V Ralevic

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem Pharmacol 65:143-51. 2003
  2. pmc Structure-activity relationships of diadenosine polyphosphates (Ap(n)As), adenosine polyphospho guanosines (Ap(n)Gs) and guanosine polyphospho guanosines (Gp(n)Gs) at P2 receptors in the rat mesenteric arterial bed
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 134:1073-83. 2001
  3. ncbi request reprint Cannabinoid modulation of perivascular sympathetic and sensory neurotransmission
    Vera Ralevic
    Centre for Integrated Systems Biology and Medicine, University of Nottingham, Nottingham, NG7 2UH, UK
    Curr Vasc Pharmacol 7:15-25. 2009
  4. pmc The involvement of smooth muscle P2X receptors in the prolonged vasorelaxation response to purine nucleotides in the rat mesenteric arterial bed
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Pharmacol 135:1988-94. 2002
  5. ncbi request reprint Cannabinoids inhibit pre- and postjunctionally sympathetic neurotransmission in rat mesenteric arteries
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, UK
    Eur J Pharmacol 444:171-81. 2002
  6. ncbi request reprint Purines as neurotransmitters and neuromodulators in blood vessels
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
    Curr Vasc Pharmacol 7:3-14. 2009
  7. pmc Endothelial nitric oxide modulates perivascular sensory neurotransmission in the rat isolated mesenteric arterial bed
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 137:19-28. 2002
  8. ncbi request reprint Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, UK
    Life Sci 71:2577-94. 2002
  9. ncbi request reprint Vasoconstrictor responsiveness of tail arteries from endotoxaemic rats
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Clifton Boulevard, Nottingham NG7 2UH, United Kingdom
    Eur J Pharmacol 460:145-53. 2003
  10. ncbi request reprint Cannabinoid activation of recombinant and endogenous vanilloid receptors
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Eur J Pharmacol 424:211-9. 2001

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem Pharmacol 65:143-51. 2003
    ..The vanilloids display the same relative potencies (resiniferatoxin>capsaicin=olvanil>PPAHV) in all of the bioassays...
  2. pmc Structure-activity relationships of diadenosine polyphosphates (Ap(n)As), adenosine polyphospho guanosines (Ap(n)Gs) and guanosine polyphospho guanosines (Gp(n)Gs) at P2 receptors in the rat mesenteric arterial bed
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 134:1073-83. 2001
    ..Regarding the purine moiety, one adenine is crucial and sufficient for vasoactivity as Gp(n)Gs were largely inactive, and Ap(n)As and Ap(n)Gs approximately equipotent...
  3. ncbi request reprint Cannabinoid modulation of perivascular sympathetic and sensory neurotransmission
    Vera Ralevic
    Centre for Integrated Systems Biology and Medicine, University of Nottingham, Nottingham, NG7 2UH, UK
    Curr Vasc Pharmacol 7:15-25. 2009
    ..The diverse prejunctional effects of cannabinoids may be novel targets for therapies designed to treat vascular disease...
  4. pmc The involvement of smooth muscle P2X receptors in the prolonged vasorelaxation response to purine nucleotides in the rat mesenteric arterial bed
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Pharmacol 135:1988-94. 2002
    ..Caution should be applied when using sodium deoxycholate to remove the endothelium because of possible damage caused by the detergent to receptors and/or the vascular smooth muscle...
  5. ncbi request reprint Cannabinoids inhibit pre- and postjunctionally sympathetic neurotransmission in rat mesenteric arteries
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, UK
    Eur J Pharmacol 444:171-81. 2002
    ..The pre-junctional action is mediated by a cannabinoid CB(1)-like receptor, but the postjunctional action does not appear to involve either cannabinoid CB(1) or CB(2) receptors...
  6. ncbi request reprint Purines as neurotransmitters and neuromodulators in blood vessels
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
    Curr Vasc Pharmacol 7:3-14. 2009
    ..This review focuses on the role of ATP as a cotransmitter in perivascular nerves in physiological and pathophysiological conditions; neuromodulator roles of purines are also discussed...
  7. pmc Endothelial nitric oxide modulates perivascular sensory neurotransmission in the rat isolated mesenteric arterial bed
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 137:19-28. 2002
    ..The source of NO is the vascular endothelium...
  8. ncbi request reprint Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, UK
    Life Sci 71:2577-94. 2002
    ..Hence, anandamide can elicit opposite actions, inhibition via CB receptors and excitation via VR1, on sensory neurotransmission. The possible biological significance of this is discussed...
  9. ncbi request reprint Vasoconstrictor responsiveness of tail arteries from endotoxaemic rats
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Clifton Boulevard, Nottingham NG7 2UH, United Kingdom
    Eur J Pharmacol 460:145-53. 2003
    ..As hypercontractility was not evoked following in vitro incubation with lipopolysaccharide, the involvement of in vivo neurohumoral factors/mechanisms in the pathology of these changes is implicated...
