Lakshminarayan R Ranganath

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Recent advances in management of alkaptonuria (invited review; best practice article)
    Lakshminarayan R Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Liverpool, UK
    J Clin Pathol 66:367-73. 2013
  2. ncbi request reprint Homocysteine and thiol metabolites in vitamin B12 deficiency
    L R Ranganath
    Department of Chemical Pathology, Epsom General Hospital, Epsom, Surrey KT18 7EG, UK
    Clin Sci (Lond) 100:111-6. 2001
  3. ncbi request reprint Nutrient regulation of post-heparin lipoprotein lipase activity in obese subjects
    L R Ranganath
    Department of Chemical Pathology, Epsom General Hospital, Surrey, UK
    Horm Metab Res 33:57-61. 2001
  4. ncbi request reprint The entero-insular axis: implications for human metabolism
    Lakshminarayan R Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Clin Chem Lab Med 46:43-56. 2008
  5. doi request reprint Incretins: pathophysiological and therapeutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1
    L R Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    J Clin Pathol 61:401-9. 2008
  6. doi request reprint Biochemical diagnosis of placental infarction/damage: acutely rising alkaline phosphatase
    L Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Liverpool, UK
    Ann Clin Biochem 45:335-8. 2008
  7. doi request reprint Natural history of alkaptonuria revisited: analyses based on scoring systems
    Lakshminarayan R Ranganath
    Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK
    J Inherit Metab Dis 34:1141-51. 2011
  8. doi request reprint Identification of alkaptonuria in the general population: a United Kingdom experience describing the challenges, possible solutions and persistent barriers
    L Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    J Inherit Metab Dis 34:723-30. 2011
  9. doi request reprint Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone
    Andrew J Preston
    Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, Bone and Joint Research Group, University of Liverpool, Liverpool, UK
    Ann Rheum Dis 73:284-9. 2014
  10. doi request reprint Cardiovascular manifestations of Alkaptonuria
    Stephen J Pettit
    Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK
    J Inherit Metab Dis 34:1177-81. 2011

Collaborators

Detail Information

Publications12

  1. doi request reprint Recent advances in management of alkaptonuria (invited review; best practice article)
    Lakshminarayan R Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Liverpool, UK
    J Clin Pathol 66:367-73. 2013
    ..Improved laboratory diagnostics to monitor the tyrosine metabolic pathway that includes plasma metabolites including tyrosine to monitor efficacy, toxicity and safety postnitisinone will also be required...
  2. ncbi request reprint Homocysteine and thiol metabolites in vitamin B12 deficiency
    L R Ranganath
    Department of Chemical Pathology, Epsom General Hospital, Epsom, Surrey KT18 7EG, UK
    Clin Sci (Lond) 100:111-6. 2001
    ..Elevated homocysteine levels directly or indirectly may up-regulate GPx. Sulphation status, as measured by plasma DHEAS, was unchanged...
  3. ncbi request reprint Nutrient regulation of post-heparin lipoprotein lipase activity in obese subjects
    L R Ranganath
    Department of Chemical Pathology, Epsom General Hospital, Surrey, UK
    Horm Metab Res 33:57-61. 2001
    ..65, p < 0.02). Intraluminal lipoprotein lipase activity is not increased in established obesity. Fat and carbohydrate nutrients may affect LPL activity differently in lean and obese subjects...
  4. ncbi request reprint The entero-insular axis: implications for human metabolism
    Lakshminarayan R Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Clin Chem Lab Med 46:43-56. 2008
    ..The potential therapeutic role in non-diabetic states, including obesity and neurodegenerative disease, is intriguing and depends upon results from ongoing research...
  5. doi request reprint Incretins: pathophysiological and therapeutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1
    L R Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    J Clin Pathol 61:401-9. 2008
    ..The use of incretins as therapeutic agents offers a new approach to the treatment of T2D...
  6. doi request reprint Biochemical diagnosis of placental infarction/damage: acutely rising alkaline phosphatase
    L Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Liverpool, UK
    Ann Clin Biochem 45:335-8. 2008
    ..The fall in hCG is also consistent with the placental damage being acute and critical. As far as we are aware this is the first description of changes in circulating proteins reflecting placental damage...
  7. doi request reprint Natural history of alkaptonuria revisited: analyses based on scoring systems
    Lakshminarayan R Ranganath
    Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK
    J Inherit Metab Dis 34:1141-51. 2011
    ....
  8. doi request reprint Identification of alkaptonuria in the general population: a United Kingdom experience describing the challenges, possible solutions and persistent barriers
    L Ranganath
    Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    J Inherit Metab Dis 34:723-30. 2011
    ..Mere identification, however, does not always lead to full engagement for epidemiological research purposes or targeting treatment since further barriers exist...
  9. doi request reprint Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone
    Andrew J Preston
    Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, Bone and Joint Research Group, University of Liverpool, Liverpool, UK
    Ann Rheum Dis 73:284-9. 2014
    ..Over time HGA is progressively deposited as a polymer (termed ochronotic pigment) in collagenous tissues, especially the cartilages of weight bearing joints, leading to severe joint disease...
  10. doi request reprint Cardiovascular manifestations of Alkaptonuria
    Stephen J Pettit
    Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK
    J Inherit Metab Dis 34:1177-81. 2011
    ..These findings are important for the clinical follow-up of patients with alkaptonuria and suggest a role for echocardiographic surveillance of patients above 40 years old...
  11. doi request reprint Development of an in vitro model to investigate joint ochronosis in alkaptonuria
    Laura Tinti
    Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3GE, UK
    Rheumatology (Oxford) 50:271-7. 2011
    ..Pigmentation is progressive over many years, leading to CTDs including severe arthropathies. To investigate the mechanism of pigmentation and to determine how it leads to arthropathy, we aimed to develop an in vitro model of ochronosis...
  12. doi request reprint Alkaptonuria--a review of surgical and autopsy pathology
    T R Helliwell
    Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool, UK
    Histopathology 53:503-12. 2008
    ..Pigmentation of the aortic and mitral valve cusps and valve rings is a result of intracellular and extracellular pigment deposition and is associated with calcification and clinically significant aortic stenosis...