B H Ramsahoye
Affiliation: University of Edinburgh
- Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzymeKatan Patel
Breakthrough Research Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
Nucleic Acids Res 38:4313-24. 2010..The proteasome inhibitor MG132 prevents DNMT1 degradation and reduces hypomethylation induced by 5-aza-dC...
- Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expressionTom Latham
Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, SIRCAMS, UK
Nucleic Acids Res 40:4794-803. 2012..Therefore, we propose that lactate may be an important transcriptional regulator, linking the metabolic state of the cell to gene transcription...
- The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cellsHelle F Jørgensen
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, London W12 0NN, UK
Genome Biol 8:R169. 2007..This poised or bivalent state is also characterized by locus replication in early S-phase in ES cells, while replication timing is delayed in cells with restricted developmental options...
- Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3aB H Ramsahoye
Department of Hematology, Western General Hospital, EH4 2XU Edinburgh, United Kingdom
Proc Natl Acad Sci U S A 97:5237-42. 2000..Analysis of genomic methylation in transgenic Drosophila expressing Dnmt3a reveals that Dnmt3a is predominantly a CpG methylase but also is able to induce methylation at CpA and at CpT...