculitis restores vascular endothelial function: lessons for atherosclerotic disease?
    K Raza
    Department of Rheumatology, University of Birmingham, Birmingham, UK
    Circulation 102:1470-2. 2000
    ..Our hypothesis that vasculitis results in arteriosclerosis by causing vascular endothelial dysfunction was tested in patients with primary systemic necrotizing vasculitis (SNV)...
  9. pmc Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis
    Karim Raza
    MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
    Arthritis Res Ther 8:R120. 2006
    ..g. IL-2, IL-4, IL-15 GMCSF, GCSF). It is likely that this process contributes to an accumulation of leukocytes in the early rheumatoid lesion and is involved in the development of the microenvironment required for persistent RA...
  10. pmc Treating very early rheumatoid arthritis
    Karim Raza
    Rheumatology Research Group, Division of Immunity and Infection, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK
    Best Pract Res Clin Rheumatol 20:849-63. 2006
    ..The rationale for, and approaches to, treatment within this very early window are discussed...
  11. doi request reprint Predicting the development of RA in patients with early undifferentiated arthritis
    Karim Raza
    Rheumatology Research Group, Division of Immunity and Infection, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Best Pract Res Clin Rheumatol 23:25-36. 2009
    ....
  12. doi request reprint The Michael Mason prize: early rheumatoid arthritis--the window narrows
    Karim Raza
    School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 49:406-10. 2010
    ..Effective public engagement, to reduce this delay, is the key to translate advances in the fields of pathology, prognostication and therapy into benefit for patients with new onset RA...
  13. doi request reprint The influence of ethnicity on the extent of, and reasons underlying, delay in general practitioner consultation in patients with RA
    Kanta Kumar
    Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, UK
    Rheumatology (Oxford) 49:1005-12. 2010
    ..The influence of ethnicity on delay in assessment has not been addressed. We studied the extent of delay in patients of South Asian origin compared with other patients and the reasons underlying this delay...
  14. pmc Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin
    Karim Raza
    MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
    Arthritis Res Ther 7:R784-95. 2005
    ..The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA...
  15. doi request reprint The 11beta-hydroxysteroid dehydrogenase enzymes--arbiters of the effects of glucocorticoids in synovium and bone
    Karim Raza
    MRC Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
    Rheumatology (Oxford) 49:2016-23. 2010
    ..This article reviews recent findings in this area that highlight the role of these enzymes in rheumatic diseases...
  16. pmc Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis
    Karim Raza
    MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
    J Rheumatol 32:231-8. 2005
    ..To study the prognostic value of antibodies to cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF), alone and in combination, in patients with very early synovitis...
  17. ncbi request reprint Ultrasound guidance allows accurate needle placement and aspiration from small joints in patients with early inflammatory arthritis
    K Raza
    MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 42:976-9. 2003
    ..To compare the accuracy of palpation-guided and high frequency ultrasound-guided needle placement in small joints and to develop a technique to obtain synovial fluid from these joints for diagnosis and research...
  18. doi request reprint Delays in assessment of patients with rheumatoid arthritis: variations across Europe
    Karim Raza
    Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Ann Rheum Dis 70:1822-5. 2011
    ..The first 3 months after symptom onset represent an important therapeutic window for rheumatoid arthritis (RA). This study investigates the extent and causes of delay in assessment of patients with RA in eight European countries...
  19. pmc Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils
    Andrew Filer
    MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Arthritis Rheum 54:2096-108. 2006
    ....
  20. doi request reprint Beliefs about medicines in patients with rheumatoid arthritis and systemic lupus erythematosus: a comparison between patients of South Asian and White British origin
    K Kumar
    Rheumatology Research Group, Division of Immunity and Infection, The University of Birmingham, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 47:690-7. 2008
    ..To assess whether patients with RA and SLE who are of South Asian origin have different beliefs about medicines in general, and about DMARDs in particular, compared with patients of White British/Irish origin...
  21. pmc Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid
    S H Wong
    Rheumatology Research Group, MRC Centre for Immune Regulation, Institute of Biomedical Research, Birmingham University, Birmingham, UK
    Rheumatology (Oxford) 48:39-44. 2009
    ..This study set out to determine whether lactoferrin can delay neutrophil apoptosis and could act as a survival factor for neutrophils in SF...
  22. ncbi request reprint Delay in presentation to primary care physicians is the main reason why patients with rheumatoid arthritis are seen late by rheumatologists
    K Kumar
    Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, The University of Birmingham, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 46:1438-40. 2007
    ..To study the delay from the time of symptom onset to assessment by a Rheumatologist in patients with rheumatoid arthritis (RA) and to determine the contributions of patient and physician dependent factors to this delay...
