Sreeram V Ramagopalan

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Life on top-working@ the Wellcome Trust Centre for Human Genetics: Scotland Yard for DNA detectives
    Sreeram V Ramagopalan
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, United Kingdom
    N Biotechnol 25:39. 2008
  2. pmc Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis
    Sarah Michelle Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford Oxford, United Kingdom
    Am J Clin Nutr 88:441-7. 2008
  3. pmc A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
    Genome Res 20:1352-60. 2010
  4. ncbi request reprint Molecular mechanisms of migraine?
    S V Ramagopalan
    Dept of Clinical Neurology, University of Oxford, Oxford, UK
    J Neurol 254:1629-35. 2007
  5. doi request reprint Rare variants in the CYP27B1 gene are associated with multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Ann Neurol 70:881-6. 2011
  6. pmc Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000369. 2009
  7. pmc Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility
    Matthew R Lincoln
    University Department of Clinical Neurology, Third Floor, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7542-7. 2009
  8. doi request reprint Parent-of-origin of HLA-DRB1*1501 and age of onset of multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Hum Genet 54:547-9. 2009
  9. doi request reprint Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neuroimmunol 196:170-2. 2008
  10. pmc HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility
    Michael J Chao
    Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 105:13069-74. 2008

Collaborators

Detail Information

Publications76

  1. doi request reprint Life on top-working@ the Wellcome Trust Centre for Human Genetics: Scotland Yard for DNA detectives
    Sreeram V Ramagopalan
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, United Kingdom
    N Biotechnol 25:39. 2008
    ..The centre houses multidisciplinary research teams in human genetics, functional genomics, bioinformatics, statistical genetics and structural biology...
  2. pmc Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis
    Sarah Michelle Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford Oxford, United Kingdom
    Am J Clin Nutr 88:441-7. 2008
    ..Recent epidemiologic, experimental, and clinical evidence support an effect for low environmental supplies of vitamin D in mediating an increased susceptibility to MS...
  3. pmc A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
    Genome Res 20:1352-60. 2010
    ..ChIP-seq determination of transcription factor binding, in combination with GWA data, provides a powerful approach to further understanding the molecular bases of complex diseases...
  4. ncbi request reprint Molecular mechanisms of migraine?
    S V Ramagopalan
    Dept of Clinical Neurology, University of Oxford, Oxford, UK
    J Neurol 254:1629-35. 2007
    ..This disease is genetically heterogeneous,with three causative genes having been identified. This review uses insights garnered from FHM to try and shed light on possible migraine disease pathogenesis...
  5. doi request reprint Rare variants in the CYP27B1 gene are associated with multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Ann Neurol 70:881-6. 2011
    ..Genetic linkage analysis and genotyping of candidate genes in families with 4 or more affected individuals more heavily loaded for susceptibility genes has not fully explained familial disease clustering...
  6. pmc Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000369. 2009
    ..These findings support a connection between the main epidemiological and genetic features of this disease with major practical implications for studies of disease mechanism and prevention...
  7. pmc Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility
    Matthew R Lincoln
    University Department of Clinical Neurology, Third Floor, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7542-7. 2009
    ..MHC disease associations may be more generally haplotypic or diplotypic...
  8. doi request reprint Parent-of-origin of HLA-DRB1*1501 and age of onset of multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Hum Genet 54:547-9. 2009
    ..4 years, paternal=30.3 years; P=0.009). HLA-DRB1*1501 exerts a modest, but significant effect on the AO of all forms of MS. Parent-of-origin effects at the MHC are further implicated in MS disease pathogenesis...
  9. doi request reprint Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neuroimmunol 196:170-2. 2008
    ..No significant transmission differences between mothers and fathers were found, suggesting that non-inherited resistance alleles do not appear to play a role in MS...
  10. pmc HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility
    Michael J Chao
    Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 105:13069-74. 2008
    ....
  11. doi request reprint Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians
    Sarah Michelle Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
    J Neurol Sci 305:116-20. 2011
    ..Previous studies have shown that serum 25-hydroxyvitamin D (25(OH)D) levels are genetically influenced. Polymorphisms in vitamin D pathway genes are candidates for association with MS susceptibility...
  12. doi request reprint No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Neuroimmunol 223:120-3. 2010
    ..We found no significant effect of DNA methylation across HLA-DRB1*1501 and HLA-DRB5 on severity, although we cannot rule out time- or tissue-specific effects of DNA methylation...
