Niall P Quinn

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Are trials of intravascular infusions of autologous mesenchymal stem cells in patients with multiple system atrophy currently justified, and are they effective?
    N Quinn
    Institute of Neurology, Queen Square, London, UK
    Clin Pharmacol Ther 83:663-5. 2008
  2. doi request reprint Tremor--some controversial aspects
    Niall P Quinn
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:18-23. 2011
  3. ncbi request reprint The natural history of Unverricht-Lundborg disease: a report of eight genetically proven cases
    Nee K Chew
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:107-13. 2008
  4. doi request reprint In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study
    Nicola Pavese
    MRC Clinical Science Centre and Division of Neuroscience and Mental Health, Imperial College, London, UK
    Exp Neurol 222:120-4. 2010
  5. pmc Deep brain stimulation effects in dystonia: time course of electrophysiological changes in early treatment
    Diane Ruge
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 26:1913-21. 2011
  6. ncbi request reprint The phenomenon of disproportionate antecollis in Parkinson's disease and multiple system atrophy
    Bart P C van de Warrenburg
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 22:2325-31. 2007
  7. ncbi request reprint A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy
    Anette Schrag
    Institute of Neurology, University College London, London, UK
    Mov Disord 25:1077-81. 2010
  8. doi request reprint GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias
    Susanne A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, United Kingdom
    Mov Disord 24:1684-8. 2009
  9. ncbi request reprint Nonmotor symptoms in Parkin gene-related parkinsonism
    Georg Kägi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 25:1279-84. 2010
  10. doi request reprint Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Mov Disord 26:1997-2003. 2011

Detail Information

Publications50

  1. doi request reprint Are trials of intravascular infusions of autologous mesenchymal stem cells in patients with multiple system atrophy currently justified, and are they effective?
    N Quinn
    Institute of Neurology, Queen Square, London, UK
    Clin Pharmacol Ther 83:663-5. 2008
    ..We argue that it behooves us to first have robust preclinical experimental evidence before launching into such studies in humans, and to control as much as possible for confounding effects when such trials come to be performed...
  2. doi request reprint Tremor--some controversial aspects
    Niall P Quinn
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:18-23. 2011
    ..In addition, the notion of a separate disorder of benign tremulous parkinsonism (BTP) has been debated. This article gives a selective viewpoint on some areas of uncertainty and controversy in tremor...
  3. ncbi request reprint The natural history of Unverricht-Lundborg disease: a report of eight genetically proven cases
    Nee K Chew
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:107-13. 2008
    ..The clinical phenotypes associated with ULD are more diverse than previously recognized and even though the long term functional outcome and survival have improved, the overall efficacy of antimyoclonic drugs remains unsatisfactory...
  4. doi request reprint In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study
    Nicola Pavese
    MRC Clinical Science Centre and Division of Neuroscience and Mental Health, Imperial College, London, UK
    Exp Neurol 222:120-4. 2010
    ..These findings suggest that parkin patients and IPD patients with similar striatal dysfunction have different patterns of monoaminergic involvement, with more widespread dysfunction in IPD...
  5. pmc Deep brain stimulation effects in dystonia: time course of electrophysiological changes in early treatment
    Diane Ruge
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 26:1913-21. 2011
    ..Clinical benefit is delayed because engrams of abnormal movement persist and take time to normalize. Our observations suggest that plasticity may be a driver of long-term therapeutic effects of deep brain stimulation in dystonia...
  6. ncbi request reprint The phenomenon of disproportionate antecollis in Parkinson's disease and multiple system atrophy
    Bart P C van de Warrenburg
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 22:2325-31. 2007
    ..However, a primary but yet unexplained neck extensor myopathy still remains the alternative possibility and longitudinal studies are necessary to settle this issue...
  7. ncbi request reprint A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy
    Anette Schrag
    Institute of Neurology, University College London, London, UK
    Mov Disord 25:1077-81. 2010
    ..Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP...
  8. doi request reprint GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias
    Susanne A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, United Kingdom
    Mov Disord 24:1684-8. 2009
    ..Brain MRI showed cerebellar atrophy in one case. Mutations in GLUT1 are one cause of apparently sporadic PED. The detection of this has important implications for treatment as ketogenic diet has been reported to be beneficial...