  23. pmc Diffuse endothelial dysfunction is common to ANCA associated systemic vasculitis and polyarteritis nodosa
    A D Filer
    Department of Rheumatology, University of Birmingham, UK
    Ann Rheum Dis 62:162-7. 2003
    ..It has previously been shown that such endothelial cell dysfunction (ECD) occurring in the brachial artery can complicate primary systemic necrotising vasculitis (SNV)...
  24. pmc Infliximab leads to a rapid but transient improvement in endothelial function in patients with primary systemic vasculitis
    K Raza
    Rheumatology Research Group, Division of Immunity and Infection, The Medical School, The University of Birmingham, and Department of Rheumatology, City Hospital, UK
    Ann Rheum Dis 65:946-8. 2006
    ..To assess the immediate effects of tumour necrosis factor alpha (TNFalpha) blockade on endothelial function in systemic vasculitis...
  25. pmc Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss
    K Kaur
    Endocrinology, School of Clinical and Experimental Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Ann Rheum Dis 69:1185-90. 2010
    ..During inflammatory arthritis synovium and bone are exposed to both these factors. This study hypothesised that glucocorticoids magnify the effects of inflammatory cytokines on local glucocorticoid production in both synovium and bone...
  26. doi request reprint 'I just thought it was normal aches and pains': a qualitative study of decision-making processes in patients with early rheumatoid arthritis
    J Sheppard
    Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, UK
    Rheumatology (Oxford) 47:1577-82. 2008
    ..However, many patients delay for prolonged periods before seeking medical advice. This study explores factors influencing the decision to seek medical advice in RA patients...
  27. doi request reprint 'It's like taking poison to kill poison but I have to get better': a qualitative study of beliefs about medicines in Rheumatoid arthritis and Systemic lupus erythematosus patients of South Asian origin
    K Kumar
    School of Immunity and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK
    Lupus 20:837-44. 2011
    ..To investigate factors that influence beliefs about medicines in patients of South Asian origin with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)...
  28. pmc Local and systemic glucocorticoid metabolism in inflammatory arthritis
    R Hardy
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Ann Rheum Dis 67:1204-10. 2008
    ..Isolated, primary synovial fibroblasts generate active glucocorticoids through expression of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). This enzyme produces cortisol from inactive cortisone (and prednisolone from prednisone)...
  29. pmc The role of chemokines in leucocyte-stromal interactions in rheumatoid arthritis
    Andrew Filer
    Rheumatology Research Group, MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
    Front Biosci 13:2674-85. 2008
    ..However an intriguing role of stromal cells has been demonstrated in the inappropriate expression of constitutive, housekeeping chemokines, which contribute to the persistence of inflammation by actively blocking its resolution...
  30. ncbi request reprint Impaired endothelial function in systemic lupus erythematosus
    M K Piper
    Department of Rheumatology, University of Birmingham, UK
    Lupus 16:84-8. 2007
    ..There was no relationship between endothelial function and the development of damage in any organ system, including the cardiovascular system during patient follow-up. Patients with SLE have impaired endothelial Lupus (2007) 16, 84-88...
  31. pmc Endothelial cells, fibroblasts and vasculitis
    Christopher D Buckley
    Department of Rheumatology, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 44:860-3. 2005
    ..It may also underlie the accelerated atherosclerosis seen in other immune-mediated rheumatic diseases, such as rheumatoid arthritis...
  32. pmc Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis
    Dagmar Scheel-Toellner
    MRC Centre of Immune Regulation, Division of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Apoptosis 13:109-17. 2008
    ..We conclude that these two intracellular pools of Bcl-2 are regulated through different mechanisms and only the cytokine-mediated regulation of the mitochondrial pool is relevant to the control of the initiation of apoptosis...
  33. ncbi request reprint Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling
    S John Curnow
    Department of Rheumatology, Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, Medical School, The University of Birmingham, UK
    J Immunol 173:5290-7. 2004
    ..However, combinations of IL-6 and soluble IL-6R were highly effective inhibitors of T cell apoptosis, suggesting that the trans-signaling pathway is likely to be a key mediator of T cell apoptosis inhibition mediated by uveitis AqH...
  34. doi request reprint Breaking communication barriers for RA patients of South Asian origin: the use of a bilingual educational audio CD and linguistically appropriate peer support and education
    Kanta Kumar
    Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
    Musculoskeletal Care 9:11-8. 2011
    ..Patient education resources are required to address language barriers, poor literacy and (potentially discordant) cultural beliefs. We have investigated a novel strategy to meet this need...
  35. pmc Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis
    Andrew Filer
    Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, Institute for Biomedical Research, The University of Birmingham, Birmingham B15 2TT, UK
    Ann Rheum Dis 70:500-7. 2011
    ..This study evaluated musculoskeletal ultrasound, a sensitive tool for the detection of synovitis and erosions, as a predictor of outcome in very early synovitis...
