David W Ray
Affiliation: University of Manchester
Hand L, Usán P, Cooper G, Xu L, Ammori B, Cunningham P, et al
. Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit. Diabetes. 2015;64:128-36 pubmed publisher
..The findings identify A20 as a mediator of adiponectin anti-inflammatory action in WAT and a potential target for mitigating obesity-related pathology. ..
Poolman T, Gibbs J, Walker A, Dickson S, Farrell L, Hensman J, et al
. Rheumatoid arthritis reprograms circadian output pathways. Arthritis Res Ther. 2019;21:47 pubmed publisher
..Circadian reprogramming in response to chronic inflammation has implications for inflammatory co-morbidities and time-of-day therapeutics. ..
Ray D. Circadian biology: rhythms leave their imprint. Curr Biol. 2015;25:R201-3 pubmed publisher
Matthews L, Berry A, Morgan D, Poolman T, Bauer K, Kramer F, et al
. Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy. Proc Natl Acad Sci U S A. 2015;112:5479-84 pubmed publisher
..We therefore reveal an unexpected role for the GR in promoting accurate chromosome segregation during mitosis, which is causally linked to tumorigenesis, making GR an authentic tumor suppressor gene. ..
Ptushkina M, Poolman T, Iqbal M, Ashe M, Petersen J, Woodburn J, et al
. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Sci Rep. 2017;7:12101 pubmed publisher
..This suggests that in organisms where GR is natively expressed, GR likely contributes to stress responses through non-transcriptional mechanisms in addition to its well-established transcriptional responses. ..