  13. doi request reprint Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex
    Michael J Chao
    Department of Clinical Neurology, Level 3 West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 7BN, UK
    Hum Mol Genet 18:261-6. 2009
    ..The comparison of transmission of the same allele in vertically affected pedigrees (AUNN) to collinear sibling pairs (ASP) may provide a useful screen for putative epigenetic marks...
  14. doi request reprint No effect of birth weight on the risk of multiple sclerosis. A population-based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Neuroepidemiology 31:181-4. 2008
    ..In a population-based Canadian cohort, we investigated whether there is any difference in birth weight for MS index cases compared to spousal controls...
  15. doi request reprint Parent-of-origin effects at the major histocompatibility complex in multiple sclerosis
    Michael J Chao
    Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Hum Mol Genet 19:3679-89. 2010
    ....
  16. pmc The inheritance of resistance alleles in multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 3:1607-13. 2007
    ..Restriction of antigen presentation by HLA-DRB1*15 seems an improbably simple mechanism of major histocompatibility complex-associated susceptibility...
  17. ncbi request reprint Parental transmission of HLA-DRB1*15 in multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Genet 122:661-3. 2008
    ..A significant over transmission of HLA-DRB1*15 from mothers was observed (chi (2) = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS...
  18. doi request reprint Childhood cow's milk allergy and the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Sci 291:86-8. 2010
    ..Frequency of CMA was compared between index cases and controls. No significant differences were found. Childhood CMA thus does not appear to be a risk factor for MS...
  19. doi request reprint Seasonality of admissions with multiple sclerosis in Scotland
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Neurol 18:1109-11. 2011
    ..Vitamin D and infectious triggers are two major candidate environmental risk factors proposed to account for this effect. We aimed to assess MS admissions in Scotland for a possible effect of seasonality...
  20. doi request reprint Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis
    Sreeram V Ramagopalan
    Dept of Clinical Neurology, University of Oxford, Level 3, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    J Neurol 255:1215-9. 2008
    ....
  21. doi request reprint No effect of parental age on risk of multiple sclerosis: a population-based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Neuroepidemiology 34:106-9. 2010
    ..In a population-based Canadian cohort, we investigated whether there is any difference in parental age at birth for MS index cases compared to spouse controls...
  22. pmc No effect of preterm birth on the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    BMC Neurol 8:30. 2008
    ..Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS...
  23. pmc Vitamin D receptor binding, chromatin states and association with multiple sclerosis
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Mol Genet 21:3575-86. 2012
    ..Further analyses in other immune cell types and functional studies are warranted to fully elucidate the role of vitamin D in the immune system...
  24. pmc Methylation of class II transactivator gene promoter IV is not associated with susceptibility to multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    BMC Med Genet 9:63. 2008
    ..In this study we sought to assess whether or not methylation of the MHC2TA promoter pIV could contribute to MS disease aetiology...
  25. pmc An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene
    Sreeram V Ramagopalan
    1Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:10. 2009
    ..Given the role of this locus in antigen presentation it has been suggested that variations in the peptide binding site of the allele may underlie allelic variation in disease risk...
  26. doi request reprint Mutations in the hemochromatosis gene and the clinical outcome of multiple sclerosis
    Sreeram V Ramagopalan
    Department of Clinical Neurology, University of Oxford, UK
    J Neuroimmunol 203:104-7. 2008
    ..The frequency of HFE mutations was not different in MS compared to the general population...
  27. doi request reprint Association of smoking with risk of multiple sclerosis: a population-based study
    Sreeram V Ramagopalan
    Medical Research Council Functional Genomics Unit and Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    J Neurol 260:1778-81. 2013
    ..No association was seen with maternal active or passive smoking exposure during pregnancy. Ever-smoking is associated with increased MS risk in males. Further work is needed to understand the mechanism underlying this association...
  28. pmc Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease
    Adam E Handel
    Medical Research Council Functional Genomics Unit and Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    BMC Med 11:163. 2013
    ..We aimed to investigate VDR binding in primary CD4+ cells from healthy volunteers...