  10. ncbi request reprint Cannabinoid activation of recombinant and endogenous vanilloid receptors
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Eur J Pharmacol 424:211-9. 2001
    ..These data demonstrate that the vasorelaxant and sensory neuromodulator properties of AM404 in the rat isolated mesenteric arterial bed are mediated by vanilloid VR1 receptors...
  11. ncbi request reprint Low pH modulation of recombinant vanilloid receptors and perivascular capsaicin-sensitive sensory neurotransmission
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, UK
    Auton Neurosci 88:36-44. 2001
    ..This likely explains why there is no evidence of an enhancement of sensitivity to capsaicin at endogenous vanilloid receptors, as observed with rVR1. When pH is reduced still further (6.0-5.5) there is direct activation of rVR1...
  12. ncbi request reprint Receptors for purines and pyrimidines
    V Ralevic
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, England
    Pharmacol Rev 50:413-92. 1998
  13. ncbi request reprint Characterization of P2 receptors modulating neural activity in rat rostral ventrolateral medulla
    V Ralevic
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, UK
    Neuroscience 94:867-78. 1999
    ..The data suggest that both P2X and P2Y receptors are involved, and that the functional expression of these receptors within the rostral ventrolateral medulla is not uniform...
  14. ncbi request reprint Sympathoinhibition by adenosine A(1) receptors, but not P2 receptors, in the hamster mesenteric arterial bed
    V Ralevic
    School of Biomedical Sciences, Queen s Medical Centre, The University of Nottingham Medical School, Nottingham, UK
    Eur J Pharmacol 387:287-93. 2000
    ..These results indicate that adenosine A(1) receptors, but not P2 receptors, inhibit prejunctionally sympathetic neurotransmission in the hamster mesenteric arterial bed...
  15. ncbi request reprint P2 receptors in the central and peripheral nervous systems modulating sympathetic vasomotor tone
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, NG7 2UH, Nottingham, UK
    J Auton Nerv Syst 81:205-11. 2000
    ....
  16. pmc Vanilloid receptors on capsaicin-sensitive sensory nerves mediate relaxation to methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arteries
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 130:1483-8. 2000
    ..In conclusion, vanilloid receptors on capsaicin-sensitive sensory nerves play an important role in the vasorelaxant action of methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arterial segments...
  17. ncbi request reprint Effect of a decrease in pH on responses mediated by P2 receptors in the rat mesenteric arterial bed
    V Ralevic
    School of Biomedical Sciences, Queen s Medical Centre, The University of Nottingham, NG7 2UH, Nottingham, UK
    Eur J Pharmacol 406:99-107. 2000
    ..There is no effect on contractions mediated via P2X receptors, but contractions to noradrenaline, methoxamine and vasopressin are greatly attenuated...
  18. pmc Mechanism of prolonged vasorelaxation to ATP in the rat isolated mesenteric arterial bed
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 132:685-92. 2001
    ..Neither prolonged nor rapid vasorelaxation to ATP involves capsaicin-sensitive sensory nerves, adenosine P1 receptors, prostanoids or K(Ca) channels...
  19. ncbi request reprint Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, NG7 2UH, Nottingham, UK
    Eur J Pharmacol 418:117-25. 2001
    ..These data show that the cannabinoid receptor agonist HU210 inhibits prejunctionally sensory neurotransmission in rat mesenteric arteries and that this action is independent of cannabinoid CB(1)- or CB(2)-like receptors...
  20. ncbi request reprint Cannabinoid modulation of peripheral autonomic and sensory neurotransmission
    Vera Ralevic
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham Medical School, Nottingham NG7 2UH, UK
    Eur J Pharmacol 472:1-21. 2003
    ..Understanding the actions of cannabinoids as modulators of peripheral neurotransmission is relevant to a variety of biological systems and possibly their disorders...
  21. pmc Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed
    P Pakdeechote
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, Nottingham, UK
    Br J Pharmacol 152:725-33. 2007
    ..This study has assessed whether cannabinoid receptor activation modulates differentially the noradrenergic and purinergic components of sympathetic vasoconstriction...
  22. pmc Delta 9-tetrahydrocannabinol inhibits electrically-evoked CGRP release and capsaicin-sensitive sensory neurogenic vasodilatation in the rat mesenteric arterial bed
    J D Wilkinson
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, Nottingham, UK
    Br J Pharmacol 152:709-16. 2007
    ....
  23. ncbi request reprint Roles of P2-purinoceptors in the cardiovascular system
    V Ralevic
    University College, London, UK
    Circulation 84:1-14. 1991
    ..The development of selective and potent antagonists to P2X- and P2Y-purinoceptors has so far remained elusive, and their therapeutic potential can only be guessed...