  9. ncbi request reprint Nonmotor symptoms in Parkin gene-related parkinsonism
    Georg Kägi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 25:1279-84. 2010
    ..The data are in keeping with a different pathological disease process in Parkin gene-related parkinsonism...
  10. doi request reprint Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Mov Disord 26:1997-2003. 2011
    ..Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias...
  11. doi request reprint Antineuronal antibodies in Parkinson's disease
    Bart P C van de Warrenburg
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 23:958-63. 2008
    ..We conclude that ANAs do not play a role in the majority of patients with IPD, but might be relevant in the pathogenesis of IPD with atypical features...
  12. doi request reprint Quality of life in Parkinson's disease: the relative importance of the symptoms
    Shibley Rahman
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London, United Kingdom
    Mov Disord 23:1428-34. 2008
    ..The implications of these results for the medical management of PD are discussed...
  13. doi request reprint Unusual familial presentation of epsilon-sarcoglycan gene mutation with falls and writer's cramp
    Vasiliki Koukouni
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 23:1913-5. 2008
    ..Leg involvement is less frequent, and to our knowledge, initial presentation with falls has not previously been described. The unusual phenotype of the family is discussed...
  14. ncbi request reprint Paroxysmal dyskinesia with interictal myoclonus and dystonia: a report of two cases
    Elisa De Grandis
    Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Parkinsonism Relat Disord 14:250-2. 2008
    ..This previously unreported association highlights the heterogeneity of paroxysmal movement disorders...
  15. ncbi request reprint ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation
    Susanne A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 25:979-84. 2010
    ..KRD should be considered in patients with dystonia-parkinsonism with iron on brain imaging and we suggest classifying as NBIA type 3...
  16. doi request reprint "Atypical" atypical parkinsonism: new genetic conditions presenting with features of progressive supranuclear palsy, corticobasal degeneration, or multiple system atrophy-a diagnostic guide
    Maria Stamelou
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK
    Mov Disord 28:1184-99. 2013
    ..The correct identification of these patients has important clinical, therapeutic, and research implications. © 2013 Movement Disorder Society. ..
  17. doi request reprint A validation exercise on the new consensus criteria for multiple system atrophy
    Yasushi Osaki
    National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Mov Disord 24:2272-6. 2009
    ..Prospective clinicopathological validation studies of the new consensus criteria, particularly incorporating in vivo structural and functional imaging results, are required to extend the current findings...
  18. ncbi request reprint Rate of clinical progression in Parkinson's disease. A prospective study
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free Hospital, University College London, London, United Kingdom
    Mov Disord 22:938-45. 2007
    ..However, disability continues to deteriorate with advancing disease and with the development of disease complications that are likely to be related to additional extrastriatal pathology...
  19. ncbi request reprint Measuring health-related quality of life in patients with progressive supranuclear palsy
    A Schrag
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, Sobell Department of Motor Neuroscience and Movement Disorders, London, UK a
    Neurocase 11:246-9. 2005
    ..The psychometric properties of this questionnaire are undergoing further evaluation...
  20. pmc Effect of electrode contact location on clinical efficacy of pallidal deep brain stimulation in primary generalised dystonia
    S Tisch
    Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, University College London, Box 146, 8 11 Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 78:1314-9. 2007
    ..To determine the effect of electrode contact location on efficacy of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for primary generalised dystonia (PGD). Subjects and..
  21. ncbi request reprint Testing the validity of the PDQ-39 in patients with MSA
    A Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London NW3 2PF, UK
    Parkinsonism Relat Disord 13:152-6. 2007
    ..However, many of the specific features of MSA are not reflected in the PDQ-39. Higher order factor analysis did not support the use of a single summary index. We conclude that the PDQ-39 has only limited validity in patients with MSA...
  22. ncbi request reprint Measuring quality of life in PSP: the PSP-QoL
    A Schrag
    Royal Free and University College Medical School, Department of Clinical Neurosciences, Institute of Neurology, University College London, UK
    Neurology 67:39-44. 2006
    ..To develop a new patient-reported outcome measure for progressive supranuclear palsy (PSP) and to test its psychometric properties...
  23. ncbi request reprint NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom
    Mov Disord 21:1960-3. 2006
    ..Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population...