  29. pmc Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies
    Sreeram V Ramagopalan
    Department of Physiology, Anatomy and Genetics and Medical Research Council Functional Genomics Unit, University of Oxford, Oxford, UK
    BMC Med 11:171. 2013
    ..Previous studies have suggested that there may be an association between vitamin D deficiency and the risk of developing immune-mediated diseases...
  30. doi request reprint The risk of developing multiple sclerosis in individuals seronegative for Epstein-Barr virus: a meta-analysis
    Julia Pakpoor
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Mult Scler 19:162-6. 2013
    ..06. Given the potential importance of this finding, we aimed to establish a more precise OR for adult and paediatric onset MS in EBV seronegative individuals...
  31. pmc Genomic regions associated with multiple sclerosis are active in B cells
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e32281. 2012
    ..Similar analyses in other immunological cell types relevant to MS and functional studies are necessary to fully elucidate how genes contribute to MS pathogenesis...
  32. doi request reprint Multiple sclerosis and the major histocompatibility complex
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, UK
    Curr Opin Neurol 22:219-25. 2009
    ..We review here some of the recent findings of MS genetics with a particular focus on genes of the major histocompatibility complex (MHC)...
  33. doi request reprint Association of infectious mononucleosis with multiple sclerosis. A population-based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Neuroepidemiology 32:257-62. 2009
    ..Here in a population-based Canadian cohort, we investigate the relationship between prior clinical infection or vaccination and the risk of MS...
  34. doi request reprint Early life child exposure and the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Sci 307:162-3. 2011
    ..Frequency of infant day care attendance was compared for index cases and controls and the results were not statistically significant. Exposure to other infants during early childhood thus does not appear to be a risk factor for MS...
  35. ncbi request reprint A genome-wide scan in forty large pedigrees with multiple sclerosis
    Cristen J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Hum Genet 52:955-62. 2007
    ..30. The inability to find significant linkage in these highly penetrant families suggests that linkage is not the optimal tool for dissecting the inheritance of MS...
  36. doi request reprint Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    J Neuroimmunol 212:142-4. 2009
    ..No significant association was found in the entire sample or when stratifying by transmitting parent, indicating that this gene plays little or no role in susceptibility to MS in the Canadian population...
  37. pmc Congenital abnormalities and multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    BMC Neurol 10:115. 2010
    ..A possible marker for this intrauterine insult is the presence of a non-fatal congenital anomaly...
  38. pmc Season of birth and anorexia nervosa
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford and Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Br J Psychiatry 198:404-5. 2011
    ..8, 95% CI 0.68-0.94, P = 0.007). These results indicate that environmental risk factor(s) are operative during gestation or immediately after birth and their identification will be important for disease prevention strategies...
  39. doi request reprint Sex ratio of infectious mononucleosis and possible relevance to multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mult Scler 19:359-61. 2013
    ..03, 95% CI 0.99-1.08). This intriguing aspect of IM epidemiology in adolescence, the atypical female excess, may be linked to the sex ratio of MS, where females predominate from adolescence...
  40. pmc Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosis
    Giammario Ragnedda
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e46730. 2012
    ....
  41. ncbi request reprint Multiple sclerosis: risk factors and their interactions
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, UK
    CNS Neurol Disord Drug Targets 11:545-55. 2012
    ..Current evidence suggests that a large part of MS could be prevented and understanding how and when during life risk factors act will ultimately aid the development of prevention strategies...
  42. doi request reprint Vitamin D-gene interactions in multiple sclerosis
    Antonio J Berlanga-Taylor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, UK
    J Neurol Sci 311:32-6. 2011
    ..In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk...
  43. pmc Seasonal distribution of psychiatric births in England
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e34866. 2012
    ..48E-05; BAD p = 0.019; RDD p = 0.015). This data has implications for future strategies of disease prevention...
  44. pmc Geography of hospital admissions for multiple sclerosis in England and comparison with the geography of hospital admissions for infectious mononucleosis: a descriptive study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 82:682-7. 2011
    ....
  45. doi request reprint The genetics of clinical outcome in multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neuroimmunol 201:183-99. 2008
    ..Recent studies implicating the role of the genotype and epistatic interactions in the MHC in determining outcome are highlighted...
  46. ncbi request reprint Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium
    Michael J Chao
    Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Hum Mol Genet 16:1951-8. 2007
    ..The frequency of allelic associations not being replicated emphasizes the requirement for constructing multi-locus haplotypes in dissecting associations in regions of tight LD...