  36. pmc Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways
    Andrew Filer
    University of Birmingham, Division of Immunity and Infection, Birmingham, UK
    Arthritis Rheum 60:1604-14. 2009
    ..This study was undertaken to investigate the hypothesis that galectin 3 induces proinflammatory effects in RA by modulating the pattern of cytokine and chemokine production in synovial fibroblasts...
  37. doi request reprint Experience with a Punjabi, Urdu and Hindi rheumatology telephone helpline
    Kanta Kumar
    Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
    Musculoskeletal Care 7:210-8. 2009
    ....
  38. ncbi request reprint The role of endothelial cell dysfunction in the cardiovascular mortality of RA
    P A Bacon
    University of Birmingham, Faculty of Medicine, Department of Rheumatology and Cardiology, Edgbaston, Birmingham B15 2TT, United Kingdom
    Int Rev Immunol 21:1-17. 2002
    ....
  39. ncbi request reprint A regional audit of the prevention and treatment of corticosteroid-induced osteoporosis in patients with rheumatic diseases in the West Midlands
    N Erb
    Department of Rheumatology, Dudley Group of Hospitals NHS Trust, The Guest Hospital, Tipton Road, Dudley, West Midlands DY1 4SE, UK
    Rheumatology (Oxford) 41:1021-4. 2002
    ..This audit assessed the prevention and management of corticosteroid-induced osteoporosis (CIOP)...
  40. pmc Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint
    Lakhvir K Assi
    Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Arthritis Rheum 56:1776-86. 2007
    ..This study was undertaken to investigate the expression of BLyS and regulation of BLyS release from the surface of neutrophils infiltrating the rheumatoid joint...
  41. pmc 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3
    Louisa E Jeffery
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 183:5458-67. 2009
    ..Our results suggest that 1,25(OH)(2)D(3) and IL-2 have direct synergistic effects on activated T cells, acting as potent anti-inflammatory agents and physiologic inducers of adaptive regulatory T cells...
  42. pmc Targeting stromal cells in chronic inflammation
    Andrew Filer
    Rheumatology Research Group, MRC Center for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Discov Med 7:20-6. 2007
    ..Therapeutic manipulation of the stromal microenvironment has been particularly effective in treating cancer and is likely to provide novel therapies to achieve improved control of chronic inflammatory disease...
  43. doi request reprint A1.53 A novel pro-inflammatory B cell population in the rheumatoid synovium can be identified by expression of FCRL4
    L Yeo
    Rheumatology Research Group, University of Birmingham, UK
    Ann Rheum Dis 73:A22-3. 2014
    ..FcRL4+ and FcRL4- CD19(+) B cells were sorted from synovial fluid using a MoFlo cell sorter. mRNA expression of 48 cytokines was determined using Taqman microfluidic cards...
  44. ncbi request reprint The assessment of T-cell apoptosis in synovial fluid
    Karim Raza
    MRC Centre for Immune Regulation, Institute for Biomedical Research Building, University of Birmingham, UK
    Methods Mol Med 136:117-38. 2007
    ..The choice of assay depends, in part, on the phase of apoptosis under investigation and this review puts this into context by introducing these phases and their regulation...
  45. ncbi request reprint The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis
    D Scheel-Toellner
    MRC Centre for Immune Regulation, Birmingham University Medical School, Birmingham B15 2TT, UK
    Biochem Biophys Res Commun 297:876-9. 2002
    ..We conclude that formation of the DISC occurs in lipid rafts and that these membrane microdomains are required for efficient Fas signalling and apoptosis...
  46. doi request reprint Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohort
    Mohammed Z Cader
    Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
    Ann Rheum Dis 70:949-55. 2011
    ..This study therefore assesses the performance of these new criteria in patients with early synovitis...
  47. ncbi request reprint Reversing myocardial microvascular disease in a patient with rheumatoid arthritis
    Karim Raza
    MRC Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, UK
    J Rheumatol 32:754-6. 2005
    ..This may be an important determinant of cardiovascular outcome in RA, and this case indicated that it can be reversed with immunosuppression...
  48. doi request reprint Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: moving toward individualized treatment decision-making
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:2241-7. 2008
    ..Recently, a prediction rule was developed to estimate the chance of progression to RA in individual patients presenting with UA. This study investigates the accuracy of this prediction rule in independent cohorts of patients with UA...
  49. pmc Annexin-1 modulates T-cell activation and differentiation
    Fulvio D'Acquisto
    William Harvey Research Institute, Bart s and The London, Queen Mary School of Medicine and Dentistry, UK
    Blood 109:1095-102. 2007
    ....