Harpal S Randeva

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. pmc Insulin and metformin regulate circulating and adipose tissue chemerin
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, U K
    Diabetes 58:1971-7. 2009
  2. ncbi request reprint Possible role of NUCB2/nesfatin-1 in adipogenesis
    Manjunath Ramanjaneya
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Curr Pharm Des 19:6976-80. 2013
  3. pmc Cardiometabolic aspects of the polycystic ovary syndrome
    Harpal S Randeva
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Endocr Rev 33:812-41. 2012
  4. pmc Microvesicle-mediated release of soluble LH/hCG receptor (LHCGR) from transfected cells and placenta explants
    Anne E Chambers
    Department of Clinical Biochemistry, Laboratory Medicine, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
    Reprod Biol Endocrinol 9:64. 2011
  5. doi request reprint Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 57:1501-7. 2008
  6. doi request reprint Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cardiovasc Res 83:566-74. 2009
  7. doi request reprint The signalling profile of recombinant human orexin-2 receptor
    Jiyou Tang
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cell Signal 20:1651-61. 2008
  8. pmc Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome
    Bee K Tan
    Edocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 59:3023-31. 2010
  9. doi request reprint Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B
    Manjunath Ramanjaneya
    Warwick Medical School, Warwick University, Gibbet Hill Road, Coventry, UK
    J Endocrinol 202:249-61. 2009
  10. doi request reprint In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    Endocrinology 150:3530-9. 2009

Collaborators

Detail Information

Publications57

  1. pmc Insulin and metformin regulate circulating and adipose tissue chemerin
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, U K
    Diabetes 58:1971-7. 2009
    ..To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects...
  2. ncbi request reprint Possible role of NUCB2/nesfatin-1 in adipogenesis
    Manjunath Ramanjaneya
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Curr Pharm Des 19:6976-80. 2013
    ..Moreover, we highlight the importance of NUCB2 and nesfatin-1 in adipose tissue, its regulation of adipogenesis and obesity-associated metabolic diseases. ..
  3. pmc Cardiometabolic aspects of the polycystic ovary syndrome
    Harpal S Randeva
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Endocr Rev 33:812-41. 2012
    ..Further insight into this network of factors may facilitate finding therapeutic targets that should ameliorate not only ovarian dysfunction but also the various cardiometabolic alterations related to the syndrome...
  4. pmc Microvesicle-mediated release of soluble LH/hCG receptor (LHCGR) from transfected cells and placenta explants
    Anne E Chambers
    Department of Clinical Biochemistry, Laboratory Medicine, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
    Reprod Biol Endocrinol 9:64. 2011
    ..Similarly cultured human early pregnancy placental explants also released LHCGR via microvesicles. These studies provide the first experimental evidence of the possible mechanistic basis of the secretion of LHCGR...
  5. doi request reprint Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 57:1501-7. 2008
    ..Ex vivo regulation of adipose tissue vaspin and the effects of metformin treatment on circulating vaspin levels in PCOS subjects were also studied...
  6. doi request reprint Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cardiovasc Res 83:566-74. 2009
    ....
  7. doi request reprint The signalling profile of recombinant human orexin-2 receptor
    Jiyou Tang
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cell Signal 20:1651-61. 2008
    ....
  8. pmc Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome
    Bee K Tan
    Edocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 59:3023-31. 2010
    ..Decreased omentin-1 levels are associated with obesity and diabetes. To study the effects of metformin treatment on omentin-1 levels in PCOS subjects and effects of omentin-1 on in vitro migration and angiogenesis...
  9. doi request reprint Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B
    Manjunath Ramanjaneya
    Warwick Medical School, Warwick University, Gibbet Hill Road, Coventry, UK
    J Endocrinol 202:249-61. 2009
    ....
  10. doi request reprint In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    Endocrinology 150:3530-9. 2009
    ..Thus, leptin increases visfatin production in AT in vivo and ex vivo via pathways involving MAPK and phosphatidylinositol 3-kinase signaling. The pleiotropic effects of leptin may be partially mediated by visfatin...
