Emma L Rawlins
Affiliation: University of Cambridge
Nikolić M, Sun D, Rawlins E. Human lung development: recent progress and new challenges. Development. 2018;145: pubmed publisher
..Together, these approaches are helping to shed light on the mechanisms underlying human lung development and disease, and may help pave the way for new therapies. ..
Watson J, Rulands S, Wilkinson A, Wuidart A, Ousset M, Van Keymeulen A, et al
. Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium. Cell Rep. 2015;12:90-101 pubmed publisher
..Additionally, we show that self-renewal of short-lived secretory cells is a feature of homeostasis. We have thus revealed early luminal commitment of cells that are morphologically indistinguishable from stem cells. ..
Lee J, Rawlins E. Developmental mechanisms and adult stem cells for therapeutic lung regeneration. Dev Biol. 2018;433:166-176 pubmed publisher
..We discuss the normal endogenous processes of lung development, homeostatic maintenance and repair and consider the research strategies required for the development of methods for human therapeutic lung regeneration. ..
Johnson J, Watson J, Nikolić M, Rawlins E. Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Biol Open. 2018;7: pubmed publisher
..This article has an associated First Person interview with the first author of the paper. ..
Balasooriya G, Johnson J, Basson M, Rawlins E. An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. Dev Cell. 2016;37:85-97 pubmed publisher
..We now demonstrate an in vivo biological function of this interaction and thus identify an active signaling mechanism that maintains quiescence in the airway epithelium. ..
Laresgoiti U, Nikolić M, Rao C, Brady J, Richardson R, Batchen E, et al
. Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate. Development. 2016;143:3686-3699 pubmed
..Further elucidation of these pathways might provide therapeutic opportunities for restoring alveolar capacity. ..
Balasooriya G, Goschorska M, Piddini E, Rawlins E. FGFR2 is required for airway basal cell self-renewal and terminal differentiation. Development. 2017;144:1600-1606 pubmed publisher
..This heterozygous phenotype illustrates that subtle changes in receptor tyrosine kinase signalling can have significant effects, perhaps providing an explanation for the numerous changes seen in cancer. ..