  47. doi request reprint Epstein-Barr virus, latitude and multiple sclerosis
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mult Scler 19:362-5. 2013
    ..06, 95% CI = 1.02-1.09, p = 0.002). Latitude-related factors may be implicated in the immune response to EBV and its role in MS aetiology...
  48. pmc Meta-analysis of the relationship between multiple sclerosis and migraine
    Julia Pakpoor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, United Kingdom
    PLoS ONE 7:e45295. 2012
    ..By meta-analysing all available data we aimed to establish an overall estimate of any association in order to more accurately inform clinicians and care-givers about a potential association between MS and migraine...
  49. ncbi request reprint Epigenetic mechanisms in multiple sclerosis and the major histocompatibility complex (MHC)
    Amy M Burrell
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
    Discov Med 11:187-96. 2011
    ..Differences in epigenetic marks characterize monozygotic twin pairs and may explain discordance. There is promise of potential therapeutic strategies to be found in the epigenetic mechanisms at work in MS...
  50. pmc Multiple sclerosis, vitamin D, and HLA-DRB1*15
    Lahiru Handunnetthi
    Wellcome Trust Centre for Human Genetics and the Department of Clinical Neurology, University of Oxford, Oxford, UK
    Neurology 74:1905-10. 2010
    ..Such interactions may hold the key for disease prevention...
  51. pmc Smoking and multiple sclerosis: an updated meta-analysis
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e16149. 2011
    ..A previous meta-analysis suggested that smoking was an important risk factor for MS but many other studies have been published since then...
  52. doi request reprint Epigenetics: molecular mechanisms and implications for disease
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Trends Mol Med 16:7-16. 2010
    ..Here, we consider how growing knowledge of epigenetics is altering our understanding of biology and medicine, and its implications for future research...
  53. doi request reprint DNase hypersensitive sites and association with multiple sclerosis
    Giulio Disanto
    Department of Physiology, Anatomy and Genetics and Medical Research Council Functional Genomics Unit, University of Oxford, South Parks Road, Oxford OX1 3PT, UK
    Hum Mol Genet 23:942-8. 2014
    ..Finally, similar cell types are involved in the etiology of other immune-mediated diseases. ..
  54. doi request reprint Integrating multiple oestrogen receptor alpha ChIP studies: overlap with disease susceptibility regions, DNase I hypersensitivity peaks and gene expression
    Adam E Handel
    Medical Research Council Functional Genomics Unit and Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    BMC Med Genomics 6:45. 2013
    ..A wealth of nuclear receptor binding data has been generated by the application of chromatin immunoprecipitation (ChIP) techniques. However, there have been relatively few attempts to apply these datasets to human complex disease or traits...
  55. pmc The epidemiology of multiple sclerosis in Scotland: inferences from hospital admissions
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e14606. 2011
    ..In this study we undertook a study of medical records across Scotland on an NHS health board level of resolution to examine the epidemiology of MS in this region...
  56. pmc Is Lamarckian evolution relevant to medicine?
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    BMC Med Genet 11:73. 2010
    ..These theories centre on the tendency for complexity to increase in organisms over time and the direct transmission of phenotypic traits from parents to offspring...
  57. doi request reprint Type 1 diabetes mellitus and multiple sclerosis: common etiological features
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Rev Endocrinol 5:655-64. 2009
    ..Similarities and differences between these two diseases draw attention to shared disease pathways but insights into each disorder are providing mutual illumination of their pathogenesis...
  58. doi request reprint Genes for multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Lancet 371:283-5. 2008
  59. pmc The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e10142. 2010
    ..We investigated whether these genetic variations were associated with alteration in gene expression...
  60. doi request reprint Epidemiology of multiple sclerosis
    Sreeram V Ramagopalan
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Neurol Clin 29:207-17. 2011
    ..It seems unlikely that MS results from a single causative event, but rather is the result of genetic and environmental factors and the interactions thereof. This article discusses the epidemiology of MS...
  61. pmc Risk of subarachnoid haemorrhage in people admitted to hospital with selected immune-mediated diseases: record-linkage studies
    Sreeram V Ramagopalan
    Unit of Health Care Epidemiology, Department of Public Health, University of Oxford, Oxford, UK
    BMC Neurol 13:176. 2013
    ..Subarachnoid hemorrhage (SAH) is a devastating cause of stroke, occurring in relatively young people. It has been suggested that some immune-mediated diseases may be associated with an increased risk of SAH...