  24. ncbi request reprint Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years
    Marwan I Hariz
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:416-21. 2008
    ..When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline...
  25. ncbi request reprint Primary lateral sclerosis mimicking atypical parkinsonism
    Ibrahim M Norlinah
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 22:2057-62. 2007
    ..However, the absence of fatiguing and decrement on repeated finger/foot tapping should help to distinguish these patients from the true atypical parkinsonian syndromes...
  26. ncbi request reprint Blepharospasm and limb dystonia caused by Mohr-Tranebjaerg syndrome with a novel splice-site mutation in the deafness/dystonia peptide gene
    Hee T Kim
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 22:1328-31. 2007
    ..This case, and a review of previously reported cases, highlights a variety of potential diagnostic pitfalls in this condition...
  27. ncbi request reprint The entity of young onset primary cervical dystonia
    Vasiliki Koukouni
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 22:843-7. 2007
    ..74% responded favorably to botulinum toxin injections, whereas none of the 13 patients treated with L-Dopa preparations had a beneficial response. The distinctive features of this entity are discussed...
  28. ncbi request reprint Atypical movement disorders in antiphospholipid syndrome
    Davide Martino
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 21:944-9. 2006
    ..Movement disorders in APS seem more clinically heterogeneous than previously thought. Oral anticoagulation should be considered in the treatment of movement disorders associated with APS...
  29. doi request reprint Reckless generosity in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 25:221-3. 2010
    ..We describe another, potentially related phenomenon putatively associated with the use of dopamine agonists in 3 patients with PD, characterized by excessive and inappropriate philanthropy...
  30. ncbi request reprint UCHL-1 is not a Parkinson's disease susceptibility gene
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 59:627-33. 2006
    ..The strongest evidence comes from a meta-analysis of small studies that reported the S18Y polymorphism as protective against PD, after pooling studies of white and Asian subjects. Here, we present data that challenge this association...
  31. ncbi request reprint Upregulation of dopamine D2 receptors in dopaminergic drug-naive patients with Parkin gene mutations
    Christoph Scherfler
    MRC Clinical Science Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 21:783-8. 2006
    ..Parkin-positive patients appear to have a greater susceptibility to the exposure to dopaminergic medication than IPD patients, which in turn might be an indirect effect of their genetic mutation...
  32. ncbi request reprint Adult-onset primary lower limb dystonia
    Susanne A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 21:767-71. 2006
    ..In this series of patients, the diagnosis was often not recognized, leading to extensive and unnecessary testing and treatment and emphasizing the need for wider recognition...
  33. ncbi request reprint The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 56:329-35. 2004
    ....
  34. ncbi request reprint Pallidotomy and incidental sequence learning in Parkinson's disease
    Richard G Brown
    Department of Psychology, PO77, Institute of Psychiatry, King s College, De Crespigny Park, London, UK
    Neuroreport 14:21-4. 2003
    ..Research on Parkinson's disease patients undergoing functional basal ganglia surgery may shed further light on the mechanisms and neuronal substrate of serial order learning in humans...
  35. ncbi request reprint Tau exon 10 +16 mutation FTDP-17 presenting clinically as sporadic young onset PSP
    H R Morris
    National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neurology 61:102-4. 2003
    ..An age at onset younger than 50 years combined with the absence of early falls may indicate the possibility of a tau mutation in clinically diagnosed PSP...
  36. ncbi request reprint Factors affecting the clinical outcome after neural transplantation in Parkinson's disease
    Paola Piccini
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Brain 128:2977-86. 2005
    ..Finally, our data provide evidence that long-term immunosuppression can be withdrawn without interfering with graft survival or the motor recovery induced by transplantation...
  37. ncbi request reprint A common LRRK2 mutation in idiopathic Parkinson's disease
    William P Gilks
    Department of Molecular Neuroscience, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Lancet 365:415-6. 2005
    ..We suggest that testing for this mutation will be important in the management and genetic counselling of patients with Parkinson's disease...
  38. ncbi request reprint Adult-onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodies
    Mark J Edwards
    Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Mov Disord 19:1190-6. 2004
    ..We suggest that there might be a causal relationship between ABGA and the clinical syndrome in these cases and that ABGA should be considered as a possible etiology for adult-onset tics...
