D B Ramsden

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc The aetiology of idiopathic Parkinson's disease
    D B Ramsden
    Department of Medicine, Division of Medical Science, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Pathol 54:369-80. 2001
  2. ncbi request reprint Parkinson's disease: the first common neurological disease due to auto-intoxication?
    A C Williams
    Division of Neurosciences, University of Birmingham, Edgbaston, Birmingham
    QJM 98:215-26. 2005
  3. ncbi request reprint Development of an in vitro model for cysteine dioxygenase expression in the brain
    S Qusti
    School of Biosciences, University of Birmingham, Edgbaston, UK
    Cell Biol Toxicol 16:243-55. 2000
  4. pmc Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene
    D B Ramsden
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK
    Mol Pathol 50:269-71. 1997
  5. ncbi request reprint Cysteine dioxygenase: regional localisation of protein and mRNA in rat brain
    R B Parsons
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    J Neurosci Res 65:78-84. 2001
  6. ncbi request reprint Hepatic localisation of rat cysteine dioxygenase
    R B Parsons
    School of Biochemistry, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK
    J Hepatol 29:595-602. 1998
  7. ncbi request reprint A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol
    M L Smith
    Department of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochim Biophys Acta 1442:238-44. 1998
  8. ncbi request reprint Wide-ranging genomic effects of plasticisers and related compounds
    N Turan
    Department of Medicine, Division of Medical Sciences, The Medical School, University of Birmingham, UK
    Curr Drug Metab 9:285-303. 2008
  9. doi request reprint Detection of endocrine disruptors - from simple assays to whole genome scanning
    E Sung
    School of Biosciences, University of Birmingham, Birmingham, UK
    Int J Androl 35:407-14. 2012
  10. pmc Expression of cysteine dioxygenase (EC 1.13.11.20) and sulfite oxidase in the human lung: a potential role for sulfate production in the protection from airborne xenobiotica
    J Millard
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mol Pathol 56:270-4. 2003