  11. doi request reprint Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity
    Manjunath Ramanjaneya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    Endocrinology 151:3169-80. 2010
    ..05) and showed positive correlation with body mass index in human. We report that nesfatin-1 is a novel depot specific adipokine preferentially produced by sc tissue, with obesity- and food deprivation-regulated expression...
  12. doi request reprint Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose
    Bee K Tan
    MBChB, FRCP, Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Diabetes 57:801-8. 2008
    ..Ex vivo and in vivo regulation of adipose tissue omentin-1 was also studied...
  13. doi request reprint Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome
    Bee K Tan
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 98:E1891-900. 2013
    ..Polycystic ovary syndrome (PCOS) is a proinflammatory state associated with obesity, diabetes, dyslipidemia, and cardiovascular complications...
  14. ncbi request reprint Raised serum, adipocyte, and adipose tissue retinol-binding protein 4 in overweight women with polycystic ovary syndrome: effects of gonadal and adrenal steroids
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 92:2764-72. 2007
    ..Recent studies have shown that serum retinol-binding protein 4 (RBP4) levels increase with obesity. Currently, no data exist on the relative expression of RBP4 in either serum or adipose tissue of PCOS women...
  15. doi request reprint Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: role of AMPK and MAPK kinase pathways
    Manjunath Ramanjaneya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Biochim Biophys Acta 1813:802-9. 2011
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  16. ncbi request reprint Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis
    Raghu Adya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cardiovasc Res 78:356-65. 2008
    ..We therefore investigated the effect of visfatin on vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP-2, MMP-9) production and the potential signalling cascades...
  17. doi request reprint Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis
    Jaspreet Kaur
    Endocrinology and Metabolism Research Group, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK
    Biochem Biophys Res Commun 391:1762-8. 2010
    ..01), key angiogenic and cell survival cascades. Our data provide the first evidence of chemerin-induced endothelial angiogenesis and MMP production and activity...
  18. doi request reprint A novel role for the adipokine visfatin/pre-B cell colony-enhancing factor 1 in prostate carcinogenesis
    Snehal T Patel
    Endocrinology and Metabolism Research Group, University of Warwick Medical School, Coventry, UK
    Peptides 31:51-7. 2010
    ..These data suggest a contributory and multifunctional role for visfatin in prostate cancer progression, with particular relevance and emphasis in an obese population...
  19. pmc Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells
    Manjunath Ramanjaneya
    Warwick Medical School, Warwick University, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Endocrinology 149:4106-15. 2008
    ..This is the first study linking orexin action on StAR expression and comprehensively describes the signaling pathways involved in regulating the complexity of hormone biosynthesis...
  20. ncbi request reprint Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term
    Emmanouil Karteris
    Division of Clinical Science, University of Warwick, Coventry, UK
    Mol Endocrinol 20:1519-34. 2006
    ..Our data indicate the presence of a novel signaling pathway mediated by mPRs that may result in a functional progestin withdrawal, shifting the balance from a quiescent state to one of contraction...
  21. doi request reprint Diurnal variation and effect of insulin on circulating high molecular weight (HMW) adiponectin and NF-κB activity in human endothelial cells
    Bee K Tan
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Atherosclerosis 214:174-7. 2011
    ..To study the diurnal variation and the effect of insulin on adiponectin multimers and nuclear factor-kappaB (NF-κB) activity in human endothelial cells...
  22. pmc Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 60:2758-62. 2011
    ..We sought to investigate the existence of FGF21 in human cerebrospinal fluid (CSF) and, if present, the relationship between CSF FGF21 with body adiposity and metabolic parameters...
  23. doi request reprint Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 96:808-16. 2011
    ..We sought to study the effects of metformin treatment (widely used in the management of PCOS women) on human endometrial adenocarcinoma cells...
  24. doi request reprint Pre-B cell colony enhancing factor (PBEF)/visfatin induces secretion of MCP-1 in human endothelial cells: role in visfatin-induced angiogenesis
    Raghu Adya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
    Atherosclerosis 205:113-9. 2009
    ..We also explored the possible autocrine/paracrine mechanisms governing this potential interaction; specifically we looked at the effect of visfatin on MCP-1's putative receptor (CCR2 receptor) in human endothelial cells...