  39. ncbi request reprint Occupational therapy in multiple system atrophy: a pilot randomized controlled trial
    Shilpa Jain
    National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Mov Disord 19:1360-4. 2004
    ..An occupational therapy program may improve functional abilities in patients with mild to moderate MSA. A larger multicenter study is needed...
  40. ncbi request reprint Do published criteria improve clinical diagnostic accuracy in multiple system atrophy?
    Y Osaki
    National Hospital for Neurology and Nuerosurgery, London, UK
    Neurology 59:1486-91. 2002
    ..To assess the accuracy of a clinical diagnosis of multiple system atrophy (MSA) and compare it to the Quinn and Consensus criteria for MSA using neuropathologically examined cases from the Queen Square Brain Bank for Neurological Disorders...
  41. ncbi request reprint Severe tongue protrusion dystonia: clinical syndromes and possible treatment
    S A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London WC1N 3BG, UK
    Neurology 67:940-3. 2006
    ..Tongue protrusion dystonia is often unresponsive to oral drugs but may benefit from botulinum toxin injections into the genioglossus muscle. Bilateral deep brain pallidal stimulation was beneficial in two cases...
  42. ncbi request reprint Quality of life in patients with orthostatic tremor
    W Gerschlager
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 250:212-5. 2003
    ..The BDI score correlated significantly with several SF-36 subscores. We conclude that OT strongly impacts on QoL. The results highlight the importance of recognizing and treating depression in patients with OT...
  43. ncbi request reprint [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
    A Gerhard
    MRC Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurology 61:686-9. 2003
    ..Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA...
  44. pmc Sequence analysis of tau in familial and sporadic progressive supranuclear palsy
    H R Morris
    University Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1NBG, UK
    J Neurol Neurosurg Psychiatry 72:388-90. 2002
    ..This suggests that usually FTDP-17 and PSP, including the rare familial form of PSP, are likely to be separate conditions and that usually PSP and typical PSP-like syndromes are not due to mutations in tau...
  45. pmc The alpha-synuclein gene in multiple system atrophy
    T Ozawa
    Department of Molecular Neuroscience, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 77:464-7. 2006
    ..The formation of alpha-synuclein aggregates may be a critical event in the pathogenesis of multiple system atrophy (MSA). However, the role of this gene in the aetiology of MSA is unknown and untested...
  46. ncbi request reprint Fourteen-year final report of the randomized PDRG-UK trial comparing three initial treatments in PD
    R Katzenschlager
    National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neurology 71:474-80. 2008
    ..Increased mortality in patients on selegiline combined with l-dopa led to premature termination of this arm after 6 years...
  47. pmc Second consensus statement on the diagnosis of multiple system atrophy
    S Gilman
    Department of Neurology, University of Michigan, 300 N Ingalls St, 3D15, Ann Arbor, MI 48109 5489, USA
    Neurology 71:670-6. 2008
    ..Since then, clinical, laboratory, neuropathologic, and imaging studies have advanced the field, requiring a fresh evaluation of diagnostic criteria. We held a second consensus conference in 2007 and present the results here...
  48. ncbi request reprint The epsilon-sarcoglycan gene in myoclonic syndromes
    E M Valente
    IRCCS CSS, San Giovanni Rotondo and CSS Mendel Institute, Rome, Italy
    Neurology 64:737-9. 2005
    ..We found mutations (three of them novel) in six (21%) of the 29 patients with essential myoclonus and myoclonic dystonia, but did not find mutations in the 29 patients with other phenotypes...
  49. pmc Parkinsonism following bilateral lesions of the globus pallidus: performance on a variety of motor tasks shows similarities with Parkinson's disease
    M Kuoppamaki
    Departmernt of Neurology, Satakunta General Hospital and Satakunnan Neurologipalvelu Oy, Pori, Finland
    J Neurol Neurosurg Psychiatry 76:482-90. 2005
    ....
  50. ncbi request reprint The European Multiple System Atrophy-Study Group (EMSA-SG)
    F Geser
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    J Neural Transm 112:1677-86. 2005
    ..Indeed, a trial on growth hormone in MSA has just been completed, and another on minocycline will be completed by the end of this year...