Wahida Rahman

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Voltage gated sodium and calcium channel blockers for the treatment of chronic inflammatory pain
    Wahida Rahman
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK Electronic address
    Neurosci Lett 557:19-26. 2013
  2. ncbi request reprint Selective ablation of dorsal horn NK1 expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones
    Wahida Rahman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neuropharmacology 54:1208-14. 2008
  3. pmc Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain
    Wahida Rahman
    Department of Neuroscience, Pharmacology and Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Mol Pain 5:45. 2009
  4. doi request reprint Peripheral nerve injury-induced changes in spinal alpha(2)-adrenoceptor-mediated modulation of mechanically evoked dorsal horn neuronal responses
    Wahida Rahman
    Department of Pharmacology, University College London, London, United Kingdom
    J Pain 9:350-9. 2008
  5. ncbi request reprint Superficial NK1 expressing spinal dorsal horn neurones modulate inhibitory neurotransmission mediated by spinal GABA(A) receptors
    Wahida Rahman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neurosci Lett 419:278-83. 2007
  6. ncbi request reprint Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation
    Wahida Rahman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Pain 123:264-74. 2006
  7. ncbi request reprint Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation
    Wahida Rahman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neurosci Lett 361:229-31. 2004
  8. pmc A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: an in vivo electrophysiological study in the rat
    Wahida Rahman
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Brain Res 1382:29-36. 2011
  9. ncbi request reprint Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin
    Rie Suzuki
    Department of Pharmacology Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Pain 117:292-303. 2005
  10. ncbi request reprint Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons
    Lars Jørgen Rygh
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 24:761-72. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Voltage gated sodium and calcium channel blockers for the treatment of chronic inflammatory pain
    Wahida Rahman
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK Electronic address
    Neurosci Lett 557:19-26. 2013
    ..This review considers the therapeutic potential for sodium and calcium channel blockers for the treatment of chronic inflammatory pain states...
  2. ncbi request reprint Selective ablation of dorsal horn NK1 expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones
    Wahida Rahman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neuropharmacology 54:1208-14. 2008
    ..Since the same neuronal population drives descending facilitation and inhibition, the reduced excitability of lamina V/VI WDR neurones seen after loss of these NK(1)+ve neurones indicates a dominant role of descending facilitation...
  3. pmc Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain
    Wahida Rahman
    Department of Neuroscience, Pharmacology and Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Mol Pain 5:45. 2009
    ....
  4. doi request reprint Peripheral nerve injury-induced changes in spinal alpha(2)-adrenoceptor-mediated modulation of mechanically evoked dorsal horn neuronal responses
    Wahida Rahman
    Department of Pharmacology, University College London, London, United Kingdom
    J Pain 9:350-9. 2008
    ..Thus, our findings suggest that peripheral nerve injury can result in the suppression of noradrenergic spinal alpha(2)-adrenoceptor-mediated inhibition of spinal dorsal horn neuronal activity evoked by low-intensity mechanical stimuli...
  5. ncbi request reprint Superficial NK1 expressing spinal dorsal horn neurones modulate inhibitory neurotransmission mediated by spinal GABA(A) receptors
    Wahida Rahman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neurosci Lett 419:278-83. 2007
    ..Thus activation of these cells predominantly drives facilitation...
  6. ncbi request reprint Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation
    Wahida Rahman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Pain 123:264-74. 2006
    ....
  7. ncbi request reprint Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation
    Wahida Rahman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neurosci Lett 361:229-31. 2004
    ..Thus 5HT3 receptor mediated descending facilitation remains unaltered at this stage after tissue injury...
  8. pmc A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: an in vivo electrophysiological study in the rat
    Wahida Rahman
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Brain Res 1382:29-36. 2011
    ..Our data, therefore, supports a pronociceptive role for 5-HT2 receptors, most likely through modulation of 5-HT2A receptor activity, on spinal nociceptive transmission under normal conditions...
  9. ncbi request reprint Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin
    Rie Suzuki
    Department of Pharmacology Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Pain 117:292-303. 2005
    ..These hypotheses are testable in patients...
  10. ncbi request reprint Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons
    Lars Jørgen Rygh
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 24:761-72. 2006
    ..Our results support the suggestion that the generation of LTP in dorsal horn neurons following peripheral injury may be one mechanism whereby acute pain can be transformed into a long-term pain state...
  11. doi request reprint The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo
    Claudia S Bauer
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK
    Biochem Soc Trans 38:525-8. 2010
    ..In the present paper, we review recent advances in our understanding of their molecular mechanisms...
  12. doi request reprint Mu-opioid and noradrenergic α(2)-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats
    Lucy A Bee
    Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK
    Pain 152:131-9. 2011
    ....
  13. doi request reprint The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin
    Claudia S Bauer
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 29:4076-88. 2009
    ....
  14. ncbi request reprint Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Brain Res 1019:68-76. 2004
    ..These excitatory influences are likely to contribute to the development and maintenance of central sensitisation in the spinal cord, and furthermore, to the behavioural manifestation of tactile allodynia...
  15. pmc Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury
    Beatrice Lana
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Pain 155:522-33. 2014
    ..This variant could therefore play a role in determining the efficacy of gabapentin in neuropathic pain. ..
  16. pmc Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis
    Matthew Thakur
    Neuropharmacology of Pain Group, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
    PLoS ONE 7:e33730. 2012
    ..This significant neuropathic component needs to be taken into account when interpreting studies using this model, particularly at doses greater than 1 mg MIA...
  17. ncbi request reprint Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain
    John A Chaddock
    Health Protection Agency, Porton Down, Salisbury, Wiltshire, United Kingdom
    Mov Disord 19:S42-7. 2004
    ..These data provide proof of principle for the concept of retargeted clostridial endopeptidases as novel analgesics...