  25. doi request reprint The anti-atherogenic aspect of metformin treatment in insulin resistant women with the polycystic ovary syndrome: role of the newly established pro-inflammatory adipokine Acute-phase Serum Amyloid A; evidence of an adipose tissue-monocyte axis
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Atherosclerosis 216:402-8. 2011
    ....
  26. doi request reprint Decreased cerebrospinal fluid/plasma ratio of the novel satiety molecule, nesfatin-1/NUCB-2, in obese humans: evidence of nesfatin-1/NUCB-2 resistance and implications for obesity treatment
    Bee K Tan
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 96:E669-73. 2011
    ..The novel adipokine, nesfatin-1/NUCB-2, reduces food intake, levels of which are elevated in overweight individuals...
  27. ncbi request reprint Plasma total homocysteine concentrations in adults with growth hormone (GH) deficiency: effects of GH replacement
    Krzysztof C Lewandowski
    Molecular Medicine Research Group, Biomedical Research Institute, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
    Mol Genet Metab 80:330-7. 2003
    ..Before firm conclusions can be drawn about the contribution of changes in plasma homocysteine concentrations to cardiovascular prognosis in adult GHD patients receiving GH replacement, further controlled studies are required...
  28. doi request reprint QRFP induces aldosterone production via PKC and T-type calcium channel-mediated pathways in human adrenocortical cells: evidence for a novel role of GPR103
    Manjunath Ramanjaneya
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry United Kingdom
    Am J Physiol Endocrinol Metab 305:E1049-58. 2013
    ..These novel data demonstrate that QRFP induces adrenal steroidogenesis in vitro by regulating key steroidogenic enzymes involving MAPK/PKC and Ca(2+) signaling pathways...
  29. ncbi request reprint G-protein coupled estrogen receptor 1 expression in rat and human heart: Protective role during ischaemic stress
    Vanlata H Patel
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Int J Mol Med 26:193-9. 2010
    ..42+/-1.3%). The results suggest that GPER under cardiac stress exerts direct protection in the heart and may serve as a potential therapeutic target for cardiac drug therapy...
  30. doi request reprint Metformin increases the novel adipokine adipolin/CTRP12: role of the AMPK pathway
    Bee K Tan
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    J Endocrinol 219:101-8. 2013
    ..Importantly, metformin's effects appear to be via the AMP-activated protein kinase signaling pathway. ..
  31. pmc Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine, by insulin
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes Care 32:129-31. 2009
    ..Lipocalin-2, a novel adipokine, has been shown to be elevated in obese, insulin-resistant, and diabetic subjects. We therefore sought to study the ex vivo and in vivo effects of insulin on lipocalin-2 levels in humans...
  32. ncbi request reprint Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex
    Emmanouil Karteris
    Biomedical Research Institute, Univ of Warwick, Gibbet Hill Rd, Coventry CV4 7AL, UK
    Am J Physiol Endocrinol Metab 288:E1089-100. 2005
    ..These findings suggest orexins as potential metabolic regulators within the HPA axis both centrally and peripherally...
  33. doi request reprint Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters
    Jing Chen
    Clinical Sciences Research Institute, University of Warwick, Coventry, UK
    Biochem J 427:377-90. 2010
    ....
  34. doi request reprint Protective actions of globular and full-length adiponectin on human endothelial cells: novel insights into adiponectin-induced angiogenesis
    Raghu Adya
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK
    J Vasc Res 49:534-43. 2012
    ..e. matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor (VEGF), in human microvascular endothelial cells (HMEC-1)...
  35. pmc Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts
    Vanlata Patel
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, United Kingdom
    PLoS ONE 9:e87102. 2014
    ..We therefore investigated the direct effect of FGF21 on cardio-protection in obese and lean hearts in response to ischemia...
