Research Topics
Species | Martin C RaffSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progressionIan Conlon
MRC Laboratory for Molecular Cell Biology, Cell Biology Unit, University College London, London WC1E 6BT, UK
J Biol 2:7. 2003..Whereas yeast cells use cell-size checkpoints, Schwann cells apparently do not. It seems likely that many mammalian cells resemble Schwann cells in this respect...- Control and maintenance of mammalian cell size: responseIan Conlon
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, London WC1E 6BT, UK
BMC Cell Biol 5:36. 2004..A response to Cooper S: Control and maintenance of mammalian cell size. BMC Cell Biol 2004, 5:35... 
Adult stem cell plasticity: fact or artifact?Martin Raff
Medical Research Council Laboratory for Molecular Cell Biology, Cell Biology Unit, University College London, London WC1E 6BT, United Kingdom
Annu Rev Cell Dev Biol 19:1-22. 2003....- Axonal self-destruction and neurodegenerationMartin C Raff
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit and the Biology Department, University College London, London WC1E 6BT, UK
Science 296:868-71. 2002..Do neurons also use this second program to prune their axonal tree during development and to conserve resources in response to chronic insults?.. 
Looking backMartin Raff
Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
Annu Rev Cell Dev Biol 27:1-23. 2011..I retired from active research in 2002 and now spend much of my time on scientific advisory boards and thinking about autism...- The mystery of intracellular developmental programmes and timersM Raff
MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, London WC1E 6BT, UK
Biochem Soc Trans 34:663-70. 2006.... - Cell number control and timing in animal development: the oligodendrocyte cell lineageM C Raff
MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, United Kingdom
Int J Dev Biol 42:263-7. 1998..In this sense, one might think of mammalian development as a prolonged metamorphosis... - New routes into the human brainMartin Raff
MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
Cell 139:1209-11. 2009..This is the territory I would explore if I were starting my research career today... - Effects of thyroid hormone on embryonic oligodendrocyte precursor cell development in vivo and in vitroS C Ahlgren
MRC Developmental Neurobiology Programme, University College London, United Kingdom
Mol Cell Neurosci 9:420-32. 1997.... - A role for Noggin in the development of oligodendrocyte precursor cellsToru Kondo
Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit and the Biology Department, University College London, London WC1E 6BT, UK
Dev Biol 267:242-51. 2004..These findings suggest that BMPs in FCS are largely responsible for the 2A-inducing activity of FCS and that Noggin may normally inhibit the formation of 2As in the developing CNS... - p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiationB Durand
Medical Research Council Developmental Neurobiology Programme, MRC Laboratory for Molecular Cell Biology, Biology Department, University College London, London, WC1E 6BT, UK
Curr Biol 8:431-40. 1998.... - Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspasesJ T Finn
Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 20:1333-41. 2000..Our results suggest that a neuron contains at least two molecularly distinct self-destruction programs, one for caspase-dependent apoptosis and another for selective axon degeneration... - Lack of replicative senescence in cultured rat oligodendrocyte precursor cellsD G Tang
MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
Science 291:868-71. 2001..Our findings suggest that some normal rodent precursor cells have an unlimited proliferative capacity if cultured in conditions that avoid both differentiation and the activation of checkpoint responses that arrest the cell cycle... - Is programmed cell death required for neural tube closure?M Weil
Medical Research Council, Laboratory for Molecular Cell Biology, London, WC1E 6BT, UK
Curr Biol 7:281-4. 1997..Here, we show that peptide caspase inhibitors block neural tube closure in explanted chick embryos, suggesting that PCD is required for this crucial developmental process... - Müller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of developmentC Neophytou
Biology Department, University College London, UK
Development 124:2345-54. 1997..These findings identify an inhibitory cell-cell interaction, which may help to explain the long delay that can occur both in vitro and in vivo between cell-cycle withdrawal and rhodopsin expression during rod development... - An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanismJ Rosenblatt
Medical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT, United Kingdom
Curr Biol 11:1847-57. 2001..Apoptosis occurring within these simple epithelia could compromise this barrier. How, then, does an epithelium remove apoptotic cells without disrupting its function as a barrier?.. - Extracellular control of cell sizeI J Conlon
MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, London WC1E 6BT, UK
Nat Cell Biol 3:918-21. 2001.... - Long-term culture of purified postnatal oligodendrocyte precursor cells. Evidence for an intrinsic maturation program that plays out over monthsD G Tang
MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, London, WC1E 6BT, United Kingdom
J Cell Biol 148:971-84. 2000..The challenge now is to determine the molecular basis of such a protracted maturation program and how the program is restrained by bFGF... - Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiationYasuhito M Tokumoto
Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
Dev Biol 245:224-34. 2002.... - Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family proteinY M Tokumoto
Medical Research Council Laboratory for Molecular Cell Biology, Cell Biology Unit, Department of Biology, University College London, London WC1E 6BT, UK
EMBO J 20:5261-8. 2001..Differentiation that occurs independently of TH and RA apparently involves a different pathway. It is likely that both pathways operate in vivo... - Retinal ganglion cell axons drive the proliferation of astrocytes in the developing rodent optic nerveJ F Burne
MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, United Kingdom
Neuron 18:223-30. 1997..Taken together with previous findings, our present results indicate that axons promote glial cell proliferation and survival in the developing optic nerve by at least three distinct mechanisms... - Differences between the clearance of apoptotic cells by professional and non-professional phagocytesR Parnaik
Medical Research Council Laboratory for Molecular Cell Biology, Medical Research Council Developmental Neurobiology Programme, University College London, London, WC1E 6BT, UK
Curr Biol 10:857-60. 2000..This arrangement favours prompt clearance by professionals if present in adequate numbers; if they are scarce, however, non-professional bystanders will reluctantly clear the apoptotic cells... - A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerveV A Wallace
Medical Research Council Developmental Neurobiology Programme, MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, London WC1E 6BT, UK
Development 126:2901-9. 1999..4) Astrocyte proliferation in the developing nerve is reduced by treatment with anti-Shh antibodies, suggesting that Shh normally helps stimulate this proliferation... - Continuous observation of multipotential retinal progenitor cells in clonal density cultureA M Jensen
MRC Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, United Kingdom
Dev Biol 188:267-79. 1997..In addition, we show that under these conditions single progenitor cells can generate both neurons and glia, in which case the neurons almost always develop before glial cells, as is the case in vivo... - The proapoptotic proteins Bax and Bak are not involved in Wallerian degenerationAlan V Whitmore
Cell Death Differ 10:260-1. 2003