  24. ncbi request reprint Evidence for the involvement of purinergic signalling in the control of respiration
    T Thomas
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, UK
    Neuroscience 107:481-90. 2001
    ..Our pharmacological data suggest that different P2X subunits in this region may co-assemble to form hetero-oligomeric assemblies as well as homomultimers within this region...
  25. doi request reprint Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: a new finding that may influence the design of anti-thrombotic agents
    P Manolopoulos
    Centre for Integrated Systems Biology and Medicine, School of Medical and Surgical Sciences, Nottingham, UK
    Platelets 19:134-45. 2008
    ..The results are discussed in relation to the possibility that acyl-CoAs may contribute as endogenous modulators of platelet function and might serve as lead compounds for the design of novel antithrombotics...
  26. pmc Evidence for the expression of multiple uracil nucleotide-stimulated P2 receptors coupled to smooth muscle contraction in porcine isolated arteries
    S J Rayment
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, UK
    Br J Pharmacol 150:604-12. 2007
    ..We have performed a comparative analysis of these receptors in endothelium-denuded smooth muscle from porcine isolated coronary and ear arteries, using pharmacological and molecular tools...
  27. pmc Antagonism of P2Y1 -induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate
    E Alefishat
    Cardiovascular Research Group and Lipid Signalling, School of Biomedical Sciences, University of Nottingham, Nottingham, UK
    Br J Pharmacol 168:1911-22. 2013
    ..This study evaluated the effect of these endogenous nucleotide derivatives at P2Y1 receptors natively expressed in rat and porcine blood vessels...
  28. ncbi request reprint Cardiovascular effects of cannabinoids
    Michael D Randall
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, UK
    Pharmacol Ther 95:191-202. 2002
    ..Pathophysiologically, the vasodilator actions of endocannabinoids have been implicated in the hypotension associated with both septic and haemorrhagic shock, but their physiological significance remains to be determined...
  29. pmc ATP is the predominant sympathetic neurotransmitter in rat mesenteric arteries at high pressure
    Nicole M Rummery
    School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 582:745-54. 2007
    ....
  30. ncbi request reprint Raised tone reveals purinergic-mediated responses to sympathetic nerve stimulation in the rat perfused mesenteric vascular bed
    Poungrat Pakdeechote
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, Nottingham, NG7 2UH, United Kingdom
    Eur J Pharmacol 563:180-6. 2007
    ..This effect is due to a postjunctional enhancement of purinergic function...
  31. ncbi request reprint A novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release
    Sarah J Rayment
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    FASEB J 21:577-85. 2007
    ..These data suggest that ADP mediates relaxation of the PCA via a novel mechanism that involves adenine nucleotide-evoked adenosine release and the subsequent activation of A2A receptors...
  32. ncbi request reprint Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed
    Marnie Duncan
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Pharmacol Exp Ther 311:411-9. 2004
    ..These data demonstrate that different classes of cannabinoid agonists attenuate sensory neurotransmission via a prejunctional site and provide evidence for mediation by a CB(1) and/or a non-CB(1)/CB(2) receptor...
  33. pmc Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 G(i/o) linked receptor
    Marnie Duncan
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 142:509-18. 2004
    ..7 These data demonstrate that noladin ether attenuates sensory neurotransmission in rat mesenteric arteries via a non-CB1 non-CB2 PTX-sensitive prejunctional site, independently of TRPV1 receptors...
  34. ncbi request reprint The effects of acute and chronic lipopolysaccharide infusion in rats on the efferent function of sensory nerves in the isolated mesenteric arterial bed
    Matthew R Farmer
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, UK
    Auton Neurosci 107:105-10. 2003
    ..Thus, the efferent function of capsaicin-sensitive sensory nerves is unaltered in the isolated mesenteric arterial bed prepared ex vivo from rats receiving lipopolysaccharide, either acutely (2 h) or chronically (24 h)...
  35. ncbi request reprint Effects of in vivo lipopolysaccharide infusion on vasoconstrictor function of rat isolated mesentery, kidney, and aorta
    Matthew R Farmer
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, United Kingdom
    J Pharmacol Exp Ther 306:538-45. 2003
    ....
  36. ncbi request reprint Involvement of purinergic signaling in cardiovascular diseases
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, United Kingdom
    Drug News Perspect 16:133-40. 2003
    ..This will open up new avenues for research into the physiological roles of purine receptors and their therapeutic potential...
  37. pmc Hypoxic vasodilatation: is an adenosine-prostaglandins- NO signalling cascade involved?
    Vera Ralevic
    J Physiol 544:2. 2002
    ..g. Busse et al. 1984; Messina et al. 1992). To date there have been few attempts to reconcile these different mechanisms...
  38. ncbi request reprint Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor
    Natalia Dovlatova
    Cardiovascular Medicine, Queen s Medical Centre, Nottingham, UK
    Thromb Haemost 100:261-70. 2008
    ..Further studies are necessary to determine whether the P2Y(14) receptor in platelets has any functionality...