  62. doi request reprint Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis
    Giulio Disanto
    Department of Physiology, Anatomy and Genetics and Medical Research Council Functional Genomics Unit, University of Oxford, UK
    Mult Scler 19:1355-8. 2013
    ....
  63. pmc Next-generation sequencing in understanding complex neurological disease
    Adam E Handel
    Department of Physiology, Anatomy and Genetics, University of Oxford, UK
    Expert Rev Neurother 13:215-27. 2013
    ..The authors highlight particular pitfalls in next-generation sequencing experiments and speculate on both clinical and research applications of these sequencing platforms for complex neurological disorders in the future...
  64. pmc Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences
    Witold Czyz
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    BMC Med 10:93. 2012
    ..Here, we explore the subject of epigenetics as another component in human phenotypic variability and its links to disease focusing particularly on evidence from MZ twin studies...
  65. doi request reprint The emerging role of vitamin D binding protein in multiple sclerosis
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    J Neurol 258:353-8. 2011
    ..Further studies are needed to elucidate the potential use of DBP as a biological marker of MS course, but may be of use given the current lack of diagnostic tools for the prediction of MS development and progression...
  66. doi request reprint Of mice and men: experimental autoimmune encephalitis and multiple sclerosis
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Clin Invest 41:1254-8. 2011
    ..Research using experimental autoimmune encephalitis (EAE) models accounts for almost 20% of the papers. published in multiple sclerosis (MS)...
  67. doi request reprint Clinical prognostic factors in multiple sclerosis: a natural history review
    Alexandra Degenhardt
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Nat Rev Neurol 5:672-82. 2009
    ..Onset of progression, relapse rate and disability in the initial 5 years could be fruitful therapeutic targets; however, longer-term clinical trials will be required to justify these end points...
  68. pmc Risk of fractures in patients with multiple sclerosis: record-linkage study
    Sreeram V Ramagopalan
    Unit of Health Care Epidemiology, Department of Public Health, University of Oxford, Oxford, UK
    BMC Neurol 12:135. 2012
    ..Patients with multiple sclerosis (MS) have been reported to be at higher risk of fracture than other people. We sought to test this hypothesis in a large database of hospital admissions in England...
  69. doi request reprint Genetic epidemiology: the use of old and new tools for multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    Trends Neurosci 31:645-52. 2008
    ..Family-based data in multiple sclerosis are applicable to other neurological traits...
  70. doi request reprint Epstein-Barr virus and multiple sclerosis: association or causation?
    Julia Pakpoor
    Department of Physiology, Anatomy and Genetics and Medical Research Council Functional Genomics Unit, University of Oxford, Oxford, UK
    Expert Rev Neurother 13:287-97. 2013
    ..Collectively, the strength of the association between EBV and MS warrants careful development and trial of anti-EBV drugs to observe any effect on MS disease course...
  71. pmc High reprint orders in medical journals and pharmaceutical industry funding: case-control study
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    BMJ 344:e4212. 2012
    ..To assess the extent to which funding and study design are associated with high reprint orders...
  72. pmc Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: record-linkage study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    BMC Med 9:1. 2011
    ..We, therefore, decided to study the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) in people admitted to hospital with a range of immune-mediated diseases...
  73. pmc Origins of magic: review of genetic and epigenetic effects
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN
    BMJ 335:1299-301. 2007
    ..To assess the evidence for a genetic basis to magic...
  74. ncbi request reprint Contribution of genetic, epigenetic and transcriptomic differences to twin discordance in multiple sclerosis
    Lahiru Handunnetthi
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
    Expert Rev Neurother 10:1379-81. 2010
    ..No consistent differences in DNA sequence, DNA methylation or gene expression were found. Here we put these findings into context and discuss their significance...
  75. pmc What is Next for the Genetics of Multiple Sclerosis?
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN Oxford, UK
    Autoimmune Dis 2011:519450. 2011
    ..In 2011, after a number of genome-wide association studies have been completed and have identified approximately 20 new genes for MS, we ask the question-what is next for the genetics of MS?..
  76. ncbi request reprint Genomewide study of multiple sclerosis
    Sreeram V Ramagopalan
    N Engl J Med 357:2199-200; author reply 2200-1. 2007