B H Ramsahoye

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme
    Katan Patel
    Breakthrough Research Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Nucleic Acids Res 38:4313-24. 2010
  2. pmc Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
    Tom Latham
    Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, SIRCAMS, UK
    Nucleic Acids Res 40:4794-803. 2012
  3. pmc The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells
    Helle F Jørgensen
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, London W12 0NN, UK
    Genome Biol 8:R169. 2007
  4. pmc Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
    B H Ramsahoye
    Department of Hematology, Western General Hospital, EH4 2XU Edinburgh, United Kingdom
    Proc Natl Acad Sci U S A 97:5237-42. 2000

Collaborators

  • Nick Gilbert
  • Duncan Sproul
  • F Lyko
  • Rudolf Jaenisch
  • Tom Latham
  • Katan Patel
  • Helle F Jørgensen
  • Jayne Culley
  • David J Harrison
  • Muhammed Karim
  • Pat Langridge-Smith
  • Larry Hayward
  • Logan Mackay
  • Shahida Din
  • Jacqueline Dickson
  • Kenneth MacLeod
  • Duncan Jodrell
  • Matthias Merkenschlager
  • Anna Terry
  • Veronique Azuara
  • Mikhail Spivakov
  • Amanda G Fisher
  • Tatyana Nesterova
  • Bradley S Cobb
  • Shannon Amoils

Detail Information

Publications4

  1. pmc Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme
    Katan Patel
    Breakthrough Research Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Nucleic Acids Res 38:4313-24. 2010
    ..The proteasome inhibitor MG132 prevents DNMT1 degradation and reduces hypomethylation induced by 5-aza-dC...
  2. pmc Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
    Tom Latham
    Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, SIRCAMS, UK
    Nucleic Acids Res 40:4794-803. 2012
    ..Therefore, we propose that lactate may be an important transcriptional regulator, linking the metabolic state of the cell to gene transcription...
  3. pmc The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells
    Helle F Jørgensen
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, London W12 0NN, UK
    Genome Biol 8:R169. 2007
    ..This poised or bivalent state is also characterized by locus replication in early S-phase in ES cells, while replication timing is delayed in cells with restricted developmental options...
  4. pmc Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
    B H Ramsahoye
    Department of Hematology, Western General Hospital, EH4 2XU Edinburgh, United Kingdom
    Proc Natl Acad Sci U S A 97:5237-42. 2000
    ..Analysis of genomic methylation in transgenic Drosophila expressing Dnmt3a reveals that Dnmt3a is predominantly a CpG methylase but also is able to induce methylation at CpA and at CpT...