Collaborators

Detail Information

Publications32

  1. pmc The aetiology of idiopathic Parkinson's disease
    D B Ramsden
    Department of Medicine, Division of Medical Science, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Pathol 54:369-80. 2001
    ....
  2. ncbi request reprint Parkinson's disease: the first common neurological disease due to auto-intoxication?
    A C Williams
    Division of Neurosciences, University of Birmingham, Edgbaston, Birmingham
    QJM 98:215-26. 2005
    ..Developing xenobiotic enzyme inhibitors of NNMT for individuals, or dietary modification for the whole population, could be an important change in thinking on primary and secondary prevention...
  3. ncbi request reprint Development of an in vitro model for cysteine dioxygenase expression in the brain
    S Qusti
    School of Biosciences, University of Birmingham, Edgbaston, UK
    Cell Biol Toxicol 16:243-55. 2000
    ..The characterization of an in vitro model for CDO expression provides a useful tool for the investigation of this important enzyme, which may have an etiological role in the pathogenesis of Parkinson's disease...
  4. pmc Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene
    D B Ramsden
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK
    Mol Pathol 50:269-71. 1997
    ..The elucidation of the structure of the 5' flanking region and the exonic organisation of the human cysteine dioxygenase type I gene...
  5. ncbi request reprint Cysteine dioxygenase: regional localisation of protein and mRNA in rat brain
    R B Parsons
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    J Neurosci Res 65:78-84. 2001
    ..CDO expression in the brain may have several possibilities functions, the most likely being the prevention of free radical production by the autoxidation of cysteine and dopamine...
  6. ncbi request reprint Hepatic localisation of rat cysteine dioxygenase
    R B Parsons
    School of Biochemistry, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK
    J Hepatol 29:595-602. 1998
    ..CDO abnormality has been implicated in a number of neurological and non-neurological diseases, with CDO deficiency possibly leading to excitotoxic damage to the brain and impaired Phase II metabolism in the liver...
  7. ncbi request reprint A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol
    M L Smith
    Department of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochim Biophys Acta 1442:238-44. 1998
    ..Thus phenotypic differences in the general population are due to differences in steady-state mRNA levels and not because of a polymorphism in the coding region of the NNMT gene...
  8. ncbi request reprint Wide-ranging genomic effects of plasticisers and related compounds
    N Turan
    Department of Medicine, Division of Medical Sciences, The Medical School, University of Birmingham, UK
    Curr Drug Metab 9:285-303. 2008
    ..CMP treatment caused most increases in mRNA levels. A mixture of DIP and CMP caused fewer changes in mRNA levels than either of the individual compounds...
  9. doi request reprint Detection of endocrine disruptors - from simple assays to whole genome scanning
    E Sung
    School of Biosciences, University of Birmingham, Birmingham, UK
    Int J Androl 35:407-14. 2012
    ..The significance of differential expressed genes was assessed based on gene ontology and pathways analyses using DAVID and GenMaPP programs. The results illustrated the very wide-ranging effects of these chemicals across the genome...
  10. pmc Expression of cysteine dioxygenase (EC 1.13.11.20) and sulfite oxidase in the human lung: a potential role for sulfate production in the protection from airborne xenobiotica
    J Millard
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mol Pathol 56:270-4. 2003
    ..Little is known about the site of expression of these two enzymes in the alveoli of the human lung...
  11. ncbi request reprint Inhibition of human benzylamine oxidase (BzAO) by analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    A J Devlin
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, U K
    Toxicol Lett 54:135-42. 1990
    ..MPTP and 1-methyl-4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-CH3-MPTP), which are potent nigrostriatal toxins, were weak inhibitors of human plasma BzAO...
  12. doi request reprint Biomarkers of endocrine disruption: cluster analysis of effects of plasticisers on Phase 1 and Phase 2 metabolism of steroids
    R H Waring
    School of Biosciences, University of Birmingham, Birmingham, UK
    Int J Androl 35:415-23. 2012
    ....
  13. pmc Huntington's disease
    S Davies
    Department of Medicine, Division of Medical Science, University of Birmingham, Birmingham B15 2TH, UK
    Mol Pathol 54:409-13. 2001
    ..Particular interest has been paid to the role of huntingtin and its associated proteins in excitotoxicity mediated via NMDA and kainate receptors...
  14. ncbi request reprint Renal localisation of rat cysteine dioxygenase
    R B Parsons
    Department of Medicine, Queen Elizabeth Hospital, University of Birmingham, Edgbaston, Birmingham, UK
    Nephron 88:340-6. 2001
    ..In order to address this, this report demonstrates the expression of CDO in the kidney...
  15. ncbi request reprint Thyroxine-binding prealbumin gene polymorphism: a population study
    M T Akbari
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK
    Clin Endocrinol (Oxf) 33:155-60. 1990
    ..The RFLP in a subject with euthyroid hyperthyroxinaemia was due to the deletion of a MspI site. All three subjects with RFLPs were heterozygous...
  16. ncbi request reprint In vitro effect of the cysteine metabolites homocysteic acid, homocysteine and cysteic acid upon human neuronal cell lines
    R B Parsons
    School of Biochemistry, University of Birmingham, Edgbaston, UK
    Neurotoxicology 19:599-603. 1998