  36. doi request reprint Leptin and adiponectin interact in the regulation of prostate cancer cell growth via modulation of p53 and bcl-2 expression
    Tina Mistry
    Department of Urology, University Hospital Coventry and Warwickshire, Coventry, UK
    BJU Int 101:1317-22. 2008
    ..To investigate the effects of leptin, full-length adiponectin (fAd) and globular adiponectin (gAd), alone and in combination, on LNCaP and PC3 prostate cancer cell proliferation, and on the expression of p53 and bcl-2 gene expression...
  37. ncbi request reprint Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals
    Harpal S Randeva
    Molecular Medicine Research Group, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
    Circulation 109:2405-10. 2004
    ..We assessed whether GH replacement, in GH-deficient adults, has any effect on plasma levels of MMP-2 and MMP-9 and on vascular endothelial growth factor (VEGF), known to activate MMPs...
  38. doi request reprint Omentin: a novel link between inflammation, diabesity, and cardiovascular disease
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, CV4 7AL Coventry, UK
    Trends Cardiovasc Med 20:143-8. 2010
    ..Thus, omentin may have beneficial effects on the metabolic syndrome and could potentially be used as a biologic marker and/or pharmacologic agent in this respect...
  39. ncbi request reprint Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system
    Emmanouil Karteris
    Biomedical Research Institute, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL
    J Clin Endocrinol Metab 89:1957-62. 2004
    ....
  40. ncbi request reprint Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants
    Jing Chen
    Molecular Medicine Research Group, Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    Mol Endocrinol 18:2790-804. 2004
    ..Moreover, food deprivation led to a greater increase in hypothalamic mOX2 beta R gene expression, compared with both mOX1R and mOX2 alpha R. This potentially implicates a fundamental physiological role for these splice variants...
  41. doi request reprint Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells: its role in MMP-2/9 production and activation
    Raghu Adya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Diabetes Care 31:758-60. 2008
    ..We investigated the activation of nuclear factor-kappaB (NF-kappaB), a well-known proinflammatory transcription factor, by visfatin in endothelial cells...
  42. ncbi request reprint Raised plasma adiponectin levels in type 1 diabetic pregnancies
    Harpal S Randeva
    Molecular Medicine Group, Biological Sciences, University of Warwick, and Metabolic Unit, University Hospitals Coventry and Warwickshire NHS Trust, UK
    Clin Endocrinol (Oxf) 65:17-21. 2006
    ..Adiponectin has antidiabetic properties. Our aim was to determine plasma adiponectin levels during pregnancy and postpartum (PP), in women with type 1 diabetic mellitus (T1DM) and nondiabetic (ND) women...
  43. doi request reprint Elevated concentrations of retinol-binding protein-4 (RBP-4) in gestational diabetes mellitus: negative correlation with soluble vascular cell adhesion molecule-1 (sVCAM-1)
    Krzysztof C Lewandowski
    Warwick Medical School, The University of Warwick, UK
    Gynecol Endocrinol 24:300-5. 2008
    ..There are, however, few data on concentrations of RBP-4 in gestational diabetes mellitus (GDM)...
  44. ncbi request reprint Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome
    Harpal S Randeva
    The Sir Quinton Hazel Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 87:4496-501. 2002
    ..The precise mechanism by which exercise is associated with a reduction in homocysteine remains to be elucidated...
  45. ncbi request reprint Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex vivo effects
    Bee K Tan
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK Department of Obstetrics and Gynaecology, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, UK Department of Endocrinology and Metabolic Diseases, Polish Mother s Memorial Research Institute, The Medical University of Lodz, Lodz, Poland
    J Endocrinol 221:111-9. 2014
    ..05 and P<0.01). This effect was inhibited by the PPARγ antagonist, GW9662 (P<0.05). Our data provide novel insights into adipolin physiology in human subjects. ..
  46. ncbi request reprint Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain
    Jing Chen
    Endocrinology and Metabolism Group, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK
    Brain Res 1103:20-4. 2006
    ..OX2betaR is expressed in detectable levels, with the exception of striatum, midbrain and anterior part of cerebellum/pons. Our novel findings demonstrate the differential expression of OX2R splice variants in the mouse brain...
  47. ncbi request reprint Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin
    Bee K Tan
    Endocrinology and Metabolism Group, Department of Biological Sciences, Warwick Medical School, The University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 91:5022-8. 2006
    ..Recent studies have shown that plasma levels of the insulin-mimetic adipokine visfatin increase with obesity. Currently, no data exist on the relative expression of visfatin in either plasma or adipose tissue of PCOS women...
  48. doi request reprint Role of adipokines in cardiovascular disease
    Harman S Mattu
    Division of Metabolic and Vascular Health, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK
    J Endocrinol 216:T17-36. 2013
    ..The flip side may show contrasting, detrimental effects in aggravating these cardiac parameters...
  49. ncbi request reprint Circadian rhythmicity of salivary leptin in healthy subjects
    Harpal S Randeva
    Molecular Medicine Research Group, Biomedical Research Institute, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    Mol Genet Metab 78:229-35. 2003
    ..Our findings suggest that there may be differential regulation of leptin (salivary) between men and women. Finally, measurement of leptin in saliva is a simple, non-invasive and may be an acceptable alternative to plasma sampling...
  50. pmc High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus
    Rebecca Ilyas
    Clinical Sciences Research Institute, University of Warwick, UK
    Immunobiology 216:126-31. 2011
    ..Mechanisms involve competitive inhibition of carbohydrate binding within sets of defined proteins, in contrast to broadly indiscriminate, irreversible glycation of proteins...
  51. ncbi request reprint Obesity and prostate cancer: a role for adipokines
    Tina Mistry
    Molecular Medicine Research Group, Biomedical Research Institute, University of Warwick Medical School, Coventry, UK
    Eur Urol 52:46-53. 2007
    ..This review provides an overview of current evidence that supports such a role for adipokines...
  52. doi request reprint Thiazolidinediones and the renal and hormonal response to water immersion-induced volume expansion in type 2 diabetes mellitus
    Niru Goenka
    Warwick Medical School, University of Warwick, Coventry, UK
    Am J Physiol Endocrinol Metab 294:E733-9. 2008
    ..This may be related to its effects in increasing natriuretic peptides and restoring the impaired cGMP excretion to volume expansion...
  53. ncbi request reprint Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity
    Nikolleta Papadopoulou
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 18:624-39. 2004
    ..Phosphorylation by PKA prevents maximal coupling of the CRH-R1alpha to Gq-protein, and thereby reduces activation of ERK 1/2...
  54. pmc Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes
    Bee K Tan
    Divisions of Metabolic and Vascular Health and Reproduction, Warwick Medical School, University of Warwick, Coventry, United Kingdom
    PLoS ONE 8:e65254. 2013
    ..We also assessed FGF21 secretion from GDM and control human placental explants...
  55. ncbi request reprint Differential effects of GH replacement on the components of the leptin system in GH-deficient individuals
    Harpal S Randeva
    Sir Quinton Hazel Molecular Medicine Research Center, Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL
    J Clin Endocrinol Metab 87:798-804. 2002
    ..However, the observed changes in free leptin and bound leptin and, more importantly, the rise in soluble leptin receptor, are not explained entirely by modifications in body composition and may be a direct result of GH/IGF-I...
  56. doi request reprint Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation
    Narendra L Reddy
    Clinical Sciences Research Laboratories N L R, T A J, S S, G T, P G M, H S R, S K, C E H, T M B, Warwick Medical School, University of Warwick, and Departments of Medical Physics S C W, Radiology O A, C E H, and Histopathology Y C Y, University Hospitals of Coventry and Warwickshire, Coventry CV2 2DX, United Kingdom
    J Clin Endocrinol Metab 99:E117-21. 2014
    ..The aim of our study was to develop and test a novel magnetic resonance (MR) imaging-based method to identify human BAT, delineate it from white adipose tissue, and validate it through immunohistochemistry...
  57. ncbi request reprint Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia
    Manu Vatish
    Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK
    Trends Mol Med 12:223-33. 2006
    ..Here, we discuss the current knowledge of NO function in the placenta, its hormonal regulation in normal pregnancy and in the pathophysiology of pre-eclampsia, its potential pathogenic mechanisms and possible use as a therapeutic target...