    ..HCYS is selectively toxic to medulloblastoma cells; this may explain why high HCYS levels result in neural tube defects in prenatal humans, where the same cell-type is involved...
  17. ncbi request reprint Cysteine dioxygenase: regional expression of activity in rat brain
    R B Parsons
    Department of Medicine, University of Birmingham, UK
    Neurosci Lett 248:101-4. 1998
    ..Protein expression appeared to correlate with activity expression when levels before and after induction were compared. This non-uniformity of expression may reflect different physiological functions of CDO in these areas...
  18. ncbi request reprint The structure of the human thyroxine binding globulin (TBG) gene
    M T Akbari
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK
    Biochim Biophys Acta 1216:446-54. 1993
    ..Other potential regulatory elements also were identified towards the 3' end of the gene...
  19. ncbi request reprint Nicotinamide homeostasis: a xenobiotic pathway that is key to development and degenerative diseases
    A C Williams
    Division of Neuroscience, University of Birmingham, Edgbaston, Birminham B15 2 TT, UK
    Med Hypotheses 65:353-62. 2005
    ..A time point will be reached when errors emerge that could not be deleted by evolutionary pressures. Finding and rectifying them will be the key to preventing many common diseases...
  20. ncbi request reprint A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism
    D J Nicholl
    Department of Clinical Neurology, Queen Elizabeth Hospital and Birmingham University, UK
    Neurology 53:1415-21. 1999
    ....
  21. pmc Mechanisms of neurodegeneration in amyotrophic lateral sclerosis
    S Cluskey
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Pathol 54:386-92. 2001
    ..This review discusses the major mechanisms of neurodegeneration in ALS, such as oxidative stress, glutaminergic excitotoxicity, damage to vital organelles, and aberrant protein aggregation...
  22. ncbi request reprint The effect of plasticisers on "sulphate supply" enzymes
    N Turan
    School of Biosciences, University of Birmingham, UK
    Mol Cell Endocrinol 244:15-9. 2005
    ..005-0.5 microM octylphenol, bis (2-ethylhexyl) phthalate and DIP treatment. Endocrine disrupting effects of some plasticisers may be a consequence of modulation of expression of enzymes supplying PAPS for hormone sulphation...
  23. pmc Progressive supranuclear palsy
    K Tawana
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Pathol 54:427-34. 2001
    ..The role of post-translational modifications in fibrillogenesis is also discussed, particularly hyperphosphorylation and glycation. However, the initiating event that causes aberrant tau processing remains unclear...
  24. ncbi request reprint Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA
    K P McCann
    Department of Clinical Neurology, University of Birmingham, Queen Elizabeth Hospital, UK
    Biochim Biophys Acta 1209:107-10. 1994
    ..The CDO-I message encodes a 200 amino-acid residue protein, the sequence of which has greater than 90% homology with the equivalent rat enzyme. The message was not expressed in a human hepatoma cell line (Hep G2)...
  25. ncbi request reprint Uncoupling proteins: targets of endocrine disruptors?
    T Pawade
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, UK
    Mol Cell Endocrinol 244:79-86. 2005
    ..The role of the endocrine system, thyroid hormones and catecholamines, in regulating expression of UCPs is also discussed...
  26. ncbi request reprint Hydrogen symbioses in evolution and disease
    A C Williams
    Division of Neurosciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    QJM 100:451-9. 2007
    ..These communicate with electrostatic nuclear centres, forming a positive feedback loop. If the proton-motive circuitry fails from loss of Redox potential, premature ageing and all-category disease can result...
  27. ncbi request reprint Activation of bovine plasma benzylamine oxidase (BzAO) by 1-methyl-4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine
    A J Devlin
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK
    Toxicol Lett 61:305-10. 1992
    ..At higher 2'-CH3MPTP concentrations, the activation was negated...
  28. ncbi request reprint Familial nephropathic non-neuropathic amyloidosis: clinical features, immunohistochemistry and chemistry
    A M Zalin
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital
    Q J Med 81:945-56. 1991
    ..Immunohistochemistry showed the protein to be apolipoprotein AI, but allele-specific DNA amplification indicated that it was not the Arg26 variant previously identified...
  29. ncbi request reprint Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenase
    S Jeremiah
    Galton Laboratory, University College London, UK
    Ann Hum Genet 60:29-33. 1996
    ..Interspecific backcross mapping in the mouse indicated that Cdo, the mouse homologue of CDO, is situated in the central region of mouse chromosome 18 which shares a region of homology with human chromosome 5...
  30. ncbi request reprint Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells
    P W L Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Curr Drug Metab 9:276-9. 2008
    ..Assay of S-COMT protein levels represents a simple and convenient method of assessing the estrogenic potential of a compound...
  31. ncbi request reprint Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk
    P W L Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Curr Drug Metab 9:304-9. 2008
    ....
  32. ncbi request reprint Human catechol-O-methyltransferase down-regulation by estradiol
    H Jiang
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, PR China
    Neuropharmacology 45:1011-8. 2003
    ..Our findings may explain the lower of COMT activity in women compared to that in men, and, in part, the beneficial effects of E2 therapy in post-menopausal Parkinson's disease patients...